Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.141 0.255 -9999.0 0.0 -0.566 8.0 8.0 IHH -0.05 0.095 -9999.0 0.0 -0.24 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.013 0.109 -9999.0 0.0 -0.365 3.0 3.0 LRPAP1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.013 0.108 0.363 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.041 0.137 -9999.0 0.0 -0.353 2.0 2.0 SMO -0.057 0.13 -9999.0 0.0 -0.369 2.0 2.0 AKT1 -0.022 0.116 -9999.0 0.0 -0.432 2.0 2.0 ARRB2 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.053 0.132 -9999.0 0.0 -0.364 2.0 2.0 STIL -0.064 0.136 -9999.0 0.0 -0.307 5.0 5.0 DHH N/PTCH2 0.005 0.081 -9999.0 0.0 -0.176 6.0 6.0 DHH N/PTCH1 -0.069 0.143 -9999.0 0.0 -0.301 8.0 8.0 PIK3CA 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.018 0.048 -9999.0 0.0 -0.261 1.0 1.0 PTHLH -0.153 0.313 -9999.0 0.0 -0.842 5.0 5.0 determination of left/right symmetry -0.053 0.132 -9999.0 0.0 -0.364 2.0 2.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.151 0.308 -9999.0 0.0 -0.83 5.0 5.0 IHH N/Hhip -0.157 0.179 -9999.0 0.0 -0.327 17.0 17.0 DHH N/Hhip -0.11 0.172 -9999.0 0.0 -0.279 17.0 17.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.053 0.132 -9999.0 0.0 -0.364 2.0 2.0 pancreas development -0.165 0.22 -9999.0 0.0 -0.38 17.0 17.0 HHAT 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.016 0.149 -9999.0 0.0 -0.51 3.0 3.0 somite specification -0.053 0.132 -9999.0 0.0 -0.364 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.066 0.119 -9999.0 0.0 -0.274 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.011 0.063 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.065 0.145 -9999.0 0.0 -0.314 8.0 8.0 SHH -0.016 0.041 -9999.0 0.0 -0.177 2.0 2.0 catabolic process -0.083 0.151 -9999.0 0.0 -0.337 8.0 8.0 SMO/Vitamin D3 -0.05 0.136 -9999.0 0.0 -0.317 2.0 2.0 SHH Np/Cholesterol/Hhip -0.091 0.13 -9999.0 0.0 -0.265 11.0 11.0 LRP2 -0.132 0.225 -9999.0 0.0 -0.415 13.0 13.0 receptor-mediated endocytosis -0.101 0.156 -9999.0 0.0 -0.374 4.0 4.0 SHH Np/Cholesterol/BOC 0.01 0.04 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO -0.029 0.13 -9999.0 0.0 -0.35 5.0 5.0 mesenchymal cell differentiation 0.091 0.129 0.263 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.055 0.134 -9999.0 0.0 -0.275 7.0 7.0 IHH N/PTCH2 -0.038 0.099 -9999.0 0.0 -0.233 5.0 5.0 CDON -0.046 0.186 -9999.0 0.0 -0.51 5.0 5.0 IHH N/PTCH1 -0.08 0.155 -9999.0 0.0 -0.339 8.0 8.0 Megalin/LRPAP1 -0.081 0.171 -9999.0 0.0 -0.371 8.0 8.0 PTCH2 -0.012 0.1 -9999.0 0.0 -0.261 5.0 5.0 SHH Np/Cholesterol 0.001 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.084 0.151 -9999.0 0.0 -0.338 8.0 8.0 HHIP -0.165 0.22 -9999.0 0.0 -0.381 17.0 17.0