rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(2), IGF1R(3), POLR2A(2), PPP2CA(1), RB1(3), TEP1(10), TERF1(6), TERT(6), TNKS(3), TP53(59), XRCC5(2) 3909142 99 65 80 8 24 10 12 18 34 1 2.32e-05 <1.00e-15 <2.05e-13 2 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25A(3), CDC25C(2), CDK4(2), MYT1(10), RB1(3), TP53(59), YWHAH(1) 2418316 88 64 74 5 19 8 14 17 30 0 4.63e-05 <1.00e-15 <2.05e-13 3 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(8), CCNE1(1), CDK4(2), MDM2(2), RB1(3), TP53(59) 2504477 78 63 67 4 18 7 14 15 24 0 2.74e-05 <1.00e-15 <2.05e-13 4 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(4), AKT1(2), ATM(8), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2), TP53(59) 2904975 82 64 71 5 16 6 14 19 27 0 3.13e-05 1.89e-15 2.30e-13 5 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(7), CDKN2A(22), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1), TP53(59) 2829804 105 64 85 3 19 12 15 15 44 0 4.62e-09 2.55e-15 2.30e-13 6 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(9), CDC25C(2), TP53(59), YWHAH(1) 2182623 79 64 67 5 17 6 12 15 29 0 0.00113 2.55e-15 2.30e-13 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CDK4(2), CDKN2A(22), MDM2(2), NXT1(1), TP53(59) 1183860 87 61 68 1 18 7 12 12 38 0 5.28e-09 3.22e-15 2.30e-13 8 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(7), ATM(8), BRCA1(5), MAPK8(2), MDM2(2), MRE11A(3), NFKBIA(2), RBBP8(9), RELA(1), TP53(59) 4111596 98 69 78 2 19 9 16 15 39 0 2.30e-07 3.55e-15 2.30e-13 9 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(7), ATM(8), ATR(9), CCNA1(3), CCNE1(1), CDC25A(3), CDK4(2), CDK6(2), CDKN2A(22), DHFR(1), GSK3B(1), RB1(3), SKP2(2), TGFB1(1), TGFB2(2), TP53(59) 4177722 126 67 103 11 21 14 20 19 52 0 3.33e-05 4.33e-15 2.30e-13 10 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP1(1), TP53(59) 972295 60 60 49 0 15 4 9 11 21 0 6.08e-08 4.55e-15 2.30e-13 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(2), DAXX(4), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1), TP53(59) 2657754 79 61 67 6 21 6 13 15 24 0 5.03e-05 4.66e-15 2.30e-13 12 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), NFKBIA(2), RELA(1), TP53(59) 1382412 65 61 54 1 15 5 10 13 22 0 2.46e-06 4.88e-15 2.30e-13 13 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(3), ATM(8), BAD(1), BCL2L1(7), CASP7(1), CASP9(1), PTK2(4), PXN(1), STAT1(1), TLN1(9), TP53(59) 3786580 97 66 80 5 22 12 14 16 33 0 1.99e-06 5.00e-15 2.30e-13 14 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNGR1(1), IFNGR2(13), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TP53(59), USH1C(3) 2561313 91 64 68 8 20 6 15 14 36 0 0.000525 5.22e-15 2.30e-13 15 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(1), BCL2L1(7), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), FAS(2), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), PARP1(5), PRF1(6), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TP53(59), TRADD(1), TRAF2(1) 5219351 108 69 87 12 23 9 20 15 40 1 0.000694 1.26e-11 5.15e-10 16 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(9), BRCA1(5), CDC25A(3), CDC25C(2), CDC34(1), EP300(4), MDM2(2), MYT1(10), PRKDC(7), RPS6KA1(2), TP53(59), YWHAH(1) 5804733 113 67 97 12 24 12 16 23 38 0 0.000461 5.04e-10 1.94e-08 17 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(9), BRCA1(5), BRCA2(7), FANCA(3), FANCC(2), FANCD2(4), FANCG(1), HUS1(1), MRE11A(3), RAD1(1), RAD17(5), RAD9A(1), TP53(59), TREX1(2) 6019773 111 69 94 12 22 13 13 25 38 0 0.00116 1.98e-09 7.16e-08 18 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(22), E2F4(4) 1272047 36 23 28 2 2 7 6 4 17 0 0.00487 1.87e-08 6.41e-07 19 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(21), MST1R(5) 903667 29 18 16 4 2 10 1 5 10 1 0.0444 3.03e-07 9.84e-06 20 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(9), HLA-DRB1(1) 414818 10 10 2 1 0 0 0 0 9 1 1.000 1.24e-05 0.000383 21 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), NCK1(3), NCKAP1(4), NTRK1(2), PIR(1), WASF1(1), WASF2(2), WASF3(17), WASL(5) 2102796 42 26 26 5 7 7 3 4 21 0 0.196 4.29e-05 0.00126 22 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A2(2), EIF4G1(7), EIF4G3(7), GHR(1), IRS1(15), PABPC1(15), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2) 3868264 59 37 32 7 4 8 8 4 35 0 0.290 5.98e-05 0.00167 23 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(1), EGR1(17), HRAS(1), KLK2(1), NGFR(1) 1157008 24 18 12 4 3 0 3 2 16 0 0.813 9.32e-05 0.00250 24 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), IFNGR2(13), JAK1(1), JAK2(2), STAT1(1) 1119538 18 15 6 2 1 0 2 1 14 0 0.732 0.000163 0.00418 25 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), HRAS(1), IGF1R(3), IRS1(15), PIK3CA(4), PIK3R1(1), SHC1(1), SOS1(12), YWHAH(1) 2597719 41 28 20 6 4 4 1 4 28 0 0.562 0.000182 0.00449 26 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAD(1), BAK1(1), BCL2L1(7), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(2), FASLG(1), HELLS(1), IKBKB(2), IRF1(2), IRF3(1), IRF5(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), NFKBIE(1), PRF1(6), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP53(59), TRADD(1), TRAF2(1) 8075426 130 70 109 15 27 15 22 18 47 1 0.000164 0.000200 0.00473 27 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(12), CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5(3), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(2), PPP2CA(1) 1311578 26 17 16 1 4 4 1 2 15 0 0.0531 0.000254 0.00580 28 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CDC25A(3), CDK4(2), CDK6(2), CDK7(1), CDKN2A(22), RB1(3), RBL1(1) 2247796 41 25 31 4 2 7 6 5 21 0 0.0262 0.000362 0.00795 29 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(9), CD4(2), HLA-DRB1(1), IL1B(1), IL6(1) 728807 14 11 6 2 0 0 1 1 11 1 0.839 0.000487 0.0104 30 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), HRAS(1), SHC1(1), SOS1(12), SRC(2) 1217272 18 15 9 2 2 3 0 1 12 0 0.431 0.000600 0.0123 31 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), HRAS(1), INSR(4), IRS1(15), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1) 3534570 43 29 22 4 5 3 1 5 29 0 0.233 0.000723 0.0144 32 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), PAK1(7), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(5) 1827255 24 17 17 3 2 6 1 3 12 0 0.252 0.00133 0.0257 33 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IFNGR2(13), IL12B(1), IL12RB2(1), IL4R(1), TGFB1(1), TGFB2(2) 2774339 41 27 20 9 4 4 2 5 25 1 0.772 0.00161 0.0300 34 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), HRAS(1), IGF1R(3), IRS1(15), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1) 3427758 42 28 21 5 4 3 1 5 29 0 0.414 0.00179 0.0321 35 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), FSHB(1), FSHR(2), GNAS(13), XPO1(1) 1342998 21 12 17 1 12 2 3 3 1 0 0.0255 0.00183 0.0321 36 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TNFRSF9(7), TNFSF9(19), TRAF2(1) 2706607 38 26 17 5 1 2 4 3 28 0 0.774 0.00207 0.0354 37 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(2), AKT2(1), AKT3(1), BAD(1), BTK(1), CDKN2A(22), DAPP1(1), GSK3A(1), GSK3B(1), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1), TEC(2), YWHAE(2), YWHAH(1) 5012663 66 35 49 9 7 12 4 7 36 0 0.0363 0.00363 0.0604 38 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(7), ATM(8), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(1), CDC25A(3), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), CDKN2A(22), DTX4(1), E2F3(3), E2F4(4), E2F5(3), EP300(4), ESPL1(5), GSK3B(1), HDAC4(4), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), RB1(3), RBL1(1), SKP2(2), SMAD4(17), TBC1D8(2), TGFB1(1), TP53(59) 15310796 213 72 188 17 45 24 36 38 69 1 9.43e-10 0.00522 0.0847 39 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(13), PLA2G3(2), PLA2G6(4) 1414538 20 15 8 6 0 2 3 1 14 0 0.982 0.00599 0.0947 40 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), DPYD(3), DPYS(9), ENPP3(2), PANK1(1), PANK2(10), PANK4(2), UPB1(2) 1948525 31 19 17 4 3 5 2 2 19 0 0.352 0.00710 0.109 41 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX3(1), ELOVL6(1), FADS1(1), FADS2(13), FASN(7), HADHA(1), HSD17B12(1), SCD(9) 2073110 35 20 16 3 3 4 3 0 24 1 0.123 0.00771 0.116 42 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(10), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1107316 17 12 8 2 3 0 3 1 10 0 0.555 0.00927 0.134 43 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2A(1), ADORA3(4), LTB4R(4), P2RY1(2), P2RY2(1), P2RY6(1) 823968 14 9 12 1 6 2 2 1 3 0 0.0443 0.00938 0.134 44 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), HRAS(1), INSR(4), IRS1(15), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(1), SOS1(12), SRF(1), STAT5A(1) 4568011 50 31 29 5 8 4 5 4 29 0 0.134 0.0102 0.142 45 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(13), IL12B(1), IL12RB2(1), IL2RA(1), IL4R(1) 1738129 20 17 8 3 1 1 0 3 15 0 0.751 0.0107 0.147 46 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(12), CRY1(1), CSNK1E(1), PER1(4) 1200896 19 12 11 1 3 0 0 3 13 0 0.234 0.0117 0.157 47 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), DPYS(9), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), HIBCH(8), MLYCD(1), UPB1(2) 3729059 49 26 36 5 13 7 9 3 16 1 0.0103 0.0119 0.157 48 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC3B(2), APOBEC3G(1), APOBEC4(9) 1001585 14 10 6 1 3 2 0 0 9 0 0.362 0.0155 0.200 49 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(1), ETS2(2), ETV6(3), ETV7(1), FMN2(7), KRAS(66), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS1(12), SOS2(1) 7375689 141 70 67 28 19 39 44 16 23 0 0.0104 0.0173 0.217 50 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(12) 2146529 25 18 16 3 4 4 1 3 13 0 0.225 0.0187 0.230 51 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4R(1), IRS1(15), JAK1(1), JAK3(3), SHC1(1), STAT6(4) 2066491 27 19 15 9 5 3 2 2 15 0 0.917 0.0191 0.230 52 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNAS(13), GNB1(2), PRKAR1A(1) 938983 20 12 16 2 11 4 2 2 1 0 0.0488 0.0227 0.268 53 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(3), HEXB(2), LCT(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(16), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1) 2267696 38 21 23 7 9 3 3 0 23 0 0.258 0.0298 0.346 54 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(2), EGFR(2), HRAS(1), PTPRB(10), RASA1(1), SHC1(1), SOS1(12), SPRY4(3), SRC(2) 3437199 38 21 27 2 2 8 4 6 17 1 0.0259 0.0309 0.352 55 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2), SHC1(1), TP53(59) 7023440 109 64 91 15 28 13 15 18 35 0 0.00111 0.0315 0.353 56 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), DPYD(3), DPYS(9), ENPP3(2), ILVBL(2), PANK1(1), PANK2(10), PANK4(2), UPB1(2), VNN1(1) 2416806 35 19 21 4 5 6 3 2 19 0 0.163 0.0397 0.437 57 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(5), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 1321286 16 12 12 4 4 2 2 2 6 0 0.587 0.0458 0.486 58 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(5), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 1321286 16 12 12 4 4 2 2 2 6 0 0.587 0.0458 0.486 59 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD4(2), FYN(8), HLA-DRB1(1), LCK(1), PTPRC(2), ZAP70(5) 1254176 20 11 13 2 3 2 1 2 12 0 0.266 0.0518 0.535 60 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TOB1(4) 1467115 19 12 14 3 7 1 0 2 9 0 0.317 0.0521 0.535 61 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT2(10), CHST2(2), CHST4(1), CHST6(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1751119 23 14 14 2 5 1 4 2 11 0 0.130 0.0580 0.586 62 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(4), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), MAP3K7(9), PIK3CA(4), PIK3R1(1), PLCB1(1), PPP1R12B(4), ROCK1(3) 3594256 35 22 25 5 4 6 3 4 18 0 0.197 0.0618 0.607 63 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD81(1), CHUK(1), CR2(8), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), KRAS(66), LILRB3(1), MALT1(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(1), SYK(2), VAV1(4) 10358917 179 75 96 26 22 53 41 21 41 1 6.90e-06 0.0620 0.607 64 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 207846 2 2 2 0 0 0 1 0 1 0 0.885 0.0657 0.625 65 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), SHC1(1), SOS1(12) 2690182 32 18 23 4 4 6 5 3 14 0 0.129 0.0659 0.625 66 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(8), CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(3), CDK4(2), CDK7(1), CDKN2A(22), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(4), E2F5(3), GBA2(2), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MYT1(10), NACA(9), POLA2(1), POLE(7), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(2), RPA3(2), TFDP2(3), TNXB(8), TP53(59) 10800979 186 70 163 22 41 23 34 33 54 1 4.49e-07 0.0759 0.708 67 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(13), RANGAP1(2) 1152807 16 8 12 2 1 2 2 4 6 1 0.328 0.0854 0.777 68 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(8), THBS1(3) 1011358 11 11 2 2 3 0 0 0 8 0 0.754 0.0871 0.777 69 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), SNX13(5), SRC(2), TERF2IP(1) 1553443 18 9 18 2 3 2 2 4 7 0 0.189 0.0871 0.777 70 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(10), B4GALT5(2), DDOST(1), DPAGT1(5), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), ST6GAL1(1) 2793520 27 18 14 6 4 1 1 4 17 0 0.868 0.0937 0.825 71 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(10), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), ST8SIA1(2) 2277446 26 15 17 2 9 4 2 0 11 0 0.0388 0.0972 0.844 72 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(6), AGT(1), AGTR2(1), KNG1(1), NOS3(6), REN(8) 1397118 23 12 16 2 4 2 7 0 10 0 0.141 0.101 0.865 73 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(4), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 948112 13 9 10 3 2 2 3 2 4 0 0.511 0.103 0.873 74 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(5), CSAD(1), GAD1(6), GAD2(5), GGT1(1) 800621 19 12 16 6 4 4 4 1 5 1 0.547 0.105 0.874 75 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(15), ABCG2(1), BCHE(5), CES1(1), CYP3A5(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4) 3108859 33 21 20 7 2 2 3 4 20 2 0.835 0.106 0.874 76 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(1), FYN(8), LRP8(1), RELN(7), VLDLR(1) 1919142 22 13 13 6 3 2 2 1 13 1 0.908 0.134 1.000 77 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(13), GNB1(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1369153 22 11 18 2 14 4 3 1 0 0 0.0207 0.146 1.000 78 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(8), ATR(9), BAI1(3), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(22), EI24(1), FAS(2), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN2(2), SESN3(2), STEAP3(2), THBS1(3), TNFRSF10B(2), TP53(59), TSC2(6), ZMAT3(2) 9141156 156 67 134 24 38 23 24 21 50 0 0.000184 0.148 1.000 79 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(1), AKT3(1), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1), SOS1(12) 2292231 27 17 18 8 6 2 2 3 14 0 0.774 0.155 1.000 80 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), AKT1(2), CAMK2D(1), CREB1(2), GNAS(13), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), RPS6KA5(1), SOS1(12) 4062723 49 27 36 6 16 6 4 5 18 0 0.0430 0.156 1.000 81 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB27A(1), RAB3A(1), RAB4A(1), RAB6A(1), RAB9A(1) 584670 10 4 10 1 5 2 2 1 0 0 0.100 0.166 1.000 82 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(1), AKT3(1), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(66), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(4), PXN(1), RAC2(1), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(1), SRC(2) 10132467 175 73 93 34 23 52 45 18 37 0 0.000657 0.173 1.000 83 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(2), FGA(5), FGB(4), FGG(2), PLAT(2), PLAU(7), SERPINE1(2) 1835921 24 11 18 7 3 4 4 4 9 0 0.670 0.177 