Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	11.0	80.0	7.0	-0.199	-0.0	1000.0	-1000.0	-0.021	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	291.0	34.0	-0.249	0.014	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by the Hedgehog family	6.0	312.0	52.0	-0.242	0.147	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	6.0	31.0	5.0	-0.149	0.014	1000.0	-1000.0	-0.019	-1000.0
TCGA08_retinoblastoma	5.0	44.0	8.0	-0.101	0.064	1000.0	-1000.0	-0.013	-1000.0
IL23-mediated signaling events	5.0	313.0	60.0	-0.519	0.014	1000.0	-1000.0	-0.153	-1000.0
Syndecan-1-mediated signaling events	4.0	169.0	34.0	-0.224	0.014	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	4.0	501.0	114.0	-0.675	0.254	1000.0	-1000.0	-0.066	-1000.0
Reelin signaling pathway	4.0	238.0	56.0	-0.211	0.021	1000.0	-1000.0	-0.071	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	332.0	82.0	-0.194	0.014	1000.0	-1000.0	-0.082	-1000.0
Thromboxane A2 receptor signaling	3.0	362.0	105.0	-0.196	0.052	1000.0	-1000.0	-0.055	-1000.0
p75(NTR)-mediated signaling	3.0	452.0	125.0	-0.224	0.041	1000.0	-1000.0	-0.095	-1000.0
IL4-mediated signaling events	3.0	359.0	91.0	-0.595	0.546	1000.0	-1000.0	-0.158	-1000.0
BMP receptor signaling	3.0	292.0	81.0	-0.235	0.041	1000.0	-1000.0	-0.085	-1000.0
amb2 Integrin signaling	3.0	288.0	82.0	-0.238	0.019	1000.0	-1000.0	-0.065	-1000.0
Ephrin B reverse signaling	3.0	191.0	48.0	-0.217	0.031	1000.0	-1000.0	-0.057	-1000.0
Endothelins	3.0	368.0	96.0	-0.256	0.034	1000.0	-1000.0	-0.076	-1000.0
Integrins in angiogenesis	3.0	290.0	84.0	-0.172	0.026	1000.0	-1000.0	-0.083	-1000.0
Glypican 2 network	3.0	13.0	4.0	-0.035	-0.019	1000.0	-1000.0	-0.018	-1000.0
Wnt signaling	3.0	21.0	7.0	-0.091	0.014	1000.0	-1000.0	-0.026	-1000.0
IL6-mediated signaling events	3.0	254.0	75.0	-0.382	0.054	1000.0	-1000.0	-0.07	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	254.0	68.0	-0.33	0.058	1000.0	-1000.0	-0.113	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	254.0	76.0	-0.149	0.021	1000.0	-1000.0	-0.074	-1000.0
Syndecan-4-mediated signaling events	3.0	222.0	67.0	-0.158	0.018	1000.0	-1000.0	-0.067	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	310.0	88.0	-0.261	0.028	1000.0	-1000.0	-0.094	-1000.0
LPA4-mediated signaling events	2.0	29.0	12.0	-0.053	0.01	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	2.0	166.0	65.0	-0.152	0.02	1000.0	-1000.0	-0.059	-1000.0
Coregulation of Androgen receptor activity	2.0	157.0	76.0	-0.104	0.03	1000.0	-1000.0	-0.027	-1000.0
IL12-mediated signaling events	2.0	217.0	87.0	-0.203	0.019	1000.0	-1000.0	-0.119	-1000.0
Visual signal transduction: Cones	2.0	87.0	38.0	-0.074	0.014	1000.0	-1000.0	-0.056	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	140.0	54.0	-0.191	0.027	1000.0	-1000.0	-0.091	-1000.0
Noncanonical Wnt signaling pathway	2.0	57.0	26.0	-0.091	0.014	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	2.0	200.0	76.0	-0.284	0.023	1000.0	-1000.0	-0.144	-1000.0
Arf6 signaling events	2.0	147.0	62.0	-0.263	0.019	1000.0	-1000.0	-0.045	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	185.0	85.0	-0.14	0.014	1000.0	-1000.0	-0.063	-1000.0
FOXA2 and FOXA3 transcription factor networks	2.0	121.0	46.0	-0.292	0.021	1000.0	-1000.0	-0.082	-1000.0
Glypican 1 network	2.0	134.0	48.0	-0.184	0.021	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	2.0	16.0	7.0	-0.073	0.032	1000.0	-1000.0	-0.008	-1000.0
FAS signaling pathway (CD95)	2.0	104.0	47.0	-0.232	0.04	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	125.0	44.0	-0.094	0.014	1000.0	-1000.0	-0.042	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	243.0	93.0	-0.158	0.091	1000.0	-1000.0	-0.073	-1000.0
EPHB forward signaling	2.0	238.0	85.0	-0.129	0.099	1000.0	-1000.0	-0.079	-1000.0
Effects of Botulinum toxin	2.0	66.0	26.0	-0.077	0.014	1000.0	-1000.0	-0.053	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	80.0	31.0	-0.252	0.014	1000.0	-1000.0	-0.056	-1000.0
