Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.037 0.116 -9999.0 0.0 -0.25 8.0 8.0 epithelial cell differentiation -0.023 0.133 -9999.0 0.0 -0.267 8.0 8.0 CYFIP2 0.011 0.089 -9999.0 0.0 -0.51 1.0 1.0 ENAH -0.042 0.163 0.568 1.0 -0.371 3.0 4.0 EGFR -0.003 0.123 -9999.0 0.0 -0.51 2.0 2.0 EPHA2 0.012 0.089 -9999.0 0.0 -0.51 1.0 1.0 MYO6 -0.032 0.149 0.506 1.0 -0.257 8.0 9.0 CTNNB1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.026 0.086 -9999.0 0.0 -0.316 2.0 2.0 AQP5 -0.104 0.189 -9999.0 0.0 -0.47 6.0 6.0 CTNND1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.042 0.117 -9999.0 0.0 -0.254 8.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.167 0.502 1.0 -0.281 9.0 10.0 EGF -0.05 0.166 -9999.0 0.0 -0.368 7.0 7.0 NCKAP1 0.013 0.089 -9999.0 0.0 -0.51 1.0 1.0 AQP3 -0.048 0.097 -9999.0 0.0 -0.33 1.0 1.0 cortical microtubule organization -0.023 0.133 -9999.0 0.0 -0.267 8.0 8.0 GO:0000145 -0.054 0.105 -9999.0 0.0 -0.242 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.137 -9999.0 0.0 -0.269 8.0 8.0 MLLT4 0.013 0.089 -9999.0 0.0 -0.51 1.0 1.0 ARF6/GDP -0.083 0.152 -9999.0 0.0 -0.511 3.0 3.0 ARF6 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.129 -9999.0 0.0 -0.375 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.149 0.608 1.0 -9999.0 0.0 1.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.024 0.144 0.506 1.0 -0.257 7.0 8.0 ARF6/GTP 0.034 0.124 -9999.0 0.0 -0.351 3.0 3.0 CDH1 -0.093 0.223 -9999.0 0.0 -0.51 8.0 8.0 EGFR/EGFR/EGF/EGF -0.067 0.174 -9999.0 0.0 -0.339 8.0 8.0 RhoA/GDP -0.019 0.129 -9999.0 0.0 -0.255 8.0 8.0 actin cytoskeleton organization -0.035 0.144 0.487 1.0 -0.252 8.0 9.0 IGF-1R heterotetramer 0.012 0.088 -9999.0 0.0 -0.51 1.0 1.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.089 -9999.0 0.0 -0.51 1.0 1.0 IGF1 -0.018 0.137 -9999.0 0.0 -0.386 4.0 4.0 DIAPH1 -0.015 0.193 -9999.0 0.0 -0.728 2.0 2.0 Wnt receptor signaling pathway 0.023 0.133 0.267 8.0 -9999.0 0.0 8.0 RHOA 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.083 0.153 -9999.0 0.0 -0.511 3.0 3.0 CTNNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.036 0.146 0.49 1.0 -0.257 8.0 9.0 EFNA1 -0.019 0.149 -9999.0 0.0 -0.51 3.0 3.0 LPP -0.054 0.107 -9999.0 0.0 -0.249 7.0 7.0 Ephrin A1/EPHA2 -0.052 0.189 -9999.0 0.0 -0.368 8.0 8.0 SEC6/SEC8 -0.042 0.113 -9999.0 0.0 -0.465 1.0 1.0 MGAT3 -0.053 0.169 0.506 1.0 -0.285 9.0 10.0 HGF/MET -0.086 0.161 -9999.0 0.0 -0.29 12.0 12.0 HGF -0.087 0.205 -9999.0 0.0 -0.427 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.038 0.117 -9999.0 0.0 -0.252 8.0 8.0 actin cable formation 0.007 0.182 0.308 5.0 -0.396 2.0 7.0 KIAA1543 -0.053 0.154 0.496 1.0 -0.275 8.0 9.0 KIFC3 -0.043 0.118 -9999.0 0.0 -0.257 8.0 8.0 NCK1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.148 0.506 1.0 -0.257 8.0 9.0 NCK1/GIT1 0.039 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.023 0.133 -9999.0 0.0 -0.267 8.0 8.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.044 0.118 -9999.0 0.0 -0.257 8.0 8.0 PIP5K1C -0.043 0.119 -9999.0 0.0 -0.257 8.0 8.0 LIMA1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.029 0.192 0.408 2.0 -0.442 3.0 5.0 adherens junction assembly -0.027 0.178 0.681 1.0 -0.529 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.049 0.146 -9999.0 0.0 -0.276 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.068 -9999.0 0.0 -0.371 1.0 1.0 MET -0.003 0.123 -9999.0 0.0 -0.51 2.0 2.0 PLEKHA7 -0.043 0.165 0.506 1.0 -0.288 8.0 9.0 mol:GTP 0.025 0.127 -9999.0 0.0 -0.373 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.024 0.144 0.322 2.0 -0.448 1.0 3.0 cortical actin cytoskeleton stabilization -0.037 0.116 -9999.0 0.0 -0.25 8.0 8.0 regulation of cell-cell adhesion -0.035 0.144 0.487 1.0 -0.252 8.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.038 0.117 -9999.0 0.0 -0.252 8.0 8.0