1.000 84 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(8), GAB2(2), HRAS(1), INPP5D(1), KRAS(66), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PRKCD(7), PRKCE(1), RAC2(1), SOS1(12), SOS2(1), SYK(2), VAV1(4) 10032462 163 73 80 28 18 48 40 17 39 1 0.000382 0.179 1.000 85 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), GRM1(13), PLCB1(1), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2215288 30 14 25 5 10 4 3 5 8 0 0.125 0.181 1.000 86 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IL12B(1) 410351 5 5 4 2 0 2 0 0 3 0 0.927 0.184 1.000 87 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(12) 2654117 25 16 16 3 3 4 1 3 14 0 0.219 0.192 1.000 88 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(4), PIK3R1(1), PTK2(4), SRC(2), TERT(6), YWHAH(1) 2309601 27 13 27 4 3 7 2 5 10 0 0.0545 0.192 1.000 89 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), WASF1(1), WASL(5) 1110886 14 9 13 4 2 5 2 2 3 0 0.538 0.209 1.000 90 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(1), AGTR2(1), CMA1(1), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), REN(8) 3503966 38 18 32 2 5 6 11 2 13 1 0.0234 0.215 1.000 91 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(2), FYN(8), ITGA1(7), L1CAM(1), RAP1B(2), SELP(3) 2156792 27 14 20 2 6 5 2 2 12 0 0.0368 0.223 1.000 92 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), CFTR(4), GNAS(13), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1) 1847524 28 14 24 3 14 6 3 4 1 0 0.0142 0.242 1.000 93 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(1), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD17B7(5), HSD3B1(2), HSD3B2(1) 1115313 16 8 13 3 2 10 2 2 0 0 0.0860 0.246 1.000 94 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(4), KLRC3(2), PAK1(7), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4) 2560493 28 14 22 5 5 3 3 5 11 1 0.331 0.261 1.000 95 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(2), GNAS(13), GNB1(2), HRAS(1), IGF1R(3), KLK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(1), SHC1(1), SOS1(12), SRC(2), STAT3(2) 4646209 47 27 34 9 17 8 4 5 13 0 0.113 0.267 1.000 96 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(7), MMP2(2), MMP9(2), RECK(3) 1043179 15 7 11 4 5 1 2 0 7 0 0.570 0.267 1.000 97 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3E(1), HLA-A(4), ICAM1(2), ITGAL(3), ITGB2(1), PRF1(6) 1201508 17 9 15 2 5 1 1 1 9 0 0.191 0.276 1.000 98 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1D(2), EEF1G(3), EEF2(3), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(7), EIF4G3(7), EIF5(1), EIF5B(8), GSPT2(1), PABPC1(15), PABPC3(5), SLC35A4(2) 6128261 69 31 49 8 8 10 14 7 30 0 0.0802 0.278 1.000 99 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F12(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), LPA(5), PLAT(2), PLAU(7), SERPINE1(2), SERPINF2(1), VWF(5) 4853964 50 21 41 9 10 9 15 4 12 0 0.121 0.287 1.000 100 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), HRAS(1), IL3RA(1), JAK2(2), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1) 2441531 24 14 15 3 5 2 3 3 11 0 0.289 0.288 1.000 101 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(1), AKT3(1), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), PTEN(2), RBL2(2), SHC1(1), SOS1(12) 2818091 31 17 22 7 3 4 5 5 14 0 0.569 0.304 1.000 102 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), CCND2(2), CDK4(2), EGR1(17), ESR2(1), FSHR(2), GJA4(1), LHCGR(1), MLH1(1), NCOR1(7), NRIP1(1), PGR(3), PRLR(3), ZP2(1) 4847218 50 22 40 7 8 5 10 9 18 0 0.0886 0.304 1.000 103 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), SNAP25(1) 443254 4 3 4 1 4 0 0 0 0 0 0.520 0.311 1.000 104 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), CDO1(5), GOT1(2), LDHB(1), SULT1B1(4), SULT1C4(1), SULT4A1(1) 1739102 16 9 11 4 1 2 2 3 8 0 0.767 0.312 1.000 105 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(3), CDC25C(2), CSK(1), SRC(2) 1270218 8 7 5 1 1 2 0 0 5 0 0.510 0.318 1.000 106 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB4(4), PSMB5(2), UBE3A(5) 1777146 18 11 16 4 6 0 3 2 7 0 0.499 0.328 1.000 107 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(3), CDC25C(2), MYT1(10), YWHAH(1) 1892958 24 10 21 5 3 4 3 5 9 0 0.419 0.337 1.000 108 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CDH1(1), CREBBP(2), EP300(4), MAP3K7(9), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5) 3530938 34 18 25 6 11 2 3 4 14 0 0.267 0.341 1.000 109 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), JUND(1) 533126 4 4 2 0 0 0 0 1 3 0 0.809 0.345 1.000 110 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(12), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(4), PER2(3), PER3(1) 2380454 27 13 19 3 5 2 2 5 13 0 0.157 0.348 1.000 111 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(3), CASP1(4), CASP10(2), CASP8(2), CASP9(1), PRF1(6) 1768091 21 11 18 5 3 4 1 2 11 0 0.625 0.359 1.000 112 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(2), CES1(1), ESD(1) 826594 9 4 8 1 4 3 2 0 0 0 0.122 0.387 1.000 113 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), NR4A3(7), WDR1(2) 1518294 20 8 15 6 5 2 1 5 7 0 0.607 0.403 1.000 114 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), BCL2L1(7), CASP9(1), CES1(1) 1546282 14 8 8 3 2 3 2 0 7 0 0.733 0.407 1.000 115 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(3), ARAF(2), ATF4(1), BRAF(3), CACNA1C(7), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(2), EP300(4), GNAQ(1), GRIA1(3), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRM1(13), GRM5(7), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), RAP1B(2), RAPGEF3(3), RPS6KA1(2), RPS6KA2(1) 13994884 201 76 127 38 39 49 49 23 39 2 9.97e-05 0.435 1.000 116 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADSB(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), DPYS(9), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2) 4003127 44 18 38 4 13 9 9 4 8 1 0.00188 0.435 1.000 117 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 156442 1 1 1 0 0 0 0 0 1 0 0.842 0.458 1.000 118 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PAK1(7), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1) 2804784 26 15 20 6 2 4 6 4 10 0 0.625 0.470 1.000 119 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3) 909411 7 4 7 0 4 0 1 0 2 0 0.150 0.473 1.000 120 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(5), AXIN1(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(8), DVL1(4), FZD1(5), GATA4(1), GSK3B(1), MAP3K7(9), RFC1(4), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), WNT1(1) 5089300 70 24 61 8 25 13 5 11 16 0 0.00128 0.474 1.000 121 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(5), FGA(5), FGB(4), FGG(2), PROC(1), PROS1(1), SERPINC1(2), TFPI(3) 2249498 27 9 25 5 3 6 11 5 2 0 0.191 0.475 1.000 122 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BCL2L1(7), BIRC2(1), CASP7(1), CASP8(2), CASP9(1), DFFB(1) 1876439 17 9 11 4 2 3 1 1 10 0 0.705 0.480 1.000 123 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(1), PSMB4(4), PSMB5(2) 1198263 14 10 13 5 4 0 3 1 6 0 0.783 0.480 1.000 124 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(1), CRKL(2), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), SOS1(12), STAT1(1), STAT5A(1) 3878813 34 18 25 6 4 3 5 6 16 0 0.408 0.483 1.000 125 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(9), GNAQ(1), GNAS(13), GNB1(2), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PPP1R12B(4), PTK2(4), ROCK2(1) 3511045 39 23 24 9 11 5 4 3 15 1 0.584 0.496 1.000 126 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(3), CASP1(4), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(7), RERE(9), WWP1(2), WWP2(3) 3324903 42 19 37 9 11 8 3 5 15 0 0.195 0.509 1.000 127 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(5), AXIN1(5), CD14(2), CTNNB1(8), DVL1(4), FZD1(5), GNAI1(1), GSK3B(1), LBP(1), LEF1(3), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1), TOLLIP(1), WNT1(1) 4297741 48 16 47 5 14 9 5 12 8 0 0.00292 0.510 1.000 128 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4) 1762032 13 6 13 1 2 4 0 3 3 1 0.0591 0.511 1.000 129 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2), HLA-DRB1(1) 325957 3 2 3 1 0 0 0 1 2 0 0.905 0.514 1.000 130 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(5), AXIN1(5), BTRC(1), CREBBP(2), CSNK1D(1), CSNK2A1(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), MAP3K7(9), NLK(1), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1) 4141671 50 19 43 5 14 8 7 8 13 0 0.00535 0.520 1.000 131 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(6), CD44(3), CSF1(2), IL1B(1), IL6R(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3) 1885145 23 10 19 7 6 1 5 4 7 0 0.565 0.521 1.000 132 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), ESCO2(8), SH3GLB1(1) 2273332 16 11 9 4 1 1 1 3 10 0 0.854 0.527 1.000 133 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BFAR(2), BTK(1), CAD(5), CASP10(2), CASP8(2), DAXX(4), DEDD(1), EGFR(2), EPHB2(3), FAF1(1), FAIM2(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(6), RALBP1(2), ROCK1(3), TP53(59), TPX2(2), TRAF2(1) 10265077 144 71 114 23 27 17 24 23 53 0 0.00562 0.533 1.000 134 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(8), BMPR1A(3), BMPR2(3) 858608 14 5 14 3 2 6 2 1 3 0 0.337 0.543 1.000 135 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RETN(3) 792995 9 4 7 1 2 0 2 1 4 0 0.399 0.552 1.000 136 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(6), ACE2(1), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(4), LNPEP(2), MME(2), NLN(1), REN(8), THOP1(1) 2922558 34 15 27 4 4 8 8 4 10 0 0.0409 0.555 1.000 137 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(5), GLS(2), GOT1(2) 1072483 11 3 11 0 2 2 2 3 1 1 0.0398 0.556 1.000 138 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), HADHB(2), HSD17B4(3), PPT1(1), PPT2(2) 1170613 10 4 10 0 2 3 1 2 2 0 0.0548 0.557 1.000 139 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(2), GNAS(13), GNB1(2), NOS3(6), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(1) 2525460 33 15 29 5 11 5 8 5 4 0 0.0937 0.564 1.000 140 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(1), UGP2(5), UXS1(1) 677287 7 5 6 2 0 1 1 3 2 0 0.823 0.567 1.000 141 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(7), ABL2(3), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), BTC(1), CAMK2D(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EGF(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GSK3B(1), HRAS(1), KRAS(66), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), NCK1(3), NCK2(2), NRG1(5), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SRC(2), STAT5A(1) 14387581 207 70 127 28 36 53 47 20 51 0 1.38e-06 0.575 1.000 142 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2D(1), PAK1(7), PTK2(4), SHC1(1), SOS1(12), SRC(2) 4656530 41 18 26 8 3 5 6 5 22 0 0.554 0.579 1.000 143 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(1), B3GNT5(1), FUT1(1), FUT2(3), ST3GAL4(2) 993382 9 6 9 2 8 0 0 1 0 0 0.289 0.585 1.000 144 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(1), EPOR(2), GRIN1(7), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1) 1773893 16 8 11 1 2 1 5 0 8 0 0.203 0.586 1.000 145 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 98584 2 1 2 1 2 0 0 0 0 0 0.803 0.596 1.000 146 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), STAT1(1), STAT3(2), STAT5A(1), THPO(1) 4123193 29 16 20 3 3 6 2 3 15 0 0.127 0.608 1.000 147 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(7), ARFGEF2(2), CLTB(2), COPA(2), GBF1(3), GPLD1(2), KDELR3(1) 2223789 21 10 16 4 4 2 3 3 8 1 0.414 0.612 1.000 148 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(4), AKT1(2), BAD(1), BCL2L1(7), CSF2RB(2), IGF1R(3), IL3RA(1), KIT(4), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1) 3032682 36 13 30 5 8 7 3 6 12 0 0.0415 0.621 1.000 149 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2) 1401634 14 5 14 1 9 2 2 0 1 0 0.0241 0.622 1.000 150 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(4), SIRT1(1) 1632389 11 6 9 0 3 1 1 2 4 0 0.106 0.623 1.000 151 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAP3K7(9), MAPK8(2), PAK1(7), PAK2(3), PRKDC(7), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1) 5426888 56 23 43 8 12 2 11 7 24 0 0.168 0.623 1.000 152 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNAS(13), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2157409 31 13 27 3 14 7 3 3 4 0 0.00686 0.633 1.000 153 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), YWHAH(1) 1962071 16 8 16 4 0 4 4 3 5 0 0.447 0.635 1.000 154 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(2), AKT2(1), AKT3(1), APAF1(3), ATM(8), BAD(1), BCL2L1(7), BIRC2(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CSF2RB(2), DFFB(1), FAS(2), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IL3RA(1), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TP53(59), TRADD(1), TRAF2(1) 11700600 151 70 132 21 38 22 19 23 49 0 9.01e-05 0.638 1.000 155 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(2), OAT(2), PRODH(1) 783236 9 3 9 1 2 1 2 1 3 0 0.214 0.643 1.000 156 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), EPO(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1) 2997076 28 13 19 3 6 2 4 3 13 0 0.156 0.650 1.000 157 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1), STAT1(1), STAT3(2), STAT5A(1) 4823694 38 18 29 6 6 6 4 6 16 0 0.218 0.652 1.000 158 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(1), AKT3(1), IARS(4), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(4), SHC1(1), SOS1(12), SOS2(1), SRC(2), STAT6(4), TYK2(2) 5126144 42 19 33 8 8 7 5 6 16 0 0.200 0.655 1.000 159 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(2), ABCB4(4), ABCC3(4), GSTP1(1) 1969378 15 9 12 3 2 3 2 4 4 0 0.418 0.656 1.000 160 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1) 830758 11 3 11 2 1 2 1 4 3 0 0.375 0.662 1.000 161 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 224782 3 1 3 0 1 1 0 1 0 0 0.348 0.679 1.000 162 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), NFS1(1), PHPT1(1), TPK1(2) 881786 6 3 6 2 1 2 2 0 1 0 0.780 0.679 1.000 163 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(3), INPPL1(5), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2) 2721003 23 12 21 5 3 4 3 5 8 0 0.367 0.687 1.000 164 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), KEAP1(1), MAFF(2), MAPK8(2), NFE2L2(1) 1253790 8 4 8 0 2 0 0 3 3 0 0.115 0.689 1.000 165 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(2), DFFB(1), NME1(1), PRF1(6), SET(1) 1470883 12 8 10 2 3 1 1 1 6 0 0.464 0.694 1.000 166 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(1), AKT3(1), CARD11(3), CBL(4), CBLB(1), CD3E(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), CTLA4(1), FYN(8), GRAP2(2), HRAS(1), IKBKB(2), ITK(1), KRAS(66), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS1(12), SOS2(1), TEC(2), VAV1(4), ZAP70(5) 14110931 222 78 119 31 30 57 44 22 68 1 1.25e-05 0.695 1.000 167 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), F10(4), F12(2), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1) 6151124 59 20 53 8 7 11 21 5 14 1 0.0683 0.699 1.000 168 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 274454 1 1 1 0 1 0 0 0 0 0 0.782 0.703 1.000 169 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDK7(1) 971537 4 4 2 1 0 0 0 0 4 0 0.899 0.706 1.000 170 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD80(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1) 1747533 12 6 12 2 1 2 2 2 5 0 0.325 0.706 1.000 171 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 305620 2 1 2 1 0 0 0 1 1 0 0.765 0.708 1.000 172 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(4), CDC25C(2), GNAI1(1), GNAS(13), GNB1(2), HRAS(1), MYT1(10), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), SRC(2) 2890315 47 20 42 7 20 11 6 6 4 0 0.00619 0.710 1.000 173 