Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	31.0	1465.0	46.0	-0.801	0.023	1000.0	-1000.0	-0.099	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	23.0	799.0	34.0	-0.272	0.014	1000.0	-1000.0	-0.083	-1000.0
IL4-mediated signaling events	19.0	1791.0	91.0	-0.711	0.616	1000.0	-1000.0	-0.158	-1000.0
IL23-mediated signaling events	19.0	1140.0	60.0	-0.504	0.016	1000.0	-1000.0	-0.19	-1000.0
Signaling events mediated by the Hedgehog family	17.0	916.0	52.0	-0.249	0.154	1000.0	-1000.0	-0.104	-1000.0
BCR signaling pathway	17.0	1702.0	99.0	-0.398	0.014	1000.0	-1000.0	-0.111	-1000.0
HIF-1-alpha transcription factor network	15.0	1215.0	76.0	-0.607	0.022	1000.0	-1000.0	-0.169	-1000.0
IL6-mediated signaling events	14.0	1054.0	75.0	-0.477	0.052	1000.0	-1000.0	-0.124	-1000.0
TCGA08_retinoblastoma	14.0	117.0	8.0	-0.174	0.063	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PTP1B	12.0	918.0	76.0	-0.336	0.078	1000.0	-1000.0	-0.095	-1000.0
amb2 Integrin signaling	12.0	1001.0	82.0	-0.211	0.014	1000.0	-1000.0	-0.1	-1000.0
Glypican 1 network	11.0	565.0	48.0	-0.355	0.022	1000.0	-1000.0	-0.066	-1000.0
Reelin signaling pathway	11.0	661.0	56.0	-0.247	0.014	1000.0	-1000.0	-0.1	-1000.0
Wnt signaling	11.0	83.0	7.0	-0.191	0.014	1000.0	-1000.0	-0.031	-1000.0
Ephrin A  reverse signaling	10.0	76.0	7.0	-0.059	-0.0	1000.0	-1000.0	-0.037	-1000.0
Noncanonical Wnt signaling pathway	10.0	263.0	26.0	-0.191	0.014	1000.0	-1000.0	-0.1	-1000.0
p75(NTR)-mediated signaling	10.0	1354.0	125.0	-0.256	0.014	1000.0	-1000.0	-0.127	-1000.0
Endothelins	10.0	1037.0	96.0	-0.203	0.017	1000.0	-1000.0	-0.106	-1000.0
TCGA08_p53	10.0	74.0	7.0	-0.129	0.068	1000.0	-1000.0	-0.019	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	1001.0	93.0	-0.183	0.095	1000.0	-1000.0	-0.109	-1000.0
Syndecan-4-mediated signaling events	10.0	721.0	67.0	-0.246	0.041	1000.0	-1000.0	-0.109	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.045	-1000.0	1000.0	-1000.0	-0.02	-1000.0
IL12-mediated signaling events	9.0	806.0	87.0	-0.225	0.045	1000.0	-1000.0	-0.148	-1000.0
Syndecan-1-mediated signaling events	9.0	310.0	34.0	-0.181	0.014	1000.0	-1000.0	-0.069	-1000.0
Glucocorticoid receptor regulatory network	9.0	1098.0	114.0	-0.53	0.205	1000.0	-1000.0	-0.1	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	672.0	68.0	-0.328	0.103	1000.0	-1000.0	-0.151	-1000.0
EGFR-dependent Endothelin signaling events	9.0	207.0	21.0	-0.281	0.014	1000.0	-1000.0	-0.096	-1000.0
Visual signal transduction: Cones	8.0	330.0	38.0	-0.161	0.014	1000.0	-1000.0	-0.087	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	138.0	17.0	-0.107	0.014	1000.0	-1000.0	-0.079	-1000.0
Arf6 signaling events	8.0	499.0	62.0	-0.281	0.014	1000.0	-1000.0	-0.076	-1000.0
BMP receptor signaling	8.0	691.0	81.0	-0.247	0.054	1000.0	-1000.0	-0.109	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	826.0	97.0	-0.174	0.031	1000.0	-1000.0	-0.109	-1000.0
Integrins in angiogenesis	8.0	717.0	84.0	-0.228	0.014	1000.0	-1000.0	-0.118	-1000.0
