E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.103 -9999.0 0.0 -0.379 8.0 8.0 KLHL20 -0.007 0.091 0.172 1.0 -0.251 16.0 17.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.012 0.079 0.267 3.0 -0.28 3.0 6.0 ENAH -0.013 0.104 -9999.0 0.0 -0.379 8.0 8.0 AP1M1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.047 -9999.0 0.0 -0.217 4.0 4.0 ABI1/Sra1/Nap1 -0.024 0.051 -9999.0 0.0 -0.167 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.285 9.0 9.0 RAPGEF1 -0.005 0.096 0.274 3.0 -0.334 8.0 11.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.11 -9999.0 0.0 -0.355 11.0 11.0 CRK -0.004 0.092 -9999.0 0.0 -0.367 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 alphaE/beta7 Integrin 0.033 0.055 -9999.0 0.0 -0.352 5.0 5.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.029 -9999.0 0.0 -0.276 1.0 1.0 DLG1 -0.009 0.095 -9999.0 0.0 -0.358 8.0 8.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.02 -9999.0 0.0 -0.161 2.0 2.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.49 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 -9999.0 0.0 -0.277 3.0 3.0 PI3K -0.001 0.03 -9999.0 0.0 -0.205 2.0 2.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.051 -9999.0 0.0 -0.356 4.0 4.0 TIAM1 0.022 0.056 -9999.0 0.0 -0.49 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.048 -9999.0 0.0 -0.263 4.0 4.0 AKT1 0.004 0.04 0.161 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.064 -9999.0 0.0 -0.49 4.0 4.0 RhoA/GDP 0.015 0.081 0.267 3.0 -0.277 3.0 6.0 actin cytoskeleton organization -0.003 0.068 0.142 1.0 -0.186 14.0 15.0 CDC42/GDP 0.015 0.081 0.267 3.0 -0.277 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.035 -9999.0 0.0 -0.238 4.0 4.0 ITGB7 0.019 0.072 -9999.0 0.0 -0.49 5.0 5.0 RAC1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.051 -9999.0 0.0 -0.28 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.043 -9999.0 0.0 -0.26 4.0 4.0 mol:GDP -0.0 0.085 0.271 3.0 -0.317 3.0 6.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.024 0.084 0.264 3.0 -0.284 3.0 6.0 RAC1/GTP/IQGAP1 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.075 0.128 2.0 -0.211 26.0 28.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.097 -9999.0 0.0 -0.394 6.0 6.0 regulation of cell-cell adhesion 0.006 0.035 -9999.0 0.0 -0.192 4.0 4.0 WASF2 -0.001 0.035 -9999.0 0.0 -0.118 4.0 4.0 Rap1/GTP 0.02 0.058 0.273 2.0 -0.239 4.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.071 -9999.0 0.0 -0.271 9.0 9.0 CCND1 -0.014 0.092 0.146 2.0 -0.264 26.0 28.0 VAV2 -0.015 0.173 -9999.0 0.0 -0.651 12.0 12.0 RAP1/GDP 0.023 0.067 0.289 2.0 -0.243 3.0 5.0 adherens junction assembly -0.007 0.094 -9999.0 0.0 -0.382 6.0 6.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.043 0.064 -9999.0 0.0 -0.263 9.0 9.0 E-cadherin/beta catenin 0.006 0.038 -9999.0 0.0 -0.277 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.102 -9999.0 0.0 -0.349 11.0 11.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.044 0.13 -9999.0 0.0 -0.407 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 ITGAE 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.112 -9999.0 0.0 -0.362 11.0 11.0