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(3), CACNA1A(7), GNA11(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAS(13), GNAZ(1), GRIA1(3), GRID2(4), GRM1(13), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), IGF1R(3), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), NOS1(7), NOS3(6), NPR1(2), NPR2(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(18) 15461334 224 77 151 40 59 45 64 30 26 0 1.05e-05 0.713 1.000 174 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1), PRF1(6) 2669345 28 12 25 4 5 6 4 1 12 0 0.196 0.719 1.000 175 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(3), FUT5(1), FUT6(1) 707432 6 3 6 1 5 1 0 0 0 0 0.233 0.726 1.000 176 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), CPOX(3), HMBS(1), PPOX(2) 1059298 8 6 8 2 2 2 1 1 2 0 0.626 0.726 1.000 177 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1) 2642202 23 11 23 3 5 6 3 2 7 0 0.0735 0.730 1.000 178 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2) 1027752 11 3 11 1 3 4 3 0 1 0 0.167 0.734 1.000 179 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1), HLA-DRB1(1) 544056 4 2 4 1 0 0 1 1 2 0 0.845 0.735 1.000 180 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(2) 529164 4 2 4 3 0 0 1 1 2 0 0.908 0.735 1.000 181 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 256508 1 1 1 0 0 0 0 1 0 0 0.796 0.738 1.000 182 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(3), CDC25C(2), CDK7(1), XPO1(1) 1204201 7 5 4 2 1 0 0 0 6 0 0.884 0.738 1.000 183 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(11), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM1(13), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM7(5), GRM8(3) 2881720 61 26 49 13 11 14 7 7 22 0 0.134 0.741 1.000 184 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(12), SRF(1), STAT1(1), STAT3(2), STAT5A(1) 5172602 39 18 30 6 4 7 4 7 17 0 0.193 0.743 1.000 185 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(3), GCNT2(2), ST8SIA1(2) 864472 8 3 8 1 5 2 1 0 0 0 0.123 0.745 1.000 186 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(3) 641413 7 2 7 3 1 1 3 2 0 0 0.814 0.746 1.000 187 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LPL(2) 727176 7 2 7 1 1 3 1 1 1 0 0.228 0.746 1.000 188 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), SOS1(12), STAT5A(1), SYK(2) 3289113 28 14 19 9 8 4 1 3 12 0 0.741 0.753 1.000 189 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), CD38(1), ENPP3(2), NADK(7), NADSYN1(4), NNT(5), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT12(1) 2977376 29 11 22 4 6 4 3 3 13 0 0.187 0.753 1.000 190 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ENPP3(2), FLAD1(5), RFK(1), TYR(3) 1335629 12 5 9 2 3 3 1 1 4 0 0.424 0.772 1.000 191 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BRAF(3), FAS(2), FASLG(1), FCGR3B(1), FYN(8), HLA-A(4), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), ITGAL(3), ITGB2(1), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), KRAS(66), LCK(1), NCR1(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK1(7), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRF1(6), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), ZAP70(5) 15802910 246 78 128 34 37 55 41 25 87 1 8.59e-06 0.775 1.000 192 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2) 775721 13 4 12 2 5 2 3 0 3 0 0.134 0.777 1.000 193 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(6), TH(1), TPH1(2) 850064 9 3 9 4 2 0 3 1 2 1 0.744 0.778 1.000 194 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(2), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), ESCO2(8), GCDH(2), HADHA(1), SH3GLB1(1) 3574631 24 13 17 5 4 3 3 3 11 0 0.549 0.781 1.000 195 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR39(3), GPR65(2), GPR75(1) 1354180 10 5 10 3 1 1 0 4 4 0 0.736 0.783 1.000 196 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(7), CASP9(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1) 2687776 25 13 19 6 2 5 3 4 11 0 0.597 0.786 1.000 197 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), ESCO1(3), ESCO2(8), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TAT(1), TPO(4) 4725962 46 18 38 9 18 5 6 5 12 0 0.0813 0.793 1.000 198 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1) 1832313 14 7 14 3 4 3 1 3 3 0 0.245 0.805 1.000 199 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(2), EPO(1), IL6(1), IL7(1), IL9(1) 854176 8 2 8 1 0 1 2 4 1 0 0.388 0.812 1.000 200 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1), CD4(2) 439716 3 1 3 1 0 0 0 1 2 0 0.839 0.823 1.000 201 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2) 1861052 11 5 10 4 1 2 1 3 4 0 0.782 0.825 1.000 202 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), IL1B(1), MAP2K6(2), MAP3K7(9), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(5), TGFBR2(5), TLR2(2) 4127875 39 17 31 6 10 5 6 4 14 0 0.0909 0.827 1.000 203 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGP2(5), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), XYLB(2) 3716054 27 13 24 5 3 6 5 4 9 0 0.353 0.828 1.000 204 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(2), ERBB3(4), NRG1(5), UBE2D1(1) 1412586 14 4 14 1 3 2 4 2 3 0 0.110 0.830 1.000 205 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(2), EP300(4), FYN(8), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1) 3893283 29 18 21 9 6 4 3 3 13 0 0.694 0.833 1.000 206 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CALML3(2), CALML6(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(2), CTNNB1(8), DCT(5), DVL1(4), DVL2(3), EDN1(3), EDNRB(2), EP300(4), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAS(13), GSK3B(1), HRAS(1), KIT(4), KRAS(66), LEF1(3), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACG(2), PRKCG(2), TCF7(2), TCF7L1(3), TCF7L2(1), TYR(3), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2) 15398834 223 72 154 51 65 55 49 29 25 0 1.96e-05 0.839 1.000 207 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), IL6(1) 860541 9 2 9 1 1 1 1 3 3 0 0.263 0.850 1.000 208 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(4), EGF(2), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(1), SRC(2) 2667516 23 9 21 2 4 6 3 3 7 0 0.0482 0.850 1.000 209 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(2), ADSS(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), CAD(5), CRAT(6), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), PC(2) 3607511 43 16 38 10 9 8 12 5 8 1 0.187 0.857 1.000 210 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), SLC2A1(4) 3501189 30 12 28 5 5 5 9 2 8 1 0.260 0.857 1.000 211 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(3), CR2(8), FCGR2B(1), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2) 2087015 22 13 20 4 5 4 1 5 7 0 0.208 0.859 1.000 212 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 572133 1 1 1 0 0 0 0 0 1 0 0.829 0.859 1.000 213 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(4) 1639934 22 5 22 6 9 3 5 1 3 1 0.226 0.860 1.000 214 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(3) 880183 6 2 6 1 1 0 3 1 1 0 0.435 0.862 1.000 215 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1) 2472306 22 6 22 2 7 3 7 3 1 1 0.0285 0.866 1.000 216 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(3), CASP9(1), DAXX(4), FAS(2), FASLG(1), MAPKAPK3(1) 1567330 16 7 14 5 3 4 3 2 4 0 0.598 0.868 1.000 217 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1) 1749661 11 5 9 0 1 3 0 1 6 0 0.0930 0.868 1.000 218 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1) 1721928 23 6 23 6 5 6 5 4 3 0 0.311 0.870 1.000 219 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1438872 6 3 6 1 2 0 2 1 1 0 0.402 0.871 1.000 220 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1438872 6 3 6 1 2 0 2 1 1 0 0.402 0.871 1.000 221 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(1) 937796 19 5 18 3 7 6 0 2 4 0 0.0316 0.873 1.000 222 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(1), FLT3(3), IL6(1), IL9(1), TGFB1(1), TGFB2(2) 1162588 10 4 9 2 1 2 4 1 2 0 0.433 0.876 1.000 223 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(1), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2) 1240198 11 3 11 2 2 1 3 4 1 0 0.352 0.876 1.000 224 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPX1(1), PRKCE(1) 1090308 13 2 13 1 4 4 1 1 2 1 0.0342 0.877 1.000 225 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(5), AOC3(2), CES1(1), DDHD1(2), ESCO1(3), ESCO2(8), LIPA(1), PLA1A(1), SH3GLB1(1) 3487308 24 14 16 5 6 4 2 3 9 0 0.388 0.883 1.000 226 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(4), GNAQ(1), GNB1(2), MYLK(8), PLCB1(1), PPP1R12B(4), ROCK1(3) 2849035 26 10 23 7 4 6 4 4 8 0 0.473 0.889 1.000 227 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(3), CREB1(2), EDN1(3), EP300(4), EPO(1), HIF1A(1), NOS3(6) 2358032 20 6 19 2 4 2 5 2 7 0 0.123 0.889 1.000 228 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 232415 1 1 1 1 0 0 1 0 0 0 0.968 0.890 1.000 229 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), AFMID(1), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1) 1833613 12 5 10 1 2 3 0 1 6 0 0.196 0.891 1.000 230 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(13), ABAT(1), ADSL(2), ADSS(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(1), CAD(5), CRAT(6), DARS(1), DARS2(1), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), NARS2(2), PC(2), PDHA1(1) 5246618 67 26 55 14 13 12 14 7 20 1 0.120 0.891 1.000 231 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), PRF1(6), SCAP(3), SREBF1(1), SREBF2(5) 2600541 26 11 22 6 5 6 1 1 13 0 0.362 0.892 1.000 232 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1), SHMT1(1), SHMT2(2) 590029 4 2 4 4 2 0 1 0 0 1 0.923 0.895 1.000 233 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2), EP300(4), ESR1(1), SRC(2) 2080195 9 4 9 1 2 3 2 1 1 0 0.145 0.897 1.000 234 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), ESCO2(8), SH3GLB1(1) 3430068 31 11 24 9 5 7 3 5 11 0 0.610 0.898 1.000 235 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(4), GNAS(13), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2) 2102491 29 12 25 4 14 3 4 6 2 0 0.0538 0.898 1.000 236 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(4), SPHK1(1), SRC(2) 3777430 31 10 31 2 5 11 3 5 7 0 0.00165 0.898 1.000 237 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1) 2405184 17 8 15 4 3 2 4 2 6 0 0.604 0.903 1.000 238 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(1), HK2(3), HK3(2), PGM1(2), PGM3(1) 1415027 10 3 10 4 4 1 2 0 3 0 0.526 0.905 1.000 239 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), PGM3(1), RENBP(1), UAP1(1) 2349416 20 7 20 6 8 3 5 1 3 0 0.353 0.906 1.000 240 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), OPRK1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1789927 11 4 11 2 5 1 3 0 2 0 0.294 0.906 1.000 241 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TAT(1), TPO(4) 3048453 36 11 35 8 17 5 7 3 4 0 0.0591 0.907 1.000 242 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), ASRGL1(1), CA5A(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), GLUD2(1), HAL(1) 2925016 22 9 21 4 4 8 3 1 5 1 0.163 0.907 1.000 243 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAPK8(2), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2), TOLLIP(1) 4134060 32 15 24 8 5 2 5 5 15 0 0.658 0.910 1.000 244 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(1), STAT3(2), STAT5A(1) 1675462 12 4 12 2 6 2 2 0 2 0 0.176 0.911 1.000 245 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(2), GNAQ(1), GNAS(13), GRM1(13), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), HTR2A(2), HTR2B(1), HTR2C(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), MAP3K2(2), MAPK7(4), NPR1(2), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACG(2), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(12), SOS2(1), SRC(2), TJP1(4), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 18444478 252 79 170 41 62 65 57 30 38 0 3.01e-08 0.911 1.000 246 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), EGFR(2), EP300(4), ERBB2(6), FARP2(1), FER(6), FYN(8), IGF1R(3), INSR(4), IQGAP1(1), LEF1(3), LMO7(5), MAP3K7(9), MET(4), MLLT4(4), NLK(1), PARD3(6), PTPN6(4), PTPRB(10), PTPRF(20), PTPRJ(2), PTPRM(6), PVRL1(13), PVRL2(11), PVRL3(1), PVRL4(1), RAC2(1), RHOA(1), SMAD3(1), SMAD4(17), SORBS1(1), SRC(2), SSX2IP(1), TCF7(2), TCF7L1(3), TCF7L2(1), TGFBR1(5), TGFBR2(5), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASF3(17), WASL(5), YES1(1) 16557979 244 66 174 25 49 33 25 29 107 1 1.03e-05 0.913 1.000 247 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(2), HTR2C(1), PLCB1(1), TUB(2) 981132 7 3 7 2 0 4 0 2 1 0 0.416 0.913 1.000 248 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1), UQCRH(1) 5276444 41 16 41 8 10 6 7 10 7 1 0.111 0.914 1.000 249 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(2), TPO(4) 1603550 21 4 21 6 9 3 4 2 2 1 0.232 0.915 1.000 250 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2), KARS(2) 644905 4 2 4 3 1 0 1 1 1 0 0.952 0.917 1.000 251 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS2(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 2070401 19 5 19 4 2 5 8 2 2 0 0.266 0.920 1.000 252 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNAS(13), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5) 3230534 40 15 36 5 19 7 5 4 5 0 0.00596 0.921 1.000 253 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNAS(13), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5) 3230534 40 15 36 5 19 7 5 4 5 0 0.00596 0.921 1.000 254 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA5A(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), HAL(1) 2614983 20 8 19 3 4 6 3 1 5 1 0.150 0.922 1.000 255 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(1), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1) 1290043 14 6 14 3 3 2 2 4 3 0 0.346 0.923 1.000 256 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(2), MAP2K6(2), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1), SP1(1) 2691532 19 8 19 8 1 2 6 4 6 0 0.890 0.924 1.000 257 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(2), SHC1(1), SOS1(12), SYK(2), VAV1(4) 4488736 32 15 23 8 8 3 3 4 13 1 0.535 0.924 1.000 258 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(4), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1971277 19 6 19 5 7 3 6 2 1 0 0.340 0.924 1.000 259 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD2(1) 630082 3 1 3 2 1 1 0 0 1 0 0.818 0.925 1.000 260 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), FARS2(2), GOT1(2), TAT(1) 1129552 8 4 7 2 0 2 3 2 1 0 0.580 0.929 1.000 261 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1) 2418149 29 8 29 8 6 6 6 6 5 0 0.315 0.930 1.000 262 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSE(1), CYP11B1(5), CYP11B2(4), HSD11B1(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1) 3763565 34 18 28 10 8 6 5 2 13 0 0.626 0.933 1.000 263 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), MAP3K1(3), MAP3K7(9), NFKBIA(2), RELA(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 3424893 24 11 17 8 3 2 7 3 9 0 0.914 0.934 1.000 264 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1) 3744303 27 13 25 4 4 4 3 5 11 0 0.271 0.935 1.000 265 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB4(4), PSMB5(2), PSMD1(2), PSMD11(1), PSMD12(2) 2189571 18 9 17 8 5 1 4 3 5 0 0.876 0.935 1.000 266 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1) 3558924 27 9 27 5 7 7 7 4 1 1 0.0852 0.936 1.000 267 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1216347 10 3 9 0 1 2 2 2 3 0 0.118 0.937 1.000 268 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(1), PFKL(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2) 1289033 15 3 15 4 5 6 1 2 1 0 0.170 0.937 1.000 269 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(2), CREBBP(2), EP300(4), NCOA3(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2855594 19 6 19 6 6 3 4 2 3 1 0.430 0.938 1.000 270 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(4), MEF2A(2), MEF2D(1), YWHAH(1) 