rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 207846 2 2 2 0 0 0 1 0 1 0 0.885 0.0657 1.000 2 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(5) 1669817 17 10 16 3 2 6 1 3 5 0 0.249 0.0795 1.000 3 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), SNX13(5), SRC(2), TERF2IP(1) 1553443 18 9 18 2 3 2 2 4 7 0 0.189 0.0871 1.000 4 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB27A(1), RAB3A(1), RAB4A(1), RAB6A(1), RAB9A(1) 584670 10 4 10 1 5 2 2 1 0 0 0.100 0.166 1.000 5 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IL12B(1) 410351 5 5 4 2 0 2 0 0 3 0 0.927 0.184 1.000 6 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(4), PIK3R1(1), PTK2(4), SRC(2), TERT(6), YWHAH(1) 2309601 27 13 27 4 3 7 2 5 10 0 0.0545 0.192 1.000 7 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), CDC42(1), WASF1(1), WASL(5) 1110886 14 9 13 4 2 5 2 2 3 0 0.538 0.209 1.000 8 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 CYP11A1(2), CYP11B1(5), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 1180949 12 8 11 4 4 2 2 2 2 0 0.591 0.289 1.000 9 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 CYP11A1(2), CYP11B1(5), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 1180949 12 8 11 4 4 2 2 2 2 0 0.591 0.289 1.000 10 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), SNAP25(1) 443254 4 3 4 1 4 0 0 0 0 0 0.520 0.311 1.000 11 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(2), CES1(1), ESD(1) 826594 9 4 8 1 4 3 2 0 0 0 0.122 0.387 1.000 12 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(8), ATR(9), CDC25C(2), YWHAH(1) 2068738 20 11 19 5 2 2 4 4 8 0 0.725 0.406 1.000 13 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(2), HRAS(1), SHC1(1), SRC(2) 847099 6 5 6 2 2 2 0 0 2 0 0.559 0.425 1.000 14 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 9 CAPN1(1), CAPNS1(3), CAPNS2(1), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(2), PPP2CA(1) 1018017 11 5 11 1 4 3 0 2 2 0 0.0942 0.440 1.000 15 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 156442 1 1 1 0 0 0 0 0 1 0 0.842 0.458 1.000 16 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(8), CDC25C(2), MYT1(10), YWHAH(1) 1761405 21 8 20 5 3 4 3 5 6 0 0.416 0.459 1.000 17 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 8 CDC25C(2), CSK(1), SRC(2) 1138665 5 5 4 1 1 2 0 0 2 0 0.503 0.472 1.000 18 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3) 909411 7 4 7 0 4 0 1 0 2 0 0.150 0.473 1.000 19 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 14 CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR2(5) 1240827 10 6 9 3 4 0 0 2 4 0 0.670 0.474 1.000 20 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(5), FGA(5), FGB(4), FGG(2), PROC(1), PROS1(1), SERPINC1(2), TFPI(3) 2249498 27 9 25 5 3 6 11 5 2 0 0.191 0.475 1.000 21 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(3), CASP1(4), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(7), RERE(9), WWP1(2), WWP2(3) 3324903 42 19 37 9 11 8 3 5 15 0 0.195 0.509 1.000 22 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(5), AXIN1(5), CD14(2), CTNNB1(8), DVL1(4), FZD1(5), GNAI1(1), GSK3B(1), LBP(1), LEF1(3), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1), TOLLIP(1), WNT1(1) 4297741 48 16 47 5 14 9 5 12 8 0 0.00292 0.510 1.000 23 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4) 1762032 13 6 13 1 2 4 0 3 3 1 0.0591 0.511 1.000 24 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2), HLA-DRB1(1) 325957 3 2 3 1 0 0 0 1 2 0 0.905 0.514 1.000 25 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(1), AGT(1), AGTR2(1), CMA1(1), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4) 3390137 30 13 28 2 4 4 11 2 8 1 0.0504 0.526 1.000 26 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(8), BMPR1A(3), BMPR2(3) 858608 14 5 14 3 2 6 2 1 3 0 0.337 0.543 1.000 27 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(5), GLS(2), GOT1(2) 1072483 11 3 11 0 2 2 2 3 1 1 0.0398 0.556 1.000 28 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), HADHB(2), HSD17B4(3), PPT1(1), PPT2(2) 1170613 10 4 10 0 2 3 1 2 2 0 0.0548 0.557 1.000 29 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 6 ADORA1(1), ADORA2A(1), P2RY1(2), P2RY2(1), P2RY6(1) 586800 6 3 6 1 3 1 2 0 0 0 0.240 0.560 1.000 30 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ARPC1A(1), ARPC2(1), ARPC3(1), NCK1(3), NCKAP1(4), NTRK1(2), PIR(1), WASF1(1), WASF2(2), WASL(5) 1962570 25 10 24 4 7 7 3 4 4 0 0.119 0.561 1.000 31 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 5 ARNTL(1), CRY1(1), CSNK1E(1), PER1(4) 965074 7 4 6 1 2 0 0 1 4 0 0.484 0.568 1.000 32 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 7 CPN2(2), CYP11A1(2), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(1) 807775 9 5 9 3 2 2 3 2 0 0 0.505 0.578 1.000 33 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 10 ADCY1(4), CFTR(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1) 1521614 15 5 15 2 5 5 1 3 1 0 0.0645 0.579 1.000 34 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(1), B3GNT5(1), FUT1(1), FUT2(3), ST3GAL4(2) 993382 9 6 9 2 8 0 0 1 0 0 0.289 0.585 1.000 35 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 98584 2 1 2 1 2 0 0 0 0 0 0.803 0.596 1.000 36 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1) 1776356 13 9 13 3 4 3 1 2 3 0 0.298 0.608 1.000 37 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2) 1401634 14 5 14 1 9 2 2 0 1 0 0.0241 0.622 1.000 38 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 5 ADCY1(4), GNB1(2), PRKAR1A(1) 613073 7 3 7 1 2 3 0 1 1 0 0.203 0.627 1.000 39 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(1), YWHAH(1) 1962071 16 8 16 4 0 4 4 3 5 0 0.447 0.635 1.000 40 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(2), OAT(2), PRODH(1) 783236 9 3 9 1 2 1 2 1 3 0 0.214 0.643 1.000 41 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 HLA-DRB1(1) 316315 1 1 1 0 0 0 0 0 1 0 1.000 0.654 1.000 42 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(8), CDC25C(2), CDK4(2), MYT1(10), RB1(3), YWHAH(1) 2172878 26 8 25 5 4 4 6 6 6 0 0.288 0.655 1.000 43 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(2), ABCB4(4), ABCC3(4), GSTP1(1) 1969378 15 9 12 3 2 3 2 4 4 0 0.418 0.656 1.000 44 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1) 830758 11 3 11 2 1 2 1 4 3 0 0.375 0.662 1.000 45 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 224782 3 1 3 0 1 1 0 1 0 0 0.348 0.679 1.000 46 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), NFS1(1), PHPT1(1), TPK1(2) 881786 6 3 6 2 1 2 2 0 1 0 0.780 0.679 1.000 47 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(3), INPPL1(5), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2) 2721003 23 12 21 5 3 4 3 5 8 0 0.367 0.687 1.000 48 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 8 CYP17A1(1), F13B(1), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2), HSD3B2(1) 1019733 11 3 11 3 2 5 2 2 0 0 0.317 0.689 1.000 49 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), KEAP1(1), MAFF(2), MAPK8(2), NFE2L2(1) 1253790 8 4 8 0 2 0 0 3 3 0 0.115 0.689 1.000 50 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), F10(4), F12(2), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1) 6151124 59 20 53 8 7 11 21 5 14 1 0.0683 0.699 1.000 51 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 5 CSF1(2), IL1B(1), MST1R(5) 700546 8 5 7 3 0 3 0 1 4 0 0.633 0.702 1.000 52 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(1) 274454 1 1 1 0 1 0 0 0 0 0 0.782 0.703 1.000 53 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 5 BAAT(1), CSAD(1), GAD1(6), GAD2(5), GGT1(1) 743944 14 7 14 6 4 3 4 1 1 1 0.657 0.704 1.000 54 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD80(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1) 1747533 12 6 12 2 1 2 2 2 5 0 0.325 0.706 1.000 55 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 305620 2 1 2 1 0 0 0 1 1 0 0.765 0.708 1.000 56 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(3), FUT5(1), FUT6(1) 707432 6 3 6 1 5 1 0 0 0 0 0.233 0.726 1.000 57 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), CPOX(3), HMBS(1), PPOX(2) 1059298 8 6 8 2 2 2 1 1 2 0 0.626 0.726 1.000 58 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1) 2642202 23 11 23 3 5 6 3 2 7 0 0.0735 0.730 1.000 59 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2) 1027752 11 3 11 1 3 4 3 0 1 0 0.167 0.734 1.000 60 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1), HLA-DRB1(1) 544056 4 2 4 1 0 0 1 1 2 0 0.845 0.735 1.000 61 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(2) 529164 4 2 4 3 0 0 1 1 2 0 0.908 0.735 1.000 62 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 256508 1 1 1 0 0 0 0 1 0 0 0.796 0.738 1.000 63 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(3), GCNT2(2), ST8SIA1(2) 864472 8 3 8 1 5 2 1 0 0 0 0.123 0.745 1.000 64 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(3) 641413 7 2 7 3 1 1 3 2 0 0 0.814 0.746 1.000 65 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LPL(2) 727176 7 2 7 1 1 3 1 1 1 0 0.228 0.746 1.000 66 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 AKT1(2), GNB1(2), NOS3(6), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(1) 2100505 18 7 18 4 2 4 6 2 4 0 0.383 0.754 1.000 67 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 26 ABAT(1), ACADL(1), ACADSB(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2) 3882215 35 12 34 3 13 8 8 4 1 1 0.00138 0.760 1.000 68 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(4), FSHB(1), FSHR(2), XPO1(1) 1017088 8 3 8 0 3 1 1 2 1 0 0.103 0.762 1.000 69 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2) 775721 13 4 12 2 5 2 3 0 3 0 0.134 0.777 1.000 70 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(6), TH(1), TPH1(2) 850064 9 3 9 4 2 0 3 1 2 1 0.744 0.778 1.000 71 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(2), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), SHC1(1) 2320009 20 10 20 4 4 5 5 2 4 0 0.162 0.781 1.000 72 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(1), GPR171(1), GPR18(1), GPR39(3), GPR65(2), GPR75(1) 1354180 10 5 10 3 1 1 0 4 4 0 0.736 0.783 1.000 73 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 CD3E(1), HLA-A(4), ICAM1(2), ITGAL(3), ITGB2(1) 1050170 11 4 11 2 4 0 1 1 5 0 0.339 0.785 1.000 74 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(2), EIF4A2(2), EIF4G1(7), EIF4G3(7), GHR(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTEN(2) 3349827 29 13 28 6 4 8 7 4 6 0 0.224 0.785 1.000 75 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(4), AKT1(2), ATM(8), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2) 2791090 23 9 23 5 1 2 6 8 6 0 0.407 0.787 1.000 76 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(4) 1181336 14 3 14 2 2 4 5 3 0 0 0.165 0.787 1.000 77 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 19 F10(4), F12(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), LPA(5), PLAT(2), SERPINE1(2), SERPINF2(1), VWF(5) 4729919 43 15 39 8 10 8 15 4 6 0 0.0959 0.788 1.000 78 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CD4(2), HLA-DRB1(1), IL1B(1), IL6(1) 630304 5 2 5 1 0 0 1 1 3 0 0.715 0.791 1.000 79 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(3), ARHGAP5(3), CASP1(4), CASP10(2), CASP8(2), CASP9(1) 1616753 15 6 14 5 2 3 1 2 7 0 0.780 0.799 1.000 80 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(7), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1) 2625208 24 9 23 3 4 5 6 3 6 0 0.0607 0.801 1.000 81 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1) 1832313 14 7 14 3 4 3 1 3 3 0 0.245 0.805 1.000 82 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(2), EPO(1), IL6(1), IL7(1), IL9(1) 854176 8 2 8 1 0 1 2 4 1 0 0.388 0.812 1.000 83 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 HLA-A(4), KLRC3(2), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4) 2403055 21 9 21 5 5 3 3 5 4 1 0.325 0.821 1.000 84 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(4), EGF(2), EGFR(2), HRAS(1), PTPRB(10), RASA1(1), SHC1(1), SRC(2) 2978173 23 8 23 2 2 7 4 5 4 1 0.0401 0.822 1.000 85 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1), CD4(2) 439716 3 1 3 1 0 0 0 1 2 0 0.839 0.823 1.000 86 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2) 1861052 11 5 10 4 1 2 1 3 4 0 0.782 0.825 1.000 87 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(7), ATM(8), BRCA1(5), MAPK8(2), MDM2(2), MRE11A(3), NFKBIA(2), RELA(1) 3746472 30 13 26 2 3 4 7 4 12 0 0.0592 0.828 1.000 88 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(4), ARHGEF1(4), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), PIK3CA(4), PIK3R1(1), PLCB1(1), ROCK1(3) 3127227 22 10 22 5 3 6 3 4 6 0 0.215 0.830 1.000 89 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(2), ERBB3(4), NRG1(5), UBE2D1(1) 1412586 14 4 14 1 3 2 4 2 3 0 0.110 0.830 1.000 90 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(2), EGFR(2), IGF1R(3), POLR2A(2), PPP2CA(1), RB1(3), TEP1(10), TERT(6), TNKS(3), XRCC5(2) 3674830 34 13 31 8 9 6 4 7 7 1 0.265 0.833 1.000 91 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD4(2), HLA-DRB1(1), LCK(1), PTPRC(2), ZAP70(5) 1088739 12 3 12 2 3 2 1 2 4 0 0.258 0.847 1.000 92 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), IL6(1) 860541 9 2 9 1 1 1 1 3 3 0 0.263 0.850 1.000 93 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(4), EGF(2), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(1), SRC(2) 2667516 23 9 21 2 4 6 3 3 7 0 0.0482 0.850 1.000 94 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 8 ADAR(2), APOBEC3B(2), APOBEC3G(1) 900759 5 2 5 1 3 2 0 0 0 0 0.359 0.857 1.000 95 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(7), COL4A5(4), COL4A6(4), SLC2A1(4) 3501189 30 12 28 5 5 5 9 2 8 1 0.260 0.857 1.000 96 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 572133 1 1 1 0 0 0 0 0 1 0 0.829 0.859 1.000 97 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(4) 1639934 22 5 22 6 9 3 5 1 3 1 0.226 0.860 1.000 98 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(3) 880183 6 2 6 1 1 0 3 1 1 0 0.435 0.862 1.000 99 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1) 2472306 22 6 22 2 7 3 7 3 1 1 0.0285 0.866 1.000 100 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(3), CASP9(1), DAXX(4), FAS(2), FASLG(1), MAPKAPK3(1) 1567330 16 7 14 5 3 4 3 2 4 0 0.598 0.868 1.000 101 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1) 1749661 11 5 9 0 1 3 0 1 6 0 0.0930 0.868 1.000 102 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1) 1721928 23 6 23 6 5 6 5 4 3 0 0.311 0.870 1.000 103 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1438872 6 3 6 1 2 0 2 1 1 0 0.402 0.871 1.000 104 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(1), JAK2(2), TYK2(2) 1438872 6 3 6 1 2 0 2 1 1 0 0.402 0.871 1.000 105 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(1) 937796 19 5 18 3 7 6 0 2 4 0 0.0316 0.873 1.000 106 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(8), CCNE1(1), CDK4(2), MDM2(2), RB1(3) 2390592 19 6 19 4 3 3 6 4 3 0 0.418 0.875 1.000 107 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(1), FLT3(3), IL6(1), IL9(1), TGFB1(1), TGFB2(2) 1162588 10 4 9 2 1 2 4 1 2 0 0.433 0.876 1.000 108 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(1), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2) 1240198 11 3 11 2 2 1 3 4 1 0 0.352 0.876 1.000 109 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPX1(1), PRKCE(1) 1090308 13 2 13 1 4 4 1 1 2 1 0.0342 0.877 1.000 110 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CDK4(2), MDM2(2), NXT1(1) 979264 6 2 6 1 3 0 3 0 0 0 0.387 0.883 1.000 111 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 23 ABAT(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), DPYD(3), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), MLYCD(1), UPB1(2) 3498025 32 12 31 4 13 6 8 3 1 1 0.00848 0.883 1.000 112 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(3), CREB1(2), EDN1(3), EP300(4), EPO(1), HIF1A(1), NOS3(6) 2358032 20 6 19 2 4 2 5 2 7 0 0.123 0.889 1.000 113 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 8 CDC25C(2), CDK7(1), XPO1(1) 1072648 4 3 3 2 1 0 0 0 3 0 0.884 0.889 1.000 114 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 232415 1 1 1 1 0 0 1 0 0 0 0.968 0.890 1.000 115 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), AFMID(1), GRHPR(2), HAO1(1), HAO2(2), MDH2(1), MTHFD1L(1), MTHFD2(1) 1833613 12 5 10 1 2 3 0 1 6 0 0.196 0.891 1.000 116 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1), SHMT1(1), SHMT2(2) 590029 4 2 4 4 2 0 1 0 0 1 0.923 0.895 1.000 117 