Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.018 0.183 -9999.0 0.0 -0.67 18.0 18.0 IHH 0.024 0.058 -9999.0 0.0 -0.52 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.02 0.107 -9999.0 0.0 -0.304 30.0 30.0 LRPAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.107 0.302 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.017 0.102 -9999.0 0.0 -0.377 6.0 6.0 SMO -0.004 0.099 -9999.0 0.0 -0.393 7.0 7.0 AKT1 -0.0 0.078 -9999.0 0.0 -0.313 2.0 2.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.057 -9999.0 0.0 -0.49 3.0 3.0 ADRBK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.003 0.098 -9999.0 0.0 -0.377 8.0 8.0 STIL -0.022 0.113 -9999.0 0.0 -0.297 21.0 21.0 DHH N/PTCH2 0.014 0.097 -9999.0 0.0 -0.356 16.0 16.0 DHH N/PTCH1 0.01 0.107 -9999.0 0.0 -0.311 24.0 24.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.085 -9999.0 0.0 -0.49 7.0 7.0 PTHLH -0.022 0.19 -9999.0 0.0 -0.69 17.0 17.0 determination of left/right symmetry -0.003 0.098 -9999.0 0.0 -0.377 8.0 8.0 PIK3R1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.022 0.188 -9999.0 0.0 -0.682 17.0 17.0 IHH N/Hhip 0.002 0.12 -9999.0 0.0 -0.386 21.0 21.0 DHH N/Hhip -0.003 0.125 -9999.0 0.0 -0.368 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.003 0.098 -9999.0 0.0 -0.377 8.0 8.0 pancreas development -0.019 0.138 -9999.0 0.0 -0.489 20.0 20.0 HHAT 0.008 0.1 -9999.0 0.0 -0.49 10.0 10.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.109 -9999.0 0.0 -0.49 12.0 12.0 somite specification -0.003 0.098 -9999.0 0.0 -0.377 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.016 0.111 -9999.0 0.0 -0.28 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.018 0.098 -9999.0 0.0 -0.286 29.0 29.0 SHH Np/Cholesterol/Megalin -0.079 0.141 -9999.0 0.0 -0.289 77.0 77.0 SHH -0.031 0.101 -9999.0 0.0 -0.372 20.0 20.0 catabolic process 0.003 0.098 -9999.0 0.0 -0.345 18.0 18.0 SMO/Vitamin D3 -0.013 0.119 -9999.0 0.0 -0.382 11.0 11.0 SHH Np/Cholesterol/Hhip -0.032 0.119 -9999.0 0.0 -0.312 36.0 36.0 LRP2 -0.119 0.219 -9999.0 0.0 -0.49 66.0 66.0 receptor-mediated endocytosis -0.07 0.137 -9999.0 0.0 -0.449 10.0 10.0 SHH Np/Cholesterol/BOC -0.008 0.086 -9999.0 0.0 -0.283 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.093 -9999.0 0.0 -0.313 20.0 20.0 mesenchymal cell differentiation 0.032 0.118 0.31 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 -0.012 0.117 -9999.0 0.0 -0.28 36.0 36.0 IHH N/PTCH2 0.018 0.093 -9999.0 0.0 -0.393 11.0 11.0 CDON 0.023 0.046 -9999.0 0.0 -0.49 2.0 2.0 IHH N/PTCH1 0.012 0.101 -9999.0 0.0 -0.347 18.0 18.0 Megalin/LRPAP1 -0.062 0.173 -9999.0 0.0 -0.356 66.0 66.0 PTCH2 0.003 0.1 -9999.0 0.0 -0.49 10.0 10.0 SHH Np/Cholesterol -0.013 0.081 -9999.0 0.0 -0.286 20.0 20.0 PTCH1 0.003 0.098 -9999.0 0.0 -0.346 18.0 18.0 HHIP -0.019 0.138 -9999.0 0.0 -0.49 20.0 20.0