Effects of Botulinum toxin	8.0	212.0	26.0	-0.14	0.014	1000.0	-1000.0	-0.075	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	274.0	31.0	-0.285	0.014	1000.0	-1000.0	-0.108	-1000.0
Insulin Pathway	8.0	604.0	74.0	-0.332	0.02	1000.0	-1000.0	-0.111	-1000.0
Visual signal transduction: Rods	8.0	464.0	52.0	-0.243	0.014	1000.0	-1000.0	-0.117	-1000.0
Thromboxane A2 receptor signaling	7.0	834.0	105.0	-0.281	0.035	1000.0	-1000.0	-0.089	-1000.0
Syndecan-2-mediated signaling events	7.0	537.0	69.0	-0.186	0.035	1000.0	-1000.0	-0.073	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	316.0	44.0	-0.124	0.014	1000.0	-1000.0	-0.063	-1000.0
LPA4-mediated signaling events	6.0	72.0	12.0	-0.048	0.011	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	6.0	477.0	76.0	-0.279	0.05	1000.0	-1000.0	-0.057	-1000.0
ErbB4 signaling events	6.0	440.0	69.0	-0.236	0.161	1000.0	-1000.0	-0.114	-1000.0
Osteopontin-mediated events	6.0	233.0	38.0	-0.103	0.014	1000.0	-1000.0	-0.127	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	350.0	54.0	-0.225	0.029	1000.0	-1000.0	-0.129	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	31.0	5.0	-0.054	-0.01	1000.0	-1000.0	-0.051	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	248.0	37.0	-0.205	0.014	1000.0	-1000.0	-0.073	-1000.0
Signaling events regulated by Ret tyrosine kinase	6.0	554.0	82.0	-0.135	0.014	1000.0	-1000.0	-0.102	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	345.0	52.0	-0.192	0.032	1000.0	-1000.0	-0.08	-1000.0
FAS signaling pathway (CD95)	6.0	285.0	47.0	-0.203	0.047	1000.0	-1000.0	-0.059	-1000.0
Nongenotropic Androgen signaling	6.0	337.0	52.0	-0.12	0.014	1000.0	-1000.0	-0.078	-1000.0
IL27-mediated signaling events	6.0	309.0	51.0	-0.195	0.051	1000.0	-1000.0	-0.106	-1000.0
LPA receptor mediated events	6.0	686.0	102.0	-0.131	0.025	1000.0	-1000.0	-0.114	-1000.0
IGF1 pathway	6.0	398.0	57.0	-0.228	0.039	1000.0	-1000.0	-0.119	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	835.0	120.0	-0.291	0.15	1000.0	-1000.0	-0.1	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	102.0	17.0	-0.1	0.015	1000.0	-1000.0	-0.049	-1000.0
Cellular roles of Anthrax toxin	5.0	216.0	39.0	-0.058	0.014	1000.0	-1000.0	-0.039	-1000.0
mTOR signaling pathway	5.0	272.0	53.0	-0.336	0.034	1000.0	-1000.0	-0.074	-1000.0
IL1-mediated signaling events	5.0	351.0	62.0	-0.17	0.062	1000.0	-1000.0	-0.123	-1000.0
HIF-2-alpha transcription factor network	5.0	227.0	43.0	-0.084	0.023	1000.0	-1000.0	-0.111	-1000.0
Ephrin B reverse signaling	5.0	274.0	48.0	-0.092	0.055	1000.0	-1000.0	-0.084	-1000.0
Syndecan-3-mediated signaling events	5.0	175.0	35.0	-0.121	0.014	1000.0	-1000.0	-0.083	-1000.0
EPHB forward signaling	5.0	440.0	85.0	-0.1	0.072	1000.0	-1000.0	-0.111	-1000.0
Plasma membrane estrogen receptor signaling	5.0	477.0	86.0	-0.227	0.017	1000.0	-1000.0	-0.1	-1000.0
Rapid glucocorticoid signaling	5.0	109.0	20.0	-0.203	0.014	1000.0	-1000.0	-0.051	-1000.0
