Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.276 -9999.0 0.0 -0.568 42.0 42.0 IHH -0.015 0.089 -9999.0 0.0 -0.538 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.045 0.144 -9999.0 0.0 -0.323 30.0 30.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.143 0.321 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.115 0.235 -9999.0 0.0 -0.595 19.0 19.0 SMO -0.13 0.239 -9999.0 0.0 -0.611 20.0 20.0 AKT1 -0.093 0.212 -9999.0 0.0 -0.701 13.0 13.0 ARRB2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.235 -9999.0 0.0 -0.6 20.0 20.0 STIL -0.077 0.157 -9999.0 0.0 -0.458 11.0 11.0 DHH N/PTCH2 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.444 6.0 6.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.511 2.0 2.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.249 0.45 -9999.0 0.0 -0.959 43.0 43.0 determination of left/right symmetry -0.128 0.235 -9999.0 0.0 -0.6 20.0 20.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.511 5.0 5.0 skeletal system development -0.246 0.444 -9999.0 0.0 -0.945 43.0 43.0 IHH N/Hhip -0.055 0.157 -9999.0 0.0 -0.423 21.0 21.0 DHH N/Hhip -0.024 0.136 -9999.0 0.0 -0.372 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.235 -9999.0 0.0 -0.6 20.0 20.0 pancreas development -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0 HHAT -0.007 0.14 -9999.0 0.0 -0.511 11.0 11.0 PI3K 0.003 0.075 -9999.0 0.0 -0.372 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.057 0.188 -9999.0 0.0 -0.511 22.0 22.0 somite specification -0.128 0.235 -9999.0 0.0 -0.6 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.455 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.007 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.091 -9999.0 0.0 -0.294 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.372 12.0 12.0 catabolic process -0.07 0.173 -9999.0 0.0 -0.337 43.0 43.0 SMO/Vitamin D3 -0.103 0.204 -9999.0 0.0 -0.529 18.0 18.0 SHH Np/Cholesterol/Hhip -0.044 0.127 -9999.0 0.0 -0.298 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.511 1.0 1.0 receptor-mediated endocytosis -0.102 0.195 -9999.0 0.0 -0.507 18.0 18.0 SHH Np/Cholesterol/BOC -0.001 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.087 -9999.0 0.0 -0.29 12.0 12.0 mesenchymal cell differentiation 0.044 0.127 0.296 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.07 0.163 -9999.0 0.0 -0.456 11.0 11.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.325 1.0 1.0 CDON 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.34 43.0 43.0 Megalin/LRPAP1 0.034 0.044 -9999.0 0.0 -0.372 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.005 0.082 -9999.0 0.0 -0.286 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.338 43.0 43.0 HHIP -0.058 0.179 -9999.0 0.0 -0.511 20.0 20.0