1099767 11 2 11 3 1 2 5 1 2 0 0.534 0.938 1.000 271 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 1485591 12 5 12 2 7 2 2 0 1 0 0.108 0.939 1.000 272 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 294107 3 1 3 0 0 1 2 0 0 0 0.408 0.939 1.000 273 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), MUT(2) 684217 3 1 3 2 0 0 0 1 2 0 0.905 0.944 1.000 274 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(1), CDKN2A(22), DAPP1(1), FLOT1(1), FLOT2(2), ITPR1(6), ITPR2(9), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(6), PREX1(8), PTEN(2), PTPRC(2), RPS6KA1(2), RPS6KA2(1), SYK(2), TEC(2), VAV1(4) 7708394 91 37 79 14 20 14 10 12 34 1 0.00343 0.946 1.000 275 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1104732 5 3 5 2 3 0 2 0 0 0 0.673 0.946 1.000 276 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1104732 5 3 5 2 3 0 2 0 0 0 0.673 0.946 1.000 277 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(9), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), HIBCH(8), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2) 5458860 43 16 36 8 14 6 6 4 13 0 0.138 0.946 1.000 278 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GGT1(1), SHMT1(1), SHMT2(2) 779743 5 3 5 4 2 1 1 0 0 1 0.875 0.946 1.000 279 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(1), FBXW7(4), RB1(3) 1151734 10 3 10 4 1 3 2 3 1 0 0.759 0.946 1.000 280 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2) 965411 9 4 9 3 3 2 0 2 2 0 0.696 0.947 1.000 281 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(2), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTH1(3), FTMT(2), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 5790895 39 18 35 7 5 10 4 5 15 0 0.196 0.947 1.000 282 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1) 1472641 12 4 12 2 6 1 0 2 3 0 0.154 0.949 1.000 283 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPHN(1), SRC(2), UBQLN1(3) 1665425 19 4 19 2 6 4 4 2 2 1 0.0346 0.950 1.000 284 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ATF4(1), CACNA1C(7), CACNA1D(14), CACNA1F(1), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(13), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), KRAS(66), LHB(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(7), MMP2(2), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(3), PRKACG(2), PRKCD(7), SOS1(12), SOS2(1), SRC(2) 17933519 249 80 155 46 48 58 56 28 56 3 2.58e-05 0.950 1.000 285 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), APOA4(2), APOC1(1), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(3), LPL(2), LRP1(12), SCARB1(1), SOAT1(1) 3769470 32 11 32 9 13 7 3 2 6 1 0.148 0.953 1.000 286 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(2), ANXA6(2), CYP11A1(2), EDN1(3), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(3), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 2883118 27 11 26 7 12 2 4 5 4 0 0.271 0.953 1.000 287 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(1), DHRS3(2), PON1(1), PON2(1) 2502339 24 8 23 6 8 4 2 5 5 0 0.256 0.954 1.000 288 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(1), AKT3(1), BRD4(5), CBL(4), CDC42(1), CDKN2A(22), F2RL2(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPPL1(5), IRS1(15), IRS2(3), IRS4(3), LNPEP(2), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SORBS1(1), SOS1(12), SOS2(1), YWHAE(2), YWHAH(1) 8315734 109 50 77 22 12 17 10 11 59 0 0.249 0.955 1.000 289 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1) 1544248 14 4 14 3 6 1 0 3 4 0 0.256 0.955 1.000 290 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), UGDH(1) 1183983 6 3 6 3 3 0 2 1 0 0 0.766 0.958 1.000 291 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), MAP3K7(9), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 3841112 29 12 22 8 6 2 6 4 11 0 0.650 0.958 1.000 292 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(8), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1) 2342244 25 9 25 8 10 5 7 1 2 0 0.280 0.960 1.000 293 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(2) 1611423 9 4 9 2 3 1 2 0 3 0 0.482 0.961 1.000 294 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 359143 3 1 3 1 0 1 1 1 0 0 0.760 0.961 1.000 295 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), MAF(2), NFATC1(4), NFATC2(5), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1728743 19 5 18 7 8 5 2 0 4 0 0.283 0.961 1.000 296 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), GREB1(4), MTA1(1), PDZK1(1), TUBA8(4) 1552600 12 4 12 2 0 8 1 1 2 0 0.0728 0.963 1.000 297 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 856979 9 2 9 3 3 0 1 2 3 0 0.580 0.964 1.000 298 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ENPP3(2), FLAD1(5), MTMR2(1), MTMR6(1), PHPT1(1), RFK(1), TYR(3) 2072626 15 5 12 5 4 4 2 1 4 0 0.741 0.965 1.000 299 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL1(1), FOSL2(2), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(1), TNFRSF11A(2) 1538193 11 2 11 3 0 2 3 5 1 0 0.525 0.965 1.000 300 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(1), HMGB1(1), TOP2A(1), TOP2B(4) 1285166 8 4 8 2 3 2 0 1 2 0 0.606 0.966 1.000 301 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(9), FASN(7), MCAT(1), OLAH(2) 2276042 23 6 22 3 8 6 2 1 5 1 0.0193 0.967 1.000 302 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1B(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 1952302 17 4 17 5 2 5 7 1 2 0 0.487 0.967 1.000 303 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(3), DDC(1), GAD1(6), GAD2(5), SLC18A3(2), TH(1), TPH1(2) 2034870 23 9 23 9 7 2 9 2 2 1 0.554 0.967 1.000 304 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), LEPR(5), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2) 1979071 14 3 14 1 0 6 1 2 5 0 0.0548 0.967 1.000 305 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(4), DDX20(1), E2F4(4), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(5) 3697332 28 10 26 8 5 8 5 4 6 0 0.358 0.967 1.000 306 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CYP2C9(1), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), ESCO2(8), HADHA(1), SH3GLB1(1) 4261309 26 14 19 8 7 1 4 3 11 0 0.798 0.968 1.000 307 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), PC(2), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(2) 2837228 23 6 22 2 5 4 6 4 4 0 0.0423 0.971 1.000 308 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(5), AXIN1(5), BTRC(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NOTCH1(7), PSEN1(1), WNT1(1) 3072054 41 8 41 7 15 13 4 6 3 0 0.00664 0.971 1.000 309 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(4), CTNNB1(8), PTK2(4), PXN(1), SRC(2), VCL(1) 2699126 32 7 32 5 14 10 2 5 1 0 0.00823 0.971 1.000 310 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(2), SCAP(3), SREBF1(1), SREBF2(5) 1732184 11 6 9 9 2 2 0 2 5 0 0.985 0.972 1.000 311 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(2), NAT2(1), XDH(6) 1085665 16 6 16 7 6 2 1 4 3 0 0.736 0.972 1.000 312 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3) 2866339 32 8 32 8 7 6 6 7 6 0 0.224 0.972 1.000 313 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), LCT(3), PGM1(2), PYGM(1), TPI1(2), TREH(1) 1870812 10 3 10 9 1 2 1 1 5 0 0.940 0.972 1.000 314 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(7), ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), ATM(8), ATR(9), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25A(3), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(22), CREBBP(2), CUL1(1), E2F3(3), EP300(4), ESPL1(5), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(2), SMAD3(1), SMAD4(17), SMC1A(1), SMC1B(2), TGFB1(1), TGFB2(2), TP53(59), YWHAE(2), YWHAH(1) 18896234 231 74 205 28 47 32 39 35 77 1 9.45e-07 0.972 1.000 315 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(5) 1455959 14 3 13 1 5 3 3 1 2 0 0.0620 0.973 1.000 316 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(1) 462012 3 1 3 0 0 3 0 0 0 0 0.378 0.974 1.000 317 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(5), CARM1(1), CREBBP(2), EP300(4), ERCC3(8), ESR1(1), GRIP1(1), GTF2E1(1), GTF2F1(4), HDAC4(4), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(3) 6548221 44 20 35 9 9 7 5 4 19 0 0.284 0.975 1.000 318 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 1195423 7 3 7 4 3 0 2 0 2 0 0.792 0.975 1.000 319 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(3), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1816641 15 5 14 3 5 2 2 2 4 0 0.345 0.976 1.000 320 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(1), CARM1(1), CYP11B1(5), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD17B7(5), HSD3B1(2), HSD3B2(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 6908049 60 25 50 13 9 19 13 5 14 0 0.106 0.978 1.000 321 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(3), OGDH(3), SDHA(3), SUCLA2(1) 1289002 11 2 11 1 3 1 3 2 2 0 0.144 0.979 1.000 322 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(2) 1495890 8 3 8 3 3 0 3 2 0 0 0.634 0.979 1.000 323 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4) 424787 6 2 6 2 1 1 1 3 0 0 0.698 0.979 1.000 324 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 325 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 326 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 327 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(2), BECN1(1), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(2), ULK3(1) 2944437 21 7 21 4 5 4 1 7 4 0 0.193 0.981 1.000 328 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(6), ATIC(2), DHFR(1), FTCD(3), MTFMT(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1) 2612027 23 6 21 6 4 3 4 5 6 1 0.356 0.982 1.000 329 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MANBA(2), NEU4(1) 2329794 15 7 15 4 6 1 2 0 6 0 0.380 0.983 1.000 330 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), SHC1(1) 4722675 37 12 37 6 10 8 9 2 8 0 0.0247 0.983 1.000 331 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1) 1903223 7 2 7 3 0 2 1 2 2 0 0.627 0.984 1.000 332 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2L1(7), CBL(4), CFLAR(2), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), IRS1(15), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PTPN6(4), SHC1(1), SOS1(12), STAT5A(1), SYK(2) 5040401 66 40 39 14 9 7 6 7 37 0 0.690 0.984 1.000 333 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(5), CREBBP(2), CTNNB1(8), DVL1(4), EP300(4), FZD1(5), GSK3B(1), LDB1(1), LEF1(3), TRRAP(9), WNT1(1) 4599247 48 11 47 8 17 9 6 11 5 0 0.0116 0.986 1.000 334 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), KERA(2), LUM(1) 496834 4 1 4 1 0 0 1 3 0 0 0.674 0.986 1.000 335 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(1), VKORC1(3) 1554661 16 3 16 6 3 5 6 1 1 0 0.524 0.986 1.000 336 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP7(1), CASP8(2), CFLAR(2), DAXX(4), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(9), MAPK8(2), PAK1(7), PAK2(3), PRKDC(7), PTPN13(6), RB1(3), SPTAN1(3) 5698541 60 25 45 14 6 3 11 11 29 0 0.756 0.987 1.000 337 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(10), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), HSD3B7(3), LCT(3), MGAM(1), PFKL(2), PFKM(2), PGM1(2), PGM3(1), RDH11(2), UGP2(5) 5384964 46 20 36 12 13 5 6 4 18 0 0.351 0.987 1.000 338 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(2), EIF4B(3), EIF4G1(7), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2), TSC1(1), TSC2(6) 3818174 40 15 39 10 9 10 10 5 6 0 0.266 0.987 1.000 339 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1) 2211453 13 4 13 4 2 2 5 2 2 0 0.564 0.987 1.000 340 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), FURIN(2), NOTCH1(7), PSEN1(1) 1369260 13 2 13 6 6 6 1 0 0 0 0.336 0.987 1.000 341 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(1), MC2R(2), MC3R(3), MC5R(2), NPY1R(2), NPY2R(3), NPY5R(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), SSTR1(4), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3) 7252236 83 27 74 21 23 9 21 12 16 2 0.0617 0.987 1.000 342 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), NOS1(7), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3580533 45 15 40 12 15 6 6 7 11 0 0.242 0.988 1.000 343 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10A(1), RPL10L(2), RPL11(1), RPL18(2), RPL18A(1), RPL22L1(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(2), RPL3L(2), RPS11(2), RPS25(1), RPS27(1), RPS28(1), RPSA(1) 3143933 25 10 23 7 7 2 4 0 12 0 0.742 0.988 1.000 344 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(1), HK2(3), HK3(2), ISYNA1(1), PGM1(2), PGM3(1) 1628441 11 3 11 5 5 1 2 0 3 0 0.550 0.988 1.000 345 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(1), AKT3(1), BAD(1), BCL2L1(7), CDC42(1), CDKN2A(22), CREB1(2), ERBB4(6), F2RL2(2), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(5), IRS1(15), IRS2(3), IRS4(3), MET(4), NOLC1(4), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTEN(2), PTK2(4), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1), TSC1(1), TSC2(6), YWHAE(2), YWHAH(1) 10779909 150 58 103 31 18 17 17 15 83 0 0.350 0.988 1.000 346 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(2) 1252099 11 2 10 5 2 1 5 1 2 0 0.871 0.988 1.000 347 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(4), PRKACG(2), PRKAR2B(1) 1392069 7 2 7 3 1 2 2 1 1 0 0.830 0.988 1.000 348 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GLS(2), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(1) 4582693 44 12 44 10 8 7 14 6 7 2 0.167 0.988 1.000 349 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), OGDHL(2), PC(2), PCK1(3), PCK2(4), SDHA(3), SUCLA2(1), SUCLG1(2) 4103283 34 9 32 6 11 4 7 4 7 1 0.0865 0.989 1.000 350 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(10), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGP(2), PIGQ(5), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(16), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1) 6794388 78 34 53 10 21 10 9 4 34 0 0.00983 0.989 1.000 351 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TPO(4), TYR(3) 1340179 19 5 19 8 9 0 5 2 3 0 0.696 0.990 1.000 352 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CAPNS1(3), CAPNS2(1), EP300(4), MEF2D(1), NFATC1(4), NFATC2(5), PPP3CA(1), PPP3CC(2) 3357673 25 10 24 8 5 6 0 4 10 0 0.494 0.990 1.000 353 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), EHHADH(1), HADHA(1) 1681105 7 3 7 2 4 0 3 0 0 0 0.510 0.990 1.000 354 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), DCT(5), DDC(1), GOT1(2), HGD(2), HPD(2), TAT(1), TH(1), TPO(4), TYR(3) 4393947 48 12 47 16 20 8 8 6 6 0 0.210 0.990 1.000 355 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(2) 530069 2 1 2 0 1 0 0 1 0 0 0.530 0.990 1.000 356 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(5), ODC1(1), SAT2(1) 4104870 25 8 24 3 11 5 5 2 1 1 0.0180 0.991 1.000 357 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELP(3) 2203724 15 5 15 5 5 3 1 3 3 0 0.374 0.991 1.000 358 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(8), HMGCS2(1), HSD17B4(3), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 5950900 46 14 39 8 10 9 9 4 14 0 0.0856 0.991 1.000 359 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2) 1446344 12 4 12 3 4 2 1 3 2 0 0.297 0.991 1.000 360 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1830349 19 3 19 7 7 5 4 2 1 0 0.470 0.992 1.000 361 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKL(2), PFKM(2), PGD(1), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1), TKTL1(1) 3371012 25 6 25 6 6 5 8 2 4 0 0.136 0.992 1.000 362 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1), TPI1(2) 532396 4 1 4 0 1 2 0 1 0 0 0.218 0.992 1.000 363 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2) 1652444 10 4 10 6 3 2 3 0 2 0 0.856 0.993 1.000 364 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5E(1), NT5M(1) 2009279 16 2 16 3 5 4 2 3 2 0 0.144 0.994 1.000 365 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(1), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGP(2), PIGQ(5), PIGS(3), PIGW(2) 