FOXM1 transcription factor network	5.0	285.0	51.0	-0.181	0.11	1000.0	-1000.0	-0.205	-1000.0
BARD1 signaling events	4.0	257.0	57.0	-0.056	0.046	1000.0	-1000.0	-0.084	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	-0.019	0.008	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	4.0	150.0	36.0	-0.078	0.014	1000.0	-1000.0	-0.076	-1000.0
Retinoic acid receptors-mediated signaling	4.0	235.0	58.0	-0.161	0.015	1000.0	-1000.0	-0.099	-1000.0
IL2 signaling events mediated by PI3K	4.0	254.0	58.0	-0.11	0.033	1000.0	-1000.0	-0.106	-1000.0
Regulation of p38-alpha and p38-beta	4.0	261.0	54.0	-0.32	0.014	1000.0	-1000.0	-0.068	-1000.0
IL2 signaling events mediated by STAT5	4.0	94.0	22.0	-0.101	0.015	1000.0	-1000.0	-0.058	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	425.0	88.0	-0.112	0.07	1000.0	-1000.0	-0.143	-1000.0
Regulation of Androgen receptor activity	4.0	326.0	70.0	-0.337	0.033	1000.0	-1000.0	-0.075	-1000.0
Aurora B signaling	4.0	286.0	67.0	-0.15	0.014	1000.0	-1000.0	-0.099	-1000.0
ErbB2/ErbB3 signaling events	3.0	216.0	65.0	-0.092	0.034	1000.0	-1000.0	-0.085	-1000.0
Caspase cascade in apoptosis	3.0	257.0	74.0	-0.075	0.02	1000.0	-1000.0	-0.068	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	539.0	136.0	-0.163	0.119	1000.0	-1000.0	-0.097	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	90.0	28.0	-0.045	0.014	1000.0	-1000.0	-0.061	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	298.0	85.0	-0.074	0.034	1000.0	-1000.0	-0.088	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	208.0	61.0	-0.18	0.041	1000.0	-1000.0	-0.093	-1000.0
EPO signaling pathway	3.0	176.0	55.0	-0.088	0.024	1000.0	-1000.0	-0.116	-1000.0
PDGFR-alpha signaling pathway	3.0	160.0	44.0	-0.049	0.025	1000.0	-1000.0	-0.075	-1000.0
Ceramide signaling pathway	3.0	276.0	76.0	-0.281	0.08	1000.0	-1000.0	-0.092	-1000.0
S1P5 pathway	3.0	52.0	17.0	-0.045	0.041	1000.0	-1000.0	-0.071	-1000.0
Canonical Wnt signaling pathway	3.0	175.0	51.0	-0.18	0.059	1000.0	-1000.0	-0.073	-1000.0
Class I PI3K signaling events	3.0	268.0	73.0	-0.32	0.028	1000.0	-1000.0	-0.088	-1000.0
Regulation of Telomerase	3.0	361.0	102.0	-0.282	0.048	1000.0	-1000.0	-0.134	-1000.0
S1P3 pathway	3.0	132.0	42.0	-0.045	0.021	1000.0	-1000.0	-0.072	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	108.0	33.0	-0.172	0.036	1000.0	-1000.0	-0.08	-1000.0
S1P4 pathway	3.0	88.0	25.0	-0.046	0.014	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	238.0	78.0	-0.105	0.039	1000.0	-1000.0	-0.095	-1000.0
p38 MAPK signaling pathway	3.0	138.0	44.0	-0.166	0.018	1000.0	-1000.0	-0.081	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	149.0	65.0	-0.054	0.056	1000.0	-1000.0	-0.077	-1000.0
Aurora A signaling	2.0	128.0	60.0	-0.074	0.03	1000.0	-1000.0	-0.076	-1000.0
Arf6 downstream pathway	2.0	120.0	43.0	-0.02	0.019	1000.0	-1000.0	-0.05	-1000.0
Aurora C signaling	2.0	18.0	7.0	-0.031	0.009	1000.0	-1000.0	-0.057	-1000.0
PLK1 signaling events	2.0	213.0	85.0	-0.029	0.03	1000.0	-1000.0	-0.065	-1000.0
