Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	72.0	505.0	7.0	-0.341	0.003	1000.0	-1000.0	-0.029	-1000.0
IL23-mediated signaling events	40.0	2449.0	60.0	-0.694	0.014	1000.0	-1000.0	-0.15	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	36.0	1247.0	34.0	-0.202	0.014	1000.0	-1000.0	-0.052	-1000.0
PDGFR-alpha signaling pathway	30.0	1362.0	44.0	-0.22	0.029	1000.0	-1000.0	-0.047	-1000.0
HIF-1-alpha transcription factor network	28.0	2172.0	76.0	-0.453	0.023	1000.0	-1000.0	-0.114	-1000.0
IL12-mediated signaling events	27.0	2362.0	87.0	-0.453	0.072	1000.0	-1000.0	-0.114	-1000.0
IL4-mediated signaling events	27.0	2499.0	91.0	-0.683	0.533	1000.0	-1000.0	-0.129	-1000.0
Wnt signaling	26.0	183.0	7.0	-0.126	-0.035	1000.0	-1000.0	-0.024	-1000.0
Glypican 2 network	25.0	101.0	4.0	-0.069	-0.021	1000.0	-1000.0	-0.024	-1000.0
Endothelins	24.0	2312.0	96.0	-0.198	0.015	1000.0	-1000.0	-0.074	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	24.0	1686.0	68.0	-0.427	0.192	1000.0	-1000.0	-0.113	-1000.0
Signaling events regulated by Ret tyrosine kinase	23.0	1919.0	82.0	-0.273	0.014	1000.0	-1000.0	-0.085	-1000.0
Reelin signaling pathway	22.0	1274.0	56.0	-0.312	0.024	1000.0	-1000.0	-0.074	-1000.0
Signaling mediated by p38-alpha and p38-beta	22.0	1010.0	44.0	-0.22	0.014	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Cones	21.0	830.0	38.0	-0.214	0.011	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	21.0	564.0	26.0	-0.157	0.014	1000.0	-1000.0	-0.055	-1000.0
Arf6 signaling events	21.0	1322.0	62.0	-0.188	0.014	1000.0	-1000.0	-0.062	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	20.0	1076.0	52.0	-0.219	0.039	1000.0	-1000.0	-0.048	-1000.0
Syndecan-3-mediated signaling events	20.0	703.0	35.0	-0.237	0.043	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	20.0	1500.0	75.0	-0.247	0.052	1000.0	-1000.0	-0.078	-1000.0
Syndecan-1-mediated signaling events	19.0	675.0	34.0	-0.202	0.014	1000.0	-1000.0	-0.049	-1000.0
Calcium signaling in the CD4+ TCR pathway	18.0	587.0	31.0	-0.218	0.014	1000.0	-1000.0	-0.085	-1000.0
Osteopontin-mediated events	17.0	657.0	38.0	-0.129	0.018	1000.0	-1000.0	-0.097	-1000.0
Glucocorticoid receptor regulatory network	17.0	2018.0	114.0	-0.404	0.336	1000.0	-1000.0	-0.063	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1636.0	93.0	-0.186	0.033	1000.0	-1000.0	-0.078	-1000.0
Visual signal transduction: Rods	17.0	895.0	52.0	-0.316	0.014	1000.0	-1000.0	-0.074	-1000.0
E-cadherin signaling events	17.0	85.0	5.0	-0.062	0.011	1000.0	-1000.0	-0.018	-1000.0
EPHB forward signaling	16.0	1363.0	85.0	-0.185	0.122	1000.0	-1000.0	-0.084	-1000.0
BMP receptor signaling	15.0	1258.0	81.0	-0.185	0.049	1000.0	-1000.0	-0.089	-1000.0
Syndecan-4-mediated signaling events	15.0	1042.0	67.0	-0.115	0.014	1000.0	-1000.0	-0.092	-1000.0
amb2 Integrin signaling	14.0	1229.0	82.0	-0.234	0.018	1000.0	-1000.0	-0.075	-1000.0
HIF-2-alpha transcription factor network	14.0	632.0	43.0	-0.204	0.135	1000.0	-1000.0	-0.085	-1000.0
Integrins in angiogenesis	14.0	1204.0	84.0	-0.132	0.031	1000.0	-1000.0	-0.085	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1787.0	120.0	-0.222	0.15	1000.0	-1000.0	-0.075	-1000.0