3323504 23 7 22 3 6 4 4 4 5 0 0.0555 0.994 1.000 366 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), GGT1(1), PAPSS1(3), PAPSS2(3), SCLY(2) 1715261 11 4 11 9 4 2 2 1 2 0 0.945 0.994 1.000 367 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G3(2), PLA2G6(4), RDH11(2) 3298698 28 7 28 9 7 3 9 6 3 0 0.592 0.994 1.000 368 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGAL(3), ITGB2(1), SELE(2) 1665164 11 4 11 5 4 1 1 3 2 0 0.675 0.994 1.000 369 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(1), TLR2(2), TLR4(1), TLR7(1), TLR9(5) 2560893 21 7 21 7 8 5 3 5 0 0 0.408 0.995 1.000 370 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), HAL(1), PRPS1(1) 3371480 19 9 18 5 8 5 4 1 1 0 0.198 0.995 1.000 371 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAPK8(2), NFKBIA(2), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(2), TLR4(1), TLR6(3), TLR7(1), TLR9(5), TOLLIP(1) 5075234 44 18 37 10 11 4 8 7 14 0 0.356 0.995 1.000 372 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ARG2(1), ASL(1), ASS1(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(1), GOT1(2), LAP3(2), NOS1(7), NOS3(6), OAT(2), P4HA1(5), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 5011975 58 17 58 12 17 10 16 8 6 1 0.0643 0.996 1.000 373 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKM(2), PGD(1), PGLS(1), PGM1(2), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 2827695 22 4 22 7 5 4 8 2 3 0 0.294 0.996 1.000 374 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(1), AKT3(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS1(15), IRS2(3), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS1(12), SOS2(1), STAT6(4) 5171604 59 30 38 15 10 10 4 6 29 0 0.619 0.996 1.000 375 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(4), PRL(4), TRH(2) 1556587 14 6 14 5 7 1 2 2 2 0 0.529 0.996 1.000 376 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDFT1(2), GGCX(1), HMGCR(3), HSD17B7(5), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1), VKORC1(3) 2692991 22 9 19 8 4 9 7 1 1 0 0.409 0.996 1.000 377 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NEU4(1) 2869103 18 7 18 6 8 1 2 0 7 0 0.428 0.997 1.000 378 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1), HADHA(1) 668241 2 1 2 0 1 0 1 0 0 0 0.545 0.997 1.000 379 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PDHA1(1), PKLR(2) 5092832 37 8 36 8 9 14 4 3 7 0 0.0811 0.997 1.000 380 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG5(1), ALG9(1), B4GALT2(10), DDOST(1), DHDDS(1), DOLPP1(2), DPAGT1(5), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1) 5934197 48 21 35 10 10 7 5 7 19 0 0.376 0.997 1.000 381 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), CREB1(2), GNAI1(1), GNAQ(1), GNAS(13), GNB1(2), HRAS(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 4896298 49 18 44 10 19 11 4 6 9 0 0.0415 0.997 1.000 382 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), AGTR2(1), EDN1(3), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1) 2828007 16 4 15 1 2 3 4 1 6 0 0.0461 0.997 1.000 383 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 146 APC(5), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(2), CSNK1A1L(3), CSNK1E(1), CSNK2A1(1), CTBP2(5), CTNNB1(8), CUL1(1), CXXC4(13), DAAM1(7), DAAM2(5), DKK2(1), DKK4(1), DVL1(4), DVL2(3), EP300(4), FBXW11(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), LEF1(3), LRP5(6), LRP6(4), MAP3K7(9), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(1), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP3CA(1), PPP3CC(2), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(3), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD3(1), SMAD4(17), SOX17(1), TCF7(2), TCF7L1(3), TCF7L2(1), TP53(59), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2) 22809677 322 81 269 59 82 43 35 54 108 0 3.44e-05 0.997 1.000 384 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), LCT(3), NAGLU(2) 2042627 15 7 15 7 4 3 1 2 5 0 0.697 0.998 1.000 385 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3) 2943836 32 8 32 10 7 6 6 7 6 0 0.387 0.998 1.000 386 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3) 1894860 12 5 12 5 6 3 1 1 1 0 0.572 0.998 1.000 387 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3) 767714 12 1 12 4 4 3 2 2 1 0 0.501 0.998 1.000 388 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(4), ACACB(9), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), CALML3(2), CALML6(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EXOC7(1), FASN(7), FBP2(1), FLOT1(1), FLOT2(2), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), GYS2(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS1(15), IRS2(3), IRS4(3), KRAS(66), LIPE(1), MAPK10(1), MAPK8(2), MAPK9(1), PCK1(3), PCK2(4), PDE3A(8), PDE3B(1), PFKL(2), PFKM(2), PHKA2(2), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAG3(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PTPRF(20), PYGB(2), PYGM(1), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOCS4(2), SORBS1(1), SOS1(12), SOS2(1), SREBF1(1), TRIP10(2), TSC1(1), TSC2(6) 22595972 280 82 180 65 55 69 47 27 80 2 0.00245 0.998 1.000 389 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(9), CYP27A1(3), CYP7A1(2), HADHB(2) 3218750 35 15 28 12 8 5 7 3 12 0 0.731 0.998 1.000 390 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(2), NOS1(7), NOS3(6), OAT(2), ODC1(1), P4HA1(5), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1) 6159133 62 18 61 9 23 12 16 6 4 1 0.00151 0.998 1.000 391 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(2), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), NAGK(1), PPAT(2), QARS(1) 5459691 48 12 48 12 8 9 15 7 7 2 0.191 0.998 1.000 392 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(1), ACAT1(2), HADHA(1) 747818 5 1 5 0 0 4 1 0 0 0 0.194 0.998 1.000 393 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 HSD3B7(3), RDH11(2) 669383 5 1 5 0 1 0 2 2 0 0 0.288 0.998 1.000 394 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(6), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1F(1), ERO1L(1), GNAS(13), PDIA4(1), PLCG1(1), PLCG2(6), SEC61A1(1), SEC61A2(2), SEC61G(1) 5129390 49 13 45 13 20 8 10 7 4 0 0.139 0.998 1.000 395 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(2), ACVR1C(1), ACVR2A(7), ACVRL1(1), AMH(1), AMHR2(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(4), CREBBP(2), CUL1(1), DCN(1), E2F4(4), E2F5(3), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), RBL1(1), RBL2(2), RHOA(1), ROCK1(3), ROCK2(1), RPS6KB2(2), SKP1(1), SMAD3(1), SMAD4(17), SMAD7(1), SMAD9(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), THBS1(3), THBS2(4), THBS4(21), ZFYVE16(4), ZFYVE9(3) 13851215 145 49 119 26 30 22 20 20 53 0 0.0248 0.998 1.000 396 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(7), CACNA1B(9), GNAS(13), GNB1(2), GNB3(2), GNG13(1), GRM4(1), ITPR3(8), KCNB1(5), PLCB2(4), PRKACG(2), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(5), TAS1R2(3), TAS1R3(2), TAS2R1(2), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R9(2), TRPM5(1) 8102105 93 30 86 18 39 12 14 11 17 0 0.00188 0.998 1.000 397 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(2), SYNJ2(2) 3082711 18 5 18 7 3 4 2 4 5 0 0.683 0.999 1.000 398 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(5), AXIN1(5), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(8), DVL1(4), DVL2(3), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(7), PPP2R5C(2), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PRKD1(2), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2) 8471618 99 35 86 27 34 18 6 15 26 0 0.0985 0.999 1.000 399 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(4), ILVBL(2), LARS2(2), PDHA1(1), VARS(2), VARS2(2) 2567615 16 4 16 5 6 4 2 3 1 0 0.499 0.999 1.000 400 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CD4(2), CREB1(2), CTSB(2), CTSS(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), HSP90AA1(7), HSP90AB1(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1), TAP2(1), TAPBP(1) 6459776 52 23 49 14 7 12 6 10 17 0 0.396 0.999 1.000 401 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(4), SRC(2), SYK(2), TBXAS1(1) 3367745 23 4 23 8 6 8 3 4 2 0 0.535 0.999 1.000 402 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(3), F2RL1(1), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(1), PLD2(3), PLD3(1), PTK2(4), RASAL1(5), SRC(2), TEC(2), VAV1(4) 3839257 37 5 37 8 10 12 6 3 5 1 0.0430 0.999 1.000 403 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), OGT(1), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1) 4445385 27 8 27 8 8 5 7 4 3 0 0.352 0.999 1.000 404 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFAT5(21), PDE6B(3), PDE6C(1), SLC6A13(1) 4986565 55 26 34 12 10 7 7 2 29 0 0.542 0.999 1.000 405 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6) 6224212 54 15 52 11 18 8 4 11 13 0 0.0647 0.999 1.000 406 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(2), AKT1(2), CDC42(1), FLNA(8), FLNC(9), FSCN3(2), GDI2(2), LIMK1(1), MYH2(3), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), ROCK1(3), ROCK2(1), VASP(1), WASF1(1), WASL(5) 6696386 65 24 58 17 10 12 14 11 18 0 0.355 0.999 1.000 407 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(2), MAP3K1(3), NCOR2(4), THRA(2), THRB(1) 2435338 14 5 14 9 3 3 3 2 3 0 0.950 0.999 1.000 408 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 691247 1 1 1 1 1 0 0 0 0 0 0.845 0.999 1.000 409 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), BDH1(1), DDHD1(2), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2) 5625967 44 12 44 10 11 11 11 8 2 1 0.0696 0.999 1.000 410 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TKTL1(1), TPI1(2) 2788686 21 4 21 2 3 5 8 2 3 0 0.0377 0.999 1.000 411 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(7), ITGB3(1), PTK2(4), PXN(1), SPTAN1(3), SRC(2), TLN1(9) 3967938 41 8 41 6 13 12 6 4 6 0 0.00453 0.999 1.000 412 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(2), YWHAH(1) 2825938 17 4 17 5 4 3 3 3 4 0 0.454 0.999 1.000 413 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SP1(1) 2902362 21 5 20 6 4 6 2 3 6 0 0.347 0.999 1.000 414 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(3), SP1(1) 913204 5 1 5 0 1 0 3 1 0 0 0.352 0.999 1.000 415 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP5(3), ARHGAP6(3), ARHGEF1(4), ARHGEF11(4), ARHGEF5(2), ARPC1A(1), ARPC2(1), ARPC3(1), BAIAP2(3), DIAPH1(4), GSN(6), LIMK1(1), MYLK(8), PIP5K1B(2), PPP1R12B(4), ROCK1(3), SRC(2), TLN1(9), VCL(1) 6383751 63 21 56 18 15 16 10 7 15 0 0.230 0.999 1.000 416 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(8), MAP2(3), PPP1CA(1), PPP2CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1) 2493140 17 5 17 6 5 4 2 4 2 0 0.671 0.999 1.000 417 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(3), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(8), NCF2(1), PAK1(7), PDGFRA(3), PIK3CA(4), PIK3R1(1), PPP1R12B(4), RALBP1(2), TRIO(9), VAV1(4), WASF1(1) 4825060 53 21 41 11 11 9 5 6 20 2 0.271 0.999 1.000 418 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(2), KARS(2) 949040 6 2 6 3 1 0 3 1 1 0 0.905 0.999 1.000 419 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(9), DGAT1(3), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GLB1(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PPAP2B(2) 6749799 68 21 61 22 26 7 9 8 18 0 0.339 0.999 1.000 420 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(3), NR1H4(1) 744421 4 2 4 2 1 2 1 0 0 0 0.621 0.999 1.000 421 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 2115781 18 6 18 9 10 1 3 1 3 0 0.784 1.000 1.000 422 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(9), DGAT1(3), DGAT2(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), GK2(4), GLB1(3), GPAM(3), LCT(3), LIPA(1), LIPF(2), LIPG(3), LPL(2), MGLL(2), PNLIP(1), PPAP2B(2) 8191634 84 24 77 26 30 11 14 11 18 0 0.229 1.000 1.000 423 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), DIAPH1(4), FYN(8), GSN(6), HRAS(1), ITGA1(7), MYLK(8), PIK3CA(4), PIK3R1(1), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9) 5148203 62 23 51 11 13 15 8 7 19 0 0.0414 1.000 1.000 424 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2D(1), CDK5(3), FYN(8), GNA11(2), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(2), MYLK(8), PLCG1(1), SHC1(1), SOS1(12), STAT1(1), STAT3(2), STAT5A(1) 5773068 52 26 34 12 8 8 6 5 25 0 0.556 1.000 1.000 425 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TPI1(2) 2500132 22 3 22 2 3 6 8 3 2 0 0.0222 1.000 1.000 426 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(12), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(1), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(2), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(1) 7780400 75 27 69 18 17 12 11 14 20 1 0.170 1.000 1.000 427 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SGMS1(2), SGPP1(1), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(1) 5034998 33 9 32 10 13 6 3 6 5 0 0.181 1.000 1.000 428 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), CARM1(1), DDC(1), FTCD(3), HAL(1), HARS2(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), UROC1(4) 5495100 42 13 40 8 12 11 11 3 5 0 0.0291 1.000 1.000 429 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(10), FBP2(1), GAA(2), GANAB(2), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), LCT(3), MGAM(1), PFKM(2), PGM1(2), PGM3(1) 4531688 35 17 26 11 10 2 6 1 16 0 0.621 1.000 1.000 430 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(2), JAK1(1), JAK2(2), JAK3(3), STAT1(1), STAT3(2), STAT5A(1), TYK2(2) 2581639 16 6 16 8 7 2 4 1 2 0 0.748 1.000 1.000 431 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(1), AKT3(1), ASAH1(1), BRAF(3), DAG1(2), EGFR(2), EPHB2(3), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), RGS20(1), SHC1(1), SOS1(12), SOS2(1), SRC(2), STAT3(2), TERF2IP(1) 8144495 76 33 63 11 15 10 9 10 32 0 0.0463 1.000 1.000 432 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(4), CCKBR(3), CCR2(1), CCR3(9), CELSR1(3), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(2), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(6), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GRM1(13), GRPR(1), LGR6(2), LPHN2(6), LPHN3(1), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(2), TSHR(3) 9325716 98 31 87 25 31 16 16 14 20 1 0.0379 1.000 1.000 433 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(1), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 3408012 29 6 29 7 7 5 9 4 4 0 0.254 1.000 1.000 434 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), EP300(4), LPL(2), NCOA2(2), PPARG(1) 2535211 11 4 11 9 4 1 2 1 3 0 0.976 1.000 1.000 435 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTTN(1), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(2), HRAS(1), IGSF5(1), JAM2(1), KRAS(66), LLGL1(5), LLGL2(2), MAGI1(2), MAGI2(7), MAGI3(1), MLLT4(4), MPDZ(2), MRAS(2), MYH1(5), MYH10(24), MYH11(5), MYH13(2), MYH14(4), MYH15(6), MYH2(3), MYH3(1), MYH4(5), MYH6(6), MYH7(6), MYH7B(8), MYH8(4), MYH9(2), MYLPF(1), PARD3(6), PARD6A(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP2R3A(5), PPP2R3B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PTEN(2), RAB13(1), RHOA(1), SPTAN1(3), SRC(2), SYMPK(7), TJP1(4), TJP2(5), TJP3(4), YES1(1) 27034758 308 80 218 64 65 69 65 43 66 0 0.000142 1.000 1.000 436 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(2), LDHB(1) 942061 3 1 3 2 1 0 1 1 0 0 0.935 1.000 1.000 437 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(3), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), SHC1(1), SOS1(12), SOS2(1), SYK(2), VAV1(4) 7356111 76 38 50 16 15 11 5 8 36 1 0.306 1.000 1.000 438 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1) 998288 5 1 5 1 0 4 0 0 1 0 0.365 1.000 1.000 439 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1) 2453807 17 2 17 5 3 2 4 4 3 1 0.392 1.000 1.000 440 