Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.088 0.174 0.303 35.0 -9999.0 0.0 35.0 KIRREL -0.033 0.138 -9999.0 0.0 -0.473 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.088 0.175 -9999.0 0.0 -0.304 35.0 35.0 PLCG1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.05 0.149 -9999.0 0.0 -0.283 20.0 20.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.046 0.123 -9999.0 0.0 -0.281 17.0 17.0 FYN -0.057 0.136 0.268 3.0 -0.266 20.0 23.0 mol:Ca2+ -0.045 0.147 -9999.0 0.0 -0.283 19.0 19.0 mol:DAG -0.044 0.148 -9999.0 0.0 -0.284 19.0 19.0 NPHS2 -0.01 0.064 -9999.0 0.0 -0.366 2.0 2.0 mol:IP3 -0.044 0.148 -9999.0 0.0 -0.284 19.0 19.0 regulation of endocytosis -0.043 0.128 -9999.0 0.0 -0.254 18.0 18.0 Nephrin/NEPH1/podocin/Cholesterol -0.057 0.142 -9999.0 0.0 -0.282 20.0 20.0 establishment of cell polarity -0.088 0.174 -9999.0 0.0 -0.303 35.0 35.0 Nephrin/NEPH1/podocin/NCK1-2 -0.034 0.147 -9999.0 0.0 -0.26 20.0 20.0 Nephrin/NEPH1/beta Arrestin2 -0.043 0.13 -9999.0 0.0 -0.257 18.0 18.0 NPHS1 -0.113 0.2 -9999.0 0.0 -0.384 32.0 32.0 Nephrin/NEPH1/podocin -0.05 0.135 -9999.0 0.0 -0.267 20.0 20.0 TJP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.044 0.149 -9999.0 0.0 -0.285 19.0 19.0 CD2AP 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.046 0.142 -9999.0 0.0 -0.273 19.0 19.0 GRB2 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.049 0.15 0.307 5.0 -0.27 19.0 24.0 cytoskeleton organization -0.065 0.133 -9999.0 0.0 -0.322 17.0 17.0 Nephrin/NEPH1 -0.058 0.125 -9999.0 0.0 -0.209 35.0 35.0 Nephrin/NEPH1/ZO-1 -0.057 0.148 -9999.0 0.0 -0.288 20.0 20.0