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2), EP300(4), ESR1(1), SRC(2) 2080195 9 4 9 1 2 3 2 1 1 0 0.145 0.897 1.000 118 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNGR1(1), JAK1(1), JAK2(2), STAT1(1) 1031743 5 2 5 2 1 0 2 1 1 0 0.742 0.898 1.000 119 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(4), SPHK1(1), SRC(2) 3777430 31 10 31 2 5 11 3 5 7 0 0.00165 0.898 1.000 120 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(1), HRAS(1), INSR(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SRF(1) 2824761 16 8 16 3 5 2 0 4 5 0 0.221 0.900 1.000 121 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 11 F13A1(2), FGA(5), FGB(4), FGG(2), PLAT(2), SERPINE1(2) 1711876 17 5 16 6 3 3 4 4 3 0 0.629 0.901 1.000 122 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 6 AGT(1), AGTR2(1), KNG1(1), NOS3(6) 930079 9 3 9 2 3 0 5 0 1 0 0.483 0.905 1.000 123 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), PGM3(1), RENBP(1), UAP1(1) 2349416 20 7 20 6 8 3 5 1 3 0 0.353 0.906 1.000 124 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), OPRK1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1789927 11 4 11 2 5 1 3 0 2 0 0.294 0.906 1.000 125 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), GOT1(2), HPD(2), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TAT(1), TPO(4) 3048453 36 11 35 8 17 5 7 3 4 0 0.0591 0.907 1.000 126 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(1), STAT3(2), STAT5A(1) 1675462 12 4 12 2 6 2 2 0 2 0 0.176 0.911 1.000 127 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(2), HTR2C(1), PLCB1(1), TUB(2) 981132 7 3 7 2 0 4 0 2 1 0 0.416 0.913 1.000 128 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(2), TPO(4) 1603550 21 4 21 6 9 3 4 2 2 1 0.232 0.915 1.000 129 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2), KARS(2) 644905 4 2 4 3 1 0 1 1 1 0 0.952 0.917 1.000 130 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 3 RANBP1(1), RANGAP1(2) 270816 3 1 3 1 1 1 1 0 0 0 0.675 0.917 1.000 131 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(4), EPHA4(2), ITGA1(7), L1CAM(1), RAP1B(2), SELP(3) 1991355 19 6 19 2 6 5 2 2 4 0 0.0354 0.917 1.000 132 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS2(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 2070401 19 5 19 4 2 5 8 2 2 0 0.266 0.920 1.000 133 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(4), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1831499 18 4 18 2 5 6 1 2 4 0 0.0303 0.921 1.000 134 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(1), PAPSS1(3), PAPSS2(3), SULT1A2(1), SULT2A1(1), SUOX(1) 1290043 14 6 14 3 3 2 2 4 3 0 0.346 0.923 1.000 135 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(2), MAP2K6(2), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1), SP1(1) 2691532 19 8 19 8 1 2 6 4 6 0 0.890 0.924 1.000 136 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(4), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1971277 19 6 19 5 7 3 6 2 1 0 0.340 0.924 1.000 137 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(4), ADCY1(4), CDC25C(2), GNAI1(1), GNB1(2), HRAS(1), MYT1(10), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), SRC(2) 2564405 34 11 33 6 11 10 4 5 4 0 0.0236 0.924 1.000 138 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD2(1) 630082 3 1 3 2 1 1 0 0 1 0 0.818 0.925 1.000 139 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), FARS2(2), GOT1(2), TAT(1) 1129552 8 4 7 2 0 2 3 2 1 0 0.580 0.929 1.000 140 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1) 2418149 29 8 29 8 6 6 6 6 5 0 0.315 0.930 1.000 141 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 10 ARRB1(1), GNB1(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1043243 9 2 9 1 5 3 1 0 0 0 0.0912 0.931 1.000 142 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 APC(5), AXIN1(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(8), DVL1(4), FZD1(5), GATA4(1), GSK3B(1), RFC1(4), TGFB1(1), TGFB2(2), TGFBR2(5), WNT1(1) 4786686 56 15 55 8 21 12 5 11 7 0 0.00432 0.933 1.000 143 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(4), AKT1(2), CAMK2D(1), CREB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), RPS6KA5(1) 3366640 24 10 24 5 7 4 2 3 8 0 0.222 0.935 1.000 144 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1) 3558924 27 9 27 5 7 7 7 4 1 1 0.0852 0.936 1.000 145 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1216347 10 3 9 0 1 2 2 2 3 0 0.118 0.937 1.000 146 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(1), PFKL(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2) 1289033 15 3 15 4 5 6 1 2 1 0 0.170 0.937 1.000 147 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(2), BAD(1), HRAS(1), IGF1R(3), PIK3CA(4), PIK3R1(1), SHC1(1), YWHAH(1) 1887910 14 7 14 5 4 3 0 3 4 0 0.580 0.938 1.000 148 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(2), CREBBP(2), EP300(4), NCOA3(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2855594 19 6 19 6 6 3 4 2 3 1 0.430 0.938 1.000 149 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(4), MEF2A(2), MEF2D(1), YWHAH(1) 1099767 11 2 11 3 1 2 5 1 2 0 0.534 0.938 1.000 150 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT2(3), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 1485591 12 5 12 2 7 2 2 0 1 0 0.108 0.939 1.000 151 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(1), ABAT(1), ADSL(2), ADSS(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), CAD(5), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), PC(2) 3436823 37 10 37 10 9 8 12 5 2 1 0.197 0.939 1.000 152 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(4), AKT1(2), BAD(1), CSF2RB(2), IGF1R(3), IL3RA(1), KIT(4), PIK3CA(4), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1) 2968072 29 8 29 5 8 7 3 6 5 0 0.0409 0.939 1.000 153 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 294107 3 1 3 0 0 1 2 0 0 0 0.408 0.939 1.000 154 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 31 AARS(1), ABAT(1), ADSL(2), ADSS(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(1), CAD(5), DARS(1), DARS2(1), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(2), GPT(1), GPT2(2), NARS2(2), PC(2), PDHA1(1) 4800780 48 15 48 13 12 11 12 7 5 1 0.135 0.942 1.000 155 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), MUT(2) 684217 3 1 3 2 0 0 0 1 2 0 0.905 0.944 1.000 156 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1104732 5 3 5 2 3 0 2 0 0 0 0.673 0.946 1.000 157 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1104732 5 3 5 2 3 0 2 0 0 0 0.673 0.946 1.000 158 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GGT1(1), SHMT1(1), SHMT2(2) 779743 5 3 5 4 2 1 1 0 0 1 0.875 0.946 1.000 159 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(1), FBXW7(4), RB1(3) 1151734 10 3 10 4 1 3 2 3 1 0 0.759 0.946 1.000 160 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2) 965411 9 4 9 3 3 2 0 2 2 0 0.696 0.947 1.000 161 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1) 1472641 12 4 12 2 6 1 0 2 3 0 0.154 0.949 1.000 162 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GPHN(1), SRC(2), UBQLN1(3) 1665425 19 4 19 2 6 4 4 2 2 1 0.0346 0.950 1.000 163 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 HRAS(1), MMP2(2), MMP9(2), RECK(3) 885158 8 2 8 3 5 0 1 0 2 0 0.563 0.950 1.000 164 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(3), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1) 2518007 22 7 21 4 4 5 4 1 8 0 0.309 0.952 1.000 165 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), APOA4(2), APOC1(1), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(3), LPL(2), LRP1(12), SCARB1(1), SOAT1(1) 3769470 32 11 32 9 13 7 3 2 6 1 0.148 0.953 1.000 166 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(1), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1) 2283944 13 7 13 3 3 3 1 2 4 0 0.295 0.953 1.000 167 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(1), DHRS3(2), PON1(1), PON2(1) 2502339 24 8 23 6 8 4 2 5 5 0 0.256 0.954 1.000 168 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), AKT2(1), AKT3(1), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1) 1922058 15 8 15 8 6 1 2 2 4 0 0.837 0.954 1.000 169 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2), THY1(1) 1544248 14 4 14 3 6 1 0 3 4 0 0.256 0.955 1.000 170 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 6 HSD11B1(1), LPL(2), NR3C1(2), PPARG(1) 764201 6 1 6 1 2 0 2 1 1 0 0.403 0.955 1.000 171 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), UGDH(1) 1183983 6 3 6 3 3 0 2 1 0 0 0.766 0.958 1.000 172 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 11 APC(5), CDH1(1), CREBBP(2), EP300(4), TGFB1(1), TGFB2(2), TGFBR2(5) 3228324 20 7 19 6 7 1 3 4 5 0 0.532 0.959 1.000 173 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(2), NFKBIA(2), RELA(1) 1268527 6 2 6 1 0 1 2 2 1 0 0.546 0.959 1.000 174 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 14 CD44(3), CSF1(2), IL1B(1), IL6R(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3) 1531935 17 5 16 7 6 1 3 4 3 0 0.643 0.960 1.000 175 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(8), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1) 2342244 25 9 25 8 10 5 7 1 2 0 0.280 0.960 1.000 176 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(2) 1611423 9 4 9 2 3 1 2 0 3 0 0.482 0.961 1.000 177 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 5 CDK5R1(1), DAB1(1), LRP8(1), RELN(7), VLDLR(1) 1671573 11 4 11 6 3 2 2 1 2 1 0.909 0.961 1.000 178 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 359143 3 1 3 1 0 1 1 1 0 0 0.760 0.961 1.000 179 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), MAF(2), NFATC1(4), NFATC2(5), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1728743 19 5 18 7 8 5 2 0 4 0 0.283 0.961 1.000 180 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(1), CR1(3), FCGR2B(1), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(2) 1782807 14 7 14 3 5 2 1 2 4 0 0.268 0.962 1.000 181 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), GREB1(4), MTA1(1), PDZK1(1), TUBA8(4) 1552600 12 4 12 2 0 8 1 1 2 0 0.0728 0.963 1.000 182 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(2), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PIK3CA(4), PIK3R1(1), RB1(3), RELA(1) 2647346 19 8 19 6 2 4 6 4 3 0 0.618 0.963 1.000 183 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 856979 9 2 9 3 3 0 1 2 3 0 0.580 0.964 1.000 184 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDK7(1) 839984 1 1 1 1 0 0 0 0 1 0 0.904 0.964 1.000 185 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL1(1), FOSL2(2), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(1), TNFRSF11A(2) 1538193 11 2 11 3 0 2 3 5 1 0 0.525 0.965 1.000 186 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 7 GCK(1), HK1(1), HK2(3), HK3(2), PGM3(1) 1230533 8 2 8 4 4 1 2 0 1 0 0.680 0.965 1.000 187 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(1), HRAS(1), IGF1R(3), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(1), SHC1(1), SRF(1) 2717949 15 7 15 4 4 2 0 4 5 0 0.416 0.965 1.000 188 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(1), HMGB1(1), TOP2A(1), TOP2B(4) 1285166 8 4 8 2 3 2 0 1 2 0 0.606 0.966 1.000 189 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 10 ARNTL(1), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(4), PER2(3), PER3(1) 2144632 15 5 14 3 4 2 2 3 4 0 0.277 0.966 1.000 190 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(9), FASN(7), MCAT(1), OLAH(2) 2276042 23 6 22 3 8 6 2 1 5 1 0.0193 0.967 1.000 191 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1B(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 1952302 17 4 17 5 2 5 7 1 2 0 0.487 0.967 1.000 192 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(3), DDC(1), GAD1(6), GAD2(5), SLC18A3(2), TH(1), TPH1(2) 2034870 23 9 23 9 7 2 9 2 2 1 0.554 0.967 1.000 193 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), LEPR(5), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2) 1979071 14 3 14 1 0 6 1 2 5 0 0.0548 0.967 1.000 194 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(4), DDX20(1), E2F4(4), ETS1(1), ETS2(2), HDAC5(1), HRAS(1), NCOR2(4), RBL1(1), RBL2(2), SIN3A(5) 3697332 28 10 26 8 5 8 5 4 6 0 0.358 0.967 1.000 195 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(5), AXIN1(5), BTRC(1), CREBBP(2), CSNK1D(1), CSNK2A1(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1) 3970551 41 11 41 5 13 8 7 8 5 0 0.00656 0.969 1.000 196 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), PC(2), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(2) 2837228 23 6 22 2 5 4 6 4 4 0 0.0423 0.971 1.000 197 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 15 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB5(2) 1053450 8 4 8 3 2 0 3 1 2 0 0.731 0.971 1.000 198 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(5), AXIN1(5), BTRC(1), CTNNB1(8), DVL1(4), FZD1(5), GSK3B(1), NOTCH1(7), PSEN1(1), WNT1(1) 3072054 41 8 41 7 15 13 4 6 3 0 0.00664 0.971 1.000 199 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(4), CTNNB1(8), PTK2(4), PXN(1), SRC(2), VCL(1) 2699126 32 7 32 5 14 10 2 5 1 0 0.00823 0.971 1.000 200 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(2), SCAP(3), SREBF1(1), SREBF2(5) 1732184 11 6 9 9 2 2 0 2 5 0 0.985 0.972 1.000 201 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(2), NAT2(1), XDH(6) 1085665 16 6 16 7 6 2 1 4 3 0 0.736 0.972 1.000 202 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3) 2866339 32 8 32 8 7 6 6 7 6 0 0.224 0.972 1.000 203 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(5) 1455959 14 3 13 1 5 3 3 1 2 0 0.0620 0.973 1.000 204 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(1) 462012 3 1 3 0 0 3 0 0 0 0 0.378 0.974 1.000 205 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CDK4(2), CDK6(2), CDK7(1), RB1(3), RBL1(1) 2025532 16 4 16 4 2 4 5 4 1 0 0.345 0.975 1.000 206 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 1195423 7 3 7 4 3 0 2 0 2 0 0.792 0.975 1.000 207 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(1), SRF(1), STAT5A(1) 3858202 23 11 23 4 8 3 4 3 5 0 0.123 0.975 1.000 208 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(3), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1816641 15 5 14 3 5 2 2 2 4 0 0.345 0.976 1.000 209 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 DLG4(1), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), NOS1(7), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3345214 38 10 38 12 15 6 6 7 4 0 0.299 0.978 1.000 210 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 10 BCAT1(2), DPYD(3), ENPP3(2), PANK1(1), PANK4(2), UPB1(2) 1692222 12 5 12 2 3 4 1 2 2 0 0.223 0.978 1.000 211 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX3(1), PLA2G3(2), PLA2G6(4) 1292474 7 2 7 6 0 2 3 1 1 0 0.983 0.979 1.000 212 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(3), OGDH(3), SDHA(3), SUCLA2(1) 1289002 11 2 11 1 3 1 3 2 2 0 0.144 0.979 1.000 213 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(1), STAT2(1), TYK2(2) 1495890 8 3 8 3 3 0 3 2 0 0 0.634 0.979 1.000 214 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4) 424787 6 2 6 2 1 1 1 3 0 0 0.698 0.979 1.000 215 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(2), APAF1(3), ATM(8), BAD(1), CASP7(1), CASP9(1), PTK2(4), PXN(1), STAT1(1), TLN1(9) 3608085 31 6 31 5 7 8 6 5 5 0 0.0707 0.980 1.000 216 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1) 1551581 7 2 7 0 3 1 1 2 0 0 0.106 0.981 1.000 217 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 218 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 219 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), SHMT1(1) 2078229 12 4 12 3 2 2 4 2 2 0 0.469 0.981 1.000 220 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(2), BECN1(1), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(2), ULK3(1) 2944437 21 7 21 4 5 4 1 7 4 0 0.193 0.981 1.000 221 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 18 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), UBE3A(5) 1632333 12 5 11 2 4 0 3 2 3 0 0.360 0.982 1.000 222 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 EPO(1), EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1) 1538574 9 2 9 1 2 1 5 0 1 0 0.334 0.982 1.000 223 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(2), AKT2(1), AKT3(1), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), PTEN(2), RBL2(2), SHC1(1) 2447918 19 9 19 7 3 3 5 4 4 0 0.644 0.983 1.000 224 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(8), ATR(9), BRCA1(5), CDC25C(2), CDC34(1), EP300(4), MDM2(2), MYT1(10), PRKDC(7), RPS6KA1(2), YWHAH(1) 5559295 