Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.068 0.251 -9999.0 0.0 -0.65 22.0 22.0 IHH -0.023 0.127 -9999.0 0.0 -0.531 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.048 0.147 -9999.0 0.0 -0.415 18.0 18.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.048 0.146 0.412 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.04 0.17 -9999.0 0.0 -0.62 7.0 7.0 SMO -0.051 0.179 -9999.0 0.0 -0.629 8.0 8.0 AKT1 -0.005 0.105 -9999.0 0.0 -0.864 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.037 -9999.0 0.0 -0.488 1.0 1.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.05 0.176 -9999.0 0.0 -0.618 8.0 8.0 STIL -0.049 0.161 -9999.0 0.0 -0.565 8.0 8.0 DHH N/PTCH2 -0.029 0.151 -9999.0 0.0 -0.452 19.0 19.0 DHH N/PTCH1 -0.038 0.171 -9999.0 0.0 -0.544 10.0 10.0 PIK3CA 0.011 0.049 -9999.0 0.0 -0.642 1.0 1.0 DHH -0.012 0.125 -9999.0 0.0 -0.584 8.0 8.0 PTHLH -0.104 0.326 -9999.0 0.0 -0.86 21.0 21.0 determination of left/right symmetry -0.05 0.176 -9999.0 0.0 -0.618 8.0 8.0 PIK3R1 0.011 0.049 -9999.0 0.0 -0.642 1.0 1.0 skeletal system development -0.102 0.322 -9999.0 0.0 -0.848 21.0 21.0 IHH N/Hhip -0.063 0.17 -9999.0 0.0 -0.407 33.0 33.0 DHH N/Hhip -0.058 0.155 -9999.0 0.0 -0.359 37.0 37.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.05 0.176 -9999.0 0.0 -0.618 8.0 8.0 pancreas development -0.068 0.184 -9999.0 0.0 -0.488 29.0 29.0 HHAT -0.008 0.118 -9999.0 0.0 -0.642 6.0 6.0 PI3K 0.016 0.052 -9999.0 0.0 -0.471 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.027 0.15 -9999.0 0.0 -0.559 13.0 13.0 somite specification -0.05 0.176 -9999.0 0.0 -0.618 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.058 0.165 -9999.0 0.0 -0.602 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.049 0.149 -9999.0 0.0 -0.45 14.0 14.0 SHH Np/Cholesterol/Megalin -0.043 0.121 -9999.0 0.0 -0.315 21.0 21.0 SHH -0.043 0.14 -9999.0 0.0 -0.372 27.0 27.0 catabolic process -0.034 0.172 -9999.0 0.0 -0.543 9.0 9.0 SMO/Vitamin D3 -0.064 0.175 -9999.0 0.0 -0.533 12.0 12.0 SHH Np/Cholesterol/Hhip -0.07 0.165 -9999.0 0.0 -0.416 25.0 25.0 LRP2 -0.009 0.089 -9999.0 0.0 -0.488 6.0 6.0 receptor-mediated endocytosis -0.072 0.163 -9999.0 0.0 -0.567 8.0 8.0 SHH Np/Cholesterol/BOC -0.026 0.109 -9999.0 0.0 -0.367 6.0 6.0 SHH Np/Cholesterol/CDO -0.025 0.108 -9999.0 0.0 -0.367 6.0 6.0 mesenchymal cell differentiation 0.07 0.164 0.413 25.0 -9999.0 0.0 25.0 mol:Vitamin D3 -0.056 0.167 -9999.0 0.0 -0.604 7.0 7.0 IHH N/PTCH2 -0.033 0.146 -9999.0 0.0 -0.439 18.0 18.0 CDON 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.034 0.173 -9999.0 0.0 -0.549 9.0 9.0 Megalin/LRPAP1 0.004 0.064 -9999.0 0.0 -0.341 6.0 6.0 PTCH2 -0.028 0.153 -9999.0 0.0 -0.571 13.0 13.0 SHH Np/Cholesterol -0.037 0.107 -9999.0 0.0 -0.286 27.0 27.0 PTCH1 -0.034 0.172 -9999.0 0.0 -0.546 9.0 9.0 HHIP -0.069 0.185 -9999.0 0.0 -0.488 29.0 29.0