Nongenotropic Androgen signaling	2.0	123.0	52.0	-0.107	0.047	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	284.0	125.0	-0.073	0.021	1000.0	-1000.0	-0.084	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	218.0	74.0	-0.151	0.058	1000.0	-1000.0	-0.079	-1000.0
BCR signaling pathway	2.0	249.0	99.0	-0.207	0.021	1000.0	-1000.0	-0.081	-1000.0
EGFR-dependent Endothelin signaling events	2.0	48.0	21.0	-0.102	0.021	1000.0	-1000.0	-0.062	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	306.0	120.0	-0.171	0.113	1000.0	-1000.0	-0.067	-1000.0
Visual signal transduction: Rods	2.0	126.0	52.0	-0.14	0.014	1000.0	-1000.0	-0.072	-1000.0
Caspase cascade in apoptosis	1.0	122.0	74.0	-0.057	0.04	1000.0	-1000.0	-0.04	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	182.0	136.0	-0.207	0.204	1000.0	-1000.0	-0.066	-1000.0
ErbB4 signaling events	1.0	123.0	69.0	-0.152	0.106	1000.0	-1000.0	-0.081	-1000.0
BARD1 signaling events	1.0	65.0	57.0	-0.035	0.046	1000.0	-1000.0	-0.049	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	28.0	28.0	-0.061	0.021	1000.0	-1000.0	-0.027	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.002	0.0	1000.0	-1000.0	-0.021	-1000.0
Osteopontin-mediated events	1.0	53.0	38.0	-0.095	0.017	1000.0	-1000.0	-0.09	-1000.0
Syndecan-2-mediated signaling events	1.0	122.0	69.0	-0.148	0.035	1000.0	-1000.0	-0.028	-1000.0
Cellular roles of Anthrax toxin	1.0	46.0	39.0	-0.042	0.015	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PTP1B	1.0	110.0	76.0	-0.191	0.022	1000.0	-1000.0	-0.07	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	81.0	65.0	-0.188	0.066	1000.0	-1000.0	-0.057	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	108.0	61.0	-0.261	0.041	1000.0	-1000.0	-0.066	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.033	0.0	1000.0	-1000.0	-0.026	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	183.0	97.0	-0.111	0.033	1000.0	-1000.0	-0.072	-1000.0
IFN-gamma pathway	1.0	93.0	68.0	-0.167	0.022	1000.0	-1000.0	-0.088	-1000.0
Nectin adhesion pathway	1.0	113.0	63.0	-0.177	0.023	1000.0	-1000.0	-0.064	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	58.0	52.0	-0.149	0.039	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	1.0	57.0	43.0	-0.124	0.036	1000.0	-1000.0	-0.062	-1000.0
S1P1 pathway	1.0	58.0	36.0	-0.071	0.014	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	22.0	15.0	-0.029	0.014	1000.0	-1000.0	-0.02	-1000.0
Retinoic acid receptors-mediated signaling	1.0	101.0	58.0	-0.128	0.028	1000.0	-1000.0	-0.066	-1000.0
Atypical NF-kappaB pathway	1.0	31.0	31.0	-0.063	0.027	1000.0	-1000.0	-0.037	-1000.0
Canonical Wnt signaling pathway	1.0	95.0	51.0	-0.261	0.073	1000.0	-1000.0	-0.06	-1000.0
Regulation of p38-alpha and p38-beta	1.0	57.0	54.0	-0.191	0.028	1000.0	-1000.0	-0.055	-1000.0
IL27-mediated signaling events	1.0	78.0	51.0	-0.141	0.077	1000.0	-1000.0	-0.087	-1000.0
LPA receptor mediated events	1.0	106.0	102.0	-0.096	0.048	1000.0	-1000.0	-0.073	-1000.0
IL2 signaling events mediated by STAT5	1.0	22.0	22.0	-0.039	0.041	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	1.0	127.0	102.0	-0.22	0.04	1000.0	-1000.0	-0.101	-1000.0
IGF1 pathway	1.0	68.0	57.0	-0.051	0.028	1000.0	-1000.0	-0.088	-1000.0
VEGFR1 specific signals	1.0	67.0	56.0	-0.063	0.014	1000.0	-1000.0	-0.046	-1000.0
S1P3 pathway	1.0	56.0	42.0	-0.172	0.021	1000.0	-1000.0	-0.035	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	34.0	33.0	-0.102	0.034	1000.0	-1000.0	-0.034	-1000.0
E-cadherin signaling in keratinocytes	1.0	78.0	43.0	-0.149	0.017	1000.0	-1000.0	-0.045	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.0	-1000.0	1000.0	-1000.0	-0.012	-1000.0
FOXM1 transcription factor network	1.0	100.0	51.0	-0.125	0.133	1000.0	-1000.0	-0.152	-1000.0