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(1), PFKL(2), PFKM(2), PLCG1(1), PRKCE(1) 3540443 18 4 18 4 3 7 3 2 3 0 0.149 1.000 1.000 441 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(7), ABLIM1(5), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CDK5(3), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(3), EFNA1(1), EPHA1(3), EPHA2(4), EPHA3(1), EPHA4(2), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(8), EPHB2(3), EPHB3(3), EPHB4(5), EPHB6(5), FYN(8), GNAI1(1), GNAI2(2), GSK3B(1), HRAS(1), KRAS(66), L1CAM(1), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NGEF(6), NRP1(2), NTN4(1), NTNG1(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(1), PPP3CA(1), PPP3CC(2), PTK2(4), RAC2(1), RASA1(1), RGS3(1), RHOA(1), RHOD(1), RND1(1), ROBO1(6), ROBO2(3), ROBO3(5), ROCK1(3), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(5), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(3), SEMA4G(2), SEMA5A(4), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(5), SLIT2(4), SLIT3(6), SRGAP1(5), SRGAP2(2), SRGAP3(7), UNC5A(6), UNC5B(2), UNC5C(4), UNC5D(10) 27722621 378 86 262 87 82 77 71 46 101 1 0.00157 1.000 1.000 442 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 2870998 16 3 16 7 3 1 5 3 4 0 0.862 1.000 1.000 443 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(4), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(4), MAP2K6(2), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(5), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), YWHAH(1) 4844684 44 12 43 12 11 9 5 6 13 0 0.195 1.000 1.000 444 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(4), FH(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), PC(2), PDHA1(1), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(2) 3930041 29 4 29 5 8 4 8 4 5 0 0.0897 1.000 1.000 445 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), EHHADH(1), GCDH(2), HADHA(1) 1073881 6 1 6 0 2 2 2 0 0 0 0.130 1.000 1.000 446 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1) 3114139 15 3 15 7 1 4 6 2 2 0 0.864 1.000 1.000 447 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2) 1149350 7 1 7 0 1 3 1 0 2 0 0.101 1.000 1.000 448 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREBBP(2), CRKL(2), DAG1(2), EGR1(17), EGR2(3), EGR3(1), GNAQ(1), MAP1B(4), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SRC(2), TERF2IP(1), TH(1) 7293433 73 36 61 24 15 9 9 9 31 0 0.753 1.000 1.000 449 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(3), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2) 5846368 41 6 41 10 14 11 7 4 5 0 0.0598 1.000 1.000 450 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(9), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(2), SOAT1(1) 4413324 47 16 40 14 11 8 11 5 12 0 0.456 1.000 1.000 451 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), FYN(8), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5) 7251970 75 28 65 12 18 13 8 12 24 0 0.0216 1.000 1.000 452 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), FYN(8), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5) 7251970 75 28 65 12 18 13 8 12 24 0 0.0216 1.000 1.000 453 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(2), AKT2(1), AKT3(1), APC(5), AXIN1(5), AXIN2(1), CTNNB1(8), DACT1(3), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(12), MVP(3), NKD1(3), NKD2(1), PSEN1(1), SENP2(1), SFRP1(2), WIF1(2) 5691860 60 17 60 14 21 12 10 8 9 0 0.0592 1.000 1.000 454 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3) 3212961 16 7 15 9 5 3 3 3 2 0 0.876 1.000 1.000 455 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), CARM1(1), DCT(5), DDC(1), ESCO1(3), ESCO2(8), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TPO(4), TYR(3) 8221564 77 21 69 21 23 14 15 9 16 0 0.163 1.000 1.000 456 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1) 1142547 5 2 5 2 0 1 2 1 1 0 0.774 1.000 1.000 457 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), CHRNA1(3), FLT1(3), FLT4(9), KDR(1), NOS3(6), PDE2A(1), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1) 5693089 58 18 55 10 20 10 12 3 13 0 0.00897 1.000 1.000 458 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), CPO(2), HBB(1), HMBS(1) 1126737 6 4 6 4 3 1 1 0 1 0 0.851 1.000 1.000 459 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP11(2), AKAP12(2), AKAP3(2), AKAP4(1), AKAP6(4), AKAP7(2), AKAP9(8), ARHGEF1(4), GNA11(2), GNA14(1), GNA15(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(6), KRAS(66), PALM2(2), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCI(3), PRKCQ(2), PRKD1(2), PRKD3(3), RHOA(1) 16268033 195 73 126 48 42 52 50 26 23 2 0.00362 1.000 1.000 460 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PCK2(4), PDHA1(1), PKLR(2) 6441941 52 14 50 13 17 14 4 3 13 1 0.0887 1.000 1.000 461 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(1), CAPNS1(3), CAPNS2(1), EGF(2), EGFR(2), HRAS(1), ITGA1(7), MYLK(8), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(4), PXN(1), TLN1(9) 4568671 49 7 49 9 16 14 8 6 5 0 0.00740 1.000 1.000 462 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), ASAH1(1), CAMP(2), CERK(1), CREB1(2), DAG1(2), EPHB2(3), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1) 4025765 34 8 34 10 10 4 4 7 9 0 0.317 1.000 1.000 463 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(2), AKT2(1), AKT3(1), ARHGAP4(1), ARHGEF11(4), BTK(1), CDC42(1), GDI2(2), INPPL1(5), ITPR1(6), ITPR2(9), ITPR3(8), LIMK1(1), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), PTEN(2), RACGAP1(2), ROCK1(3), ROCK2(1), WASF1(1), WASL(5) 9750327 92 31 79 26 17 18 17 10 30 0 0.392 1.000 1.000 464 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2) 4556690 26 4 26 4 7 6 6 5 2 0 0.0898 1.000 1.000 465 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(4), CSK(1), CTLA4(1), DAG1(2), EPHB2(3), FBXW7(4), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFAT5(21), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(1), SOS1(12), SOS2(1), VAV1(4), ZAP70(5) 7845919 92 38 60 12 18 13 8 8 44 1 0.0501 1.000 1.000 466 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), PON1(1) 4052828 42 12 40 14 15 5 8 7 7 0 0.409 1.000 1.000 467 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(1), CRKL(2), DOCK1(2), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PAK1(7), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), PXN(1), RAP1B(2), RASA1(1), SOS1(12), SRC(2), STAT3(2) 6204579 64 25 49 14 9 16 6 8 25 0 0.268 1.000 1.000 468 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(2), SPTLC2(1), UGCG(1) 3398444 19 4 19 7 7 5 1 1 5 0 0.384 1.000 1.000 469 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK2(3), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SOS1(12), SYK(2), VAV1(4) 5947854 59 20 49 14 11 12 6 9 20 1 0.286 1.000 1.000 470 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), DFFB(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(3), TNFRSF10B(2), TNFSF12(1), TRADD(1), TRAF2(1) 4682039 28 6 28 7 8 5 5 2 8 0 0.247 1.000 1.000 471 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(1), GOT1(2), TAT(1) 1195184 6 3 5 2 1 1 3 1 0 0 0.744 1.000 1.000 472 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(9), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), PRIM1(1), RFC1(4), RFC2(1), RFC3(1), RPA1(1), RPA2(2), RPA3(2), RPS27A(1), UBB(1) 7019158 57 17 57 14 16 7 14 9 10 1 0.195 1.000 1.000 473 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLB(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLG(4), POLH(1), POLI(1), POLK(3), POLL(2), POLM(3), POLQ(2), PRIM1(1), REV1(1), REV3L(3) 5643269 35 8 34 5 7 6 7 10 5 0 0.0457 1.000 1.000 474 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CHUK(1), DAXX(4), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 6839344 55 20 47 17 12 7 9 9 18 0 0.571 1.000 1.000 475 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(5), AR(3), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(2), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2) 7462220 66 23 61 16 16 7 10 9 24 0 0.241 1.000 1.000 476 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), BCL2L1(7), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(4), DFFB(1), FAS(2), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(6), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 6087655 58 18 48 15 11 10 11 5 21 0 0.519 1.000 1.000 477 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(4), LARS2(2), PDHA1(1) 1369898 9 3 9 3 3 2 1 3 0 0 0.597 1.000 1.000 478 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3E(1), FYN(8), HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), PTPN7(1), RASA1(1), RELA(1), SHC1(1), SOS1(12), VAV1(4), ZAP70(5) 6635119 69 27 52 11 11 12 8 9 28 1 0.0760 1.000 1.000 479 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(6), PSEN1(1) 1254241 10 2 10 3 1 5 1 2 1 0 0.523 1.000 1.000 480 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(2), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGAM4(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2) 8023443 66 11 66 18 24 15 12 5 10 0 0.0574 1.000 1.000 481 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SOS1(12), SYK(2), VAV1(4) 5291350 46 15 36 12 9 9 3 7 17 1 0.432 1.000 1.000 482 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), LPO(4), MPO(2), TPO(4) 1163833 14 4 14 5 8 0 3 1 2 0 0.510 1.000 1.000 483 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(5), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), RYR1(18) 6404613 60 19 56 15 22 5 11 7 15 0 0.158 1.000 1.000 484 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(1), C1QA(1), C1QC(1), C1R(1), C1S(4), C3(6), C3AR1(2), C5(1), C5AR1(1), C6(6), C7(4), C8A(5), C9(1), CD46(1), CD55(1), CD59(2), CFB(6), CFD(1), CFH(4), CFI(3), CR1(3), CR2(8), F10(4), F12(2), F13A1(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(3), PLAT(2), PLAU(7), PLAUR(6), PROC(1), PROS1(1), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(3), THBD(3), VWF(5) 12501194 136 41 119 34 29 21 26 23 37 0 0.173 1.000 1.000 485 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL2(1), CUL3(1), FBXW11(1), FBXW7(4), ITCH(2), SKP1(1), SKP2(2), TCEB1(1), TCEB2(1), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(3) 5575104 38 10 37 10 11 9 6 6 6 0 0.322 1.000 1.000 486 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(1), GTF2E2(2), GTF2F1(4), GTF2H1(1), GTF2H4(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(7), TAF1L(3), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(3), TAF6(1), TAF6L(3), TAF7L(1) 4963264 39 16 35 12 8 3 9 6 13 0 0.850 1.000 1.000 487 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(3), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(2), RDH11(2), SETD1A(17), SETDB1(2), SHMT1(1), SHMT2(2), SUV39H2(2) 8064679 68 28 49 19 16 7 13 6 25 1 0.570 1.000 1.000 488 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), APOA5(3), AQP7(4), CPT1B(4), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(1), CYP7A1(2), CYP8B1(1), EHHADH(1), FABP4(1), FADS2(13), GK2(4), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(4), PLTP(1), PPARA(1), PPARD(1), PPARG(1), SCD(9), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(1), SORBS1(1), UCP1(1) 9036825 90 30 70 16 21 18 15 5 30 1 0.0177 1.000 1.000 489 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(6), ARRB2(2), CALML3(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(1), CNGB1(10), GUCA1A(1), GUCA1C(1), PDC(1), PRKACG(2), PRKG1(1), PRKG2(1) 4229394 37 13 32 13 12 5 9 3 8 0 0.661 1.000 1.000 490 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK1(7), PLCG1(1), SHC1(1), SOS1(12), SRC(2) 3966035 36 20 21 12 4 5 3 4 20 0 0.939 1.000 1.000 491 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(1), KYNU(1), TDO2(1), TPH1(2), WARS(2) 7580798 58 14 56 18 19 8 16 9 6 0 0.336 1.000 1.000 492 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CLOCK(12), CRY1(1), DNAJA1(1), ETV6(3), GFRA1(3), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(4), PER2(3), PURA(1), TOB1(4), TUBB3(1), UCP3(1), UGP2(5), ZFR(1) 5092245 52 21 39 17 10 5 4 11 22 0 0.870 1.000 1.000 493 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2) 6724999 54 7 54 16 19 12 10 5 8 0 0.123 1.000 1.000 494 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM1(2), PGM3(1), PKLR(2), TPI1(2) 6724999 54 7 54 16 19 12 10 5 8 0 0.123 1.000 1.000 495 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(3), ESR1(1), ESR2(1), ESRRA(2), NR0B1(1), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(3), PPARA(1), PPARD(1), PPARG(1), RARB(2), RARG(2), ROR1(3), RORA(1), RORC(1), THRA(2), THRB(1) 5945212 49 13 47 16 17 9 7 5 11 0 0.260 1.000 1.000 496 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(1), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(4), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 7928447 76 21 68 21 18 15 16 7 20 0 0.288 1.000 1.000 497 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(1), AKT3(1), CASP8(2), CCL3(1), CD14(2), CD40(1), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(1), LBP(1), LY96(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K7(9), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(2), TLR3(2), TLR4(1), TLR5(2), TLR6(3), TLR7(1), TLR8(1), TLR9(5), TOLLIP(1) 12462580 103 32 95 27 22 18 19 14 30 0 0.126 1.000 1.000 498 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(2), ACVR2A(7), AMH(1), AMHR2(5), BMP2(2), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CCR9(1), CD40(1), CSF1(2), CSF1R(4), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CL1(1), CXCL16(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPO(1), EPOR(2), FAS(2), FASLG(1), FLT1(3), FLT3(3), FLT4(9), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1R2(4), IL1RAP(2), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(1), INHBC(1), KDR(1), KIT(4), LEPR(5), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(2), PDGFC(2), PDGFRA(3), PDGFRB(4), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(3), RELT(1), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(7), TNFSF12(1), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TNFSF9(19), TPO(4), TSLP(1), VEGFB(1), XCR1(2) 24702730 275 72 224 44 63 51 35 40 85 1 3.71e-06 1.000 1.000 499 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), DLG4(1), LPA(5), MAP2K4(2), MAP3K1(3), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1), PTK2(4), RDX(3), ROCK1(3), ROCK2(1), SRF(1), TBXA2R(2) 6822191 50 13 50 14 8 8 13 10 11 0 0.477 1.000 1.000 500 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(2), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1) 6285969 52 19 48 14 13 7 9 5 18 0 0.423 1.000 1.000 501 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1) 1591340 9 1 9 1 2 2 3 0 2 0 0.256 1.000 1.000 502 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CAPNS2(1), CRKL(2), CSK(1), FYN(8), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(4), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SOS1(12), SRC(2), TLN1(9), VCL(1), ZYX(1) 6610962 76 28 57 12 18 15 7 6 30 0 0.0293 1.000 1.000 503 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 164 ADORA1(1), ADORA2A(1), ADORA3(4), ADRA1A(2), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR3(9), CCR4(3), CCR7(1), CCR9(1), CHML(3), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(2), GPR50(1), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LHCGR(1), LTB4R(4), MC3R(3), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPY1R(2), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), RRH(1), SSTR1(4), SSTR4(3), SUCNR1(1), TBXA2R(2), TRHR(1) 17011496 172 43 158 41 48 22 48 29 24 1 0.00374 1.000 1.000 504 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NR1I3(1), PAK1(7), PDE3A(8), PDE3B(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1), VASP(1) 6797469 59 26 48 17 12 9 9 4 25 0 0.576 1.000 1.000 505 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(2), CHAT(3), CPT1B(4), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(6), PPAP2B(2) 7038470 60 13 60 17 21 7 13 9 10 0 0.200 