Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.006 0.036 0.254 1.0 -0.158 21.0 22.0 KIRREL -0.003 0.044 0.216 19.0 -0.34 1.0 20.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.006 0.036 0.158 21.0 -0.255 1.0 22.0 PLCG1 -0.004 0.023 0.242 5.0 -9999.0 0.0 5.0 ARRB2 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.009 0.034 0.169 6.0 -0.175 1.0 7.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.005 0.037 0.199 1.0 -0.214 1.0 2.0 FYN -0.003 0.025 0.165 2.0 -0.278 1.0 3.0 mol:Ca2+ 0.008 0.034 0.161 7.0 -0.197 1.0 8.0 mol:DAG 0.009 0.034 0.164 7.0 -0.198 1.0 8.0 NPHS2 -0.009 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.009 0.034 0.164 7.0 -0.198 1.0 8.0 regulation of endocytosis -0.017 0.044 0.127 19.0 -0.263 1.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.006 0.032 0.136 21.0 -0.196 1.0 22.0 establishment of cell polarity -0.006 0.036 0.158 21.0 -0.254 1.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 0.021 0.048 0.168 8.0 -0.182 1.0 9.0 Nephrin/NEPH1/beta Arrestin2 -0.017 0.045 0.132 19.0 -0.266 1.0 20.0 NPHS1 -0.008 0.019 0.219 3.0 -9999.0 0.0 3.0 Nephrin/NEPH1/podocin -0.004 0.05 0.136 19.0 -0.279 1.0 20.0 TJP1 -0.005 0.019 0.242 2.0 -0.308 1.0 3.0 NCK1 0.012 0.065 0.242 42.0 -9999.0 0.0 42.0 NCK2 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.009 0.035 0.167 7.0 -0.199 1.0 8.0 CD2AP -0.004 0.026 0.242 5.0 -0.308 1.0 6.0 Nephrin/NEPH1/podocin/GRB2 0.008 0.033 0.18 3.0 -0.199 1.0 4.0 GRB2 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.008 0.028 0.154 4.0 -0.179 1.0 5.0 cytoskeleton organization -0.001 0.036 0.217 1.0 -0.223 1.0 2.0 Nephrin/NEPH1 0.006 0.028 0.131 21.0 -0.17 1.0 22.0 Nephrin/NEPH1/ZO-1 -0.007 0.033 0.143 21.0 -0.205 2.0 23.0