Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	21.0	1002.0	46.0	-0.702	0.036	1000.0	-1000.0	-0.113	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	494.0	34.0	-0.113	0.032	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	14.0	1120.0	76.0	-0.371	0.04	1000.0	-1000.0	-0.111	-1000.0
Signaling events mediated by the Hedgehog family	13.0	681.0	52.0	-0.131	0.047	1000.0	-1000.0	-0.044	-1000.0
IL23-mediated signaling events	13.0	811.0	60.0	-0.473	0.032	1000.0	-1000.0	-0.111	-1000.0
IL4-mediated signaling events	12.0	1128.0	91.0	-0.7	0.622	1000.0	-1000.0	-0.144	-1000.0
Wnt signaling	10.0	72.0	7.0	-0.087	0.022	1000.0	-1000.0	-0.01	-1000.0
EGFR-dependent Endothelin signaling events	10.0	222.0	21.0	-0.164	0.043	1000.0	-1000.0	-0.045	-1000.0
Glypican 1 network	9.0	466.0	48.0	-0.184	0.055	1000.0	-1000.0	-0.026	-1000.0
Reelin signaling pathway	9.0	543.0	56.0	-0.111	0.076	1000.0	-1000.0	-0.034	-1000.0
IL6-mediated signaling events	9.0	713.0	75.0	-0.41	0.044	1000.0	-1000.0	-0.066	-1000.0
TCGA08_retinoblastoma	9.0	73.0	8.0	-0.07	0.04	1000.0	-1000.0	-0.005	-1000.0
BCR signaling pathway	9.0	923.0	99.0	-0.169	0.033	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PTP1B	8.0	667.0	76.0	-0.19	0.044	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	8.0	1087.0	125.0	-0.121	0.078	1000.0	-1000.0	-0.047	-1000.0
amb2 Integrin signaling	8.0	735.0	82.0	-0.147	0.04	1000.0	-1000.0	-0.029	-1000.0
Endothelins	8.0	785.0	96.0	-0.173	0.044	1000.0	-1000.0	-0.057	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	765.0	93.0	-0.067	0.044	1000.0	-1000.0	-0.046	-1000.0
Noncanonical Wnt signaling pathway	7.0	192.0	26.0	-0.087	0.031	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	7.0	391.0	52.0	-0.097	0.031	1000.0	-1000.0	-0.023	-1000.0
IL12-mediated signaling events	6.0	550.0	87.0	-0.148	0.048	1000.0	-1000.0	-0.08	-1000.0
Syndecan-1-mediated signaling events	6.0	215.0	34.0	-0.075	0.031	1000.0	-1000.0	-0.032	-1000.0
Ephrin A  reverse signaling	6.0	46.0	7.0	-0.009	0.026	1000.0	-1000.0	-0.003	-1000.0
Thromboxane A2 receptor signaling	6.0	643.0	105.0	-0.164	0.043	1000.0	-1000.0	-0.039	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	641.0	97.0	-0.099	0.056	1000.0	-1000.0	-0.063	-1000.0
Glucocorticoid receptor regulatory network	6.0	779.0	114.0	-0.419	0.159	1000.0	-1000.0	-0.055	-1000.0
TCGA08_p53	6.0	45.0	7.0	-0.058	0.04	1000.0	-1000.0	-0.01	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	190.0	31.0	-0.163	0.031	1000.0	-1000.0	-0.042	-1000.0
Insulin Pathway	6.0	460.0	74.0	-0.187	0.073	1000.0	-1000.0	-0.043	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.009	-1000.0
Visual signal transduction: Cones	5.0	212.0	38.0	-0.052	0.042	1000.0	-1000.0	-0.009	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	295.0	54.0	-0.111	0.045	1000.0	-1000.0	-0.04	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.062	0.031	1000.0	-1000.0	-0.041	-1000.0
Syndecan-2-mediated signaling events	5.0	362.0	69.0	-0.055	0.051	1000.0	-1000.0	-0.036	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	26.0	5.0	-0.01	0.022	1000.0	-1000.0	0.013	-1000.0
Arf6 signaling events	5.0	340.0	62.0	-0.164	0.068	1000.0	-1000.0	-0.025	-1000.0
BMP receptor signaling	5.0	436.0	81.0	-0.115	0.063	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	5.0	277.0	53.0	-0.189	0.045	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	247.0	44.0	-0.061	0.032	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	5.0	481.0	84.0	-0.094	0.062	1000.0	-1000.0	-0.038	-1000.0
Effects of Botulinum toxin	5.0	141.0	26.0	-0.057	0.029	1000.0	-1000.0	-0.007	-1000.0
LPA receptor mediated events	5.0	548.0	102.0	-0.101	0.036	1000.0	-1000.0	-0.07	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	346.0	68.0	-0.206	0.074	1000.0	-1000.0	-0.086	-1000.0