1.000 1.000 506 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(1), JAK2(2), PTPRU(6), REG1A(1), STAT1(1) 1574697 12 4 11 6 6 0 3 1 2 0 0.797 1.000 1.000 507 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(1), BCKDHB(1), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 4962374 32 5 32 4 7 10 7 3 5 0 0.0173 1.000 1.000 508 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(4), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PAK1(7), PLCG1(1), PLCG2(6), PTPRZ1(3), RELA(1), SRC(2), TCIRG1(1), TJP1(4) 9749002 75 20 68 16 11 16 17 13 18 0 0.102 1.000 1.000 509 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CPT1B(4), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3) 6735400 52 5 52 12 17 16 8 5 6 0 0.0296 1.000 1.000 510 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), TRAF2(1), TRAF5(1) 4810431 30 8 30 10 6 8 5 5 6 0 0.298 1.000 1.000 511 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(3), CD1C(1), CD1D(6), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(1), CD3E(1), CD4(2), CD44(3), CD5(2), CD55(1), CD59(2), CR1(3), CR2(8), CSF1(2), CSF1R(4), CSF2RA(1), CSF3R(2), DNTT(3), EPO(1), EPOR(2), FCGR1A(1), FLT3(3), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL1R2(4), IL2RA(1), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(2), THPO(1), TPO(4) 11303688 113 34 103 27 23 20 18 25 27 0 0.0965 1.000 1.000 512 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(2), HGS(2) 1766551 9 1 9 0 0 4 2 2 1 0 0.0535 1.000 1.000 513 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(1), AKT3(1), BCL2L1(7), CBL(4), CBLB(1), CCND2(2), CCND3(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(4), EPO(1), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNGR2(13), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(5), LIF(2), LIFR(5), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(2), PIAS4(3), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRL(4), PRLR(3), PTPN6(4), SOCS4(2), SOCS5(2), SOCS7(1), SOS1(12), SOS2(1), SPRED1(1), SPRED2(1), SPRY4(3), STAM(5), STAM2(1), STAT1(1), STAT2(1), STAT3(2), STAT5A(1), STAT6(4), TPO(4), TSLP(1), TYK2(2) 20114610 191 59 158 45 45 31 22 30 63 0 0.0667 1.000 1.000 514 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(7), ACTN1(1), AKT1(2), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(3), BCAR1(2), BRAF(3), CDC42(1), CDKN2A(22), CRK(1), CSE1L(2), DOCK1(2), EPHB2(3), FYN(8), GRB7(5), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGB3BP(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(6), PTEN(2), PTK2(4), ROCK1(3), ROCK2(1), SHC1(1), SOS1(12), SOS2(1), SRC(2), TERF2IP(1), TLN1(9), TLN2(7), VASP(1), ZYX(1) 17125676 185 54 149 40 35 32 23 24 71 0 0.0447 1.000 1.000 515 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(1), CR2(8), CSK(1), DAG1(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(5), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPRC(2), SHC1(1), SOS1(12), SOS2(1), SYK(2), VAV1(4) 10278517 103 35 87 21 23 20 11 13 35 1 0.0340 1.000 1.000 516 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(4), ASH2L(2), CARM1(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(4), EZH2(3), FBXO11(1), HCFC1(3), HSF4(1), KDM6A(3), MEN1(3), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(4), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SATB1(10), SETD1A(17), SETD2(6), SETD8(1), SETDB1(2), STK38(2), SUV39H2(2), SUV420H1(3), SUV420H2(2), SUZ12(1), WHSC1(1), WHSC1L1(5) 16685783 106 45 78 23 10 13 18 17 48 0 0.500 1.000 1.000 517 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(1), STAT2(1), TYK2(2) 1725787 14 5 13 6 8 0 4 1 1 0 0.670 1.000 1.000 518 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1) 1840976 12 2 12 7 3 4 4 0 1 0 0.838 1.000 1.000 519 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(1), POLG(4), RRM1(1) 1787566 14 3 14 3 3 6 1 1 3 0 0.126 1.000 1.000 520 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(1), AKT1(2), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(2), EDN1(3), ELSPBP1(2), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MYH2(3), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 7037646 61 16 59 15 19 11 10 7 14 0 0.0760 1.000 1.000 521 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), AFMID(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(3), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2) 8366147 66 12 65 13 23 11 18 7 7 0 0.0207 1.000 1.000 522 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(3), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CRADD(2), DAXX(4), DFFB(1), GSN(6), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(4), PAK2(3), PRKCD(7), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(4), RASA1(1), RB1(3), RELA(1), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 9654596 81 23 72 20 14 10 20 11 26 0 0.269 1.000 1.000 523 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AK3(1), CAD(5), CTPS2(1), DPYD(3), DPYS(9), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), NME1(1), NME4(1), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2) 11254964 81 22 73 24 18 13 15 19 16 0 0.368 1.000 1.000 524 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB2(1), JAK2(2), TYK2(2) 2048364 11 3 11 4 2 1 2 3 3 0 0.697 1.000 1.000 525 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1) 2025420 10 1 10 2 1 1 4 1 3 0 0.459 1.000 1.000 526 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(4), ABCA10(3), ABCA12(12), ABCA13(9), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(5), ABCA8(6), ABCA9(7), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(4), ABCB5(6), ABCB6(2), ABCC10(3), ABCC11(2), ABCC12(3), ABCC2(15), ABCC3(4), ABCC4(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(2), ABCD1(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(4), TAP1(1), TAP2(1) 16443359 146 33 132 35 27 30 20 32 33 4 0.0271 1.000 1.000 527 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(5), CTPS2(1), DPYD(3), DPYS(9), DUT(1), NME1(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), RRM1(1), TYMS(1), UMPS(2), UPB1(2) 8020338 61 14 56 16 17 14 11 7 12 0 0.117 1.000 1.000 528 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BAD(1), CABIN1(4), CAMK4(2), CD3E(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR2(3), EGR3(1), EP300(4), FCER1A(1), FOSL1(1), GATA3(2), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(2), NCK2(2), NFAT5(21), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(7), PPP3CC(2), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4) 12695825 114 37 88 25 26 20 12 9 46 1 0.127 1.000 1.000 529 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1) 2142667 7 2 7 3 1 2 3 1 0 0 0.799 1.000 1.000 530 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), EHHADH(1), HADHA(1), SCP2(1) 2317433 10 1 10 0 4 3 2 0 1 0 0.0319 1.000 1.000 531 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CITED2(1), CPT1B(4), CREBBP(2), DUT(1), EHHADH(1), EP300(4), HSD17B4(3), LPL(2), ME1(2), NCOR1(7), NCOR2(4), NFKBIA(2), NR1H3(3), NRIP1(1), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTGS2(1), RB1(3), RELA(1), SP1(1), STAT5A(1) 8802872 56 12 56 18 15 15 10 8 8 0 0.221 1.000 1.000 532 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2) 2326713 18 2 18 2 6 4 4 1 3 0 0.0546 1.000 1.000 533 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1) 2519690 12 2 12 5 0 4 5 2 1 0 0.801 1.000 1.000 534 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), ETV5(1), IL12B(1), IL12RB2(1), JAK2(2), MAP2K6(2), MAPK8(2), TYK2(2) 2590830 12 3 12 4 3 1 2 2 4 0 0.511 1.000 1.000 535 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ENPP3(2), ENTPD2(2), FHIT(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NPR1(2), NPR2(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(3), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(5), PKLR(2), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1) 17892163 136 25 136 30 48 33 23 13 17 2 0.000946 1.000 1.000 536 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(1), AKT3(1), ARRB1(1), ARRB2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(1), CACNG3(2), CACNG5(4), CD14(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP16(1), DUSP6(2), DUSP7(1), ECSIT(6), EGF(2), EGFR(2), FAS(2), FASLG(1), FGF10(14), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FLNA(8), FLNB(3), FLNC(9), HRAS(1), IKBKB(2), IL1B(1), IL1R2(4), JUND(1), KRAS(66), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MOS(1), MRAS(2), NF1(2), NFATC2(5), NFATC4(4), NFKB2(1), NLK(1), NR4A1(3), NTF3(6), NTRK1(2), NTRK2(3), PAK1(7), PAK2(3), PDGFRA(3), PDGFRB(4), PLA2G3(2), PLA2G6(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTPN5(1), PTPN7(1), RAC2(1), RAP1B(2), RAPGEF2(4), RASA1(1), RASA2(1), RASGRF2(4), RASGRP1(2), RASGRP2(1), RASGRP3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS1(12), SOS2(1), SRF(1), STK4(2), STMN1(1), TAOK1(2), TAOK2(23), TGFB1(1), TGFB2(2), TGFBR1(5), TGFBR2(5), TNFRSF1A(2), TP53(59), TRAF2(1) 40646147 513 86 363 103 113 85 85 65 160 5 1.47e-05 1.000 1.000 537 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(5), APC2(2), ARAF(2), ARHGEF1(4), ARHGEF12(4), ARHGEF6(1), ARHGEF7(3), ARPC1A(1), ARPC2(1), ARPC3(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BRAF(3), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(4), DIAPH2(1), DIAPH3(15), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF10(14), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FN1(8), GIT1(4), GSN(6), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KRAS(66), LIMK1(1), LIMK2(2), MOS(1), MRAS(2), MYH10(24), MYH14(4), MYH9(2), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(4), PTK2(4), PXN(1), RAC2(1), RDX(3), RHOA(1), ROCK1(3), ROCK2(1), SCIN(1), SOS1(12), SOS2(1), SSH1(3), SSH2(1), SSH3(1), TIAM1(6), TIAM2(1), VAV1(4), VCL(1), WASF1(1), WASF2(2), WASL(5) 38826006 420 86 286 98 74 85 81 44 134 2 0.0102 1.000 1.000 538 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GLCE(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(3), NDST4(2) 2925902 30 6 30 7 12 4 9 3 2 0 0.128 1.000 1.000 539 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 3128781 16 5 16 6 4 3 5 2 2 0 0.628 1.000 1.000 540 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(2), CHAT(3), CHPT1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(8), ETNK2(1), GPAM(3), GPD1(1), GPD2(1), LYPLA2(1), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2), PTDSS1(2), PTDSS2(1), SH3GLB1(1) 9209282 68 22 61 23 21 7 12 10 18 0 0.581 1.000 1.000 541 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 238 ADORA1(1), ADORA2A(1), ADORA3(4), ADRA1A(2), ADRA2A(1), ADRA2B(4), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CCKAR(6), CCKBR(3), CGA(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHB(1), FSHR(2), GABBR1(11), GABBR2(1), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GABRB1(3), GABRB2(2), GABRB3(3), GABRD(5), GABRE(2), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(1), GLRA2(3), GLRB(1), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(3), GRIA4(1), GRID1(6), GRID2(4), GRIK1(1), GRIK2(4), GRIK3(3), GRIK4(1), GRIK5(1), GRIN1(7), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRIN3A(4), GRIN3B(2), GRM1(13), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM6(6), GRM7(5), GRM8(3), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LEPR(5), LHB(1), LHCGR(1), LTB4R(4), LTB4R2(1), MC2R(2), MC3R(3), MC5R(2), MCHR1(1), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR2(1), NPY1R(2), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PRL(4), PRLR(3), PRSS1(3), PTGDR(2), PTGER3(1), PTGFR(1), RXFP1(1), SSTR1(4), SSTR4(3), SSTR5(4), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), THRA(2), THRB(1), TRHR(1), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 31017226 361 60 336 90 107 56 75 53 69 1 9.99e-05 1.000 1.000 542 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), CLK3(3), CLK4(1), COL2A1(4), CPSF1(3), CPSF2(4), CPSF3(3), CPSF4(1), CSTF1(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(3), DHX16(4), DHX38(1), DHX8(1), DHX9(10), DICER1(7), FUS(2), METTL3(1), NCBP2(1), NONO(1), PABPN1(2), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(3), PRPF8(4), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B1(1), SF3B2(1), SF3B5(1), SNRPB(1), SNRPE(2), SNRPN(3), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF1(3), U2AF2(2), XRN2(3) 14643566 103 36 91 27 27 14 14 17 30 1 0.355 1.000 1.000 543 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(1), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(3), CAPN5(2), CAPN6(2), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), FYN(8), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), MAP2K6(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(3), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(4), PXN(1), RAC2(1), RAP1B(2), ROCK1(3), ROCK2(1), SDCCAG8(1), SEPP1(1), SHC1(1), SORBS1(1), SOS1(12), SRC(2), TLN1(9), TNS1(4), VASP(1), VCL(1), ZYX(1) 18803029 154 42 130 41 31 32 29 15 47 0 0.139 1.000 1.000 544 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(3), CCND2(2), CCND3(1), CDC42(1), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), CRK(1), CRKL(2), CTNNB1(8), DIAPH1(4), DOCK1(2), EGF(2), EGFR(2), ERBB2(6), FARP2(1), FLNA(8), FLNB(3), FLNC(9), FLT1(3), FN1(8), FYN(8), GSK3B(1), HRAS(1), IBSP(2), IGF1R(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KDR(1), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYLK(8), MYLK2(3), MYLPF(1), PAK1(7), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RELN(7), RHOA(1), ROCK1(3), ROCK2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(12), SOS2(1), SRC(2), THBS1(3), THBS2(4), THBS4(21), TLN1(9), TLN2(7), TNC(10), TNN(2), TNR(9), TNXB(8), VASP(1), VAV1(4), VCL(1), VEGFB(1), VTN(2), VWF(5), ZYX(1) 51787173 487 81 432 124 124 91 78 67 122 5 0.00270 1.000 1.000 545 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 CHAD(1), COL11A1(5), COL11A2(3), COL17A1(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), DES(1), DSC1(4), DSC2(5), DSC3(5), DSG1(2), DSG2(2), DSG4(5), FN1(8), GJA3(1), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(1), GJC2(2), GJC3(2), GJD4(2), IBSP(2), INA(3), ITGB4(7), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT15(4), KRT16(1), KRT19(1), KRT2(3), KRT20(2), KRT27(1), KRT28(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(2), KRT7(3), KRT73(10), KRT74(2), KRT75(1), KRT76(4), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(6), PRPH(1), RELN(7), THBS1(3), THBS2(4), THBS4(21), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5) 34817327 361 75 325 97 104 55 60 49 89 4 0.0252 1.000 1.000 546 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD44(3), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A1(20), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), DAG1(2), FN1(8), FNDC1(6), FNDC3A(1), GP5(2), GP6(2), GP9(2), HMMR(6), HSPG2(2), IBSP(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), RELN(7), SDC3(1), SDC4(2), SV2A(4), SV2C(1), THBS1(3), THBS2(4), THBS4(21), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5) 31473748 299 65 266 81 75 52 55 41 72 4 0.0623 1.000 1.000 547 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY7(3), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(2), ATP2A1(3), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B3(6), ATP2B4(1), AVPR1B(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(6), CCKBR(3), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GNA11(2), GNA14(1), GNA15(2), GNAQ(1), GNAS(13), GRIN1(7), GRIN2A(6), GRIN2C(5), GRIN2D(5), GRM1(13), GRM5(7), GRPR(1), HRH2(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), LHCGR(1), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), P2RX2(1), P2RX7(1), PDE1B(1), PDGFRA(3), PDGFRB(4), PHKA2(2), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(18), RYR2(10), RYR3(17), SLC25A4(1), SLC8A1(1), SLC8A2(3), SLC8A3(2), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(3) 