Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	41.0	291.0	7.0	-0.166	0.019	1000.0	-1000.0	-0.0	-1000.0
IL23-mediated signaling events	29.0	1768.0	60.0	-0.52	0.028	1000.0	-1000.0	-0.08	-1000.0
Signaling mediated by p38-alpha and p38-beta	26.0	1162.0	44.0	-0.152	0.027	1000.0	-1000.0	-0.016	-1000.0
Reelin signaling pathway	23.0	1291.0	56.0	-0.156	0.056	1000.0	-1000.0	-0.026	-1000.0
Signaling events regulated by Ret tyrosine kinase	22.0	1870.0	82.0	-0.122	0.029	1000.0	-1000.0	-0.049	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	21.0	716.0	34.0	-0.073	0.029	1000.0	-1000.0	-0.019	-1000.0
Wnt signaling	21.0	150.0	7.0	-0.061	-0.003	1000.0	-1000.0	-0.007	-1000.0
IL12-mediated signaling events	20.0	1792.0	87.0	-0.352	0.047	1000.0	-1000.0	-0.051	-1000.0
IL4-mediated signaling events	20.0	1821.0	91.0	-0.557	0.413	1000.0	-1000.0	-0.088	-1000.0
Noncanonical Wnt signaling pathway	18.0	479.0	26.0	-0.099	0.028	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	18.0	1443.0	76.0	-0.211	0.042	1000.0	-1000.0	-0.053	-1000.0
Endothelins	18.0	1760.0	96.0	-0.153	0.045	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	18.0	1586.0	85.0	-0.105	0.068	1000.0	-1000.0	-0.045	-1000.0
PDGFR-alpha signaling pathway	17.0	774.0	44.0	-0.162	0.037	1000.0	-1000.0	-0.032	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1215.0	68.0	-0.263	0.13	1000.0	-1000.0	-0.074	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	16.0	853.0	52.0	-0.107	0.049	1000.0	-1000.0	-0.022	-1000.0
Syndecan-3-mediated signaling events	16.0	593.0	35.0	-0.123	0.071	1000.0	-1000.0	-0.024	-1000.0
Glypican 2 network	16.0	64.0	4.0	-0.023	0.007	1000.0	-1000.0	0.014	-1000.0
ErbB2/ErbB3 signaling events	15.0	1029.0	65.0	-0.154	0.041	1000.0	-1000.0	-0.047	-1000.0
Syndecan-1-mediated signaling events	15.0	543.0	34.0	-0.094	0.028	1000.0	-1000.0	-0.029	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1457.0	93.0	-0.095	0.041	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Rods	15.0	799.0	52.0	-0.163	0.031	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	14.0	549.0	38.0	-0.114	0.03	1000.0	-1000.0	-0.008	-1000.0
Arf6 signaling events	14.0	887.0	62.0	-0.096	0.05	1000.0	-1000.0	-0.042	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	424.0	31.0	-0.133	0.029	1000.0	-1000.0	-0.028	-1000.0
Syndecan-4-mediated signaling events	13.0	873.0	67.0	-0.075	0.031	1000.0	-1000.0	-0.031	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1563.0	120.0	-0.155	0.084	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	12.0	660.0	54.0	-0.156	0.038	1000.0	-1000.0	-0.034	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1258.0	97.0	-0.065	0.039	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	12.0	1387.0	114.0	-0.261	0.217	1000.0	-1000.0	-0.042	-1000.0
IL6-mediated signaling events	12.0	946.0	75.0	-0.162	0.044	1000.0	-1000.0	-0.044	-1000.0
Thromboxane A2 receptor signaling	11.0	1197.0	105.0	-0.04	0.036	1000.0	-1000.0	-0.032	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	544.0	46.0	-0.252	0.029	1000.0	-1000.0	-0.071	-1000.0
amb2 Integrin signaling	11.0	956.0	82.0	-0.128	0.032	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	11.0	709.0	62.0	-0.083	0.06	1000.0	-1000.0	-0.029	-1000.0
FOXM1 transcription factor network	11.0	573.0	51.0	-0.118	0.057	1000.0	-1000.0	-0.083	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	192.0	17.0	-0.041	0.043	1000.0	-1000.0	-0.014	-1000.0
Osteopontin-mediated events	10.0	386.0	38.0	-0.06	0.031	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	10.0	865.0	81.0	-0.075	0.055	1000.0	-1000.0	-0.027	-1000.0
Signaling mediated by p38-gamma and p38-delta	10.0	158.0	15.0	-0.038	0.029	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	10.0	529.0	52.0	-0.097	0.051	1000.0	-1000.0	-0.022	-1000.0