51 22 48 12 9 8 8 12 14 0 0.341 0.983 1.000 225 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MANBA(2), NEU4(1) 2329794 15 7 15 4 6 1 2 0 6 0 0.380 0.983 1.000 226 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(1), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), SHC1(1) 4722675 37 12 37 6 10 8 9 2 8 0 0.0247 0.983 1.000 227 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1) 1903223 7 2 7 3 0 2 1 2 2 0 0.627 0.984 1.000 228 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(7), ATM(8), ATR(9), CCNA1(3), CCNE1(1), CDK4(2), CDK6(2), DHFR(1), GSK3B(1), RB1(3), SKP2(2), TGFB1(1), TGFB2(2) 3841573 42 16 40 11 6 7 11 7 11 0 0.459 0.984 1.000 229 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), SH3GLB1(1) 2106530 8 3 8 2 1 1 1 3 2 0 0.590 0.985 1.000 230 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), ST8SIA1(2) 2173447 16 5 16 2 9 4 2 0 1 0 0.0385 0.985 1.000 231 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(1), GLB1(3), HEXB(2), LCT(3), ST3GAL1(2), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1) 2180014 22 8 21 7 9 3 2 0 8 0 0.277 0.985 1.000 232 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 14 ABCG2(1), BCHE(5), CES1(1), CYP3A5(1), UGT1A10(1), UGT1A3(1) 2380967 10 7 9 7 0 1 2 3 3 1 0.980 0.986 1.000 233 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(5), CREBBP(2), CTNNB1(8), DVL1(4), EP300(4), FZD1(5), GSK3B(1), LDB1(1), LEF1(3), TRRAP(9), WNT1(1) 4599247 48 11 47 8 17 9 6 11 5 0 0.0116 0.986 1.000 234 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), KERA(2), LUM(1) 496834 4 1 4 1 0 0 1 3 0 0 0.674 0.986 1.000 235 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), SCAP(3), SREBF1(1), SREBF2(5) 2449203 20 7 18 6 4 5 1 1 9 0 0.496 0.986 1.000 236 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(1), VKORC1(3) 1554661 16 3 16 6 3 5 6 1 1 0 0.524 0.986 1.000 237 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 15 ACE2(1), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(4), LNPEP(2), MME(2), NLN(1), THOP1(1) 2455519 20 6 20 4 3 6 6 4 1 0 0.136 0.987 1.000 238 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCR(1), CRKL(2), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), STAT1(1), STAT5A(1) 3508640 22 9 22 6 4 2 5 5 6 0 0.497 0.987 1.000 239 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(2), EIF4B(3), EIF4G1(7), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), PTEN(2), TSC1(1), TSC2(6) 3818174 40 15 39 10 9 10 10 5 6 0 0.266 0.987 1.000 240 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), FDXR(1), SHMT1(1) 2211453 13 4 13 4 2 2 5 2 2 0 0.564 0.987 1.000 241 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 11 ACAA1(1), ACOX3(1), ELOVL6(1), FADS1(1), FASN(7), HADHA(1), HSD17B12(1) 1850619 13 3 13 3 3 4 3 0 2 1 0.161 0.987 1.000 242 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), FURIN(2), NOTCH1(7), PSEN1(1) 1369260 13 2 13 6 6 6 1 0 0 0 0.336 0.987 1.000 243 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10A(1), RPL10L(2), RPL11(1), RPL18(2), RPL18A(1), RPL22L1(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(2), RPL3L(2), RPS11(2), RPS25(1), RPS27(1), RPS28(1), RPSA(1) 3143933 25 10 23 7 7 2 4 0 12 0 0.742 0.988 1.000 244 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(2) 1252099 11 2 10 5 2 1 5 1 2 0 0.871 0.988 1.000 245 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(4), PRKACG(2), PRKAR2B(1) 1392069 7 2 7 3 1 2 2 1 1 0 0.830 0.988 1.000 246 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GLS(2), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(1) 4582693 44 12 44 10 8 7 14 6 7 2 0.167 0.988 1.000 247 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(3), FH(1), IDH1(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), OGDHL(2), PC(2), PCK1(3), PCK2(4), SDHA(3), SUCLA2(1), SUCLG1(2) 4103283 34 9 32 6 11 4 7 4 7 1 0.0865 0.989 1.000 248 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(2), BAD(1), CASP9(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1) 2623166 18 8 18 6 2 5 3 4 4 0 0.598 0.989 1.000 249 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 JUND(1) 450994 1 1 1 0 0 0 0 1 0 0 0.801 0.989 1.000 250 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 CDK5R1(1), CSNK1D(1), DRD1(2), PLCB1(1), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1798348 14 2 14 3 7 2 1 4 0 0 0.219 0.989 1.000 251 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(4), MPO(2), PRDX1(1), PRDX5(1), TPO(4), TYR(3) 1340179 19 5 19 8 9 0 5 2 3 0 0.696 0.990 1.000 252 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CAPNS1(3), CAPNS2(1), EP300(4), MEF2D(1), NFATC1(4), NFATC2(5), PPP3CA(1), PPP3CC(2) 3357673 25 10 24 8 5 6 0 4 10 0 0.494 0.990 1.000 253 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), EHHADH(1), HADHA(1) 1681105 7 3 7 2 4 0 3 0 0 0 0.510 0.990 1.000 254 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), DCT(5), DDC(1), GOT1(2), HGD(2), HPD(2), TAT(1), TH(1), TPO(4), TYR(3) 4393947 48 12 47 16 20 8 8 6 6 0 0.210 0.990 1.000 255 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD86(1), HLA-DRB1(1), IFNGR1(1), IL12B(1), IL12RB2(1), IL2RA(1), IL4R(1) 1650334 7 4 7 3 1 1 0 3 2 0 0.754 0.990 1.000 256 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 10 APEX1(1), CREBBP(2), DFFB(1), NME1(1), SET(1) 1319545 6 3 6 2 2 0 1 1 2 0 0.698 0.990 1.000 257 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(2) 530069 2 1 2 0 1 0 0 1 0 0 0.530 0.990 1.000 258 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(5), ODC1(1), SAT2(1) 4104870 25 8 24 3 11 5 5 2 1 1 0.0180 0.991 1.000 259 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT2(1), B3GNT7(1), CHST2(2), CHST4(1), CHST6(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1647120 13 4 13 2 5 1 4 2 1 0 0.130 0.991 1.000 260 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELP(3) 2203724 15 5 15 5 5 3 1 3 3 0 0.374 0.991 1.000 261 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2) 1446344 12 4 12 3 4 2 1 3 2 0 0.297 0.991 1.000 262 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2) 1830349 19 3 19 7 7 5 4 2 1 0 0.470 0.992 1.000 263 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 8 HK1(1), LCT(3), PYGM(1), TPI1(2), TREH(1) 1686318 8 2 8 9 1 2 1 1 3 0 0.975 0.992 1.000 264 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1), TPI1(2) 532396 4 1 4 0 1 2 0 1 0 0 0.218 0.992 1.000 265 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(1), AKT3(1), IARS(4), IL4R(1), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(4), SHC1(1), SOS2(1), SRC(2), STAT6(4), TYK2(2) 4755971 30 10 30 8 8 6 5 5 6 0 0.245 0.992 1.000 266 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 12 ARHGAP5(3), ARHGEF1(4), GNAQ(1), GNB1(2), MYLK(8), PLCB1(1), ROCK1(3) 2553126 22 6 22 7 4 6 4 4 4 0 0.457 0.993 1.000 267 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(8), CCND2(2), CDK4(2), ESR2(1), FSHR(2), GJA4(1), LHCGR(1), MLH1(1), NCOR1(7), NRIP1(1), PGR(3), PRLR(3), ZP2(1) 4698408 33 8 33 7 8 5 8 7 5 0 0.143 0.993 1.000 268 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5) 2904624 27 7 27 4 10 6 3 3 5 0 0.0295 0.993 1.000 269 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(4), CD3E(1), CD4(2), CREBBP(2), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(5) 2904624 27 7 27 4 10 6 3 3 5 0 0.0295 0.993 1.000 270 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2) 1652444 10 4 10 6 3 2 3 0 2 0 0.856 0.993 1.000 271 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 23 ASNS(3), ASRGL1(1), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), GLUD2(1), HAL(1) 2843531 19 6 19 4 4 8 2 1 3 1 0.184 0.993 1.000 272 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5E(1), NT5M(1) 2009279 16 2 16 3 5 4 2 3 2 0 0.144 0.994 1.000 273 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(1), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SRF(1), STAT1(1), STAT3(2), STAT5A(1) 4453521 26 9 26 6 6 5 4 5 6 0 0.277 0.994 1.000 274 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), GGT1(1), PAPSS1(3), PAPSS2(3), SCLY(2) 1715261 11 4 11 9 4 2 2 1 2 0 0.945 0.994 1.000 275 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G3(2), PLA2G6(4), RDH11(2) 3298698 28 7 28 9 7 3 9 6 3 0 0.592 0.994 1.000 276 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGAL(3), ITGB2(1), SELE(2) 1665164 11 4 11 5 4 1 1 3 2 0 0.675 0.994 1.000 277 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 26 ANXA6(2), CYP11A1(2), EDN1(3), EDNRB(2), HSD11B1(1), PTGDR(2), PTGDS(3), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 2720260 21 7 20 6 9 2 4 2 4 0 0.388 0.994 1.000 278 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(1), BIRC2(1), CASP7(1), CASP8(2), CASP9(1), DFFB(1) 1811829 10 2 10 4 2 3 1 1 3 0 0.709 0.995 1.000 279 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 14 BCAT1(2), BCAT2(1), DPYD(3), ENPP3(2), ILVBL(2), PANK1(1), PANK4(2), UPB1(2), VNN1(1) 2160503 16 5 16 2 5 5 2 2 2 0 0.0793 0.995 1.000 280 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(4), TRH(2) 1492774 10 3 10 4 4 1 2 1 2 0 0.656 0.995 1.000 281 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(1), TLR2(2), TLR4(1), TLR7(1), TLR9(5) 2560893 21 7 21 7 8 5 3 5 0 0 0.408 0.995 1.000 282 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP7A(3), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(2), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1), UQCRH(1) 4984670 34 12 34 7 9 4 6 8 7 0 0.197 0.995 1.000 283 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), STAT1(1), STAT3(2), STAT5A(1), THPO(1) 3753020 17 7 17 3 3 5 2 2 5 0 0.178 0.995 1.000 284 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), HAL(1), PRPS1(1) 3371480 19 9 18 5 8 5 4 1 1 0 0.198 0.995 1.000 285 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 24 BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1) 3449742 19 8 19 4 2 3 2 5 7 0 0.487 0.996 1.000 286 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), DDC(1), EPX(4), ESCO1(3), GOT1(2), HPD(2), LPO(4), MPO(2), SH3GLB1(1), TAT(1), TPO(4) 4559160 38 10 37 7 18 5 6 5 4 0 0.0289 0.996 1.000 287 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(8), ATR(9), BRCA1(5), BRCA2(7), FANCA(3), FANCC(2), FANCD2(4), FANCG(1), HUS1(1), MRE11A(3), RAD1(1), RAD9A(1), TREX1(2) 5713347 47 20 44 11 7 9 5 9 17 0 0.446 0.996 1.000 288 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), GLB1(3), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NEU4(1) 2869103 18 7 18 6 8 1 2 0 7 0 0.428 0.997 1.000 289 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 20 ASNS(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(5), GLS(2), HAL(1) 2533498 17 5 17 3 4 6 2 1 3 1 0.171 0.997 1.000 290 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(2), DAXX(4), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(1) 2543869 20 5 19 6 6 2 5 4 3 0 0.504 0.997 1.000 291 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(1), EGF(2), EGFR(2), HRAS(1), JAK1(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SRF(1), STAT1(1), STAT3(2), STAT5A(1) 4802429 27 9 27 6 4 6 4 6 7 0 0.248 0.997 1.000 292 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 11 CASR(3), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM7(5), GRM8(3) 2288279 37 11 36 11 8 12 5 5 7 0 0.221 0.997 1.000 293 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 20 AOX1(1), CD38(1), ENPP3(2), NADSYN1(4), NNT(5), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT12(1) 2697413 19 3 19 4 6 4 3 3 3 0 0.186 0.997 1.000 294 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1), HADHA(1) 668241 2 1 2 0 1 0 1 0 0 0 0.545 0.997 1.000 295 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 22 GPLD1(2), PGAP1(1), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGQ(5), PIGS(3), PIGW(2) 3283446 21 6 21 3 6 4 4 4 3 0 0.0555 0.997 1.000 296 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PDHA1(1), PKLR(2) 5092832 37 8 36 8 9 14 4 3 7 0 0.0811 0.997 1.000 297 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), AGTR2(1), EDN1(3), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1) 2828007 16 4 15 1 2 3 4 1 6 0 0.0461 0.997 1.000 298 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 26 CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(1), IL12B(1), IL12RB2(1), IL4R(1), TGFB1(1), TGFB2(2) 2588041 19 7 18 8 4 4 2 5 4 0 0.699 0.997 1.000 299 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 ANKHD1(3), EEF1D(2), EEF1G(3), EEF2(3), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(7), EIF4G3(7), EIF5(1), GSPT2(1), PABPC3(5), SLC35A4(2) 5610537 46 11 45 8 8 10 13 6 9 0 0.0879 0.997 1.000 300 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), LCT(3), NAGLU(2) 2042627 15 7 15 7 4 3 1 2 5 0 0.697 0.998 1.000 301 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKL(2), PFKM(2), PGD(1), PGLS(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1), TKTL1(1) 3186518 23 5 23 6 6 5 8 2 2 0 0.198 0.998 1.000 302 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(2), EP300(4), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1) 3727846 21 10 20 9 6 4 3 3 5 0 0.691 0.998 1.000 303 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(1), C1S(4), C3(6), C5(1), C6(6), C7(4), C8A(5), C9(1), MASP1(3) 2943836 32 8 32 10 7 6 6 7 6 0 0.387 0.998 1.000 304 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3) 1894860 12 5 12 5 6 3 1 1 1 0 0.572 0.998 1.000 305 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3) 767714 12 1 12 4 4 3 2 2 1 0 0.501 0.998 1.000 306 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 16 AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1) 2110623 9 3 9 4 1 1 3 2 2 0 0.860 0.998 1.000 307 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(4), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2) 1776581 16 3 16 3 5 2 2 5 2 0 0.248 0.998 1.000 308 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(2), HRAS(1), IL3RA(1), JAK2(2), PTPN6(4), SHC1(1), STAT5A(1) 2071358 12 4 12 3 5 1 3 2 1 0 0.384 0.998 1.000 309 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(5), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(1), GFPT2(1), GLS(2), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), NAGK(1), PPAT(2), QARS(1) 5459691 48 12 48 12 8 9 15 7 7 2 0.191 0.998 1.000 310 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AOC2(5), AOC3(2), CES1(1), DDHD1(2), ESCO1(3), LIPA(1), PLA1A(1), SH3GLB1(1) 3320506 16 6 15 3 6 4 2 3 1 0 0.158 0.998 1.000 311 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(1), ACAT1(2), HADHA(1) 747818 5 1 5 0 0 4 1 0 0 0 0.194 0.998 1.000 312 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 HSD3B7(3), RDH11(2) 669383 5 1 5 0 1 0 2 2 0 0 0.288 0.998 1.000 313 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(2), IL4R(1), JAK1(1), JAK3(3), SHC1(1), STAT6(4) 1726855 12 4 12 8 5 3 1 2 1 0 0.897 0.998 1.000 314 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR4(3), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(1), MC2R(2), MC3R(3), MC5R(2), NPY1R(2), NPY2R(3), NPY5R(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), SSTR1(4), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3) 7153733 74 20 73 20 23 9 21 12 8 1 0.0457 0.998 1.000 315 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(2), SYNJ2(2) 3082711 18 5 18 7 3 4 2 4 5 0 0.683 0.999 1.000 316 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(3), ARG1(1), ARG2(1), ASL(1), ASS1(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(1), GOT1(2), LAP3(2), NOS1(7), NOS3(6), OAT(2), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 4854135 53 14 53 12 17 7 14 8 6 1 0.127 0.999 1.000 317 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG2(2), AKT1(2), CDC42(1), FLNA(8), FLNC(9), FSCN3(2), GDI2(2), LIMK1(1), MYH2(3), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), ROCK1(3), ROCK2(1), VASP(1), WASF1(1), WASL(5) 6538948 58 19 57 17 10 12 14 11 11 0 0.349 0.999 1.000 318 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(4), ILVBL(2), LARS2(2), PDHA1(1), VARS(2), VARS2(2) 2567615 16 4 16 5 6 4 2 3 1 0 0.499 0.999 1.000 319 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(4), SRC(2), SYK(2), TBXAS1(1) 3367745 23 4 23 8 6 8 3 4 2 0 0.535 0.999 1.000 320 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(2), AKT2(1), AKT3(1), BAD(1), BTK(1), DAPP1(1), GSK3A(1), GSK3B(1), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1), TEC(2), YWHAE(2), YWHAH(1) 4551779 32 11 32 9 7 8 3 5 9 0 0.309 0.999 1.000 321 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(3), F2RL1(1), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(1), PLD2(3), PLD3(1), PTK2(4), RASAL1(5), SRC(2), TEC(2), VAV1(4) 