Nectin adhesion pathway	2.0	165.0	63.0	-0.051	0.041	1000.0	-1000.0	-0.103	-1000.0
Signaling events mediated by HDAC Class III	2.0	84.0	40.0	-0.076	0.022	1000.0	-1000.0	-0.054	-1000.0
TRAIL signaling pathway	2.0	99.0	48.0	-0.03	0.044	1000.0	-1000.0	-0.088	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	219.0	83.0	-0.16	0.055	1000.0	-1000.0	-0.092	-1000.0
FoxO family signaling	2.0	169.0	64.0	-0.235	0.106	1000.0	-1000.0	-0.091	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	41.0	15.0	-0.007	0.03	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	109.0	45.0	-0.066	0.048	1000.0	-1000.0	-0.112	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.014	-1000.0	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	311.0	125.0	-0.061	0.074	1000.0	-1000.0	-0.122	-1000.0
TCGA08_rtk_signaling	2.0	52.0	26.0	-0.058	0.051	1000.0	-1000.0	-0.033	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	210.0	74.0	-0.281	0.071	1000.0	-1000.0	-0.125	-1000.0
PDGFR-beta signaling pathway	2.0	262.0	97.0	-0.199	0.052	1000.0	-1000.0	-0.108	-1000.0
Canonical NF-kappaB pathway	1.0	57.0	39.0	-0.058	0.08	1000.0	-1000.0	-0.104	-1000.0
Signaling events mediated by HDAC Class II	1.0	123.0	75.0	-0.052	0.032	1000.0	-1000.0	-0.081	-1000.0
Circadian rhythm pathway	1.0	28.0	22.0	-0.016	0.047	1000.0	-1000.0	-0.083	-1000.0
Insulin-mediated glucose transport	1.0	37.0	32.0	-0.045	0.035	1000.0	-1000.0	-0.08	-1000.0
IFN-gamma pathway	1.0	122.0	68.0	-0.166	0.048	1000.0	-1000.0	-0.121	-1000.0
ceramide signaling pathway	1.0	63.0	49.0	-0.058	0.036	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class I	1.0	117.0	104.0	-0.062	0.054	1000.0	-1000.0	-0.084	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	70.0	36.0	-0.054	0.026	1000.0	-1000.0	-0.085	-1000.0
Atypical NF-kappaB pathway	1.0	49.0	31.0	-0.048	0.034	1000.0	-1000.0	-0.064	-1000.0
Arf6 trafficking events	1.0	132.0	71.0	-0.177	0.047	1000.0	-1000.0	-0.093	-1000.0
VEGFR1 specific signals	1.0	69.0	56.0	-0.034	0.061	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by PRL	1.0	61.0	34.0	-0.051	0.035	1000.0	-1000.0	-0.05	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.018	0.051	1000.0	-1000.0	-0.086	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	44.0	68.0	-0.045	0.054	1000.0	-1000.0	-0.082	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	67.0	76.0	-0.026	0.064	1000.0	-1000.0	-0.106	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.003	0.033	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling in keratinocytes	0.0	38.0	43.0	-0.019	0.047	1000.0	-1000.0	-0.089	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	-0.004	0.014	1000.0	-1000.0	-0.058	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.012	0.032	1000.0	-1000.0	-0.069	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.012	0.014	1000.0	-1000.0	-0.083	-1000.0
Total	738	45593	7203	-21.7541947701	-1994.35058555	131000	-131000	-11.5950466961	-131000