Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.112 -9999.0 0.0 -0.292 18.0 18.0 epithelial cell differentiation 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.511 1.0 1.0 ENAH -0.015 0.107 0.282 2.0 -0.332 6.0 8.0 EGFR -0.033 0.17 -9999.0 0.0 -0.511 17.0 17.0 EPHA2 -0.015 0.146 -9999.0 0.0 -0.511 12.0 12.0 MYO6 -0.01 0.095 0.358 1.0 -0.284 14.0 15.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.051 -9999.0 0.0 -0.318 2.0 2.0 AQP5 -0.063 0.173 -9999.0 0.0 -0.478 20.0 20.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.511 5.0 5.0 mol:PI-4-5-P2 -0.006 0.083 0.356 1.0 -0.256 13.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.107 0.356 1.0 -0.284 19.0 20.0 EGF -0.032 0.151 -9999.0 0.0 -0.511 13.0 13.0 NCKAP1 0.025 0.047 -9999.0 0.0 -0.511 1.0 1.0 AQP3 -0.099 0.194 -9999.0 0.0 -0.475 29.0 29.0 cortical microtubule organization 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 GO:0000145 -0.025 0.074 0.342 1.0 -0.245 13.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.096 -9999.0 0.0 -0.272 12.0 12.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.055 0.111 -9999.0 0.0 -0.427 8.0 8.0 ARF6 0.024 0.062 -9999.0 0.0 -0.511 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.023 0.123 -9999.0 0.0 -0.356 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.059 -9999.0 0.0 -0.274 1.0 1.0 PVRL2 0.027 0.045 -9999.0 0.0 -0.511 1.0 1.0 ZYX -0.012 0.081 -9999.0 0.0 -0.26 14.0 14.0 ARF6/GTP 0.023 0.13 -9999.0 0.0 -0.346 13.0 13.0 CDH1 0.005 0.113 -9999.0 0.0 -0.511 7.0 7.0 EGFR/EGFR/EGF/EGF -0.043 0.155 -9999.0 0.0 -0.319 32.0 32.0 RhoA/GDP 0.036 0.09 -9999.0 0.0 -0.256 12.0 12.0 actin cytoskeleton organization -0.034 0.094 -9999.0 0.0 -0.324 11.0 11.0 IGF-1R heterotetramer -0.008 0.14 -9999.0 0.0 -0.51 11.0 11.0 GIT1 0.024 0.062 -9999.0 0.0 -0.511 2.0 2.0 IGF1R -0.008 0.14 -9999.0 0.0 -0.511 11.0 11.0 IGF1 -0.049 0.181 -9999.0 0.0 -0.511 20.0 20.0 DIAPH1 0.013 0.172 -9999.0 0.0 -0.62 6.0 6.0 Wnt receptor signaling pathway -0.034 0.093 0.27 12.0 -9999.0 0.0 12.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.103 -9999.0 0.0 -0.418 7.0 7.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.035 0.097 -9999.0 0.0 -0.332 11.0 11.0 EFNA1 0.019 0.076 -9999.0 0.0 -0.511 3.0 3.0 LPP -0.02 0.065 0.351 1.0 -0.257 8.0 9.0 Ephrin A1/EPHA2 -0.001 0.13 -9999.0 0.0 -0.308 20.0 20.0 SEC6/SEC8 -0.007 0.067 -9999.0 0.0 -0.251 10.0 10.0 MGAT3 -0.025 0.108 0.358 1.0 -0.288 19.0 20.0 HGF/MET 0.021 0.094 -9999.0 0.0 -0.256 14.0 14.0 HGF 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.112 -9999.0 0.0 -0.295 18.0 18.0 actin cable formation 0.036 0.124 0.338 6.0 -0.287 5.0 11.0 KIAA1543 -0.024 0.073 0.345 1.0 -0.249 12.0 13.0 KIFC3 -0.003 0.079 0.358 1.0 -0.26 11.0 12.0 NCK1 0.02 0.062 -9999.0 0.0 -0.511 2.0 2.0 EXOC3 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.005 0.082 0.358 1.0 -0.263 12.0 13.0 NCK1/GIT1 0.027 0.068 -9999.0 0.0 -0.372 4.0 4.0 mol:GDP 0.034 0.093 -9999.0 0.0 -0.27 12.0 12.0 EXOC4 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.001 0.076 0.358 1.0 -0.26 10.0 11.0 PIP5K1C -0.007 0.084 0.358 1.0 -0.26 13.0 14.0 LIMA1 -0.0 0.128 -9999.0 0.0 -0.511 9.0 9.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.13 0.33 4.0 -0.39 6.0 10.0 adherens junction assembly -0.014 0.103 0.346 1.0 -0.485 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.039 0.149 -9999.0 0.0 -0.289 36.0 36.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.036 -9999.0 0.0 -0.372 1.0 1.0 MET 0.02 0.076 -9999.0 0.0 -0.511 3.0 3.0 PLEKHA7 -0.005 0.082 0.358 1.0 -0.261 12.0 13.0 mol:GTP 0.021 0.121 -9999.0 0.0 -0.353 12.0 12.0 establishment of epithelial cell apical/basal polarity 0.015 0.115 0.439 3.0 -0.292 1.0 4.0 cortical actin cytoskeleton stabilization -0.015 0.112 -9999.0 0.0 -0.292 18.0 18.0 regulation of cell-cell adhesion -0.034 0.094 -9999.0 0.0 -0.324 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.112 -9999.0 0.0 -0.295 18.0 18.0