E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.1 0.23 -9999.0 0.0 -0.467 10.0 10.0 KLHL20 -0.052 0.091 -9999.0 0.0 -0.345 2.0 2.0 CYFIP2 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 Rac1/GDP -0.033 0.15 -9999.0 0.0 -0.399 1.0 1.0 ENAH -0.108 0.23 -9999.0 0.0 -0.467 10.0 10.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.057 0.097 -9999.0 0.0 -0.371 1.0 1.0 ABI1/Sra1/Nap1 -0.038 0.067 -9999.0 0.0 -0.221 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.069 0.158 -9999.0 0.0 -0.307 11.0 11.0 RAPGEF1 -0.072 0.202 -9999.0 0.0 -0.395 10.0 10.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.11 0.236 -9999.0 0.0 -0.486 10.0 10.0 CRK -0.087 0.217 -9999.0 0.0 -0.433 10.0 10.0 E-cadherin/gamma catenin/alpha catenin -0.084 0.189 -9999.0 0.0 -0.377 10.0 10.0 alphaE/beta7 Integrin 0.009 0.071 -9999.0 0.0 -0.413 1.0 1.0 IQGAP1 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 NCKAP1 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 Rap1/GTP/I-afadin 0.017 0.056 -9999.0 0.0 -0.314 1.0 1.0 DLG1 -0.1 0.23 -9999.0 0.0 -0.467 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.042 0.07 -9999.0 0.0 -0.265 1.0 1.0 MLLT4 -0.002 0.097 -9999.0 0.0 -0.574 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.017 0.056 -9999.0 0.0 -0.315 1.0 1.0 PI3K -0.053 0.09 -9999.0 0.0 -0.35 1.0 1.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.11 0.217 -9999.0 0.0 -0.448 10.0 10.0 TIAM1 -0.002 0.097 -9999.0 0.0 -0.574 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.056 0.144 -9999.0 0.0 -0.289 10.0 10.0 AKT1 -0.03 0.051 -9999.0 0.0 -0.19 1.0 1.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.149 0.263 -9999.0 0.0 -0.573 10.0 10.0 RhoA/GDP -0.033 0.149 -9999.0 0.0 -0.396 1.0 1.0 actin cytoskeleton organization -0.006 0.084 -9999.0 0.0 -0.241 2.0 2.0 CDC42/GDP -0.033 0.149 -9999.0 0.0 -0.396 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.06 0.143 -9999.0 0.0 -0.281 10.0 10.0 ITGB7 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.06 0.153 -9999.0 0.0 -0.307 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.064 0.144 -9999.0 0.0 -0.296 10.0 10.0 mol:GDP -0.048 0.17 -9999.0 0.0 -0.398 2.0 2.0 CDC42/GTP/IQGAP1 0.009 0.061 -9999.0 0.0 -0.353 1.0 1.0 JUP -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 p120 catenin/RhoA/GDP -0.035 0.151 -9999.0 0.0 -0.405 1.0 1.0 RAC1/GTP/IQGAP1 0.009 0.061 -9999.0 0.0 -0.353 1.0 1.0 PIP5K1C/AP1M1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.083 -9999.0 0.0 -0.251 3.0 3.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.107 0.25 -9999.0 0.0 -0.492 10.0 10.0 regulation of cell-cell adhesion -0.051 0.085 -9999.0 0.0 -0.321 1.0 1.0 WASF2 -0.019 0.034 -9999.0 0.0 -0.139 1.0 1.0 Rap1/GTP -0.066 0.111 -9999.0 0.0 -0.43 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.066 0.168 -9999.0 0.0 -0.581 1.0 1.0 CCND1 -0.013 0.103 -9999.0 0.0 -0.318 3.0 3.0 VAV2 -0.081 0.215 -9999.0 0.0 -0.423 10.0 10.0 RAP1/GDP -0.028 0.138 -9999.0 0.0 -0.399 1.0 1.0 adherens junction assembly -0.102 0.241 -9999.0 0.0 -0.474 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.056 0.162 -9999.0 0.0 -0.554 1.0 1.0 E-cadherin/beta catenin -0.103 0.166 -9999.0 0.0 -0.37 10.0 10.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.1 0.23 -9999.0 0.0 -0.467 10.0 10.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.087 0.164 -9999.0 0.0 -0.648 2.0 2.0 E-cadherin/beta catenin/alpha catenin -0.076 0.167 -9999.0 0.0 -0.345 10.0 10.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.114 0.241 -9999.0 0.0 -0.498 10.0 10.0