Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	161.0	14194.0	88.0	-0.71	0.075	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by the Hedgehog family	143.0	7466.0	52.0	-0.438	0.23	1000.0	-1000.0	-0.038	-1000.0
Endothelins	93.0	8967.0	96.0	-0.377	0.106	1000.0	-1000.0	-0.054	-1000.0
Fc-epsilon receptor I signaling in mast cells	67.0	6585.0	97.0	-0.145	0.023	1000.0	-1000.0	-0.059	-1000.0
Thromboxane A2 receptor signaling	61.0	6430.0	105.0	-0.201	0.055	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	59.0	5438.0	91.0	-0.806	0.486	1000.0	-1000.0	-0.116	-1000.0
Aurora B signaling	59.0	3953.0	67.0	-0.297	0.286	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-alpha and p38-beta	56.0	2486.0	44.0	-0.106	0.022	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	55.0	4536.0	82.0	-0.501	0.035	1000.0	-1000.0	-0.04	-1000.0
TCGA08_retinoblastoma	55.0	443.0	8.0	-0.01	0.096	1000.0	-1000.0	-0.002	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	52.0	2722.0	52.0	-0.261	0.048	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	50.0	353.0	7.0	-0.0	0.151	1000.0	-1000.0	-0.013	-1000.0
Signaling events regulated by Ret tyrosine kinase	41.0	3427.0	82.0	-0.111	0.055	1000.0	-1000.0	-0.061	-1000.0
Nongenotropic Androgen signaling	38.0	1980.0	52.0	-0.112	0.075	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	2964.0	78.0	-0.155	0.05	1000.0	-1000.0	-0.049	-1000.0
BMP receptor signaling	37.0	3077.0	81.0	-0.274	0.148	1000.0	-1000.0	-0.044	-1000.0
Integrins in angiogenesis	35.0	2952.0	84.0	-0.331	0.127	1000.0	-1000.0	-0.044	-1000.0
Calcium signaling in the CD4+ TCR pathway	35.0	1112.0	31.0	-0.171	0.024	1000.0	-1000.0	-0.039	-1000.0
Arf6 signaling events	33.0	2075.0	62.0	-0.135	0.043	1000.0	-1000.0	-0.041	-1000.0
PLK1 signaling events	33.0	2828.0	85.0	-0.027	0.156	1000.0	-1000.0	-0.025	-1000.0
Canonical Wnt signaling pathway	30.0	1544.0	51.0	-0.337	0.155	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	29.0	3720.0	125.0	-0.13	0.051	1000.0	-1000.0	-0.052	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	28.0	1962.0	68.0	-0.182	0.04	1000.0	-1000.0	-0.072	-1000.0
Presenilin action in Notch and Wnt signaling	27.0	1653.0	61.0	-0.338	0.155	1000.0	-1000.0	-0.041	-1000.0
Reelin signaling pathway	27.0	1556.0	56.0	-0.068	0.059	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	27.0	108.0	4.0	0.028	0.057	1000.0	-1000.0	0.013	-1000.0
IL6-mediated signaling events	27.0	2071.0	75.0	-0.461	0.048	1000.0	-1000.0	-0.066	-1000.0
Coregulation of Androgen receptor activity	26.0	1978.0	76.0	-0.324	0.095	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	25.0	967.0	38.0	-0.04	0.126	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	25.0	893.0	35.0	-0.244	0.056	1000.0	-1000.0	-0.027	-1000.0
FOXM1 transcription factor network	25.0	1316.0	51.0	0.022	0.35	1000.0	-1000.0	-0.122	-1000.0
LPA4-mediated signaling events	24.0	289.0	12.0	-0.098	-0.0	1000.0	-1000.0	-0.025	-1000.0
IL23-mediated signaling events	24.0	1481.0	60.0	-0.196	0.023	1000.0	-1000.0	-0.115	-1000.0
HIF-1-alpha transcription factor network	23.0	1750.0	76.0	-0.108	0.138	1000.0	-1000.0	-0.109	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	23.0	2025.0	85.0	-0.103	0.031	1000.0	-1000.0	-0.044	-1000.0
FOXA2 and FOXA3 transcription factor networks	23.0	1084.0	46.0	-0.69	0.106	1000.0	-1000.0	-0.115	-1000.0
TCR signaling in naïve CD8+ T cells	23.0	2153.0	93.0	-0.06	0.032	1000.0	-1000.0	-0.048	-1000.0
Plasma membrane estrogen receptor signaling	23.0	1997.0	86.0	-0.11	0.038	1000.0	-1000.0	-0.052	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	760.0	33.0	-0.164	0.095	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	23.0	1615.0	70.0	-0.352	0.144	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	22.0	2580.0	114.0	-0.326	0.074	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	21.0	1864.0	87.0	-0.176	0.044	1000.0	-1000.0	-0.078	-1000.0
