Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.091 0.201 -9999.0 0.0 -0.567 10.0 10.0 IHH -0.127 0.234 -9999.0 0.0 -0.461 30.0 30.0 SHH Np/Cholesterol/GAS1 -0.033 0.127 -9999.0 0.0 -0.283 18.0 18.0 LRPAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.033 0.126 0.281 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.095 0.213 -9999.0 0.0 -0.485 13.0 13.0 SMO -0.107 0.216 -9999.0 0.0 -0.51 13.0 13.0 AKT1 -0.031 0.148 -9999.0 0.0 -0.729 2.0 2.0 ARRB2 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.086 -9999.0 0.0 -0.458 3.0 3.0 ADRBK1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.105 0.213 -9999.0 0.0 -0.501 13.0 13.0 STIL -0.075 0.179 0.267 1.0 -0.383 16.0 17.0 DHH N/PTCH2 -0.001 0.131 -9999.0 0.0 -0.337 11.0 11.0 DHH N/PTCH1 -0.091 0.187 -9999.0 0.0 -0.45 13.0 13.0 PIK3CA 0.026 0.05 -9999.0 0.0 -0.458 1.0 1.0 DHH -0.012 0.131 -9999.0 0.0 -0.412 9.0 9.0 PTHLH -0.131 0.277 -9999.0 0.0 -0.814 9.0 9.0 determination of left/right symmetry -0.105 0.213 -9999.0 0.0 -0.501 13.0 13.0 PIK3R1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.13 0.274 -9999.0 0.0 -0.804 9.0 9.0 IHH N/Hhip -0.113 0.198 -9999.0 0.0 -0.346 36.0 36.0 DHH N/Hhip -0.044 0.162 -9999.0 0.0 -0.315 23.0 23.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.105 0.213 -9999.0 0.0 -0.501 13.0 13.0 pancreas development -0.045 0.165 -9999.0 0.0 -0.393 17.0 17.0 HHAT 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.042 0.037 -9999.0 0.0 -0.297 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.023 0.146 -9999.0 0.0 -0.401 12.0 12.0 somite specification -0.105 0.213 -9999.0 0.0 -0.501 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.091 0.173 -9999.0 0.0 -0.394 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.019 0.113 -9999.0 0.0 -0.264 15.0 15.0 SHH Np/Cholesterol/Megalin -0.03 0.107 -9999.0 0.0 -0.215 23.0 23.0 SHH -0.033 0.117 -9999.0 0.0 -0.313 14.0 14.0 catabolic process -0.088 0.181 -9999.0 0.0 -0.342 27.0 27.0 SMO/Vitamin D3 -0.097 0.21 -9999.0 0.0 -0.453 17.0 17.0 SHH Np/Cholesterol/Hhip -0.047 0.135 -9999.0 0.0 -0.268 23.0 23.0 LRP2 -0.013 0.117 -9999.0 0.0 -0.334 11.0 11.0 receptor-mediated endocytosis -0.107 0.203 -9999.0 0.0 -0.456 17.0 17.0 SHH Np/Cholesterol/BOC -0.013 0.097 -9999.0 0.0 -0.239 14.0 14.0 SHH Np/Cholesterol/CDO -0.013 0.094 -9999.0 0.0 -0.233 14.0 14.0 mesenchymal cell differentiation 0.047 0.135 0.266 23.0 -9999.0 0.0 23.0 mol:Vitamin D3 -0.078 0.188 -9999.0 0.0 -0.396 17.0 17.0 IHH N/PTCH2 -0.071 0.167 -9999.0 0.0 -0.303 30.0 30.0 CDON 0.021 0.062 -9999.0 0.0 -0.39 2.0 2.0 IHH N/PTCH1 -0.083 0.187 -9999.0 0.0 -0.343 28.0 28.0 Megalin/LRPAP1 0.015 0.086 -9999.0 0.0 -0.232 10.0 10.0 PTCH2 0.012 0.092 -9999.0 0.0 -0.424 4.0 4.0 SHH Np/Cholesterol -0.02 0.091 -9999.0 0.0 -0.237 14.0 14.0 PTCH1 -0.089 0.182 -9999.0 0.0 -0.343 27.0 27.0 HHIP -0.045 0.166 -9999.0 0.0 -0.394 17.0 17.0