3839257 37 5 37 8 10 12 6 3 5 1 0.0430 0.999 1.000 322 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 EGFR(2), GNB1(2), HRAS(1), IGF1R(3), KLK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(1), SHC1(1), SRC(2), STAT3(2) 3950126 22 9 22 8 8 6 2 3 3 0 0.427 0.999 1.000 323 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), OGT(1), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1) 4445385 27 8 27 8 8 5 7 4 3 0 0.352 0.999 1.000 324 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(2), ACOT11(2), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1) 3407829 16 5 16 3 4 3 3 3 3 0 0.273 0.999 1.000 325 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6) 6224212 54 15 52 11 18 8 4 11 13 0 0.0647 0.999 1.000 326 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), IFNGR1(1), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(3) 2359633 19 5 19 8 5 2 7 3 2 0 0.774 0.999 1.000 327 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(2), MAP3K1(3), NCOR2(4), THRA(2), THRB(1) 2435338 14 5 14 9 3 3 3 2 3 0 0.950 0.999 1.000 328 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 691247 1 1 1 1 1 0 0 0 0 0 0.845 0.999 1.000 329 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 22 ALDOB(1), FBP2(1), GPI(2), H6PD(5), PFKM(2), PGD(1), PGLS(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 2643201 20 3 20 7 5 4 8 2 1 0 0.392 0.999 1.000 330 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(4), CREB1(2), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 4570388 36 9 35 9 10 10 2 5 9 0 0.152 0.999 1.000 331 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 26 CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(7), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1) 5098330 40 10 40 8 11 2 11 7 9 0 0.187 0.999 1.000 332 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), BDH1(1), DDHD1(2), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2) 5625967 44 12 44 10 11 11 11 8 2 1 0.0696 0.999 1.000 333 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TKTL1(1), TPI1(2) 2788686 21 4 21 2 3 5 8 2 3 0 0.0377 0.999 1.000 334 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(2), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(1), DAPP1(1), FLOT1(1), FLOT2(2), ITPR1(6), ITPR2(9), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(6), PREX1(8), PTEN(2), PTPRC(2), RPS6KA1(2), RPS6KA2(1), SYK(2), TEC(2), VAV1(4) 7617683 69 23 65 14 20 11 9 11 17 1 0.0365 0.999 1.000 335 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(1), ITGA1(7), ITGB3(1), PTK2(4), PXN(1), SPTAN1(3), SRC(2), TLN1(9) 3967938 41 8 41 6 13 12 6 4 6 0 0.00453 0.999 1.000 336 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(2), YWHAH(1) 2825938 17 4 17 5 4 3 3 3 4 0 0.454 0.999 1.000 337 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(1), DHRS3(2), ESCO1(3), SH3GLB1(1) 3263266 23 3 23 7 5 7 3 5 3 0 0.393 0.999 1.000 338 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SP1(1) 2902362 21 5 20 6 4 6 2 3 6 0 0.347 0.999 1.000 339 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(3), SP1(1) 913204 5 1 5 0 1 0 3 1 0 0 0.352 0.999 1.000 340 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), AMD1(1), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(1), CKB(2), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(2), NOS1(7), NOS3(6), OAT(2), ODC1(1), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1) 6001293 57 15 56 9 23 9 14 6 4 1 0.00436 0.999 1.000 341 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(8), MAP2(3), PPP1CA(1), PPP2CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1) 2493140 17 5 17 6 5 4 2 4 2 0 0.671 0.999 1.000 342 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 50 ARSE(1), CARM1(1), CYP11B1(5), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 6377571 43 14 41 13 7 13 12 5 6 0 0.365 0.999 1.000 343 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(2), KARS(2) 949040 6 2 6 3 1 0 3 1 1 0 0.905 0.999 1.000 344 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(5), CARM1(1), CREBBP(2), EP300(4), ESR1(1), GRIP1(1), GTF2E1(1), GTF2F1(4), HDAC4(4), HDAC5(1), HDAC6(1), NCOR2(4), NR0B1(1), NRIP1(1), POLR2A(2), TBP(3) 6329201 36 13 32 9 9 6 5 4 12 0 0.330 0.999 1.000 345 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ADCY4(1), ADCY6(2), ADCY8(3), CACNA1A(7), CACNA1B(9), GNB1(2), GNB3(2), GNG13(1), GRM4(1), ITPR3(8), KCNB1(5), PLCB2(4), PRKACG(2), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(5), TAS1R2(3), TAS1R3(2), TAS2R1(2), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R9(2), TRPM5(1) 7776195 80 23 77 17 30 11 12 10 17 0 0.00670 0.999 1.000 346 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(1), ARFGAP1(1), ARFGEF2(2), CLTB(2), COPA(2), GBF1(3), GPLD1(2), KDELR3(1) 2084329 14 3 14 4 4 2 3 3 1 1 0.411 0.999 1.000 347 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(3), NR1H4(1) 744421 4 2 4 2 1 2 1 0 0 0 0.621 0.999 1.000 348 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 2115781 18 6 18 9 10 1 3 1 3 0 0.784 1.000 1.000 349 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(3), DIAPH1(4), HRAS(1), ITGA1(7), MYLK(8), PIK3CA(4), PIK3R1(1), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9) 4781881 48 10 48 10 12 15 8 7 6 0 0.0558 1.000 1.000 350 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), ME3(1), PGK1(2), PKLR(2), RPE(2), TKT(1), TPI1(2) 2500132 22 3 22 2 3 6 8 3 2 0 0.0222 1.000 1.000 351 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SGMS1(2), SGPP1(1), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(2), SPTLC2(1), UGCG(1), UGT8(1) 5034998 33 9 32 10 13 6 3 6 5 0 0.181 1.000 1.000 352 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 38 ALAS2(2), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTMT(2), GUSB(1), HMBS(1), PPOX(2), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 5444974 28 10 28 7 3 9 3 5 8 0 0.336 1.000 1.000 353 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 20 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), IL1B(1), MAP2K6(2), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR2(5), TLR2(2) 3825261 25 6 25 6 6 4 6 4 5 0 0.231 1.000 1.000 354 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), CARM1(1), DDC(1), FTCD(3), HAL(1), HARS2(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), UROC1(4) 5495100 42 13 40 8 12 11 11 3 5 0 0.0291 1.000 1.000 355 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 SP1(1) 858410 1 1 1 0 0 0 1 0 0 0 0.841 1.000 1.000 356 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(2), JAK1(1), JAK2(2), JAK3(3), STAT1(1), STAT3(2), STAT5A(1), TYK2(2) 2581639 16 6 16 8 7 2 4 1 2 0 0.748 1.000 1.000 357 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(1), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 3408012 29 6 29 7 7 5 9 4 4 0 0.254 1.000 1.000 358 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), EP300(4), LPL(2), NCOA2(2), PPARG(1) 2535211 11 4 11 9 4 1 2 1 3 0 0.976 1.000 1.000 359 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 22 AKR1B1(1), GUSB(1), RPE(2), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), XYLB(2) 3278915 14 5 14 5 1 4 4 2 3 0 0.734 1.000 1.000 360 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(2), LDHB(1) 942061 3 1 3 2 1 0 1 1 0 0 0.935 1.000 1.000 361 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1) 998288 5 1 5 1 0 4 0 0 1 0 0.365 1.000 1.000 362 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), DHFR(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1) 2453807 17 2 17 5 3 2 4 4 3 1 0.392 1.000 1.000 363 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 CD4(2), CREB1(2), CTSB(2), CTSS(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), HSP90AB1(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1), TAP2(1), TAPBP(1) 6223972 45 19 44 13 7 11 6 8 13 0 0.384 1.000 1.000 364 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 19 ALG5(1), B4GALT5(2), DDOST(1), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), ST6GAL1(1) 2574591 12 4 12 6 4 1 1 4 2 0 0.869 1.000 1.000 365 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CYP2C9(1), DHRS1(1), DHRS2(1), DHRS3(2), EHHADH(1), ESCO1(3), HADHA(1), SH3GLB1(1) 4094507 18 7 18 6 7 1 4 3 3 0 0.607 1.000 1.000 366 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(1), ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2) 3051954 26 6 26 9 8 5 7 3 3 0 0.465 1.000 1.000 367 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), DHFR(1), FTCD(3), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(1), SHMT2(2), TYMS(1) 2521871 20 3 20 5 4 3 4 5 3 1 0.249 1.000 1.000 368 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(1), PFKL(2), PFKM(2), PLCG1(1), PRKCE(1) 3540443 18 4 18 4 3 7 3 2 3 0 0.149 1.000 1.000 369 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DGAT1(3), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GLB1(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PPAP2B(2) 6583003 59 12 59 19 26 7 9 8 9 0 0.178 1.000 1.000 370 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DGAT1(3), DGAT2(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), GK2(4), GLB1(3), GPAM(3), LCT(3), LIPA(1), LIPF(2), LIPG(3), LPL(2), MGLL(2), PNLIP(1), PPAP2B(2) 8024838 75 15 75 23 30 11 14 11 9 0 0.114 1.000 1.000 371 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K6(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2), TOLLIP(1) 3962940 23 7 22 8 4 2 5 5 7 0 0.702 1.000 1.000 372 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(8), NCF2(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), RALBP1(2), TRIO(9), VAV1(4), WASF1(1) 4289581 39 9 38 11 11 9 5 6 6 2 0.257 1.000 1.000 373 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 2870998 16 3 16 7 3 1 5 3 4 0 0.862 1.000 1.000 374 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(5), AXIN1(5), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(8), DVL1(4), DVL2(3), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PPP2R5C(2), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PRKD1(2), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2) 7968223 80 23 79 26 33 17 5 14 11 0 0.114 1.000 1.000 375 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(4), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(4), MAP2K6(2), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(5), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), YWHAH(1) 4844684 44 12 43 12 11 9 5 6 13 0 0.195 1.000 1.000 376 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(2), AKT2(1), AKT3(1), ASAH1(1), BRAF(3), DAG1(2), EGFR(2), EPHB2(3), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), RGS20(1), SHC1(1), SOS2(1), SRC(2), STAT3(2), TERF2IP(1) 7774322 64 24 60 11 15 9 9 9 22 0 0.0588 1.000 1.000 377 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(4), FH(1), IDH2(3), IDH3A(2), IDH3G(1), MDH2(1), OGDH(3), PC(2), PDHA1(1), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(2) 3930041 29 4 29 5 8 4 8 4 5 0 0.0897 1.000 1.000 378 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), EHHADH(1), GCDH(2), HADHA(1) 1073881 6 1 6 0 2 2 2 0 0 0 0.130 1.000 1.000 379 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5) 7086533 67 21 64 12 18 13 8 12 16 0 0.0211 1.000 1.000 380 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(7), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(8), CTTN(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(3), ROCK2(1), TLR4(1), TLR5(2), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1), WASL(5) 7086533 67 21 64 12 18 13 8 12 16 0 0.0211 1.000 1.000 381 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF2(1) 3114139 15 3 15 7 1 4 6 2 2 0 0.864 1.000 1.000 382 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2) 1149350 7 1 7 0 1 3 1 0 2 0 0.101 1.000 1.000 383 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(3), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGK1(2), PKLR(2), TPI1(2) 5846368 41 6 41 10 14 11 7 4 5 0 0.0598 1.000 1.000 384 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 18 GNAQ(1), GNB1(2), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PTK2(4), ROCK2(1) 2790723 13 3 13 7 2 4 2 2 3 0 0.865 1.000 1.000 385 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(2), AKT2(1), AKT3(1), APC(5), AXIN1(5), AXIN2(1), CTNNB1(8), DACT1(3), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(12), MVP(3), NKD1(3), NKD2(1), PSEN1(1), SENP2(1), SFRP1(2), WIF1(2) 5691860 60 17 60 14 21 12 10 8 9 0 0.0592 1.000 1.000 386 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3) 3212961 16 7 15 9 5 3 3 3 2 0 0.876 1.000 1.000 387 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 9 B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1003317 7 2 7 2 3 0 3 1 0 0 0.557 1.000 1.000 388 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 9 ACP5(1), ENPP3(2), RFK(1), TYR(3) 1159571 7 1 7 2 2 3 1 1 0 0 0.508 1.000 1.000 389 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(1), ACACA(4), ACACB(9), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2) 5348738 35 8 35 8 14 6 6 4 5 0 0.136 1.000 1.000 390 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1) 1142547 5 2 5 2 0 1 2 1 1 0 0.774 1.000 1.000 391 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), CHRNA1(3), FLT1(3), FLT4(9), KDR(1), NOS3(6), PDE2A(1), PDE3A(8), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1) 5693089 58 18 55 10 20 10 12 3 13 0 0.00897 1.000 1.000 392 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), CPO(2), HBB(1), HMBS(1) 1126737 6 4 6 4 3 1 1 0 1 0 0.851 1.000 1.000 393 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(8), CCNA1(3), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(4), E2F5(3), GBA2(2), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MYT1(10), NACA(9), POLA2(1), POLE(7), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(2), RPA3(2), TNXB(8) 10347133 99 24 99 22 26 16 25 21 10 1 0.0157 1.000 1.000 394 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), ME3(1), PC(2), PCK1(3), PCK2(4), PDHA1(1), PKLR(2) 6441941 52 14 50 13 17 14 4 3 13 1 0.0887 1.000 1.000 395 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(1), CAPNS1(3), CAPNS2(1), EGF(2), EGFR(2), HRAS(1), ITGA1(7), MYLK(8), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(4), PXN(1), TLN1(9) 4568671 49 7 49 9 16 14 8 6 5 0 0.00740 1.000 1.000 396 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAPK8(2), NFKBIA(2), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(2), TLR4(1), TLR6(3), TLR7(1), TLR9(5), TOLLIP(1) 4904114 35 10 35 10 10 4 8 7 6 0 0.390 1.000 1.000 397 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), ASAH1(1), CAMP(2), CERK(1), CREB1(2), DAG1(2), EPHB2(3), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1) 4025765 34 8 34 10 10 4 4 7 9 0 0.317 1.000 1.000 398 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MLYCD(1), MUT(2), SUCLA2(1), SUCLG1(2) 4556690 26 4 26 4 7 6 6 5 2 0 0.0898 1.000 1.000 399 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), PON1(1) 4052828 42 12 40 14 15 5 8 7 7 0 0.409 1.000 1.000 400 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(1), GLB1(3), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(2), SPTLC2(1), UGCG(1) 3398444 19 4 19 7 7 5 1 1 5 0 0.384 1.000 1.000 401 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), DFFB(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(3), TNFRSF10B(2), TNFSF12(1), TRADD(1), TRAF2(1) 4682039 28 6 28 7 8 5 5 2 8 0 0.247 1.000 1.000 402 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 38 APAF1(3), BAK1(1), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), FAS(2), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), PARP1(5), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 4889518 36 12 34 12 7 4 12 4 8 1 0.712 1.000 1.000 403 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(1), GOT1(2), TAT(1) 1195184 6 3 5 2 1 1 3 1 0 0 0.744 1.000 1.000 404 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(9), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), PRIM1(1), RFC1(4), RFC2(1), RFC3(1), RPA1(1), RPA2(2), RPA3(2), RPS27A(1), UBB(1) 7019158 57 17 57 14 16 7 14 9 10 1 0.195 1.000 1.000 405 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(3), BAD(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(4), DFFB(1), FAS(2), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(6), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 6023045 51 15 47 15 11 10 11 5 14 0 0.520 1.000 1.000 406 