E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.023 0.134 -9999.0 0.0 -0.397 14.0 14.0 KLHL20 -0.007 0.107 0.205 1.0 -0.306 9.0 10.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.511 1.0 1.0 Rac1/GDP 0.001 0.103 0.248 1.0 -0.28 6.0 7.0 ENAH -0.023 0.139 -9999.0 0.0 -0.403 15.0 15.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.062 -9999.0 0.0 -0.511 2.0 2.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.075 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.031 0.058 -9999.0 0.0 -0.2 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.082 -9999.0 0.0 -0.289 7.0 7.0 RAPGEF1 -0.015 0.123 -9999.0 0.0 -0.384 10.0 10.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.511 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.146 -9999.0 0.0 -0.412 15.0 15.0 CRK -0.016 0.129 -9999.0 0.0 -0.389 13.0 13.0 E-cadherin/gamma catenin/alpha catenin 0.017 0.124 -9999.0 0.0 -0.335 16.0 16.0 alphaE/beta7 Integrin 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.047 -9999.0 0.0 -0.511 1.0 1.0 Rap1/GTP/I-afadin 0.051 0.044 -9999.0 0.0 -0.289 2.0 2.0 DLG1 -0.018 0.108 -9999.0 0.0 -0.366 11.0 11.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.043 -9999.0 0.0 -0.253 2.0 2.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.053 0.044 -9999.0 0.0 -0.289 2.0 2.0 PI3K -0.01 0.057 -9999.0 0.0 -0.333 2.0 2.0 ARF6 0.024 0.062 -9999.0 0.0 -0.511 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.002 0.136 -9999.0 0.0 -0.391 16.0 16.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.039 0.096 -9999.0 0.0 -0.272 12.0 12.0 AKT1 0.005 0.054 0.155 1.0 -0.209 4.0 5.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.511 5.0 5.0 CDH1 0.005 0.113 -9999.0 0.0 -0.511 7.0 7.0 RhoA/GDP 0.006 0.101 0.25 1.0 -0.279 5.0 6.0 actin cytoskeleton organization -0.002 0.079 0.156 2.0 -0.223 8.0 10.0 CDC42/GDP 0.003 0.103 0.25 1.0 -0.283 5.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.102 -9999.0 0.0 -0.268 20.0 20.0 ITGB7 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.043 0.102 -9999.0 0.0 -0.289 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.071 -9999.0 0.0 -0.269 7.0 7.0 mol:GDP -0.014 0.109 0.251 1.0 -0.319 7.0 8.0 CDC42/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.004 0.134 -9999.0 0.0 -0.511 10.0 10.0 p120 catenin/RhoA/GDP 0.008 0.111 0.257 1.0 -0.289 4.0 5.0 RAC1/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.037 -9999.0 0.0 -0.372 1.0 1.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.076 0.13 1.0 -0.228 12.0 13.0 NME1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.025 0.14 -9999.0 0.0 -0.403 15.0 15.0 regulation of cell-cell adhesion -0.0 0.061 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.003 0.046 -9999.0 0.0 -0.14 6.0 6.0 Rap1/GTP 0.01 0.083 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.042 0.121 -9999.0 0.0 -0.29 16.0 16.0 CCND1 -0.011 0.093 0.149 1.0 -0.286 12.0 13.0 VAV2 -0.04 0.225 -9999.0 0.0 -0.667 12.0 12.0 RAP1/GDP 0.013 0.093 0.265 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.024 0.136 -9999.0 0.0 -0.391 15.0 15.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.045 -9999.0 0.0 -0.511 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.024 0.111 -9999.0 0.0 -0.279 16.0 16.0 E-cadherin/beta catenin -0.004 0.083 -9999.0 0.0 -0.349 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.026 0.139 -9999.0 0.0 -0.403 15.0 15.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.511 2.0 2.0 Rac1/GTP -0.062 0.154 -9999.0 0.0 -0.494 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.039 0.082 -9999.0 0.0 -0.316 7.0 7.0 ITGAE 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.149 -9999.0 0.0 -0.421 15.0 15.0