Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.218 0.331 -9999.0 0.0 -0.632 12.0 12.0 IHH -0.083 0.148 -9999.0 0.0 -0.456 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.032 0.151 -9999.0 0.0 -0.442 4.0 4.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.032 0.149 0.438 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 -0.097 0.185 -9999.0 0.0 -0.501 4.0 4.0 SMO -0.109 0.194 -9999.0 0.0 -0.501 5.0 5.0 AKT1 -0.031 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.107 0.191 -9999.0 0.0 -0.494 5.0 5.0 STIL -0.115 0.195 -9999.0 0.0 -0.556 4.0 4.0 DHH N/PTCH2 -0.04 0.135 -9999.0 0.0 -0.341 6.0 6.0 DHH N/PTCH1 -0.12 0.205 -9999.0 0.0 -0.534 5.0 5.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.001 0.082 -9999.0 0.0 -0.487 1.0 1.0 PTHLH -0.231 0.367 -9999.0 0.0 -0.819 8.0 8.0 determination of left/right symmetry -0.107 0.191 -9999.0 0.0 -0.494 5.0 5.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.228 0.362 -9999.0 0.0 -0.808 8.0 8.0 IHH N/Hhip -0.231 0.229 -9999.0 0.0 -0.439 19.0 19.0 DHH N/Hhip -0.175 0.212 -9999.0 0.0 -0.393 17.0 17.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.107 0.191 -9999.0 0.0 -0.494 5.0 5.0 pancreas development -0.241 0.272 -9999.0 0.0 -0.527 17.0 17.0 HHAT -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 PI3K 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.035 0.162 -9999.0 0.0 -0.573 3.0 3.0 somite specification -0.107 0.191 -9999.0 0.0 -0.494 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.119 0.188 -9999.0 0.0 -0.457 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.044 0.118 -9999.0 0.0 -0.264 8.0 8.0 SHH Np/Cholesterol/Megalin -0.125 0.184 -9999.0 0.0 -0.326 15.0 15.0 SHH -0.017 0.105 -9999.0 0.0 -0.365 3.0 3.0 catabolic process -0.135 0.22 -9999.0 0.0 -0.63 4.0 4.0 SMO/Vitamin D3 -0.111 0.188 -9999.0 0.0 -0.51 4.0 4.0 SHH Np/Cholesterol/Hhip -0.148 0.188 -9999.0 0.0 -0.335 17.0 17.0 LRP2 -0.2 0.27 -9999.0 0.0 -0.536 14.0 14.0 receptor-mediated endocytosis -0.177 0.216 -9999.0 0.0 -0.532 7.0 7.0 SHH Np/Cholesterol/BOC -0.005 0.081 -9999.0 0.0 -0.273 3.0 3.0 SHH Np/Cholesterol/CDO -0.05 0.179 -9999.0 0.0 -0.478 5.0 5.0 mesenchymal cell differentiation 0.147 0.187 0.332 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.118 0.19 -9999.0 0.0 -0.458 6.0 6.0 IHH N/PTCH2 -0.085 0.163 -9999.0 0.0 -0.352 9.0 9.0 CDON -0.068 0.203 -9999.0 0.0 -0.573 5.0 5.0 IHH N/PTCH1 -0.135 0.222 -9999.0 0.0 -0.634 4.0 4.0 Megalin/LRPAP1 -0.136 0.198 -9999.0 0.0 -0.382 14.0 14.0 PTCH2 -0.056 0.173 -9999.0 0.0 -0.487 5.0 5.0 SHH Np/Cholesterol -0.013 0.081 -9999.0 0.0 -0.281 3.0 3.0 PTCH1 -0.135 0.221 -9999.0 0.0 -0.633 4.0 4.0 HHIP -0.242 0.272 -9999.0 0.0 -0.528 17.0 17.0