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLB(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLG(4), POLH(1), POLI(1), POLK(3), POLL(2), POLM(3), POLQ(2), PRIM1(1), REV1(1), REV3L(3) 5643269 35 8 34 5 7 6 7 10 5 0 0.0457 1.000 1.000 407 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(5), AR(3), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(2), GNA15(2), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2) 7462220 66 23 61 16 16 7 10 9 24 0 0.241 1.000 1.000 408 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ACTG2(2), ADCY3(6), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1F(1), ERO1L(1), PDIA4(1), PLCG1(1), PLCG2(6), SEC61A1(1), SEC61A2(2), SEC61G(1) 4803480 36 7 36 12 11 7 8 6 4 0 0.346 1.000 1.000 409 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(4), LARS2(2), PDHA1(1) 1369898 9 3 9 3 3 2 1 3 0 0 0.597 1.000 1.000 410 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(6), PSEN1(1) 1254241 10 2 10 3 1 5 1 2 1 0 0.523 1.000 1.000 411 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), LPO(4), MPO(2), TPO(4) 1163833 14 4 14 5 8 0 3 1 2 0 0.510 1.000 1.000 412 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(5), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNJ5(1), RYR1(18) 6404613 60 19 56 15 22 5 11 7 15 0 0.158 1.000 1.000 413 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 39 ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG5(1), ALG9(1), DDOST(1), DHDDS(1), DOLPP1(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1) 5715268 33 9 33 10 10 7 5 7 4 0 0.380 1.000 1.000 414 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL2(1), CUL3(1), FBXW11(1), FBXW7(4), ITCH(2), SKP1(1), SKP2(2), TCEB1(1), TCEB2(1), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(3) 5575104 38 10 37 10 11 9 6 6 6 0 0.322 1.000 1.000 415 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CHUK(1), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(5), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1) 3746242 29 6 28 10 7 6 5 4 7 0 0.527 1.000 1.000 416 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(1), GTF2E2(2), GTF2F1(4), GTF2H1(1), GTF2H4(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(7), TAF1L(3), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(3), TAF6(1), TAF6L(3), TAF7L(1) 4963264 39 16 35 12 8 3 9 6 13 0 0.850 1.000 1.000 417 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(7), ATM(8), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC20(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK4(2), DTX4(1), E2F3(3), E2F4(4), E2F5(3), EP300(4), ESPL1(5), GSK3B(1), HDAC4(4), HDAC5(1), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), RB1(3), RBL1(1), SKP2(2), TBC1D8(2), TGFB1(1) 14819734 112 29 110 17 27 17 26 23 18 1 0.00104 1.000 1.000 418 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 3669992 20 4 20 8 5 2 6 4 3 0 0.693 1.000 1.000 419 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(4), CRK(1), CRKL(2), DOCK1(2), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3CA(4), PIK3R1(1), PTEN(2), PTK2(4), PXN(1), RAP1B(2), RASA1(1), SRC(2), STAT3(2) 5676968 45 12 45 14 9 15 6 7 8 0 0.302 1.000 1.000 420 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(5), AOC3(2), AOX1(1), CARM1(1), DCT(5), DDC(1), ESCO1(3), GOT1(2), HEMK1(1), HGD(2), HPD(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TH(1), TPO(4), TYR(3) 8054762 69 13 68 19 23 14 15 9 8 0 0.0929 1.000 1.000 421 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(2), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), WDR1(2) 1362277 13 2 13 5 4 2 1 5 1 0 0.568 1.000 1.000 422 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 67 ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), EGFR(2), EP300(4), ERBB2(6), FARP2(1), FER(6), IGF1R(3), INSR(4), IQGAP1(1), LEF1(3), LMO7(5), MET(4), MLLT4(4), NLK(1), PARD3(6), PTPN6(4), PTPRB(10), PTPRJ(2), PTPRM(6), PVRL3(1), PVRL4(1), RAC2(1), RHOA(1), SMAD3(1), SORBS1(1), SRC(2), SSX2IP(1), TCF7(2), TCF7L1(3), TCF7L2(1), TGFBR2(5), TJP1(4), VCL(1), WASF1(1), WASF2(2), WASL(5), YES1(1) 14957286 144 30 139 20 37 31 24 25 26 1 2.80e-05 1.000 1.000 423 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2F1(2), CYP2J2(2), CYP3A5(1), CYP3A7(3), CYP4B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(1), KYNU(1), TDO2(1), TPH1(2), WARS(2) 7580798 58 14 56 18 19 8 16 9 6 0 0.336 1.000 1.000 424 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(1) 1481672 7 1 7 3 2 3 2 0 0 0 0.738 1.000 1.000 425 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 57 A4GALT(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT4(1), FUT5(1), FUT6(1), GCNT2(2), PIGB(2), PIGG(2), PIGL(2), PIGO(2), PIGQ(5), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1) 6562649 50 14 49 10 21 10 8 4 7 0 0.0111 1.000 1.000 426 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(1), ACAD9(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(2), SOAT1(1) 4246528 38 7 38 11 11 8 11 5 3 0 0.225 1.000 1.000 427 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CD3E(1), HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), PTPN7(1), RASA1(1), RELA(1), SHC1(1), VAV1(4), ZAP70(5) 6099509 49 11 48 11 11 11 8 8 10 1 0.0923 1.000 1.000 428 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PAK2(3), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SYK(2), VAV1(4) 5577681 47 11 46 14 11 11 6 8 10 1 0.326 1.000 1.000 429 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(8), ATR(9), BAI1(3), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK6(2), EI24(1), FAS(2), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN2(2), SESN3(2), STEAP3(2), TNFRSF10B(2), TSC2(6), ZMAT3(2) 8609913 72 22 71 22 20 16 15 9 12 0 0.296 1.000 1.000 430 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(1), ACSS2(2), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKL(2), PFKM(2), PGAM1(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2) 7838949 64 10 64 18 24 15 12 5 8 0 0.0767 1.000 1.000 431 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(2), SHC1(1), SYK(2), VAV1(4) 4118563 20 5 20 8 8 2 3 3 3 1 0.613 1.000 1.000 432 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(3), ESR1(1), ESR2(1), ESRRA(2), NR0B1(1), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(3), PPARA(1), PPARD(1), PPARG(1), RARB(2), RARG(2), ROR1(3), RORA(1), RORC(1), THRA(2), THRB(1) 5945212 49 13 47 16 17 9 7 5 11 0 0.260 1.000 1.000 433 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), DLG4(1), LPA(5), MAP2K4(2), MAP3K1(3), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1), PTK2(4), RDX(3), ROCK1(3), ROCK2(1), SRF(1), TBXA2R(2) 6822191 50 13 50 14 8 8 13 10 11 0 0.477 1.000 1.000 434 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(2), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(3), PLD2(3), PLD3(1) 6285969 52 19 48 14 13 7 9 5 18 0 0.423 1.000 1.000 435 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1) 1591340 9 1 9 1 2 2 3 0 2 0 0.256 1.000 1.000 436 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(2), CHAT(3), CPT1B(4), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(6), PPAP2B(2) 7038470 60 13 60 17 21 7 13 9 10 0 0.200 1.000 1.000 437 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(1), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(1), HSD17B4(3), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 5840778 38 6 38 8 10 9 9 4 6 0 0.0838 1.000 1.000 438 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(1), JAK2(2), PTPRU(6), REG1A(1), STAT1(1) 1574697 12 4 11 6 6 0 3 1 2 0 0.797 1.000 1.000 439 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(4), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PLCG1(1), PLCG2(6), PTPRZ1(3), RELA(1), SRC(2), TCIRG1(1), TJP1(4) 9591564 68 14 67 16 11 16 17 13 11 0 0.100 1.000 1.000 440 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 15 CARS2(2), GOT1(2), LDHB(1), SULT1C4(1), SULT4A1(1) 1599186 7 1 7 4 1 1 2 2 1 0 0.902 1.000 1.000 441 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 9 GCK(1), HK1(1), HK2(3), HK3(2), ISYNA1(1), PGM3(1) 1443947 9 2 9 5 5 1 2 0 1 0 0.692 1.000 1.000 442 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(1), BCKDHB(1), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 4962374 32 5 32 4 7 10 7 3 5 0 0.0173 1.000 1.000 443 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(3), BAD(1), BAK1(1), BIRC2(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(2), FASLG(1), HELLS(1), IKBKB(2), IRF1(2), IRF3(1), IRF5(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(2), NFKBIA(2), NFKBIE(1), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TRADD(1), TRAF2(1) 7745593 58 17 56 15 11 10 14 7 15 1 0.292 1.000 1.000 444 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 AKT1(2), AKT2(1), AKT3(1), ARHGAP4(1), ARHGEF11(4), BTK(1), CDC42(1), GDI2(2), INPPL1(5), ITPR1(6), ITPR2(9), ITPR3(8), LIMK1(1), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), PTEN(2), RACGAP1(2), ROCK1(3), ROCK2(1), WASF1(1), WASL(5) 9592889 85 26 78 26 17 18 17 10 23 0 0.387 1.000 1.000 445 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CPT1B(4), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3) 6735400 52 5 52 12 17 16 8 5 6 0 0.0296 1.000 1.000 446 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), TRAF2(1), TRAF5(1) 4810431 30 8 30 10 6 8 5 5 6 0 0.298 1.000 1.000 447 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2) 6540505 52 6 52 16 19 12 10 5 6 0 0.160 1.000 1.000 448 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(2), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(2), ALDOB(1), BPGM(1), DLAT(4), ENO1(2), ENO2(1), FBP2(1), GCK(1), GPI(2), HK1(1), HK2(3), HK3(2), LDHB(1), PDHA1(1), PFKM(2), PGAM1(1), PGK1(2), PGM3(1), PKLR(2), TPI1(2) 6540505 52 6 52 16 19 12 10 5 6 0 0.160 1.000 1.000 449 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(3), CD14(2), CD19(1), CD1A(2), CD1B(3), CD1C(1), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(1), CD3E(1), CD4(2), CD44(3), CD5(2), CD55(1), CD59(2), CR1(3), CSF1(2), CSF1R(4), CSF2RA(1), CSF3R(2), DNTT(3), EPO(1), EPOR(2), FCGR1A(1), FLT3(3), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL2RA(1), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(2), THPO(1), TPO(4) 10799283 95 25 92 26 22 16 18 22 17 0 0.161 1.000 1.000 450 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(2), HGS(2) 1766551 9 1 9 0 0 4 2 2 1 0 0.0535 1.000 1.000 451 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 50 CCKBR(3), CCR2(1), CELSR1(3), CELSR2(6), CELSR3(11), CHRM2(3), CHRM3(1), EMR2(3), EMR3(1), FSHR(2), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(6), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GRPR(1), LGR6(2), LPHN2(6), LPHN3(1), LTB4R2(1), P2RY13(2), PTGFR(1), SMO(2), TAAR5(2), TSHR(3) 8729648 72 17 72 22 26 13 14 13 6 0 0.0749 1.000 1.000 452 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 88 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(2), GNAQ(1), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), HTR2A(2), HTR2B(1), HTR2C(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP3K2(2), MAPK7(4), NPR1(2), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACG(2), PRKCG(2), PRKG1(1), PRKG2(1), SOS2(1), SRC(2), TJP1(4), TUBA1A(3), TUBA1C(1), TUBA3C(1), TUBA3D(3), TUBA3E(3), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 17349828 148 35 144 37 50 32 23 20 23 0 0.00510 1.000 1.000 453 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 41 CBL(4), CSK(1), CTLA4(1), DAG1(2), EPHB2(3), FBXW7(4), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(1), SOS2(1), VAV1(4), ZAP70(5) 6891296 52 11 52 12 18 10 8 7 8 1 0.102 1.000 1.000 454 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(1), STAT2(1), TYK2(2) 1725787 14 5 13 6 8 0 4 1 1 0 0.670 1.000 1.000 455 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(1), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(2), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(1) 7204743 56 16 56 12 14 9 9 12 12 0 0.104 1.000 1.000 456 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1) 1840976 12 2 12 7 3 4 4 0 1 0 0.838 1.000 1.000 457 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(2), AKT2(1), AKT3(1), APAF1(3), ATM(8), BAD(1), BIRC2(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CSF2RB(2), DFFB(1), FAS(2), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IL3RA(1), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 11522105 85 21 83 21 23 18 11 12 21 0 0.0877 1.000 1.000 458 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 32 ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CAPNS2(1), CRKL(2), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PTK2(4), PXN(1), ROCK1(3), SHC1(1), SRC(2), TLN1(9), VCL(1), ZYX(1) 5779443 52 13 52 12 18 14 7 5 8 0 0.0318 1.000 1.000 459 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 18 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), PDE6B(3), PDE6C(1), SLC6A13(1) 4559553 34 10 30 12 10 5 7 2 10 0 0.693 1.000 1.000 460 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), NR1I3(1), PDE3A(8), PDE3B(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1), VASP(1) 6640031 52 20 47 17 12 9 9 4 18 0 0.569 1.000 1.000 461 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(1), ADORA2A(1), ADRA1A(2), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(6), CCKBR(3), CCR1(1), CCR10(2), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CHML(3), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHR(2), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(2), GPR50(1), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LHCGR(1), MC3R(3), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPY1R(2), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OR1C1(2), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), RRH(1), SSTR1(4), SSTR4(3), SUCNR1(1), TBXA2R(2), TRHR(1) 16675825 155 37 151 40 45 21 48 28 13 0 0.00605 1.000 1.000 462 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(1), POLG(4), RRM1(1) 1787566 14 3 14 3 3 6 1 1 3 0 0.126 1.000 1.000 463 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(1), CSK(1), DAG1(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(6), ITPR2(9), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(5), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPRC(2), SHC1(1), SOS2(1), SYK(2), VAV1(4) 9604136 83 23 78 20 23 17 11 9 22 1 0.0471 1.000 1.000 464 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 243 ACVR1B(2), AMH(1), AMHR2(5), BMP2(2), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CD40(1), CSF1(2), CSF1R(4), CSF2RA(1), CSF2RB(2), CSF3R(2), CX3CL1(1), CXCL16(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPO(1), EPOR(2), FAS(2), FASLG(1), FLT1(3), FLT3(3), FLT4(9), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1RAP(2), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(1), INHBC(1), KDR(1), KIT(4), LEPR(5), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(2), PDGFC(2), PDGFRA(3), PDGFRB(4), PF4V1(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB1(1), TGFB2(2), TGFBR2(5), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(1), TNFSF12(1), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(4), TSLP(1), VEGFB(1), XCR1(2) 23934981 207 48 202 41 57 48 34 39 29 0 8.21e-06 1.000 1.000 465 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(1), AKT1(2), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(2), EDN1(3), ELSPBP1(2), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MYH2(3), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3R1(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 7037646 61 16 59 15 19 11 10 7 14 0 0.0760 1.000 1.000 466 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(7), ABL2(3), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), BTC(1), CAMK2D(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EGF(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GSK3B(1), HRAS(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), NCK1(3), NCK2(2), NRG1(5), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SRC(2), STAT5A(1) 13796211 122 34 119 27 36 23 17 12 34 0 0.0218 1.000 1.000 467 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMD1(2), PSMD11(1), PSMD12(2) 2044758 12 3 12 6 3 1 4 3 1 0 0.845 1.000 1.000 468 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), AFMID(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(5), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(3), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2) 8366147 66 12 65 13 23 11 18 7 7 0 0.0207 1.000 1.000 469 