Syndecan-4-mediated signaling events	5.0	368.0	67.0	-0.091	0.043	1000.0	-1000.0	-0.038	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	657.0	120.0	-0.132	0.076	1000.0	-1000.0	-0.043	-1000.0
Coregulation of Androgen receptor activity	4.0	348.0	76.0	-0.26	0.08	1000.0	-1000.0	-0.037	-1000.0
Cellular roles of Anthrax toxin	4.0	161.0	39.0	-0.036	0.032	1000.0	-1000.0	-0.022	-1000.0
Ceramide signaling pathway	4.0	342.0	76.0	-0.164	0.084	1000.0	-1000.0	-0.034	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	181.0	37.0	-0.078	0.052	1000.0	-1000.0	-0.033	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	243.0	52.0	-0.088	0.075	1000.0	-1000.0	-0.045	-1000.0
Nongenotropic Androgen signaling	4.0	240.0	52.0	-0.052	0.052	1000.0	-1000.0	-0.033	-1000.0
IL27-mediated signaling events	4.0	225.0	51.0	-0.092	0.051	1000.0	-1000.0	-0.043	-1000.0
IGF1 pathway	4.0	249.0	57.0	-0.088	0.055	1000.0	-1000.0	-0.04	-1000.0
Plasma membrane estrogen receptor signaling	4.0	370.0	86.0	-0.089	0.057	1000.0	-1000.0	-0.055	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	390.0	88.0	-0.081	0.043	1000.0	-1000.0	-0.082	-1000.0
FOXM1 transcription factor network	4.0	224.0	51.0	-0.076	0.064	1000.0	-1000.0	-0.143	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	77.0	17.0	-0.045	0.052	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	3.0	44.0	12.0	-0.028	0.011	1000.0	-1000.0	-0.017	-1000.0
ErbB4 signaling events	3.0	246.0	69.0	-0.108	0.078	1000.0	-1000.0	-0.037	-1000.0
Osteopontin-mediated events	3.0	129.0	38.0	-0.056	0.034	1000.0	-1000.0	-0.051	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	183.0	61.0	-0.08	0.079	1000.0	-1000.0	-0.041	-1000.0
IL1-mediated signaling events	3.0	231.0	62.0	-0.043	0.077	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	319.0	82.0	-0.027	0.032	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	3.0	157.0	43.0	-0.034	0.053	1000.0	-1000.0	-0.058	-1000.0
Ephrin B reverse signaling	3.0	186.0	48.0	-0.045	0.036	1000.0	-1000.0	-0.029	-1000.0
S1P1 pathway	3.0	136.0	36.0	-0.062	0.032	1000.0	-1000.0	-0.05	-1000.0
Retinoic acid receptors-mediated signaling	3.0	213.0	58.0	-0.081	0.063	1000.0	-1000.0	-0.033	-1000.0
Canonical Wnt signaling pathway	3.0	199.0	51.0	-0.08	0.14	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	3.0	206.0	54.0	-0.126	0.065	1000.0	-1000.0	-0.044	-1000.0
Rapid glucocorticoid signaling	3.0	75.0	20.0	-0.083	0.03	1000.0	-1000.0	-0.005	-1000.0
Regulation of Androgen receptor activity	3.0	257.0	70.0	-0.307	0.037	1000.0	-1000.0	-0.054	-1000.0
ErbB2/ErbB3 signaling events	2.0	157.0	65.0	-0.05	0.046	1000.0	-1000.0	-0.048	-1000.0
Caspase cascade in apoptosis	2.0	210.0	74.0	-0.063	0.065	1000.0	-1000.0	-0.042	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	397.0	136.0	-0.184	0.096	1000.0	-1000.0	-0.043	-1000.0
BARD1 signaling events	2.0	134.0	57.0	-0.042	0.062	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	196.0	85.0	-0.028	0.061	1000.0	-1000.0	-0.045	-1000.0
EPO signaling pathway	2.0	156.0	55.0	-0.033	0.041	1000.0	-1000.0	-0.04	-1000.0
PDGFR-alpha signaling pathway	2.0	94.0	44.0	-0.018	0.062	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	2.0	147.0	63.0	-0.006	0.074	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by HDAC Class III	2.0	81.0	40.0	-0.055	0.056	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	2.0	36.0	17.0	-0.011	0.032	1000.0	-1000.0	-0.017	-1000.0
ceramide signaling pathway	2.0	146.0	49.0	-0.009	0.045	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	173.0	83.0	-0.076	0.064	1000.0	-1000.0	-0.034	-1000.0
FoxO family signaling	2.0	149.0	64.0	-0.191	0.062	1000.0	-1000.0	-0.057	-1000.0
FAS signaling pathway (CD95)	2.0	134.0	47.0	-0.151	0.049	1000.0	-1000.0	-0.046	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	103.0	36.0	-0.042	0.05	1000.0	-1000.0	-0.043	-1000.0