Angiopoietin receptor Tie2-mediated signaling	10.0	913.0	88.0	-0.124	0.031	1000.0	-1000.0	-0.065	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	158.0	17.0	-0.037	0.041	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PTP1B	9.0	749.0	76.0	-0.114	0.031	1000.0	-1000.0	-0.028	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	605.0	61.0	-0.088	0.071	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	9.0	1009.0	102.0	-0.104	0.031	1000.0	-1000.0	-0.063	-1000.0
BCR signaling pathway	9.0	952.0	99.0	-0.063	0.048	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	9.0	27.0	3.0	-0.005	0.005	1000.0	-1000.0	-0.014	-1000.0
Regulation of Androgen receptor activity	9.0	641.0	70.0	-0.165	0.033	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	8.0	348.0	43.0	-0.094	0.051	1000.0	-1000.0	-0.04	-1000.0
Integrins in angiogenesis	8.0	742.0	84.0	-0.06	0.061	1000.0	-1000.0	-0.041	-1000.0
Canonical Wnt signaling pathway	8.0	433.0	51.0	-0.088	0.068	1000.0	-1000.0	-0.035	-1000.0
Aurora B signaling	8.0	598.0	67.0	-0.171	0.049	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	7.0	551.0	74.0	-0.046	0.062	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by the Hedgehog family	7.0	375.0	52.0	-0.046	0.033	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	607.0	85.0	-0.169	0.042	1000.0	-1000.0	-0.041	-1000.0
p75(NTR)-mediated signaling	7.0	991.0	125.0	-0.061	0.071	1000.0	-1000.0	-0.041	-1000.0
Ephrin B reverse signaling	7.0	350.0	48.0	-0.029	0.033	1000.0	-1000.0	-0.016	-1000.0
FAS signaling pathway (CD95)	7.0	354.0	47.0	-0.166	0.044	1000.0	-1000.0	-0.046	-1000.0
IL2 signaling events mediated by PI3K	7.0	427.0	58.0	-0.069	0.041	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by STAT5	7.0	160.0	22.0	-0.056	0.029	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	7.0	160.0	21.0	-0.04	0.041	1000.0	-1000.0	-0.035	-1000.0
Insulin Pathway	7.0	547.0	74.0	-0.066	0.06	1000.0	-1000.0	-0.032	-1000.0
Plasma membrane estrogen receptor signaling	7.0	682.0	86.0	-0.071	0.064	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	581.0	78.0	-0.06	0.032	1000.0	-1000.0	-0.039	-1000.0
LPA4-mediated signaling events	6.0	82.0	12.0	-0.033	0.002	1000.0	-1000.0	-0.016	-1000.0
Coregulation of Androgen receptor activity	6.0	492.0	76.0	-0.164	0.069	1000.0	-1000.0	-0.015	-1000.0
ErbB4 signaling events	6.0	472.0	69.0	-0.128	0.049	1000.0	-1000.0	-0.026	-1000.0
Cellular roles of Anthrax toxin	6.0	265.0	39.0	-0.065	0.025	1000.0	-1000.0	-0.015	-1000.0
Glypican 1 network	6.0	303.0	48.0	-0.059	0.042	1000.0	-1000.0	-0.028	-1000.0
Nectin adhesion pathway	6.0	433.0	63.0	-0.037	0.067	1000.0	-1000.0	-0.037	-1000.0
Ceramide signaling pathway	6.0	530.0	76.0	-0.046	0.049	1000.0	-1000.0	-0.025	-1000.0
S1P1 pathway	6.0	244.0	36.0	-0.087	0.029	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	6.0	391.0	58.0	-0.063	0.055	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	6.0	318.0	51.0	-0.085	0.028	1000.0	-1000.0	-0.056	-1000.0
TCGA08_rtk_signaling	6.0	176.0	26.0	-0.084	0.055	1000.0	-1000.0	-0.008	-1000.0
S1P3 pathway	6.0	253.0	42.0	-0.02	0.044	1000.0	-1000.0	-0.032	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	710.0	136.0	-0.136	0.134	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	150.0	28.0	-0.02	0.051	1000.0	-1000.0	-0.014	-1000.0
Syndecan-2-mediated signaling events	5.0	375.0	69.0	-0.065	0.042	1000.0	-1000.0	-0.024	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	0.005	0.032	1000.0	-1000.0	0.014	-1000.0
Aurora C signaling	5.0	38.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.013	-1000.0
PLK1 signaling events	5.0	446.0	85.0	-0.029	0.048	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	5.0	292.0	49.0	-0.025	0.041	1000.0	-1000.0	-0.033	-1000.0
Regulation of p38-alpha and p38-beta	5.0	314.0	54.0	-0.062	0.063	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	725.0	125.0	-0.051	0.054	1000.0	-1000.0	-0.032	-1000.0