Syndecan-1-mediated signaling events	21.0	734.0	34.0	-0.09	0.151	1000.0	-1000.0	-0.048	-1000.0
Nectin adhesion pathway	20.0	1292.0	63.0	-0.031	0.125	1000.0	-1000.0	-0.042	-1000.0
Wnt signaling	20.0	145.0	7.0	0.007	0.056	1000.0	-1000.0	-0.015	-1000.0
Caspase cascade in apoptosis	19.0	1408.0	74.0	-0.068	0.083	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	19.0	1351.0	69.0	-0.129	0.165	1000.0	-1000.0	-0.05	-1000.0
Glypican 1 network	19.0	950.0	48.0	-0.137	0.086	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	18.0	657.0	36.0	-0.105	0.022	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	18.0	863.0	47.0	-0.2	0.061	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	17.0	941.0	54.0	-0.068	0.072	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	17.0	2117.0	120.0	-0.14	0.06	1000.0	-1000.0	-0.046	-1000.0
TCGA08_p53	16.0	118.0	7.0	-0.03	0.022	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Rods	16.0	851.0	52.0	-0.04	0.093	1000.0	-1000.0	-0.036	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	251.0	17.0	-0.035	0.032	1000.0	-1000.0	-0.035	-1000.0
p75(NTR)-mediated signaling	14.0	1821.0	125.0	-0.049	0.147	1000.0	-1000.0	-0.075	-1000.0
PDGFR-alpha signaling pathway	14.0	627.0	44.0	-0.13	0.046	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	240.0	17.0	-0.017	0.031	1000.0	-1000.0	-0.025	-1000.0
Noncanonical Wnt signaling pathway	13.0	362.0	26.0	-0.052	0.056	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PTP1B	13.0	1028.0	76.0	-0.047	0.057	1000.0	-1000.0	-0.036	-1000.0
Effects of Botulinum toxin	13.0	338.0	26.0	-0.036	0.03	1000.0	-1000.0	-0.017	-1000.0
BCR signaling pathway	13.0	1340.0	99.0	-0.089	0.053	1000.0	-1000.0	-0.053	-1000.0
S1P4 pathway	13.0	331.0	25.0	-0.029	0.032	1000.0	-1000.0	-0.026	-1000.0
Osteopontin-mediated events	12.0	473.0	38.0	-0.047	0.13	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	12.0	734.0	60.0	-0.04	0.206	1000.0	-1000.0	-0.027	-1000.0
Ephrin B reverse signaling	12.0	604.0	48.0	-0.058	0.063	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	12.0	266.0	21.0	-0.025	0.049	1000.0	-1000.0	-0.044	-1000.0
Regulation of nuclear SMAD2/3 signaling	11.0	1515.0	136.0	-0.204	0.145	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	320.0	28.0	-0.11	0.043	1000.0	-1000.0	-0.031	-1000.0
Hedgehog signaling events mediated by Gli proteins	11.0	753.0	65.0	-0.519	0.055	1000.0	-1000.0	-0.039	-1000.0
mTOR signaling pathway	11.0	589.0	53.0	-0.018	0.092	1000.0	-1000.0	-0.039	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	848.0	74.0	-0.138	0.049	1000.0	-1000.0	-0.071	-1000.0
HIF-2-alpha transcription factor network	10.0	464.0	43.0	-0.072	0.074	1000.0	-1000.0	-0.062	-1000.0
Syndecan-4-mediated signaling events	10.0	692.0	67.0	-0.032	0.086	1000.0	-1000.0	-0.043	-1000.0
Syndecan-2-mediated signaling events	9.0	677.0	69.0	-0.034	0.086	1000.0	-1000.0	-0.041	-1000.0
Cellular roles of Anthrax toxin	9.0	351.0	39.0	-0.06	0.023	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	9.0	522.0	58.0	-0.155	0.045	1000.0	-1000.0	-0.036	-1000.0
LPA receptor mediated events	9.0	947.0	102.0	-0.061	0.041	1000.0	-1000.0	-0.055	-1000.0
ErbB2/ErbB3 signaling events	8.0	552.0	65.0	-0.038	0.033	1000.0	-1000.0	-0.058	-1000.0
IL2 signaling events mediated by PI3K	8.0	466.0	58.0	-0.02	0.117	1000.0	-1000.0	-0.038	-1000.0
EPHB forward signaling	8.0	685.0	85.0	-0.043	0.072	1000.0	-1000.0	-0.069	-1000.0
Regulation of p38-alpha and p38-beta	8.0	435.0	54.0	-0.043	0.053	1000.0	-1000.0	-0.046	-1000.0
IL27-mediated signaling events	8.0	446.0	51.0	-0.068	0.029	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	8.0	182.0	22.0	0.004	0.076	1000.0	-1000.0	-0.039	-1000.0
IGF1 pathway	8.0	459.0	57.0	-0.055	0.058	1000.0	-1000.0	-0.053	-1000.0
PDGFR-beta signaling pathway	8.0	808.0	97.0	-0.046	0.066	1000.0	-1000.0	-0.057	-1000.0