Regulation of Androgen receptor activity	1.0	117.0	70.0	-0.178	0.02	1000.0	-1000.0	-0.055	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	20.0	17.0	-0.021	0.023	1000.0	-1000.0	-0.04	-1000.0
Aurora B signaling	1.0	120.0	67.0	-0.139	0.014	1000.0	-1000.0	-0.061	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	-0.035	0.044	1000.0	-1000.0	-0.044	-1000.0
Canonical NF-kappaB pathway	0.0	13.0	39.0	-0.019	0.059	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class II	0.0	30.0	75.0	-0.072	0.041	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.009	0.031	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	16.0	17.0	-0.022	0.038	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	-0.002	0.021	1000.0	-1000.0	-0.018	-1000.0
Aurora A signaling	0.0	52.0	60.0	-0.14	0.03	1000.0	-1000.0	-0.029	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.025	0.028	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	0.0	15.0	55.0	-0.03	0.071	1000.0	-1000.0	-0.077	-1000.0
PLK1 signaling events	0.0	56.0	85.0	-0.044	0.031	1000.0	-1000.0	-0.041	-1000.0
Insulin-mediated glucose transport	0.0	18.0	32.0	-0.14	0.036	1000.0	-1000.0	-0.042	-1000.0
PDGFR-alpha signaling pathway	0.0	38.0	44.0	-0.161	0.027	1000.0	-1000.0	-0.053	-1000.0
mTOR signaling pathway	0.0	19.0	53.0	-0.017	0.031	1000.0	-1000.0	-0.052	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	23.0	68.0	-0.14	0.05	1000.0	-1000.0	-0.042	-1000.0
Ceramide signaling pathway	0.0	57.0	76.0	-0.091	0.038	1000.0	-1000.0	-0.043	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	24.0	37.0	-0.047	0.036	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	0.0	34.0	40.0	-0.107	0.025	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	0.0	46.0	48.0	-0.044	0.039	1000.0	-1000.0	-0.057	-1000.0
IL1-mediated signaling events	0.0	58.0	62.0	-0.07	0.063	1000.0	-1000.0	-0.084	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.016	0.014	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	0.0	13.0	49.0	-0.016	0.05	1000.0	-1000.0	-0.045	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	73.0	83.0	-0.14	0.054	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class I	0.0	30.0	104.0	-0.072	0.043	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	0.0	40.0	64.0	-0.14	0.107	1000.0	-1000.0	-0.068	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	11.0	36.0	-0.047	0.041	1000.0	-1000.0	-0.064	-1000.0
Syndecan-3-mediated signaling events	0.0	33.0	35.0	-0.099	0.041	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by PI3K	0.0	48.0	58.0	-0.105	0.05	1000.0	-1000.0	-0.073	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	30.0	45.0	-0.033	0.053	1000.0	-1000.0	-0.089	-1000.0
TCGA08_rtk_signaling	0.0	20.0	26.0	-0.084	0.042	1000.0	-1000.0	-0.017	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.002	0.033	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events	0.0	28.0	73.0	-0.191	0.037	1000.0	-1000.0	-0.059	-1000.0
Arf6 trafficking events	0.0	10.0	71.0	-0.036	0.043	1000.0	-1000.0	-0.068	-1000.0
Insulin Pathway	0.0	52.0	74.0	-0.105	0.037	1000.0	-1000.0	-0.077	-1000.0
Plasma membrane estrogen receptor signaling	0.0	71.0	86.0	-0.047	0.037	1000.0	-1000.0	-0.074	-1000.0
Rapid glucocorticoid signaling	0.0	17.0	20.0	-0.03	0.019	1000.0	-1000.0	-0.014	-1000.0
PDGFR-beta signaling pathway	0.0	88.0	97.0	-0.106	0.031	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by PRL	0.0	20.0	34.0	-0.059	0.022	1000.0	-1000.0	-0.027	-1000.0
S1P4 pathway	0.0	17.0	25.0	-0.016	0.024	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	0.0	8.0	78.0	-0.032	0.049	1000.0	-1000.0	-0.072	-1000.0
p38 MAPK signaling pathway	0.0	41.0	44.0	-0.135	0.027	1000.0	-1000.0	-0.062	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.009	0.035	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.016	0.041	1000.0	-1000.0	-0.028	-1000.0
Total	192	14222	7203	-17.488301554	-994.522518981	131000	-131000	-7.51188536814	-131000