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(2), AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD81(1), CHUK(1), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), LILRB3(1), MALT1(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(1), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(1), SYK(2), VAV1(4) 9563938 84 20 82 24 22 20 11 11 19 1 0.118 1.000 1.000 470 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 APAF1(3), BIRC2(1), CASP2(3), CASP7(1), CASP8(2), CASP9(1), CFLAR(2), CHUK(1), CRADD(2), DAXX(4), DFFB(1), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(4), PAK2(3), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(4), RASA1(1), RB1(3), RELA(1), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 9264991 68 14 67 19 13 10 19 10 16 0 0.361 1.000 1.000 471 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB2(1), JAK2(2), TYK2(2) 2048364 11 3 11 4 2 1 2 3 3 0 0.697 1.000 1.000 472 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1) 2025420 10 1 10 2 1 1 4 1 3 0 0.459 1.000 1.000 473 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(2), SHC1(1), SYK(2), VAV1(4) 4921177 34 6 33 12 9 8 3 6 7 1 0.487 1.000 1.000 474 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(2), AKT2(1), AKT3(1), CASP8(2), CCL3(1), CD14(2), CD40(1), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(1), LBP(1), LY96(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(3), TLR2(2), TLR3(2), TLR4(1), TLR5(2), TLR6(3), TLR7(1), TLR8(1), TLR9(5), TOLLIP(1) 12291460 94 25 93 27 21 18 19 14 22 0 0.136 1.000 1.000 475 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), APOA5(3), AQP7(4), CPT1B(4), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(1), CYP7A1(2), CYP8B1(1), EHHADH(1), FABP4(1), GK2(4), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(4), PLTP(1), PPARA(1), PPARD(1), PPARG(1), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(1), SORBS1(1), UCP1(1) 8814334 68 14 67 16 21 18 15 5 8 1 0.0216 1.000 1.000 476 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 28 ARHGAP4(1), ARHGAP5(3), ARHGAP6(3), ARHGEF1(4), ARHGEF11(4), ARHGEF5(2), ARPC1A(1), ARPC2(1), ARPC3(1), BAIAP2(3), DIAPH1(4), LIMK1(1), MYLK(8), PIP5K1B(2), ROCK1(3), SRC(2), TLN1(9), VCL(1) 5886957 53 12 53 17 14 16 10 7 6 0 0.270 1.000 1.000 477 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(7), ANAPC1(2), ANAPC2(2), ANAPC4(2), ANAPC5(4), ATM(8), ATR(9), BUB1(1), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25C(2), CDC6(1), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CREBBP(2), CUL1(1), E2F3(3), EP300(4), ESPL1(5), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(5), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(2), SMAD3(1), SMC1A(1), SMC1B(2), TGFB1(1), TGFB2(2), YWHAE(2), YWHAH(1) 18405172 130 33 127 28 29 25 29 20 26 1 0.0258 1.000 1.000 478 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1) 2142667 7 2 7 3 1 2 3 1 0 0 0.799 1.000 1.000 479 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), EHHADH(1), HADHA(1), SCP2(1) 2317433 10 1 10 0 4 3 2 0 1 0 0.0319 1.000 1.000 480 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(1), CAD(5), CTPS2(1), DPYD(3), DUT(1), NME1(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), RRM1(1), TYMS(1), UMPS(2), UPB1(2) 7899426 52 8 52 15 17 13 10 7 5 0 0.124 1.000 1.000 481 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CITED2(1), CPT1B(4), CREBBP(2), DUT(1), EHHADH(1), EP300(4), HSD17B4(3), LPL(2), ME1(2), NCOR1(7), NCOR2(4), NFKBIA(2), NR1H3(3), NRIP1(1), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTGS2(1), RB1(3), RELA(1), SP1(1), STAT5A(1) 8802872 56 12 56 18 15 15 10 8 8 0 0.221 1.000 1.000 482 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2) 2326713 18 2 18 2 6 4 4 1 3 0 0.0546 1.000 1.000 483 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1) 2519690 12 2 12 5 0 4 5 2 1 0 0.801 1.000 1.000 484 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 16 CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(1), TRAF2(1) 2576464 12 2 12 4 1 2 4 3 2 0 0.713 1.000 1.000 485 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 67 ADH1A(2), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(1), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(4), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1) 7570823 63 12 61 21 16 14 15 7 11 0 0.394 1.000 1.000 486 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 84 ACVR1B(2), ACVR1C(1), ACVRL1(1), AMH(1), AMHR2(5), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(4), CREBBP(2), CUL1(1), DCN(1), E2F4(4), E2F5(3), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBA(1), INHBC(1), LEFTY2(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), RBL1(1), RBL2(2), RHOA(1), ROCK1(3), ROCK2(1), RPS6KB2(2), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(2), SP1(1), TGFB1(1), TGFB2(2), TGFBR2(5), THBS2(4), ZFYVE16(4), ZFYVE9(3) 12834158 92 19 91 24 21 19 18 17 17 0 0.134 1.000 1.000 487 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), ETV5(1), IL12B(1), IL12RB2(1), JAK2(2), MAP2K6(2), MAPK8(2), TYK2(2) 2590830 12 3 12 4 3 1 2 2 4 0 0.511 1.000 1.000 488 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP27B1(1), DHCR7(1), FDFT1(2), GGCX(1), HMGCR(3), LSS(1), MVD(2), MVK(1), NSDHL(1), SQLE(1), VKORC1(3) 2597411 17 4 17 8 4 4 7 1 1 0 0.735 1.000 1.000 489 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(1), ATP5C1(1), ATP5G3(3), ATP5J(1), ENPP3(2), ENTPD2(2), FHIT(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NPR1(2), NPR2(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(3), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(5), PKLR(2), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(2), POLQ(2), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1) 17892163 136 25 136 30 48 33 23 13 17 2 0.000946 1.000 1.000 490 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 BAD(1), CABIN1(4), CAMK4(2), CD3E(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(4), FCER1A(1), FOSL1(1), GATA3(2), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(1), MYF5(2), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PPP3CC(2), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4) 11980428 83 18 82 22 26 18 12 9 17 1 0.0700 1.000 1.000 491 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(1), EPO(1), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), STAT5A(1) 2626903 16 3 16 3 6 1 4 2 3 0 0.215 1.000 1.000 492 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(4), ABCA10(3), ABCA12(12), ABCA13(9), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(6), ABCA6(4), ABCA7(5), ABCA8(6), ABCA9(7), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(4), ABCB5(6), ABCB6(2), ABCC10(3), ABCC11(2), ABCC12(3), ABCC3(4), ABCC4(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(2), ABCD1(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(4), TAP1(1), TAP2(1) 16010028 131 26 127 35 27 30 20 31 20 3 0.0310 1.000 1.000 493 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 52 ASH1L(4), ASH2L(2), CARM1(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(4), EZH2(3), FBXO11(1), HCFC1(3), HSF4(1), KDM6A(3), MEN1(3), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM9(4), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SETD2(6), SETD8(1), SETDB1(2), STK38(2), SUV39H2(2), SUV420H1(3), SUV420H2(2), SUZ12(1), WHSC1(1) 15621364 74 22 70 21 10 13 16 15 20 0 0.465 1.000 1.000 494 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(1), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), STAT5A(1), SYK(2) 2918940 16 4 16 9 8 3 1 2 2 0 0.800 1.000 1.000 495 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GLCE(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(3), NDST4(2) 2925902 30 6 30 7 12 4 9 3 2 0 0.128 1.000 1.000 496 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 3128781 16 5 16 6 4 3 5 2 2 0 0.628 1.000 1.000 497 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(1), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 3253773 15 3 15 8 2 2 7 3 1 0 0.937 1.000 1.000 498 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 232 ADORA1(1), ADORA2A(1), ADRA1A(2), ADRA2A(1), ADRA2B(4), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), C5AR1(1), CALCR(1), CCKAR(6), CCKBR(3), CGA(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(2), DRD3(1), DRD5(2), EDNRB(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(1), FSHB(1), FSHR(2), GABBR2(1), GABRA2(1), GABRA4(5), GABRA5(4), GABRA6(1), GABRB1(3), GABRB2(2), GABRB3(3), GABRD(5), GABRE(2), GABRG1(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(1), GLRA2(3), GLRB(1), GNRHR(1), GPR156(1), GPR50(1), GPR83(1), GRIA1(3), GRIA4(1), GRID1(6), GRID2(4), GRIK1(1), GRIK2(4), GRIK3(3), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRIN3A(4), GRIN3B(2), GRM2(3), GRM3(2), GRM4(1), GRM5(7), GRM6(6), GRM7(5), GRM8(3), GRPR(1), HCRTR1(1), HCRTR2(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), LEPR(5), LHB(1), LHCGR(1), LTB4R2(1), MC2R(2), MC3R(3), MC5R(2), MCHR1(1), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR2(1), NPY1R(2), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRK1(1), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(1), P2RX7(1), P2RY1(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(6), PRLR(3), PRSS1(3), PTGDR(2), PTGER3(1), PTGFR(1), RXFP1(1), SSTR1(4), SSTR4(3), SSTR5(4), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), THRA(2), THRB(1), TRHR(1), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 29887485 318 53 311 87 98 53 73 49 44 1 0.000457 1.000 1.000 499 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AK3(1), CAD(5), CTPS2(1), DPYD(3), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), NME1(1), NME4(1), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2) 10978889 69 15 68 23 18 12 14 19 6 0 0.382 1.000 1.000 500 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 63 A2M(1), C1QA(1), C1QC(1), C1R(1), C1S(4), C3(6), C3AR1(2), C5(1), C5AR1(1), C6(6), C7(4), C8A(5), C9(1), CD46(1), CD55(1), CD59(2), CFB(6), CFD(1), CFH(4), CR1(3), F10(4), F12(2), F13A1(2), F13B(1), F5(5), F8(5), FGA(5), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(3), PLAT(2), PROC(1), PROS1(1), SERPINA1(2), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(3), THBD(3), VWF(5) 11814989 112 26 107 32 27 18 26 20 21 0 0.211 1.000 1.000 501 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 185 ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(3), CCND2(2), CCND3(1), CDC42(1), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), CRK(1), CRKL(2), CTNNB1(8), DIAPH1(4), DOCK1(2), EGF(2), EGFR(2), ERBB2(6), FARP2(1), FLNA(8), FLNB(3), FLNC(9), FLT1(3), FN1(8), GSK3B(1), HRAS(1), IBSP(2), IGF1R(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), KDR(1), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYLK(8), MYLK2(3), MYLPF(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RELN(7), RHOA(1), ROCK1(3), ROCK2(1), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SRC(2), THBS2(4), TLN1(9), TLN2(7), TNC(10), TNN(2), TNR(9), TNXB(8), VASP(1), VAV1(4), VCL(1), VEGFB(1), VTN(2), VWF(5), ZYX(1) 49912723 413 68 405 121 111 86 75 65 71 5 0.0108 1.000 1.000 502 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 133 CHAD(1), COL11A1(5), COL11A2(3), COL17A1(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), COMP(4), DES(1), DSC1(4), DSC2(5), DSC3(5), DSG1(2), DSG2(2), DSG4(5), FN1(8), GJA3(1), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(1), GJC2(2), GJC3(2), GJD4(2), IBSP(2), INA(3), ITGB4(7), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT15(4), KRT16(1), KRT19(1), KRT2(3), KRT20(2), KRT27(1), KRT28(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(2), KRT7(3), KRT74(2), KRT75(1), KRT76(4), KRT77(2), KRT79(2), KRT82(1), KRT83(2), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(6), PRPH(1), RELN(7), THBS2(4), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5) 33599907 307 63 303 94 93 51 57 48 54 4 0.0712 1.000 1.000 503 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 235 ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(1), AKT3(1), ARRB1(1), ARRB2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(1), CACNG3(2), CACNG5(4), CD14(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP16(1), DUSP6(2), DUSP7(1), EGF(2), EGFR(2), FAS(2), FASLG(1), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FLNA(8), FLNB(3), FLNC(9), HRAS(1), IKBKB(2), IL1B(1), JUND(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(2), MOS(1), MRAS(2), NF1(2), NFATC2(5), NFATC4(4), NFKB2(1), NLK(1), NR4A1(3), NTRK1(2), NTRK2(3), PAK2(3), PDGFRA(3), PDGFRB(4), PLA2G3(2), PLA2G6(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTPN5(1), PTPN7(1), RAC2(1), RAP1B(2), RAPGEF2(4), RASA1(1), RASA2(1), RASGRF2(4), RASGRP1(2), RASGRP2(1), RASGRP3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS2(1), SRF(1), STK4(2), STMN1(1), TAOK1(2), TGFB1(1), TGFB2(2), TGFBR2(5), TNFRSF1A(2), TRAF2(1) 38260666 288 53 280 101 91 46 46 44 57 4 0.331 1.000 1.000 504 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 195 ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(5), APC2(2), ARAF(2), ARHGEF1(4), ARHGEF12(4), ARHGEF6(1), ARHGEF7(3), ARPC1A(1), ARPC2(1), ARPC3(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BRAF(3), CD14(2), CDC42(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(4), DIAPH2(1), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF12(1), FGF14(2), FGF17(1), FGF2(1), FGF23(1), FGF5(2), FGFR2(1), FGFR3(4), FGFR4(3), FN1(8), GIT1(4), HRAS(1), IQGAP1(1), IQGAP2(1), IQGAP3(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LIMK1(1), LIMK2(2), MOS(1), MRAS(2), MYH14(4), MYH9(2), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(4), PXN(1), RAC2(1), RDX(3), RHOA(1), ROCK1(3), ROCK2(1), SCIN(1), SOS2(1), SSH1(3), SSH2(1), SSH3(1), TIAM1(6), TIAM2(1), VAV1(4), VCL(1), WASF1(1), WASF2(2), WASL(5) 36793289 272 53 265 93 70 55 50 36 59 2 0.355 1.000 1.000 505 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 80 AGRN(2), CD44(3), CHAD(1), COL11A1(5), COL11A2(3), COL1A2(5), COL2A1(4), COL3A1(4), COL4A1(4), COL4A2(5), COL4A4(7), COL4A6(4), COL5A2(6), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(7), COL6A6(4), DAG1(2), FN1(8), FNDC1(6), FNDC3A(1), GP5(2), GP6(2), GP9(2), HSPG2(2), IBSP(2), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), LAMA1(10), LAMA2(9), LAMA3(3), LAMA4(3), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(2), LAMB4(2), LAMC1(3), LAMC2(1), LAMC3(3), RELN(7), SDC3(1), SDC4(2), SV2C(1), THBS2(4), TNC(10), TNN(2), TNR(9), TNXB(8), VTN(2), VWF(5) 29999578 245 52 241 77 63 48 52 39 39 4 0.139 1.000 1.000 506 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 163 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY7(3), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(2), ATP2A1(3), ATP2A2(3), ATP2B1(5), ATP2B2(1), ATP2B4(1), AVPR1B(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1F(1), CACNA1G(7), CACNA1H(1), CACNA1I(7), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(6), CCKBR(3), CD38(1), CHRM2(3), CHRM3(1), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GNA11(2), GNA14(1), GNA15(2), GNAQ(1), GRIN2A(6), GRIN2C(5), GRIN2D(5), GRM5(7), GRPR(1), HRH2(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), LHCGR(1), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), P2RX2(1), P2RX7(1), PDE1B(1), PDGFRA(3), PDGFRB(4), PHKA2(2), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PPID(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(18), RYR2(10), RYR3(17), SLC25A4(1), SLC8A1(1), SLC8A2(3), SLC8A3(2), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(2), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(3) 36151204 351 50 341 111 116 53 75 54 50 3 0.0228 1.000 1.000 507 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 119 ABL1(7), ABLIM1(5), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(3), EFNA1(1), EPHA1(3), EPHA2(4), EPHA3(1), EPHA4(2), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(8), EPHB2(3), EPHB3(3), EPHB4(5), EPHB6(5), GNAI1(1), GNAI2(2), GSK3B(1), HRAS(1), L1CAM(1), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NRP1(2), NTN4(1), NTNG1(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(1), PPP3CA(1), PPP3CC(2), PTK2(4), RAC2(1), RASA1(1), RGS3(1), RHOA(1), RHOD(1), RND1(1), ROBO1(6), ROBO2(3), ROBO3(5), ROCK1(3), ROCK2(1), SEMA3A(1), SEMA3C(1), SEMA3D(5), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(2), SEMA4C(3), SEMA4G(2), SEMA5A(4), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(5), SLIT2(4), SLIT3(6), SRGAP1(5), SRGAP2(2), SRGAP3(7), UNC5B(2), UNC5C(4) 