E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.046 0.101 -9999.0 0.0 -0.325 61.0 61.0 KLHL20 -0.058 0.078 0.474 1.0 -0.27 19.0 20.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.23 6.0 -0.25 19.0 25.0 ENAH -0.047 0.102 -9999.0 0.0 -0.322 63.0 63.0 AP1M1 0.026 0.009 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 RAP1A 0.029 0.004 -9999.0 0.0 -0.003 9.0 9.0 CTNNB1 0.027 0.01 -9999.0 0.0 -0.019 24.0 24.0 CDC42/GTP -0.058 0.05 0.116 23.0 -0.233 2.0 25.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.046 -9999.0 0.0 -0.141 8.0 8.0 RAPGEF1 -0.046 0.098 0.237 4.0 -0.308 53.0 57.0 CTNND1 0.029 0.004 -9999.0 0.0 -0.005 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.112 -9999.0 0.0 -0.324 65.0 65.0 CRK -0.045 0.101 -9999.0 0.0 -0.318 58.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.042 -9999.0 0.0 -0.156 18.0 18.0 alphaE/beta7 Integrin 0.04 0.014 -9999.0 0.0 -0.162 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.039 0.042 -9999.0 0.0 -0.13 21.0 21.0 DLG1 -0.032 0.102 0.193 1.0 -0.325 51.0 52.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.159 8.0 8.0 MLLT4 0.025 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.047 0.024 -9999.0 0.0 -0.129 1.0 1.0 PI3K -0.053 0.054 -9999.0 0.0 -0.207 7.0 7.0 ARF6 0.028 0.006 -9999.0 0.0 -0.006 14.0 14.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.175 18.0 18.0 TIAM1 0.028 0.008 -9999.0 0.0 -0.004 27.0 27.0 E-cadherin(dimer)/Ca2+ 0.052 0.041 -9999.0 0.0 -0.131 7.0 7.0 AKT1 -0.012 0.069 0.134 54.0 -0.145 1.0 55.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.024 0.013 -9999.0 0.0 -0.005 85.0 85.0 RhoA/GDP -0.043 0.08 0.231 6.0 -0.248 20.0 26.0 actin cytoskeleton organization -0.043 0.059 0.411 1.0 -0.215 9.0 10.0 CDC42/GDP -0.043 0.08 0.231 6.0 -0.251 18.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.056 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.003 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.003 29.0 29.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.044 -9999.0 0.0 -0.141 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.031 -9999.0 0.0 -0.121 7.0 7.0 mol:GDP -0.042 0.084 0.233 6.0 -0.272 22.0 28.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.132 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.046 0.083 0.23 7.0 -0.255 18.0 25.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.132 2.0 2.0 PIP5K1C/AP1M1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.028 0.005 -9999.0 0.0 -0.002 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.045 0.057 0.092 3.0 -0.129 146.0 149.0 NME1 0.027 0.008 -9999.0 0.0 -0.001 44.0 44.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.324 65.0 65.0 regulation of cell-cell adhesion -0.053 0.041 0.082 24.0 -0.206 2.0 26.0 WASF2 -0.03 0.035 0.096 5.0 -0.103 40.0 45.0 Rap1/GTP -0.054 0.058 0.153 23.0 -0.251 2.0 25.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.062 -9999.0 0.0 -0.151 18.0 18.0 CCND1 -0.054 0.069 0.105 3.0 -0.157 146.0 149.0 VAV2 -0.039 0.165 -9999.0 0.0 -0.628 27.0 27.0 RAP1/GDP -0.045 0.067 0.242 4.0 -0.245 4.0 8.0 adherens junction assembly -0.046 0.101 -9999.0 0.0 -0.315 65.0 65.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.227 2.0 6.0 E-cadherin/beta catenin -0.021 0.045 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.045 0.1 -9999.0 0.0 -0.327 59.0 59.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.089 0.112 0.567 1.0 -0.39 36.0 37.0 E-cadherin/beta catenin/alpha catenin 0.048 0.03 -9999.0 0.0 -0.145 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.114 -9999.0 0.0 -0.33 65.0 65.0