TCGA08_retinoblastoma	5.0	45.0	8.0	-0.005	0.028	1000.0	-1000.0	-0.002	-1000.0
Rapid glucocorticoid signaling	5.0	116.0	20.0	-0.086	0.027	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in keratinocytes	5.0	249.0	43.0	-0.04	0.032	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	5.0	148.0	25.0	-0.011	0.037	1000.0	-1000.0	-0.015	-1000.0
Circadian rhythm pathway	4.0	103.0	22.0	-0.075	0.032	1000.0	-1000.0	-0.028	-1000.0
EPO signaling pathway	4.0	262.0	55.0	-0.039	0.069	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	4.0	291.0	68.0	-0.076	0.068	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	162.0	37.0	-0.035	0.063	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	4.0	223.0	48.0	-0.005	0.061	1000.0	-1000.0	-0.023	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	224.0	45.0	-0.03	0.074	1000.0	-1000.0	-0.043	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	142.0	33.0	-0.091	0.07	1000.0	-1000.0	-0.032	-1000.0
PDGFR-beta signaling pathway	4.0	456.0	97.0	-0.076	0.073	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PRL	4.0	139.0	34.0	-0.026	0.037	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	4.0	24.0	5.0	0.001	0.052	1000.0	-1000.0	0.013	-1000.0
Canonical NF-kappaB pathway	3.0	121.0	39.0	-0.031	0.063	1000.0	-1000.0	-0.017	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	214.0	65.0	-0.021	0.067	1000.0	-1000.0	-0.046	-1000.0
Arf6 downstream pathway	3.0	147.0	43.0	-0.035	0.047	1000.0	-1000.0	-0.022	-1000.0
Insulin-mediated glucose transport	3.0	109.0	32.0	-0.051	0.053	1000.0	-1000.0	-0.021	-1000.0
mTOR signaling pathway	3.0	187.0	53.0	-0.029	0.039	1000.0	-1000.0	-0.029	-1000.0
S1P5 pathway	3.0	66.0	17.0	-0.005	0.027	1000.0	-1000.0	-0.007	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	315.0	83.0	-0.037	0.056	1000.0	-1000.0	-0.027	-1000.0
TCGA08_p53	3.0	25.0	7.0	-0.004	0.027	1000.0	-1000.0	-0.01	-1000.0
FoxO family signaling	3.0	224.0	64.0	-0.04	0.078	1000.0	-1000.0	-0.05	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	281.0	74.0	-0.057	0.062	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events	3.0	288.0	73.0	-0.071	0.056	1000.0	-1000.0	-0.031	-1000.0
IGF1 pathway	3.0	218.0	57.0	-0.014	0.054	1000.0	-1000.0	-0.026	-1000.0
VEGFR1 specific signals	3.0	220.0	56.0	-0.037	0.054	1000.0	-1000.0	-0.038	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	46.0	23.0	-0.014	0.056	1000.0	-1000.0	-0.02	-1000.0
BARD1 signaling events	2.0	170.0	57.0	-0.047	0.061	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	137.0	68.0	-0.03	0.056	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class III	2.0	90.0	40.0	-0.05	0.051	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class I	2.0	276.0	104.0	-0.05	0.067	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	100.0	36.0	-0.052	0.056	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	2.0	91.0	31.0	-0.0	0.033	1000.0	-1000.0	-0.014	-1000.0
Effects of Botulinum toxin	2.0	77.0	26.0	-0.0	0.034	1000.0	-1000.0	-0.003	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	158.0	76.0	-0.014	0.067	1000.0	-1000.0	-0.047	-1000.0
Regulation of Telomerase	2.0	237.0	102.0	-0.04	0.072	1000.0	-1000.0	-0.042	-1000.0
p38 MAPK signaling pathway	2.0	121.0	44.0	-0.055	0.049	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class II	1.0	91.0	75.0	-0.036	0.078	1000.0	-1000.0	-0.02	-1000.0
PLK2 and PLK4 events	1.0	3.0	3.0	0.013	0.029	1000.0	-1000.0	-0.015	-1000.0
Aurora A signaling	1.0	94.0	60.0	-0.002	0.054	1000.0	-1000.0	-0.012	-1000.0
Arf6 trafficking events	1.0	129.0	71.0	-0.052	0.053	1000.0	-1000.0	-0.026	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	13.0	27.0	-0.0	0.069	1000.0	-1000.0	-0.023	-1000.0
Arf1 pathway	0.0	34.0	54.0	-0.0	0.048	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.076	1000.0	-1000.0	-0.0	-1000.0
Total	1089	64978	7203	-10.7597205744	6.74502573556	131000	-131000	-3.9249679641	-131000