26144030 251 50 244 84 81 44 40 39 46 1 0.204 1.000 1.000 508 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADRA1A(2), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(2), ATP1B3(1), ATP2A2(3), ATP2B1(5), ATP2B2(1), CACNA1A(7), CACNA1B(9), CACNA1C(7), CACNA1E(8), CACNA1S(4), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), ITPR1(6), ITPR2(9), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(1), PLCB3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SLC8A3(2), YWHAH(1) 25047928 224 44 216 83 83 38 40 25 35 3 0.260 1.000 1.000 509 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(5), APC2(2), AXIN1(5), AXIN2(1), BTRC(1), CAMK2D(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(2), CSNK1A1L(3), CSNK1E(1), CSNK2A1(1), CTBP2(5), CTNNB1(8), CUL1(1), DAAM1(7), DAAM2(5), DKK2(1), DKK4(1), DVL1(4), DVL2(3), EP300(4), FBXW11(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GSK3B(1), LEF1(3), LRP5(6), LRP6(4), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP3CA(1), PPP3CC(2), PRICKLE1(3), PRICKLE2(3), PRKACG(2), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(3), ROCK2(1), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD3(1), SOX17(1), TCF7(2), TCF7L1(3), TCF7L2(1), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2) 21887692 203 44 198 59 63 36 26 40 38 0 0.0353 1.000 1.000 510 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(4), ACTA2(2), ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF4(1), ATP2A2(3), CALCA(1), CAMK2D(1), CNN2(1), CORIN(3), DGKZ(3), ETS2(2), GABPA(2), GBA2(2), GNAQ(1), GNB1(2), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK5(2), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(1), ITPR1(6), ITPR2(9), ITPR3(8), MAFF(2), MIB1(1), MYLK2(3), NOS1(7), NOS3(6), OXTR(1), PDE4D(3), PLCB3(4), PLCG1(1), PLCG2(6), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCQ(2), PRKD1(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(2), RYR1(18), RYR2(10), RYR3(17), SLC8A1(1), SP1(1), TNXB(8), YWHAH(1) 23945909 206 43 198 70 68 32 39 26 39 2 0.213 1.000 1.000 511 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 127 ACACA(4), ACACB(9), AKT1(2), AKT2(1), AKT3(1), ARAF(2), BAD(1), BRAF(3), CALML3(2), CALML6(1), CBL(4), CBLB(1), CRK(1), CRKL(2), EXOC7(1), FASN(7), FBP2(1), FLOT1(1), FLOT2(2), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), GYS2(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS2(3), IRS4(3), LIPE(1), MAPK10(1), MAPK8(2), MAPK9(1), PCK1(3), PCK2(4), PDE3A(8), PDE3B(1), PFKL(2), PFKM(2), PHKA2(2), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACG(2), PRKAG3(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PYGB(2), PYGM(1), RPS6KB2(2), SHC1(1), SHC2(2), SHC4(2), SOCS4(2), SORBS1(1), SOS2(1), SREBF1(1), TRIP10(2), TSC1(1), TSC2(6) 21317648 167 42 164 60 51 39 16 18 41 2 0.283 1.000 1.000 512 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTN1(1), ACTN2(4), ACTN4(1), AKT1(2), AKT2(1), AKT3(1), AMOTL1(2), ASH1L(4), CDC42(1), CDK4(2), CGN(1), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTTN(1), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(2), HRAS(1), IGSF5(1), JAM2(1), LLGL1(5), LLGL2(2), MAGI1(2), MAGI2(7), MAGI3(1), MLLT4(4), MPDZ(2), MRAS(2), MYH1(5), MYH11(5), MYH13(2), MYH14(4), MYH15(6), MYH2(3), MYH3(1), MYH4(5), MYH6(6), MYH7(6), MYH7B(8), MYH8(4), MYH9(2), MYLPF(1), PARD3(6), PARD6A(1), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PPP2R3A(5), PPP2R3B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PTEN(2), RAB13(1), RHOA(1), SPTAN1(3), SRC(2), SYMPK(7), TJP1(4), TJP2(5), TJP3(4), YES1(1) 26037646 206 40 204 61 61 40 34 35 36 0 0.0706 1.000 1.000 513 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALML3(2), CALML6(1), CDIPT(2), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPP5D(1), INPP5E(1), INPPL1(5), ITPKB(3), ITPR1(6), ITPR2(9), ITPR3(8), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(9), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PRKCG(2), PTEN(2), SYNJ2(2) 17295099 139 37 132 40 43 22 18 22 34 0 0.0965 1.000 1.000 514 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 145 AKT1(2), AKT2(1), AKT3(1), CBL(4), CBLB(1), CCND2(2), CCND3(1), CREBBP(2), CSF2RA(1), CSF2RB(2), CSF3R(2), EP300(4), EPO(1), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB2(1), IL20RA(2), IL21(1), IL21R(1), IL22RA1(2), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(1), IL4R(1), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(5), LIF(2), LIFR(5), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRLR(3), PTPN6(4), SOCS4(2), SOCS5(2), SOCS7(1), SOS2(1), SPRED1(1), SPRED2(1), STAM(5), STAM2(1), STAT1(1), STAT2(1), STAT3(2), STAT5A(1), STAT6(4), TPO(4), TSLP(1), TYK2(2) 19308639 149 36 145 42 42 30 22 27 28 0 0.0668 1.000 1.000 515 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(2), BRAF(3), CACNA1A(7), GNA11(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GRIA1(3), GRID2(4), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HRAS(1), IGF1R(3), ITPR1(6), ITPR2(9), ITPR3(8), NOS1(7), NOS3(6), NPR1(2), NPR2(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(2), PPP2R2A(2), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(18) 14736857 132 36 128 36 47 13 30 21 21 0 0.135 1.000 1.000 516 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(3), ATIC(2), ENPP3(2), ENTPD2(2), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GMPR(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IMPDH1(2), IMPDH2(2), NME1(1), NME4(1), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5E(1), NT5M(1), NUDT2(1), NUDT9(3), PAICS(2), PAPSS1(3), PAPSS2(3), PDE10A(6), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(2), PDE9A(1), PFAS(5), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(1), POLE(7), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3A(1), POLR3B(3), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(6) 22583683 166 35 164 43 54 31 27 33 19 2 0.0140 1.000 1.000 517 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 CADM1(1), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(4), CDH2(4), CDH4(3), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(4), CNTN2(1), CNTNAP1(1), CNTNAP2(7), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(4), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(2), NFASC(3), NLGN1(4), NLGN2(2), NLGN3(5), NRCAM(1), NRXN1(2), NRXN2(5), NRXN3(4), PDCD1(1), PTPRC(2), PTPRM(6), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELP(3), SIGLEC1(9), VCAN(10) 19545961 164 35 164 58 49 35 34 22 24 0 0.128 1.000 1.000 518 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(7), MYBPC1(5), MYBPC3(3), MYH3(1), MYH6(6), MYH7(6), MYH8(4), MYL1(1), MYL3(1), MYOM1(3), NEB(14), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(3), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(88) 18946046 164 34 162 48 41 41 37 23 20 2 0.265 1.000 1.000 519 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(4), ADCY8(3), ARAF(2), ATF4(1), BRAF(3), CACNA1C(7), CALML3(2), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(2), EP300(4), GNAQ(1), GRIA1(3), GRIN2A(6), GRIN2B(5), GRIN2C(5), GRIN2D(5), GRM5(7), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKCG(2), RAP1B(2), RAPGEF3(3), RPS6KA1(2), RPS6KA2(1) 13360998 115 33 111 35 36 18 17 15 27 2 0.255 1.000 1.000 520 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(7), ACTN1(1), AKT1(2), AKT2(1), AKT3(1), ARHGEF6(1), ARHGEF7(3), BCAR1(2), BRAF(3), CDC42(1), CRK(1), CSE1L(2), DOCK1(2), EPHB2(3), GRB7(5), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGB3BP(1), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PIK3CA(4), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(6), PTEN(2), PTK2(4), ROCK1(3), ROCK2(1), SHC1(1), SOS2(1), SRC(2), TERF2IP(1), TLN1(9), TLN2(7), VASP(1), ZYX(1) 16341917 136 33 130 40 35 28 22 22 29 0 0.160 1.000 1.000 521 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 119 ARAF(2), BRAF(3), FAS(2), FASLG(1), FCGR3B(1), HLA-A(4), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(1), ITGAL(3), ITGB2(1), KIR2DL1(2), KIR2DL3(1), KIR3DL1(3), KLRC3(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(2), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), ZAP70(5) 14379958 113 30 110 33 36 22 11 17 26 1 0.0944 1.000 1.000 522 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), CALML3(2), CALML6(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(2), CTNNB1(8), DCT(5), DVL1(4), DVL2(3), EDN1(3), EDNRB(2), EP300(4), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD9(2), GNAI1(1), GNAI2(2), GNAO1(2), GNAQ(1), GSK3B(1), HRAS(1), KIT(4), LEF1(3), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACG(2), PRKCG(2), TCF7(2), TCF7L1(3), TCF7L2(1), TYR(3), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2) 15009165 144 29 141 49 56 25 17 21 25 0 0.0968 1.000 1.000 523 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 87 AKT1(2), AKT3(1), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(3), CAPN5(2), CAPN6(2), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(4), ITGA8(2), ITGAD(2), ITGAE(8), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(2), ITGB8(3), MAP2K6(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(3), PAK2(3), PAK4(1), PAK6(1), PIK3R2(3), PTK2(4), PXN(1), RAC2(1), RAP1B(2), ROCK1(3), ROCK2(1), SDCCAG8(1), SEPP1(1), SHC1(1), SORBS1(1), SRC(2), TLN1(9), TNS1(4), VASP(1), VCL(1), ZYX(1) 18109981 127 29 125 41 31 31 29 14 22 0 0.150 1.000 1.000 524 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 79 ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(3), BUB1(1), CDIPT(2), CDKL1(1), CLK1(3), CLK2(1), CLK4(1), CSNK2A1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKQ(3), DGKZ(3), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(3), MOS(1), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(9), PIK3CA(4), PIK3CB(3), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCG1(1), PLCG2(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(2), PRKG1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), STK11(2) 15355170 116 29 114 37 44 17 12 19 24 0 0.274 1.000 1.000 525 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 57 AKT1(2), AKT2(1), AKT3(1), BAD(1), CDC42(1), CREB1(2), ERBB4(6), F2RL2(2), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(5), IRS2(3), IRS4(3), MET(4), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTEN(2), PTK2(4), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1), TSC1(1), TSC2(6), YWHAE(2), YWHAH(1) 9562124 83 29 80 29 18 13 15 13 24 0 0.608 1.000 1.000 526 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN16(1), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(4), CTNNA3(3), CTNNB1(8), CTNND1(2), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(2), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(4), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PLCG2(6), PRKCG(2), PTK2(4), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(3), RAPGEF4(3), RASSF5(1), RHOA(1), RHOH(1), ROCK1(3), ROCK2(1), SIPA1(4), THY1(1), VASP(1), VAV1(4), VCL(1) 17399019 135 28 134 47 46 29 15 21 22 2 0.218 1.000 1.000 527 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 89 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), ATF4(1), CACNA1C(7), CACNA1F(1), CACNA1S(4), CALML3(2), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(6), ITPR2(9), ITPR3(8), LHB(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP2(2), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(3), PRKACG(2), SOS2(1), SRC(2) 16218517 130 26 126 43 39 24 22 17 26 2 0.212 1.000 1.000 528 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CLK2(1), CLK3(3), CLK4(1), COL2A1(4), CPSF1(3), CPSF2(4), CPSF4(1), CSTF1(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(3), DHX16(4), DHX38(1), DHX8(1), DICER1(7), FUS(2), METTL3(1), NCBP2(1), NONO(1), PABPN1(2), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(3), PRPF8(4), PTBP1(2), PTBP2(1), RBM5(1), RNGTT(2), SF3A2(1), SF3B1(1), SF3B2(1), SF3B5(1), SNRPB(1), SNRPE(2), SNRPN(3), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF2(2), XRN2(3) 14018926 87 26 85 25 26 11 14 17 19 0 0.392 1.000 1.000 529 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG10(1), ALG10B(2), ALG11(3), ALG12(3), ALG13(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT5(2), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHST2(2), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), EXT1(2), EXT2(3), EXTL1(2), EXTL2(2), EXTL3(5), GALNT1(2), GALNT10(4), GALNT13(1), GALNT14(1), GALNT2(2), GALNT5(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), XYLT1(4), XYLT2(4) 15318073 109 25 107 35 36 17 26 16 14 0 0.211 1.000 1.000 530 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 87 AKT1(2), AKT2(1), AKT3(1), CARD11(3), CBL(4), CBLB(1), CD3E(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), CTLA4(1), GRAP2(2), HRAS(1), IKBKB(2), ITK(1), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK2(3), PAK4(1), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(1), PPP3CA(1), PPP3CC(2), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS2(1), TEC(2), VAV1(4), ZAP70(5) 12927112 108 25 106 30 30 25 14 14 24 1 0.0869 1.000 1.000 531 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 INPP4A(1), INPP4B(1), INPP5A(1), INPP5E(1), INPPL1(5), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD3(1), PLCD4(3), PLCE1(4), PLCG1(1), PLCG2(6), PTEN(2), SYNJ2(2) 10206678 71 24 69 27 15 13 11 14 18 0 0.597 1.000 1.000 532 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMP8A(1), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(1), DHH(2), FBXW11(1), GLI1(5), GLI2(2), GLI3(8), GSK3B(1), HHIP(4), LRP2(3), PRKACG(2), PTCH1(4), PTCH2(6), SMO(2), STK36(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(2), WNT2B(2), WNT3A(2), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(2), ZIC2(4) 8457489 78 24 76 30 31 15 14 6 12 0 0.481 1.000 1.000 533 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(2), AKT2(1), AKT3(1), BRD4(5), CBL(4), CDC42(1), F2RL2(2), FLOT1(1), FLOT2(2), GSK3A(1), GSK3B(1), INPPL1(5), IRS2(3), IRS4(3), LNPEP(2), PARD3(6), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PTEN(2), RPS6KA1(2), RPS6KA2(1), SHC1(1), SORBS1(1), SOS2(1), YWHAE(2), YWHAH(1) 7515214 60 24 57 21 12 13 8 9 18 0 0.616 1.000 1.000 534 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 73 AGL(3), AMY2A(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX56(2), DHX58(2), ENPP3(2), EP400(7), ERCC2(1), G6PC2(1), GAA(2), GANC(1), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), IFIH1(4), MGAM(1), MOV10L1(5), NUDT8(1), PGM3(1), PYGB(2), PYGM(1), RAD54L(3), RUVBL2(3), SETX(5), SI(3), SKIV2L2(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2A3(1), UGT2B10(1), UGT2B15(1), UGT2B28(1), UGT2B4(1), UXS1(1) 15691923 99 23 97 45 23 21 19 16 19 1 0.946 1.000 1.000 535 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 89 ADCY1(4), ADCY2(1), ADCY3(6), ADCY4(1), ADCY5(4), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP11(2), AKAP12(2), AKAP3(2), AKAP4(1), AKAP6(4), AKAP7(2), AKAP9(8), ARHGEF1(4), GNA11(2), GNA14(1), GNA15(2), GNAI2(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(6), PALM2(2), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE7B(1), PDE8A(1), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(2), PRKD1(2), PRKD3(3), RHOA(1) 15824924 117 21 117 47 41 23 19 18 14 2 0.558 1.000 1.000 536 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(9), ACSL1(1), ACSL3(3), ACSL5(2), ACSL6(1), ADIPOR1(2), AKT1(2), AKT2(1), AKT3(1), CAMKK1(1), CHUK(1), CPT1B(4), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS2(3), IRS4(3), JAK1(1), JAK2(2), JAK3(3), LEPR(5), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(3), PCK2(4), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(3), PRKCQ(2), RELA(1), SLC2A1(4), STAT3(2), STK11(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 11313621 98 21 97 33 28 20 15 13 21 1 0.229 1.000 1.000 537 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREBBP(2), CRKL(2), DAG1(2), EGR3(1), GNAQ(1), MAP1B(4), MAP2K4(2), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SRC(2), TERF2IP(1), TH(1) 7013676 53 21 53 21 15 9 7 7 15 0 0.631 1.000 1.000 538 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(1), ETS2(2), ETV6(3), ETV7(1), FMN2(7), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS2(1) 6941757 63 20 60 27 19 9 14 8 13 0 0.895 1.000 1.000 539 