Syndecan-3-mediated signaling events	2.0	90.0	35.0	-0.041	0.078	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by PI3K	2.0	162.0	58.0	-0.055	0.056	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	125.0	45.0	-0.033	0.077	1000.0	-1000.0	-0.048	-1000.0
EPHB forward signaling	2.0	227.0	85.0	-0.06	0.106	1000.0	-1000.0	-0.055	-1000.0
Glypican 2 network	2.0	9.0	4.0	0.014	0.032	1000.0	-1000.0	0.01	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	282.0	125.0	-0.022	0.068	1000.0	-1000.0	-0.043	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	149.0	74.0	-0.164	0.076	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by STAT5	2.0	55.0	22.0	-0.053	0.032	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events	2.0	198.0	73.0	-0.126	0.057	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	2.0	284.0	102.0	-0.167	0.074	1000.0	-1000.0	-0.067	-1000.0
PDGFR-beta signaling pathway	2.0	202.0	97.0	-0.111	0.072	1000.0	-1000.0	-0.043	-1000.0
S1P4 pathway	2.0	59.0	25.0	-0.001	0.04	1000.0	-1000.0	-0.027	-1000.0
Aurora B signaling	2.0	197.0	67.0	-0.125	0.062	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class II	1.0	85.0	75.0	-0.034	0.08	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	45.0	28.0	-0.0	0.056	1000.0	-1000.0	-0.024	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	114.0	65.0	-0.004	0.074	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	1.0	9.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.009	-1000.0
PLK1 signaling events	1.0	141.0	85.0	-0.009	0.06	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	1.0	133.0	68.0	-0.063	0.045	1000.0	-1000.0	-0.055	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	15.0	15.0	-0.001	0.031	1000.0	-1000.0	-0.026	-1000.0
TCGA08_rtk_signaling	1.0	30.0	26.0	-0.038	0.069	1000.0	-1000.0	-0.016	-1000.0
Arf6 trafficking events	1.0	101.0	71.0	-0.146	0.057	1000.0	-1000.0	-0.029	-1000.0
S1P3 pathway	1.0	80.0	42.0	-0.012	0.048	1000.0	-1000.0	-0.039	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	57.0	33.0	-0.075	0.074	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by PRL	1.0	36.0	34.0	-0.026	0.046	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	114.0	78.0	-0.049	0.051	1000.0	-1000.0	-0.063	-1000.0
p38 MAPK signaling pathway	1.0	85.0	44.0	-0.063	0.059	1000.0	-1000.0	-0.027	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	14.0	23.0	0.007	0.056	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	0.0	30.0	39.0	-0.008	0.07	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.015	0.032	1000.0	-1000.0	-0.013	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.009	0.065	1000.0	-1000.0	-0.039	-1000.0
Aurora A signaling	0.0	56.0	60.0	-0.006	0.063	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	0.0	41.0	43.0	-0.04	0.055	1000.0	-1000.0	-0.027	-1000.0
Insulin-mediated glucose transport	0.0	29.0	32.0	-0.006	0.052	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	49.0	68.0	-0.043	0.058	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	0.0	14.0	48.0	-0.0	0.076	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	0.0	103.0	104.0	-0.055	0.074	1000.0	-1000.0	-0.036	-1000.0
Atypical NF-kappaB pathway	0.0	17.0	31.0	-0.0	0.042	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	46.0	76.0	-0.014	0.077	1000.0	-1000.0	-0.059	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.065	1000.0	-1000.0	-0.029	-1000.0
VEGFR1 specific signals	0.0	39.0	56.0	-0.014	0.08	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in keratinocytes	0.0	25.0	43.0	-0.028	0.061	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.031	0.061	1000.0	-1000.0	0.012	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.0	0.054	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.083	1000.0	-1000.0	0.0	-1000.0
Total	501	32805	7203	-12.2954920636	7.73225201798	131000	-131000	-5.16550584248	-131000