E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.016 0.061 -9999.0 0.0 -0.391 13.0 13.0 KLHL20 -0.046 0.068 0.301 1.0 -0.311 6.0 7.0 CYFIP2 -0.012 0.042 -9999.0 0.0 -0.308 11.0 11.0 Rac1/GDP -0.022 0.042 -9999.0 0.0 -0.24 15.0 15.0 ENAH -0.017 0.06 -9999.0 0.0 -0.391 13.0 13.0 AP1M1 -0.004 0.018 0.242 3.0 -9999.0 0.0 3.0 RAP1B -0.004 0.023 0.242 5.0 -9999.0 0.0 5.0 RAP1A -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 CTNNB1 -0.005 0.015 0.242 2.0 -9999.0 0.0 2.0 CDC42/GTP -0.023 0.029 -9999.0 0.0 -0.167 15.0 15.0 ABI1/Sra1/Nap1 -0.037 0.045 -9999.0 0.0 -0.112 102.0 102.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.002 0.029 0.151 3.0 -0.161 14.0 17.0 RAPGEF1 -0.019 0.053 -9999.0 0.0 -0.348 13.0 13.0 CTNND1 -0.006 0.001 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.062 -9999.0 0.0 -0.375 15.0 15.0 CRK -0.018 0.057 -9999.0 0.0 -0.372 13.0 13.0 E-cadherin/gamma catenin/alpha catenin -0.005 0.042 -9999.0 0.0 -0.189 26.0 26.0 alphaE/beta7 Integrin -0.007 0.011 0.17 1.0 -0.212 1.0 2.0 IQGAP1 -0.006 0.021 0.242 1.0 -0.308 2.0 3.0 NCKAP1 -0.002 0.031 0.242 9.0 -9999.0 0.0 9.0 Rap1/GTP/I-afadin -0.003 0.04 0.148 6.0 -0.159 29.0 35.0 DLG1 -0.003 0.073 -9999.0 0.0 -0.391 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.039 -9999.0 0.0 -0.157 16.0 16.0 MLLT4 -0.021 0.066 -9999.0 0.0 -0.308 29.0 29.0 ARF6/GTP/NME1/Tiam1 0.011 0.035 0.147 31.0 -0.159 2.0 33.0 PI3K -0.039 0.049 -9999.0 0.0 -0.2 16.0 16.0 ARF6 -0.006 0.013 -9999.0 0.0 -0.308 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.016 0.045 -9999.0 0.0 -0.227 24.0 24.0 TIAM1 -0.006 0.019 0.242 2.0 -0.308 1.0 3.0 E-cadherin(dimer)/Ca2+ 0.001 0.028 0.14 1.0 -0.15 15.0 16.0 AKT1 -0.025 0.03 -9999.0 0.0 -0.135 8.0 8.0 PIK3R1 -0.075 0.127 -9999.0 0.0 -0.308 131.0 131.0 CDH1 -0.013 0.045 -9999.0 0.0 -0.308 13.0 13.0 RhoA/GDP -0.02 0.041 -9999.0 0.0 -0.238 15.0 15.0 actin cytoskeleton organization -0.034 0.051 0.254 1.0 -0.22 6.0 7.0 CDC42/GDP -0.02 0.041 -9999.0 0.0 -0.238 15.0 15.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.012 0.042 -9999.0 0.0 -0.197 26.0 26.0 ITGB7 -0.006 0.016 0.242 1.0 -0.308 1.0 2.0 RAC1 -0.006 0.013 -9999.0 0.0 -0.308 1.0 1.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.001 0.03 0.151 1.0 -0.161 15.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.0 0.026 0.137 2.0 -0.148 15.0 17.0 mol:GDP -0.021 0.047 -9999.0 0.0 -0.271 15.0 15.0 CDC42/GTP/IQGAP1 0.003 0.013 0.154 1.0 -0.175 2.0 3.0 JUP -0.013 0.045 -9999.0 0.0 -0.308 13.0 13.0 p120 catenin/RhoA/GDP -0.021 0.042 -9999.0 0.0 -0.245 14.0 14.0 RAC1/GTP/IQGAP1 0.002 0.015 0.154 1.0 -0.175 3.0 4.0 PIP5K1C/AP1M1 -0.006 0.013 0.17 3.0 -9999.0 0.0 3.0 RHOA -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 CDC42 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 positive regulation of S phase of mitotic cell cycle -0.045 0.07 0.355 1.0 -0.16 125.0 126.0 NME1 0.007 0.054 0.242 29.0 -9999.0 0.0 29.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.016 0.061 -9999.0 0.0 -0.391 13.0 13.0 regulation of cell-cell adhesion -0.021 0.026 -9999.0 0.0 -0.149 15.0 15.0 WASF2 -0.031 0.035 -9999.0 0.0 -0.118 33.0 33.0 Rap1/GTP -0.022 0.035 0.114 5.0 -0.184 15.0 20.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.039 -9999.0 0.0 -0.163 27.0 27.0 CCND1 -0.056 0.086 0.394 1.0 -0.196 139.0 140.0 VAV2 -0.022 0.078 -9999.0 0.0 -0.444 16.0 16.0 RAP1/GDP -0.02 0.039 -9999.0 0.0 -0.206 14.0 14.0 adherens junction assembly -0.016 0.059 -9999.0 0.0 -0.367 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 PIP5K1C -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.019 0.034 0.142 1.0 -0.279 2.0 3.0 E-cadherin/beta catenin -0.008 0.039 -9999.0 0.0 -0.267 12.0 12.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.017 0.06 -9999.0 0.0 -0.391 13.0 13.0 PIK3CA 0.047 0.102 0.242 122.0 -9999.0 0.0 122.0 Rac1/GTP -0.07 0.105 0.404 1.0 -0.406 12.0 13.0 E-cadherin/beta catenin/alpha catenin -0.0 0.031 0.155 2.0 -0.177 15.0 17.0 ITGAE -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.063 -9999.0 0.0 -0.383 15.0 15.0