Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.041 -9999.0 0.0 -0.233 4.0 4.0 epithelial cell differentiation 0.049 0.046 -9999.0 0.0 -0.261 4.0 4.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.011 0.051 0.27 1.0 -9999.0 0.0 1.0 EGFR 0.014 0.084 -9999.0 0.0 -0.49 7.0 7.0 EPHA2 0.027 0.033 -9999.0 0.0 -0.49 1.0 1.0 MYO6 -0.018 0.046 0.176 1.0 -0.312 5.0 6.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.157 -9999.0 0.0 -0.467 30.0 30.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.015 0.033 0.175 1.0 -0.25 4.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.074 0.175 1.0 -0.254 25.0 26.0 EGF -0.01 0.125 -9999.0 0.0 -0.49 16.0 16.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.013 0.093 -9999.0 0.0 -0.423 10.0 10.0 cortical microtubule organization 0.049 0.046 -9999.0 0.0 -0.261 4.0 4.0 GO:0000145 -0.015 0.031 0.161 1.0 -0.238 4.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.048 -9999.0 0.0 -0.263 4.0 4.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.49 1.0 1.0 ARF6/GDP -0.024 0.029 -9999.0 0.0 -0.235 4.0 4.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.035 -9999.0 0.0 -0.28 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.03 -9999.0 0.0 -0.236 3.0 3.0 PVRL2 0.025 0.033 -9999.0 0.0 -0.49 1.0 1.0 ZYX -0.015 0.034 0.176 1.0 -0.253 4.0 5.0 ARF6/GTP 0.067 0.038 -9999.0 0.0 -0.263 1.0 1.0 CDH1 0.018 0.064 -9999.0 0.0 -0.49 4.0 4.0 EGFR/EGFR/EGF/EGF 0.015 0.093 -9999.0 0.0 -0.252 26.0 26.0 RhoA/GDP 0.051 0.045 -9999.0 0.0 -0.251 4.0 4.0 actin cytoskeleton organization -0.02 0.047 0.163 1.0 -0.306 6.0 7.0 IGF-1R heterotetramer 0.007 0.1 -9999.0 0.0 -0.489 10.0 10.0 GIT1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.1 -9999.0 0.0 -0.49 10.0 10.0 IGF1 0.011 0.09 -9999.0 0.0 -0.49 8.0 8.0 DIAPH1 0.044 0.099 -9999.0 0.0 -0.538 3.0 3.0 Wnt receptor signaling pathway -0.049 0.046 0.261 4.0 -9999.0 0.0 4.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.029 -9999.0 0.0 -0.236 4.0 4.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.048 0.164 1.0 -0.313 6.0 7.0 EFNA1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.03 0.167 1.0 -0.24 3.0 4.0 Ephrin A1/EPHA2 0.041 0.045 -9999.0 0.0 -0.249 4.0 4.0 SEC6/SEC8 -0.022 0.037 -9999.0 0.0 -0.251 6.0 6.0 MGAT3 -0.035 0.075 0.176 1.0 -0.258 25.0 26.0 HGF/MET 0.007 0.106 -9999.0 0.0 -0.261 33.0 33.0 HGF 0.003 0.109 -9999.0 0.0 -0.49 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.041 -9999.0 0.0 -0.234 4.0 4.0 actin cable formation 0.032 0.073 0.31 5.0 -9999.0 0.0 5.0 KIAA1543 -0.018 0.039 0.163 1.0 -0.252 6.0 7.0 KIFC3 -0.016 0.033 0.176 1.0 -0.253 4.0 5.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.016 0.033 0.176 1.0 -0.249 4.0 5.0 NCK1/GIT1 0.039 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.049 0.046 -9999.0 0.0 -0.261 4.0 4.0 EXOC4 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.034 0.176 1.0 -0.253 4.0 5.0 PIP5K1C -0.015 0.033 0.176 1.0 -0.253 4.0 5.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.061 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.036 0.129 -9999.0 0.0 -0.689 8.0 8.0 IGF-1R heterotetramer/IGF1 0.02 0.089 -9999.0 0.0 -0.264 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.039 -9999.0 0.0 -0.356 2.0 2.0 MET -0.013 0.139 -9999.0 0.0 -0.49 20.0 20.0 PLEKHA7 -0.018 0.041 0.176 1.0 -0.264 6.0 7.0 mol:GTP 0.059 0.034 -9999.0 0.0 -0.278 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.01 0.088 0.32 5.0 -0.289 1.0 6.0 cortical actin cytoskeleton stabilization 0.016 0.041 -9999.0 0.0 -0.233 4.0 4.0 regulation of cell-cell adhesion -0.02 0.047 0.163 1.0 -0.306 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.041 -9999.0 0.0 -0.234 4.0 4.0