TCGA08_rtk_signaling	7.0	196.0	26.0	-0.064	0.081	1000.0	-1000.0	-0.016	-1000.0
Insulin Pathway	7.0	525.0	74.0	-0.089	0.06	1000.0	-1000.0	-0.061	-1000.0
IFN-gamma pathway	6.0	444.0	68.0	-0.027	0.066	1000.0	-1000.0	-0.057	-1000.0
Ceramide signaling pathway	6.0	522.0	76.0	-0.012	0.06	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	561.0	83.0	-0.067	0.041	1000.0	-1000.0	-0.039	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	306.0	45.0	-0.019	0.051	1000.0	-1000.0	-0.051	-1000.0
Class I PI3K signaling events	6.0	467.0	73.0	-0.029	0.042	1000.0	-1000.0	-0.044	-1000.0
S1P3 pathway	6.0	274.0	42.0	-0.11	0.043	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PRL	6.0	229.0	34.0	-0.036	0.064	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in keratinocytes	6.0	260.0	43.0	-0.05	0.063	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	171.0	34.0	-0.032	0.051	1000.0	-1000.0	-0.033	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.011	0.03	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	5.0	276.0	55.0	-0.011	0.06	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class III	5.0	203.0	40.0	-0.079	0.042	1000.0	-1000.0	-0.031	-1000.0
TRAIL signaling pathway	5.0	263.0	48.0	-0.037	0.059	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	5.0	273.0	49.0	-0.0	0.033	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class I	5.0	533.0	104.0	-0.043	0.055	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class II	4.0	307.0	75.0	-0.034	0.056	1000.0	-1000.0	-0.036	-1000.0
BARD1 signaling events	4.0	244.0	57.0	-0.042	0.089	1000.0	-1000.0	-0.037	-1000.0
IL1-mediated signaling events	4.0	268.0	62.0	-0.02	0.041	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	4.0	258.0	64.0	-0.022	0.072	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	325.0	76.0	-0.013	0.06	1000.0	-1000.0	-0.061	-1000.0
VEGFR1 specific signals	4.0	266.0	56.0	-0.13	0.056	1000.0	-1000.0	-0.048	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	17.0	5.0	0.017	0.028	1000.0	-1000.0	0.007	-1000.0
Insulin-mediated glucose transport	3.0	97.0	32.0	-0.009	0.043	1000.0	-1000.0	-0.031	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	124.0	37.0	-0.013	0.052	1000.0	-1000.0	-0.032	-1000.0
Regulation of Telomerase	3.0	374.0	102.0	-0.041	0.068	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	3.0	149.0	44.0	-0.003	0.054	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	2.0	102.0	39.0	-0.006	0.046	1000.0	-1000.0	-0.03	-1000.0
Arf6 downstream pathway	2.0	115.0	43.0	-0.045	0.046	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	155.0	68.0	-0.034	0.048	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	98.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.038	-1000.0
Arf6 trafficking events	2.0	196.0	71.0	-0.055	0.04	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	1.0	29.0	22.0	-0.006	0.048	1000.0	-1000.0	-0.034	-1000.0
S1P5 pathway	1.0	32.0	17.0	-0.015	0.03	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	27.0	15.0	-0.011	0.022	1000.0	-1000.0	-0.031	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.011	0.024	1000.0	-1000.0	-0.012	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.021	0.021	1000.0	-1000.0	-0.008	-1000.0
Arf1 pathway	1.0	71.0	54.0	-0.005	0.031	1000.0	-1000.0	-0.019	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	0.003	0.042	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	-0.01	0.022	1000.0	-1000.0	-0.032	-1000.0
Atypical NF-kappaB pathway	0.0	13.0	31.0	-0.008	0.023	1000.0	-1000.0	-0.029	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.01	0.053	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.021	0.042	1000.0	-1000.0	0.01	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.06	1000.0	-1000.0	0.0	-1000.0
Total	2465	159775	7203	-14.2962428751	9.53910428448	131000	-131000	-5.41761685503	-131000