38157707 408 61 372 118 128 58 79 58 81 4 0.0122 1.000 1.000 548 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADRA1A(2), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B3(6), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1D(14), CACNA1E(8), CACNA1S(4), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(1), PLCB3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SLC8A3(2), YWHAH(1) 26370353 256 54 230 87 84 40 41 28 59 4 0.287 1.000 1.000 549 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2A(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX55(19), DDX56(2), DHX58(2), ENPP3(2), EP400(7), ERCC2(1), ERCC3(8), G6PC2(1), GAA(2), GANC(1), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), IFIH1(4), MGAM(1), MOV10L1(5), NUDT8(1), PGM1(2), PGM3(1), PYGB(2), PYGM(1), RAD54L(3), RUVBL2(3), SETX(5), SI(3), SKIV2L2(1), SMARCA2(8), TREH(1), UGDH(1), UGP2(5), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), UXS1(1) 17121387 149 53 116 47 26 25 20 18 59 1 0.870 1.000 1.000 550 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 CADM1(1), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(4), CDH2(4), CDH3(9), CDH4(3), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(4), CNTN2(1), CNTNAP1(1), CNTNAP2(7), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(2), NFASC(3), NLGN1(4), NLGN2(2), NLGN3(5), NRCAM(1), NRXN1(2), NRXN2(5), NRXN3(4), PDCD1(1), PTPRC(2), PTPRF(20), PTPRM(6), PVRL1(13), PVRL2(11), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELP(3), SIGLEC1(9), VCAN(10) 20604902 217 52 176 63 54 36 34 23 70 0 0.156 1.000 1.000 551 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(2), ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF4(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(3), DGKZ(3), ETS2(2), GABPA(2), GBA2(2), GNAQ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(1), ITPR1(6), ITPR2(9), ITPR3(8), MAFF(2), MIB1(1), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), PDE4D(3), PLCB3(4), PLCG1(1), PLCG2(6), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCH(5), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SP1(1), TNXB(8), YWHAH(1) 24325259 218 49 203 70 69 32 40 27 48 2 0.185 1.000 1.000 552 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX55(19), DDX56(2), DHFR(1), DHX58(2), EP400(7), ERCC2(1), ERCC3(8), FPGS(3), GCH1(1), GGH(1), IFIH1(4), MOV10L1(5), NUDT8(1), QDPR(2), RAD54L(3), RUVBL2(3), SETX(5), SKIV2L2(1), SMARCA2(8) 8745606 110 41 79 30 17 18 10 14 50 1 0.704 1.000 1.000 553 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(2), CALML6(1), CDIPT(2), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPP5D(1), INPP5E(1), INPPL1(5), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PRKCG(2), PTEN(2), SYNJ2(2) 17462490 143 39 133 40 43 22 18 22 38 0 0.0987 1.000 1.000 554 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(3), BUB1(1), CDIPT(2), CDKL1(1), CLK1(3), CLK2(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(3), MOS(1), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(7), PRKCE(1), PRKCG(2), PRKCH(5), PRKCQ(2), PRKD1(2), PRKG1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), STK11(2), TGFBR1(5) 15866014 133 38 123 37 48 18 13 20 34 0 0.158 1.000 1.000 555 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ENPP3(2), ENTPD2(2), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GMPR(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NME4(1), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT2(1), NUDT9(3), PAICS(2), PAPSS1(3), PAPSS2(3), PDE10A(6), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(1), PFAS(5), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(6) 22738846 169 36 165 43 54 31 27 33 22 2 0.0143 1.000 1.000 556 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(7), MYBPC1(5), MYBPC3(3), MYH3(1), MYH6(6), MYH7(6), MYH8(4), MYL1(1), MYL3(1), MYOM1(3), NEB(14), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(3), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(88) 18946046 164 34 162 48 41 41 37 23 20 2 0.265 1.000 1.000 557 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(3), CHUK(1), CREB1(2), DAXX(4), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K7(9), MAP3K9(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(2), MEF2D(1), NFKBIA(2), PAK1(7), PAK2(3), RELA(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), RPS6KB2(2), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TRADD(1), TRAF2(1) 13515549 106 33 90 36 23 19 19 7 38 0 0.807 1.000 1.000 558 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(10), B4GALT5(2), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHST2(2), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), DPAGT1(5), EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), XYLT1(4), XYLT2(4) 15537002 124 32 109 35 36 17 26 16 29 0 0.210 1.000 1.000 559 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(9), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADIPOR1(2), AKT1(2), AKT2(1), AKT3(1), CAMKK1(1), CHUK(1), CPT1B(4), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS1(15), IRS2(3), IRS4(3), JAK1(1), JAK2(2), JAK3(3), LEPR(5), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(3), PCK2(4), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(3), PRKCQ(2), RELA(1), SLC2A1(4), STAT3(2), STK11(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 11653257 113 30 100 34 28 20 16 13 35 1 0.258 1.000 1.000 560 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(1), CSNK1G3(7), DHH(2), FBXW11(1), GLI1(5), GLI2(2), GLI3(8), GSK3B(1), HHIP(4), LRP2(3), PRKACG(2), PTCH1(4), PTCH2(6), SMO(2), STK36(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2), ZIC2(4) 8586477 85 28 78 30 31 15 14 6 19 0 0.489 1.000 1.000 561 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(2), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(4), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(3), RAPGEF4(3), RASSF5(1), RHOA(1), RHOH(1), ROCK1(3), ROCK2(1), SIPA1(4), THY1(1), VASP(1), VAV1(4), VCL(1) 17399019 135 28 134 47 46 29 15 21 22 2 0.218 1.000 1.000 562 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(1), INPP5A(1), INPP5E(1), INPPL1(5), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PLCZ1(4), PTEN(2), SYNJ2(2) 10374069 75 26 70 27 15 13 11 14 22 0 0.603 1.000 1.000 563 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(13), CARS2(2), DARS(1), DARS2(1), EARS2(1), EPRS(1), FARS2(2), FARSB(1), GARS(5), HARS2(1), IARS(4), KARS(2), LARS2(2), MTFMT(3), NARS2(2), PARS2(1), QARS(1), RARS(1), RARS2(3), TARS(2), VARS(2), VARS2(2), WARS(2) 7458004 56 25 46 17 12 8 11 7 18 0 0.709 1.000 1.000 564 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(2), DAXX(4), HRAS(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K7(9), MAP3K9(2), MAPKAPK5(1), MEF2A(2), MEF2D(1), RPS6KA5(1), SHC1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(5), TRADD(1), TRAF2(1) 5122030 43 22 33 15 11 2 8 4 18 0 0.883 1.000 1.000 565 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(3), APH1A(2), CREBBP(2), CTBP2(5), DLL4(1), DTX1(3), DTX2(4), DTX4(1), DVL1(4), DVL2(3), EP300(4), JAG1(2), JAG2(3), LFNG(1), MAML1(2), MAML2(3), MAML3(13), NCOR2(4), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RFNG(1), SNW1(1) 9997723 90 21 79 44 26 21 15 9 19 0 0.917 1.000 1.000 566 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(3), CREB1(2), DUSP6(2), MOS(1), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS1(12), SOS2(1) 4123510 27 21 18 12 5 2 2 1 17 0 0.993 1.000 1.000 567 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP4F2(2), CYP4F3(3), EPX(4), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX5(1), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4) 3886097 46 19 40 18 18 3 8 2 14 1 0.824 1.000 1.000 568 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(8), GTF2E1(1), GTF2E2(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3B(3), POLR3E(3), TAF5(1), TAF6(1), TBP(3) 4808651 38 18 30 12 9 5 7 3 14 0 0.750 1.000 1.000 569 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(1), CYP4F2(2), CYP4F3(3), DHRS4(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), LTA4H(1), PLA2G3(2), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 5432487 47 17 41 24 14 7 10 2 13 1 0.969 1.000 1.000 570 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(1), AKT3(1), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(1), RICTOR(5), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), STK11(2), TSC1(1), TSC2(6), ULK1(2), ULK3(1), VEGFB(1) 7464509 59 17 58 20 16 15 7 5 16 0 0.568 1.000 1.000 571 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(8), GTF2E1(1), GTF2F1(4), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(2), TBP(3) 3500081 28 17 21 17 4 3 4 1 15 1 0.999 1.000 1.000 572 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2A(2), ENPP3(2), GAA(2), GANAB(2), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), MGAM(1), PGM1(2), PGM3(1), PYGB(2), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A3(1), UGT1A4(4), UGT1A8(4), UGT2B15(1), UGT2B4(1), UXS1(1) 7862722 51 17 49 18 15 11 10 5 10 0 0.561 1.000 1.000 573 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(1), CDC42(1), CREB1(2), DUSP10(1), MAP2K4(2), MAP2K6(2), MAP3K10(3), MAP3K4(2), MAP3K7(9), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1), SRF(1) 4720025 31 16 24 13 6 3 4 3 15 0 0.928 1.000 1.000 574 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(3), SHC1(1), SOS1(12), SRF(1), STAT3(2) 3349604 29 15 20 13 5 3 3 3 15 0 0.976 1.000 1.000 575 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), B3GALT4(1), CDR1(1), DGKI(2), FAU(1), IL6ST(3), RPL10(3), RPL11(1), RPL18(2), RPL18A(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL3L(2), RPL4(3), RPL7A(1), RPLP0(1), RPLP2(1), RPS11(2), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1) 7289271 50 14 48 28 12 7 10 6 15 0 0.997 1.000 1.000 576 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), FPR1(1), GNA15(2), GNB1(2), HRAS(1), MAP2K6(2), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PAK1(7), PLCB1(1), PPP3CA(1), PPP3CC(2), RELA(1) 5346036 44 13 37 16 8 8 10 5 13 0 0.811 1.000 1.000 577 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), DAO(2), DMGDH(3), GARS(5), GLDC(1), HSD3B7(3), PHGDH(1), PSAT1(4), RDH11(2), SARDH(2), SHMT1(1), SHMT2(2), TARS(2) 5989642 40 13 38 16 18 10 5 5 1 1 0.428 1.000 1.000 578 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), DRD1(2), DRD3(1), DRD5(2), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1) 3620486 37 13 36 15 11 8 9 6 3 0 0.561 1.000 1.000 579 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), CPT1B(4), DAO(2), DMGDH(3), GARS(5), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(6), SARDH(2), SHMT1(1), SHMT2(2), TARS(2) 5892341 45 11 44 17 17 12 6 5 4 1 0.363 1.000 1.000 580 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHSY1(1), DSE(3), XYLT1(4), XYLT2(4) 2093780 20 11 18 12 8 2 5 1 4 0 0.884 1.000 1.000 581 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(1), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1) 4887718 30 10 30 14 10 5 4 2 9 0 0.759 1.000 1.000 582 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1) 2547691 28 9 24 11 5 6 3 4 10 0 0.686 1.000 1.000 583 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CD97(1), CRHR2(1), ELTD1(5), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(6), LPHN3(1), VIPR1(1), VIPR2(1) 3748711 31 9 31 13 6 6 4 10 5 0 0.593 1.000 1.000 584 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3) 3148313 33 9 29 13 7 8 5 3 10 0 0.596 1.000 1.000 585 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADHA(1), PLOD1(2), PLOD2(2), SHMT1(1), SHMT2(2) 5142488 32 9 29 15 10 5 11 1 4 1 0.791 1.000 1.000 586 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(5), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1) 3877189 32 9 29 13 7 6 5 4 10 0 0.806 1.000 1.000 587 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(5), IARS(4), KARS(2), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2) 4367632 24 8 23 9 7 4 7 5 1 0 0.644 1.000 1.000 588 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), HSD3B7(3), MTMR2(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(2), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1) 5205202 37 8 37 15 12 6 13 4 2 0 0.562 1.000 1.000 589 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1), UAP1(1) 3977329 28 8 28 13 10 3 8 3 4 0 0.827 1.000 1.000 590 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2) 2891470 20 8 20 11 5 5 2 2 6 0 0.838 1.000 1.000 591 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(1), C6(6), C7(4), ICAM1(2), IL6(1), ITGAL(3), ITGB2(1), SELP(3) 3394873 27 8 27 11 8 7 5 2 5 0 0.547 1.000 1.000 592 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4) 962323 13 7 11 11 4 4 2 0 3 0 0.941 1.000 1.000 593 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), RELA(1) 3878270 23 7 23 11 5 8 3 3 4 0 0.700 1.000 1.000 594 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4) 962323 13 7 11 11 4 4 2 0 3 0 0.941 1.000 1.000 595 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(1), SRC(2), STAT3(2) 2135891 21 7 20 12 8 6 4 0 3 0 0.831 1.000 1.000 596 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), DNMT3A(5), DNMT3B(2), MTFMT(3), MTR(1), TAT(1) 2870011 15 6 13 14 4 2 3 2 4 0 0.999 1.000 1.000 597 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PAPSS1(3), PAPSS2(3), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SCLY(2) 3452640 26 6 26 11 6 6 9 2 3 0 0.655 1.000 1.000 598 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(2), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(6), REG1A(1), SOAT1(1) 1925859 17 6 16 11 8 3 4 0 2 0 0.911 1.000 1.000 599 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(2), PMM2(1), TPI1(2) 3330512 24 5 24 11 9 4 8 1 2 0 0.611 1.000 1.000 600 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2) 3217607 27 5 27 12 9 4 6 4 4 0 0.799 1.000 1.000 601 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1), PNPO(1), PSAT1(4) 668920 6 5 5 4 3 1 2 0 0 0 0.816 1.000 1.000 602 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1) 724490 8 4 8 5 6 1 0 1 0 0 0.877 1.000 1.000 603 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP23(2), SNAP25(1), SNAP29(3), STX11(1), STX12(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VTI1A(1) 2332365 14 4 14 10 8 0 1 2 3 0 0.939 1.000 1.000 604 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(3), PDHA1(1), SLC18A3(2) 985290 9 3 9 7 4 0 4 1 0 0 0.929 1.000 1.000 605 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1), SLC25A11(1) 1282632 9 3 9 5 4 4 0 1 0 0 0.678 1.000 1.000 606 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(5), DNMT3B(2), MTR(1) 2403812 10 3 10 12 4 1 3 2 0 0 0.998 1.000 1.000 607 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(1), CDC34(1), CUL1(1), RB1(3), SKP2(2) 1187640 11 3 11 5 2 3 3 3 0 0 0.775 1.000 1.000 608 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(1), IL9(1) 1360609 4 2 4 3 0 2 1 1 0 0 0.838 1.000 1.000 609 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), NOX1(2), RELA(1), XDH(6) 1378242 10 2 10 6 2 3 3 2 0 0 0.886 1.000 1.000 610 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(1), RB1(3), SKP2(2) 1183936 7 2 7 4 1 1 2 3 0 0 0.907 1.000 1.000 611 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(1), MTNR1B(1), PTGDR(2), PTGFR(1), TBXA2R(2) 1607912 7 2 7 5 2 2 3 0 0 0 0.834 1.000 1.000 612 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), SQLE(1) 591668 3 1 3 3 1 1 1 0 0 0 0.922 1.000 1.000 613 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 927392 2 1 2 3 1 1 0 0 0 0 0.942 1.000 1.000 614 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1), UXS1(1) 534709 2 1 2 2 0 0 1 1 0 0 0.978 1.000 1.000 615 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 444961 3 1 3 3 1 1 1 0 0 0 0.921 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 68977 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000