Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.03 0.172 -9999.0 0.0 -0.56 14.0 14.0 IHH 0.011 0.064 -9999.0 0.0 -0.223 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.003 0.063 -9999.0 0.0 -0.198 11.0 11.0 LRPAP1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.003 0.063 0.197 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 0.003 0.136 -9999.0 0.0 -0.517 6.0 6.0 SMO -0.018 0.131 -9999.0 0.0 -0.544 6.0 6.0 AKT1 -0.008 0.129 -9999.0 0.0 -0.48 7.0 7.0 ARRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.018 -9999.0 0.0 -0.165 1.0 1.0 ADRBK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.133 -9999.0 0.0 -0.535 6.0 6.0 STIL -0.002 0.11 0.294 1.0 -0.361 4.0 5.0 DHH N/PTCH2 0.01 0.097 -9999.0 0.0 -0.338 10.0 10.0 DHH N/PTCH1 -0.001 0.122 -9999.0 0.0 -0.326 17.0 17.0 PIK3CA 0.023 0.039 -9999.0 0.0 -0.46 1.0 1.0 DHH 0.013 0.08 -9999.0 0.0 -0.334 7.0 7.0 PTHLH -0.046 0.228 -9999.0 0.0 -0.742 14.0 14.0 determination of left/right symmetry -0.01 0.133 -9999.0 0.0 -0.535 6.0 6.0 PIK3R1 0.025 0.039 -9999.0 0.0 -0.46 1.0 1.0 skeletal system development -0.045 0.226 -9999.0 0.0 -0.734 14.0 14.0 IHH N/Hhip 0.01 0.07 -9999.0 0.0 -0.186 4.0 4.0 DHH N/Hhip 0.004 0.079 -9999.0 0.0 -0.331 4.0 4.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.133 -9999.0 0.0 -0.535 6.0 6.0 pancreas development -0.004 0.071 -9999.0 0.0 -0.164 26.0 26.0 HHAT 0.018 0.067 -9999.0 0.0 -0.46 3.0 3.0 PI3K 0.033 0.044 -9999.0 0.0 -0.33 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.093 -9999.0 0.0 -0.288 12.0 12.0 somite specification -0.01 0.133 -9999.0 0.0 -0.535 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.018 0.094 -9999.0 0.0 -0.276 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.004 0.065 0.162 1.0 -0.264 6.0 7.0 SHH Np/Cholesterol/Megalin 0.002 0.045 -9999.0 0.0 -0.252 1.0 1.0 SHH -0.016 0.051 0.227 2.0 -0.33 1.0 3.0 catabolic process -0.01 0.116 -9999.0 0.0 -0.345 15.0 15.0 SMO/Vitamin D3 -0.006 0.125 -9999.0 0.0 -0.428 6.0 6.0 SHH Np/Cholesterol/Hhip -0.001 0.063 0.173 4.0 -0.158 13.0 17.0 LRP2 0.017 0.036 -9999.0 0.0 -0.165 6.0 6.0 receptor-mediated endocytosis -0.012 0.118 -9999.0 0.0 -0.425 6.0 6.0 SHH Np/Cholesterol/BOC 0.005 0.041 -9999.0 0.0 -0.252 1.0 1.0 SHH Np/Cholesterol/CDO 0.007 0.04 -9999.0 0.0 -0.236 1.0 1.0 mesenchymal cell differentiation 0.001 0.063 0.158 13.0 -0.171 4.0 17.0 mol:Vitamin D3 0.003 0.118 -9999.0 0.0 -0.334 6.0 6.0 IHH N/PTCH2 0.016 0.087 -9999.0 0.0 -0.342 7.0 7.0 CDON 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.002 0.12 -9999.0 0.0 -0.347 15.0 15.0 Megalin/LRPAP1 0.033 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.004 0.096 -9999.0 0.0 -0.362 9.0 9.0 SHH Np/Cholesterol -0.001 0.036 -9999.0 0.0 -0.251 1.0 1.0 PTCH1 -0.01 0.116 -9999.0 0.0 -0.346 15.0 15.0 HHIP -0.004 0.071 -9999.0 0.0 -0.165 26.0 26.0