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(2), AKT2(1), AKT3(1), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPKAPK3(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PPP3CA(1), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(4), PXN(1), RAC2(1), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(1), SRC(2) 9641696 88 20 85 33 23 21 15 11 18 0 0.518 1.000 1.000 540 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 BRAF(3), CHUK(1), CREB1(2), DAXX(4), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K9(2), MAP4K1(3), MAP4K2(3), MAP4K3(2), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(2), MEF2D(1), NFKBIA(2), PAK2(3), RELA(1), RPS6KA1(2), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), RPS6KB2(2), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1) 13055497 85 20 83 36 19 18 19 7 22 0 0.892 1.000 1.000 541 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(1), AKT3(1), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(1), RICTOR(5), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), STK11(2), TSC1(1), TSC2(6), ULK1(2), ULK3(1), VEGFB(1) 7464509 59 17 58 20 16 15 7 5 16 0 0.568 1.000 1.000 542 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 38 ALPI(4), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(3), DDX50(3), DDX51(1), DDX54(2), DDX56(2), DHFR(1), DHX58(2), EP400(7), ERCC2(1), FPGS(3), GCH1(1), GGH(1), IFIH1(4), MOV10L1(5), NUDT8(1), QDPR(2), RAD54L(3), RUVBL2(3), SETX(5), SKIV2L2(1) 7937775 75 16 72 28 16 16 10 14 18 1 0.684 1.000 1.000 543 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(2), CHAT(3), CHPT1(1), DGKA(1), DGKB(3), DGKD(3), DGKG(1), DGKH(1), DGKI(2), DGKQ(3), DGKZ(3), ESCO1(3), ETNK2(1), GPAM(3), GPD1(1), GPD2(1), LYPLA2(1), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2), PTDSS1(2), PTDSS2(1), SH3GLB1(1) 9042480 60 15 60 21 21 7 12 10 10 0 0.454 1.000 1.000 544 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(2), AKT2(1), AKT3(1), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(3), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(6), PRKCE(1), RAC2(1), SOS2(1), SYK(2), VAV1(4) 9244373 70 15 69 27 18 18 9 8 16 1 0.511 1.000 1.000 545 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 31 AKT1(2), BAD(1), CBL(4), CFLAR(2), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PTPN6(4), SHC1(1), STAT5A(1), SYK(2) 4265982 32 15 32 13 9 6 5 6 6 0 0.697 1.000 1.000 546 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(3), APH1A(2), CREBBP(2), CTBP2(5), DLL4(1), DTX1(3), DTX2(4), DTX4(1), DVL1(4), DVL2(3), EP300(4), JAG1(2), JAG2(3), LFNG(1), MAML1(2), MAML2(3), NCOR2(4), NOTCH1(7), NOTCH2(4), NOTCH3(7), NOTCH4(4), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RFNG(1), SNW1(1) 9710569 77 14 77 37 26 21 14 9 7 0 0.719 1.000 1.000 547 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(1), BFAR(2), BTK(1), CAD(5), CASP10(2), CASP8(2), DAXX(4), DEDD(1), EGFR(2), EPHB2(3), FAF1(1), FAIM2(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(6), RALBP1(2), ROCK1(3), TPX2(2), TRAF2(1) 9724180 64 14 62 23 12 11 16 12 13 0 0.663 1.000 1.000 548 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 36 AARS(1), CARS2(2), DARS(1), DARS2(1), EARS2(1), EPRS(1), FARS2(2), FARSB(1), GARS(5), HARS2(1), IARS(4), KARS(2), LARS2(2), NARS2(2), PARS2(1), QARS(1), RARS(1), RARS2(3), TARS(2), VARS(2), VARS2(2), WARS(2) 7092698 40 13 39 15 11 7 9 7 6 0 0.680 1.000 1.000 549 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(1), CHRM4(1), CHRM5(3), DRD1(2), DRD3(1), DRD5(2), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(2), HTR2B(1), HTR2C(1), HTR4(2), HTR5A(4), HTR7(1) 3620486 37 13 36 15 11 8 9 6 3 0 0.561 1.000 1.000 550 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(2), AKT2(1), AKT3(1), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), ITPKB(3), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(6), SHC1(1), SOS2(1), SYK(2), VAV1(4) 6558926 43 13 43 16 15 8 5 7 7 1 0.472 1.000 1.000 551 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 25 CASP10(2), CASP7(1), CASP8(2), CFLAR(2), DAXX(4), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(7), PTPN13(6), RB1(3), SPTAN1(3) 5369983 44 12 42 14 5 3 11 11 14 0 0.780 1.000 1.000 552 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(3), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(2), RDH11(2), SETDB1(2), SHMT1(1), SHMT2(2), SUV39H2(2) 7620637 51 12 48 19 16 7 13 6 8 1 0.572 1.000 1.000 553 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(8), B3GALT4(1), CDR1(1), DGKI(2), FAU(1), IL6ST(3), RPL11(1), RPL18(2), RPL18A(1), RPL28(1), RPL32(1), RPL34(1), RPL35(1), RPL3L(2), RPL4(3), RPL7A(1), RPLP0(1), RPLP2(1), RPS11(2), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(1), RPS6KB2(2), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1) 7228554 47 12 47 27 12 7 10 6 12 0 0.996 1.000 1.000 554 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), CPT1B(4), DAO(2), DMGDH(3), GARS(5), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(6), SARDH(2), SHMT1(1), SHMT2(2), TARS(2) 5892341 45 11 44 17 17 12 6 5 4 1 0.363 1.000 1.000 555 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(2), CHST12(1), CHST14(1), CHSY1(1), DSE(3), XYLT1(4), XYLT2(4) 2093780 20 11 18 12 8 2 5 1 4 0 0.884 1.000 1.000 556 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 29 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX5(1), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4) 3666126 38 11 38 18 18 3 8 2 6 1 0.825 1.000 1.000 557 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 35 CDK7(1), GTF2E1(1), GTF2E2(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2E(1), POLR3B(3), POLR3E(3), TAF5(1), TAF6(1), TBP(3) 4589631 30 11 27 12 9 4 7 3 7 0 0.797 1.000 1.000 558 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(1), BAD(1), BRAF(3), CREB1(2), DUSP6(2), MOS(1), RPS6KA1(2), RPS6KA2(1), SHC1(1), SOS2(1) 3753337 15 11 15 12 5 1 2 0 7 0 0.997 1.000 1.000 559 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 38 AGL(3), AMY2A(2), ENPP3(2), GAA(2), GANAB(2), GBE1(4), GCK(1), GPI(2), GUSB(1), GYS1(1), GYS2(1), HK1(1), HK2(3), HK3(2), MGAM(1), PGM3(1), PYGB(2), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1), UXS1(1) 7383667 41 11 41 18 13 10 9 5 4 0 0.757 1.000 1.000 560 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 27 ARSB(2), ARSE(1), CYP11B1(5), HSD11B1(1), HSD17B2(2), HSD3B1(2), HSD3B2(1), STS(3), SULT2A1(1), UGT1A10(1), UGT1A3(1), UGT2B15(1), UGT2B4(1) 3328667 22 10 21 10 6 5 4 2 5 0 0.800 1.000 1.000 561 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP2B6(1), CYP2C18(3), CYP2C9(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A22(1), CYP4F2(2), DHRS4(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), LTA4H(1), PLA2G3(2), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 5212516 39 10 39 24 14 7 10 2 5 1 0.970 1.000 1.000 562 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(1), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B1(2), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1) 4887718 30 10 30 14 10 5 4 2 9 0 0.759 1.000 1.000 563 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(1), DAXX(4), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(2), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 6459994 43 10 42 17 11 7 8 8 9 0 0.658 1.000 1.000 564 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 CDC42(1), CREB1(2), DAXX(4), HRAS(1), MAP2K4(2), MAP2K6(2), MAP3K1(3), MAP3K9(2), MAPKAPK5(1), MEF2A(2), MEF2D(1), RPS6KA5(1), SHC1(1), STAT1(1), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1) 4819416 29 10 27 15 7 1 8 4 9 0 0.969 1.000 1.000 565 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 GTF2E1(1), GTF2F1(4), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(2), TBP(3) 3281061 20 10 18 17 4 2 4 1 8 1 1.000 1.000 1.000 566 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 37 ARNTL(1), AZIN1(1), CRY1(1), DNAJA1(1), ETV6(3), GFRA1(3), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(4), PER2(3), PURA(1), TUBB3(1), UCP3(1), ZFR(1) 4619051 31 9 29 17 9 4 4 7 7 0 0.959 1.000 1.000 567 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CD97(1), CRHR2(1), ELTD1(5), EMR1(2), EMR2(3), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(6), LPHN3(1), VIPR1(1), VIPR2(1) 3748711 31 9 31 13 6 6 4 10 5 0 0.593 1.000 1.000 568 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(1), AGXT2(1), ALAS2(2), AOC2(5), AOC3(2), CHDH(1), DAO(2), DMGDH(3), GARS(5), GLDC(1), HSD3B7(3), PHGDH(1), RDH11(2), SARDH(2), SHMT1(1), SHMT2(2), TARS(2) 5885557 36 9 35 16 15 9 5 5 1 1 0.587 1.000 1.000 569 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(2), ACAT1(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(4), GCDH(2), HADHA(1), PLOD1(2), PLOD2(2), SHMT1(1), SHMT2(2) 5142488 32 9 29 15 10 5 11 1 4 1 0.791 1.000 1.000 570 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(1), AKT3(1), BAD(1), GSK3A(1), GSK3B(1), IL4R(1), IRS2(3), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS2(1), STAT6(4) 4461795 32 9 32 14 10 9 3 5 5 0 0.619 1.000 1.000 571 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(5), IARS(4), KARS(2), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2) 4367632 24 8 23 9 7 4 7 5 1 0 0.644 1.000 1.000 572 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), HSD3B7(3), MTMR2(1), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(2), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1) 5205202 37 8 37 15 12 6 13 4 2 0 0.562 1.000 1.000 573 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 29 AKR1B1(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), HSD3B7(3), LCT(3), MGAM(1), PFKL(2), PFKM(2), PGM3(1), RDH11(2) 4953893 29 8 29 12 13 4 6 2 4 0 0.529 1.000 1.000 574 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CYB5R1(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), GNPDA2(1), HEXB(2), HK1(1), HK2(3), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1), UAP1(1) 3977329 28 8 28 13 10 3 8 3 4 0 0.827 1.000 1.000 575 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(3), GNS(1), GUSB(1), HEXB(2), HGSNAT(1), HPSE(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2) 2891470 20 8 20 11 5 5 2 2 6 0 0.838 1.000 1.000 576 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(1), C6(6), C7(4), ICAM1(2), IL6(1), ITGAL(3), ITGB2(1), SELP(3) 3394873 27 8 27 11 8 7 5 2 5 0 0.547 1.000 1.000 577 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(3), MAP3K1(3), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2), SHC1(1) 6738435 41 8 41 15 12 9 7 7 6 0 0.514 1.000 1.000 578 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(2), ATF1(1), CDC42(1), CREB1(2), DUSP10(1), MAP2K4(2), MAP2K6(2), MAP3K10(3), MAP3K4(2), MAPK11(1), MAPK12(1), MAPKAPK5(1), MYEF2(1), NR2C2(1), SRF(1) 4548905 22 8 22 13 5 3 4 3 7 0 0.943 1.000 1.000 579 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 34 AGT(1), AGTR2(1), CAMK2D(1), GNA11(2), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(2), MYLK(8), PLCG1(1), SHC1(1), STAT1(1), STAT3(2), STAT5A(1) 5155326 29 7 29 12 8 7 6 4 4 0 0.612 1.000 1.000 580 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4) 962323 13 7 11 11 4 4 2 0 3 0 0.941 1.000 1.000 581 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(4), PXN(1), RELA(1) 3878270 23 7 23 11 5 8 3 3 4 0 0.700 1.000 1.000 582 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(2), CAMK1G(1), FPR1(1), GNA15(2), GNB1(2), HRAS(1), MAP2K6(2), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(5), NFATC3(2), NFATC4(4), NFKBIA(2), PLCB1(1), PPP3CA(1), PPP3CC(2), RELA(1) 5188598 37 7 36 16 8 8 10 5 6 0 0.807 1.000 1.000 583 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 22 AKR1B1(1), FBP2(1), GAA(2), GANAB(2), GCK(1), GLB1(3), HK1(1), HK2(3), HK3(2), LCT(3), MGAM(1), PFKM(2), PGM3(1) 4243195 23 7 23 11 10 2 6 1 4 0 0.711 1.000 1.000 584 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), HS3ST3B1(1), XYLT1(4), XYLT2(4) 962323 13 7 11 11 4 4 2 0 3 0 0.941 1.000 1.000 585 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(6), ARRB2(2), CALML3(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(1), GUCA1A(1), GUCA1C(1), PDC(1), PRKACG(2), PRKG1(1), PRKG2(1) 3886167 27 7 27 13 12 4 7 2 2 0 0.787 1.000 1.000 586 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(1), SRC(2), STAT3(2) 2135891 21 7 20 12 8 6 4 0 3 0 0.831 1.000 1.000 587 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(1), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PAPSS1(3), PAPSS2(3), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SCLY(2) 3452640 26 6 26 11 6 6 9 2 3 0 0.655 1.000 1.000 588 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(2), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(6), REG1A(1), SOAT1(1) 1925859 17 6 16 11 8 3 4 0 2 0 0.911 1.000 1.000 589 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(1), HK2(3), HK3(2), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(2), PMM2(1), TPI1(2) 3330512 24 5 24 11 9 4 8 1 2 0 0.611 1.000 1.000 590 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G3(2), PLA2G6(4), PLD2(3), PPAP2B(2) 3217607 27 5 27 12 9 4 6 4 4 0 0.799 1.000 1.000 591 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(2), JAK3(3), SHC1(1), SRF(1), STAT3(2) 2979431 17 5 17 13 5 2 3 2 5 0 0.985 1.000 1.000 592 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(1), SRC(2) 3438424 17 5 17 12 4 4 3 3 3 0 0.960 1.000 1.000 593 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1) 724490 8 4 8 5 6 1 0 1 0 0 0.877 1.000 1.000 594 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1) 2484628 23 4 23 11 5 6 3 4 5 0 0.683 1.000 1.000 595 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(4), GPX6(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3) 3085250 28 4 28 13 7 8 5 3 5 0 0.594 1.000 1.000 596 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP23(2), SNAP25(1), SNAP29(3), STX11(1), STX12(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VTI1A(1) 2332365 14 4 14 10 8 0 1 2 3 0 0.939 1.000 1.000 597 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(3), PDHA1(1), SLC18A3(2) 985290 9 3 9 7 4 0 4 1 0 0 0.929 1.000 1.000 598 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(1), EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2D(1), PTK2(4), SHC1(1), SRC(2) 4128919 22 3 22 8 3 4 6 4 5 0 0.627 1.000 1.000 599 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 AHCY(2), AMD1(1), DNMT3A(5), DNMT3B(2), MTR(1), TAT(1) 2779855 12 3 12 13 4 2 3 2 1 0 0.997 1.000 1.000 600 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1), SLC25A11(1) 1282632 9 3 9 5 4 4 0 1 0 0 0.678 1.000 1.000 601 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(5), DNMT3B(2), MTR(1) 2403812 10 3 10 12 4 1 3 2 0 0 0.998 1.000 1.000 602 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(1), CDC34(1), CUL1(1), RB1(3), SKP2(2) 1187640 11 3 11 5 2 3 3 3 0 0 0.775 1.000 1.000 603 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 10 CDK5R1(1), HRAS(1), KLK2(1), NGFR(1) 926066 4 2 4 4 3 0 1 0 0 0 0.944 1.000 1.000 604 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(1), IL9(1) 1360609 4 2 4 3 0 2 1 1 0 0 0.838 1.000 1.000 605 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), NOX1(2), RELA(1), XDH(6) 1378242 10 2 10 6 2 3 3 2 0 0 0.886 1.000 1.000 606 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(1), RB1(3), SKP2(2) 1183936 7 2 7 4 1 1 2 3 0 0 0.907 1.000 1.000 607 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(1), MTNR1B(1), PTGDR(2), PTGFR(1), TBXA2R(2) 1607912 7 2 7 5 2 2 3 0 0 0 0.834 1.000 1.000 608 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 5 UGDH(1), UXS1(1) 534709 2 1 2 2 0 0 1 1 0 0 0.978 1.000 1.000 609 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 15 ACP5(1), ENPP3(2), MTMR2(1), MTMR6(1), PHPT1(1), RFK(1), TYR(3) 1896568 10 1 10 5 3 4 2 1 0 0 0.798 1.000 1.000 610 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 4 AOX1(1), PNPO(1) 564835 2 1 2 4 0 0 2 0 0 0 0.991 1.000 1.000 611 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), SQLE(1) 591668 3 1 3 3 1 1 1 0 0 0 0.922 1.000 1.000 612 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 927392 2 1 2 3 1 1 0 0 0 0 0.942 1.000 1.000 613 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(1), UXS1(1) 534709 2 1 2 2 0 0 1 1 0 0 0.978 1.000 1.000 614 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 444961 3 1 3 3 1 1 1 0 0 0 0.921 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 68977 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 5 519274 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000