Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.162 0.339 -9999.0 0.0 -1.005 12.0 12.0 IHH -0.241 0.363 -9999.0 0.0 -0.741 42.0 42.0 SHH Np/Cholesterol/GAS1 -0.133 0.258 -9999.0 0.0 -0.569 29.0 29.0 LRPAP1 0.009 0.057 -9999.0 0.0 -0.627 1.0 1.0 dorsoventral neural tube patterning 0.132 0.255 0.564 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.148 0.303 -9999.0 0.0 -0.687 20.0 20.0 SMO -0.164 0.322 -9999.0 0.0 -0.737 20.0 20.0 AKT1 -0.046 0.14 -9999.0 0.0 -0.645 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.119 -9999.0 0.0 -0.758 3.0 3.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.16 0.314 -9999.0 0.0 -0.718 20.0 20.0 STIL -0.154 0.3 -9999.0 0.0 -0.701 21.0 21.0 DHH N/PTCH2 -0.085 0.226 -9999.0 0.0 -0.622 17.0 17.0 DHH N/PTCH1 -0.171 0.278 -9999.0 0.0 -0.722 15.0 15.0 PIK3CA 0.008 0.069 -9999.0 0.0 -0.758 1.0 1.0 DHH -0.07 0.236 -9999.0 0.0 -0.73 14.0 14.0 PTHLH -0.205 0.427 -9999.0 0.0 -1.236 13.0 13.0 determination of left/right symmetry -0.16 0.314 -9999.0 0.0 -0.718 20.0 20.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.201 0.416 -9999.0 0.0 -1.203 13.0 13.0 IHH N/Hhip -0.249 0.339 -9999.0 0.0 -0.595 55.0 55.0 DHH N/Hhip -0.162 0.279 -9999.0 0.0 -0.593 34.0 34.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.16 0.314 -9999.0 0.0 -0.718 20.0 20.0 pancreas development -0.129 0.286 -9999.0 0.0 -0.694 25.0 25.0 HHAT 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.005 0.051 -9999.0 0.0 -0.573 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.09 0.253 -9999.0 0.0 -0.7 18.0 18.0 somite specification -0.16 0.314 -9999.0 0.0 -0.718 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.168 0.305 -9999.0 0.0 -0.71 23.0 23.0 SHH Np/Cholesterol/PTCH2 -0.095 0.201 -9999.0 0.0 -0.518 18.0 18.0 SHH Np/Cholesterol/Megalin -0.113 0.193 -9999.0 0.0 -0.479 19.0 19.0 SHH -0.075 0.218 -9999.0 0.0 -0.543 22.0 22.0 catabolic process -0.142 0.262 -9999.0 0.0 -0.511 34.0 34.0 SMO/Vitamin D3 -0.176 0.332 -9999.0 0.0 -0.758 23.0 23.0 SHH Np/Cholesterol/Hhip -0.155 0.255 -9999.0 0.0 -0.58 26.0 26.0 LRP2 -0.057 0.199 -9999.0 0.0 -0.637 13.0 13.0 receptor-mediated endocytosis -0.221 0.292 -9999.0 0.0 -0.733 24.0 24.0 SHH Np/Cholesterol/BOC -0.086 0.179 -9999.0 0.0 -0.469 19.0 19.0 SHH Np/Cholesterol/CDO -0.082 0.168 -9999.0 0.0 -0.422 24.0 24.0 mesenchymal cell differentiation 0.154 0.252 0.574 26.0 -9999.0 0.0 26.0 mol:Vitamin D3 -0.167 0.309 -9999.0 0.0 -0.714 23.0 23.0 IHH N/PTCH2 -0.17 0.272 -9999.0 0.0 -0.512 45.0 45.0 CDON 0.003 0.089 -9999.0 0.0 -0.693 2.0 2.0 IHH N/PTCH1 -0.144 0.266 -9999.0 0.0 -0.518 34.0 34.0 Megalin/LRPAP1 -0.053 0.148 -9999.0 0.0 -0.466 14.0 14.0 PTCH2 -0.021 0.157 -9999.0 0.0 -0.715 6.0 6.0 SHH Np/Cholesterol -0.077 0.166 -9999.0 0.0 -0.433 22.0 22.0 PTCH1 -0.142 0.263 -9999.0 0.0 -0.705 10.0 10.0 HHIP -0.129 0.286 -9999.0 0.0 -0.695 25.0 25.0