Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.045 -9999.0 0.0 -0.191 32.0 32.0 epithelial cell differentiation 0.006 0.026 0.129 2.0 -0.149 15.0 17.0 CYFIP2 -0.012 0.042 -9999.0 0.0 -0.308 11.0 11.0 ENAH -0.008 0.038 0.173 3.0 -9999.0 0.0 3.0 EGFR -0.03 0.083 0.242 1.0 -0.308 46.0 47.0 EPHA2 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 MYO6 -0.012 0.035 0.143 11.0 -0.152 19.0 30.0 CTNNB1 -0.005 0.015 0.242 2.0 -9999.0 0.0 2.0 ABI1/Sra1/Nap1 0.008 0.032 0.157 10.0 -0.177 11.0 21.0 AQP5 0.019 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.022 -9999.0 0.0 -0.143 15.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.026 -9999.0 0.0 -0.143 20.0 20.0 EGF -0.003 0.027 0.242 7.0 -9999.0 0.0 7.0 NCKAP1 -0.002 0.031 0.242 9.0 -9999.0 0.0 9.0 AQP3 -0.119 0.17 -9999.0 0.0 -0.388 160.0 160.0 cortical microtubule organization 0.006 0.026 0.129 2.0 -0.149 15.0 17.0 GO:0000145 -0.013 0.021 -9999.0 0.0 -0.136 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.006 0.027 0.141 2.0 -0.15 15.0 17.0 MLLT4 -0.021 0.066 -9999.0 0.0 -0.308 29.0 29.0 ARF6/GDP -0.018 0.02 -9999.0 0.0 -0.135 15.0 15.0 ARF6 -0.006 0.013 -9999.0 0.0 -0.308 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.049 0.158 68.0 -9999.0 0.0 68.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.04 0.077 -9999.0 0.0 -0.22 74.0 74.0 PVRL2 -0.006 0.016 0.242 1.0 -0.308 1.0 2.0 ZYX -0.031 0.051 -9999.0 0.0 -0.149 86.0 86.0 ARF6/GTP 0.027 0.043 0.263 3.0 -0.152 1.0 4.0 CDH1 -0.013 0.045 -9999.0 0.0 -0.308 13.0 13.0 EGFR/EGFR/EGF/EGF -0.026 0.042 -9999.0 0.0 -0.147 59.0 59.0 RhoA/GDP -0.014 0.023 -9999.0 0.0 -0.143 17.0 17.0 actin cytoskeleton organization -0.013 0.033 -9999.0 0.0 -0.271 1.0 1.0 IGF-1R heterotetramer -0.07 0.123 -9999.0 0.0 -0.307 121.0 121.0 GIT1 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 IGF1R -0.07 0.124 -9999.0 0.0 -0.308 121.0 121.0 IGF1 -0.016 0.06 0.242 3.0 -0.308 21.0 24.0 DIAPH1 -0.003 0.08 -9999.0 0.0 -0.527 12.0 12.0 Wnt receptor signaling pathway -0.006 0.026 0.149 15.0 -0.129 2.0 17.0 RHOA -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 RhoA/GTP -0.018 0.021 -9999.0 0.0 -0.136 16.0 16.0 CTNNA1 -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 VCL -0.013 0.033 -9999.0 0.0 -0.276 1.0 1.0 EFNA1 0.006 0.053 0.242 27.0 -9999.0 0.0 27.0 LPP -0.019 0.034 -9999.0 0.0 -0.329 2.0 2.0 Ephrin A1/EPHA2 -0.015 0.02 -9999.0 0.0 -0.142 14.0 14.0 SEC6/SEC8 -0.024 0.035 -9999.0 0.0 -0.151 38.0 38.0 MGAT3 -0.015 0.026 -9999.0 0.0 -0.145 20.0 20.0 HGF/MET -0.017 0.028 -9999.0 0.0 -0.142 26.0 26.0 HGF -0.004 0.021 0.242 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.045 -9999.0 0.0 -0.192 32.0 32.0 actin cable formation -0.022 0.057 0.149 3.0 -0.219 12.0 15.0 KIAA1543 -0.015 0.026 -9999.0 0.0 -0.392 1.0 1.0 KIFC3 -0.014 0.023 -9999.0 0.0 -0.144 15.0 15.0 NCK1 0.012 0.065 0.242 42.0 -9999.0 0.0 42.0 EXOC3 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 ACTN1 -0.016 0.031 -9999.0 0.0 -0.156 24.0 24.0 NCK1/GIT1 0.006 0.047 0.17 43.0 -9999.0 0.0 43.0 mol:GDP 0.006 0.026 0.129 2.0 -0.149 15.0 17.0 EXOC4 -0.004 0.021 0.242 4.0 -9999.0 0.0 4.0 STX4 -0.014 0.023 -9999.0 0.0 -0.144 15.0 15.0 PIP5K1C -0.014 0.023 -9999.0 0.0 -0.144 15.0 15.0 LIMA1 -0.015 0.053 -9999.0 0.0 -0.308 18.0 18.0 ABI1 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 ROCK1 -0.007 0.041 0.185 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.013 0.031 -9999.0 0.0 -0.55 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.048 0.061 -9999.0 0.0 -0.147 151.0 151.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.017 0.046 0.17 1.0 -0.212 30.0 31.0 MET 0.014 0.089 0.242 59.0 -0.308 12.0 71.0 PLEKHA7 -0.014 0.025 -9999.0 0.0 -0.153 15.0 15.0 mol:GTP 0.028 0.047 0.153 68.0 -9999.0 0.0 68.0 establishment of epithelial cell apical/basal polarity -0.025 0.036 -9999.0 0.0 -0.252 4.0 4.0 cortical actin cytoskeleton stabilization -0.013 0.045 -9999.0 0.0 -0.191 32.0 32.0 regulation of cell-cell adhesion -0.013 0.033 -9999.0 0.0 -0.271 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.045 -9999.0 0.0 -0.192 32.0 32.0