Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.046 0.124 -9999.0 0.0 -0.245 10.0 10.0 epithelial cell differentiation -0.058 0.142 -9999.0 0.0 -0.286 10.0 10.0 CYFIP2 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 ENAH -0.025 0.142 -9999.0 0.0 -0.378 3.0 3.0 EGFR -0.019 0.135 -9999.0 0.0 -0.573 2.0 2.0 EPHA2 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 MYO6 -0.055 0.138 -9999.0 0.0 -0.268 10.0 10.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.008 0.085 -9999.0 0.0 -0.345 2.0 2.0 AQP5 -0.15 0.205 -9999.0 0.0 -0.515 7.0 7.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.047 0.134 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.085 0.172 -9999.0 0.0 -0.395 4.0 4.0 EGF -0.091 0.214 -9999.0 0.0 -0.524 7.0 7.0 NCKAP1 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 AQP3 -0.106 0.151 -9999.0 0.0 -0.582 2.0 2.0 cortical microtubule organization -0.058 0.142 -9999.0 0.0 -0.286 10.0 10.0 GO:0000145 -0.046 0.128 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.056 0.144 -9999.0 0.0 -0.289 10.0 10.0 MLLT4 -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 ARF6/GDP -0.087 0.164 -9999.0 0.0 -0.543 3.0 3.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.001 0.13 -9999.0 0.0 -0.41 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.129 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.048 0.136 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.005 0.121 -9999.0 0.0 -0.57 1.0 1.0 CDH1 -0.149 0.263 -9999.0 0.0 -0.573 10.0 10.0 EGFR/EGFR/EGF/EGF -0.13 0.178 -9999.0 0.0 -0.672 2.0 2.0 RhoA/GDP -0.074 0.119 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.047 0.134 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.002 0.096 -9999.0 0.0 -0.572 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.002 0.097 -9999.0 0.0 -0.573 1.0 1.0 IGF1 -0.047 0.172 -9999.0 0.0 -0.53 4.0 4.0 DIAPH1 -0.04 0.175 -9999.0 0.0 -0.76 2.0 2.0 Wnt receptor signaling pathway 0.058 0.142 0.286 10.0 -9999.0 0.0 10.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.087 0.164 -9999.0 0.0 -0.543 3.0 3.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.048 0.137 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.035 0.162 -9999.0 0.0 -0.573 3.0 3.0 LPP -0.039 0.13 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.101 0.19 -9999.0 0.0 -0.627 3.0 3.0 SEC6/SEC8 -0.071 0.121 -9999.0 0.0 -0.494 1.0 1.0 MGAT3 -0.087 0.174 -9999.0 0.0 -0.402 4.0 4.0 HGF/MET -0.151 0.151 -9999.0 0.0 -0.538 2.0 2.0 HGF -0.14 0.249 -9999.0 0.0 -0.539 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.046 0.125 -9999.0 0.0 -0.247 10.0 10.0 actin cable formation -0.006 0.141 -9999.0 0.0 -0.411 2.0 2.0 KIAA1543 -0.1 0.208 -9999.0 0.0 -0.533 5.0 5.0 KIFC3 -0.048 0.136 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.136 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.058 0.142 -9999.0 0.0 -0.286 10.0 10.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.136 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.048 0.136 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.032 0.163 -9999.0 0.0 -0.46 3.0 3.0 adherens junction assembly -0.082 0.211 -9999.0 0.0 -0.534 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.104 0.15 -9999.0 0.0 -0.512 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.009 0.071 -9999.0 0.0 -0.413 1.0 1.0 MET -0.019 0.135 -9999.0 0.0 -0.573 2.0 2.0 PLEKHA7 -0.07 0.159 -9999.0 0.0 -0.297 10.0 10.0 mol:GTP -0.002 0.129 -9999.0 0.0 -0.407 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.024 0.14 -9999.0 0.0 -0.468 1.0 1.0 cortical actin cytoskeleton stabilization -0.046 0.124 -9999.0 0.0 -0.245 10.0 10.0 regulation of cell-cell adhesion -0.047 0.134 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.046 0.125 -9999.0 0.0 -0.247 10.0 10.0