Class IB PI3K non-lipid kinase events	14.0	42.0	3.0	-0.034	-1000.0	1000.0	-1000.0	-0.009	-1000.0
Thromboxane A2 receptor signaling	13.0	1406.0	105.0	-0.132	0.04	1000.0	-1000.0	-0.067	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	618.0	46.0	-0.31	0.015	1000.0	-1000.0	-0.062	-1000.0
IL1-mediated signaling events	13.0	839.0	62.0	-0.201	0.066	1000.0	-1000.0	-0.097	-1000.0
EGFR-dependent Endothelin signaling events	13.0	273.0	21.0	-0.132	0.021	1000.0	-1000.0	-0.068	-1000.0
ErbB2/ErbB3 signaling events	12.0	828.0	65.0	-0.282	0.021	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by PTP1B	12.0	970.0	76.0	-0.192	0.036	1000.0	-1000.0	-0.074	-1000.0
BCR signaling pathway	12.0	1277.0	99.0	-0.168	0.026	1000.0	-1000.0	-0.079	-1000.0
Angiopoietin receptor Tie2-mediated signaling	12.0	1068.0	88.0	-0.169	0.019	1000.0	-1000.0	-0.096	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	594.0	54.0	-0.312	0.029	1000.0	-1000.0	-0.09	-1000.0
Signaling events mediated by the Hedgehog family	11.0	609.0	52.0	-0.104	0.07	1000.0	-1000.0	-0.059	-1000.0
Presenilin action in Notch and Wnt signaling	11.0	728.0	61.0	-0.193	0.059	1000.0	-1000.0	-0.075	-1000.0
Glypican 1 network	11.0	541.0	48.0	-0.134	0.021	1000.0	-1000.0	-0.05	-1000.0
Nongenotropic Androgen signaling	11.0	615.0	52.0	-0.087	0.031	1000.0	-1000.0	-0.057	-1000.0
Rapid glucocorticoid signaling	11.0	220.0	20.0	-0.217	0.014	1000.0	-1000.0	-0.018	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	195.0	17.0	-0.122	0.025	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	10.0	128.0	12.0	-0.066	0.014	1000.0	-1000.0	-0.018	-1000.0
Caspase cascade in apoptosis	10.0	776.0	74.0	-0.102	0.024	1000.0	-1000.0	-0.037	-1000.0
JNK signaling in the CD4+ TCR pathway	10.0	185.0	17.0	-0.121	0.014	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	10.0	1259.0	125.0	-0.132	0.043	1000.0	-1000.0	-0.092	-1000.0
Signaling mediated by p38-gamma and p38-delta	10.0	163.0	15.0	-0.042	0.014	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	10.0	1062.0	102.0	-0.174	0.026	1000.0	-1000.0	-0.083	-1000.0
FOXM1 transcription factor network	10.0	511.0	51.0	-0.144	0.074	1000.0	-1000.0	-0.157	-1000.0
ErbB4 signaling events	9.0	657.0	69.0	-0.261	0.068	1000.0	-1000.0	-0.077	-1000.0
Syndecan-2-mediated signaling events	9.0	645.0	69.0	-0.161	0.035	1000.0	-1000.0	-0.044	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	-0.026	0.004	1000.0	-1000.0	-0.022	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	938.0	97.0	-0.18	0.039	1000.0	-1000.0	-0.081	-1000.0
Ephrin B reverse signaling	9.0	470.0	48.0	-0.1	0.034	1000.0	-1000.0	-0.065	-1000.0
Canonical Wnt signaling pathway	9.0	477.0	51.0	-0.193	0.09	1000.0	-1000.0	-0.067	-1000.0
Aurora B signaling	9.0	638.0	67.0	-0.206	0.017	1000.0	-1000.0	-0.075	-1000.0
Coregulation of Androgen receptor activity	8.0	662.0	76.0	-0.222	0.049	1000.0	-1000.0	-0.033	-1000.0
Nectin adhesion pathway	8.0	521.0	63.0	-0.076	0.026	1000.0	-1000.0	-0.069	-1000.0
TRAIL signaling pathway	8.0	397.0	48.0	-0.059	0.025	1000.0	-1000.0	-0.064	-1000.0
Retinoic acid receptors-mediated signaling	8.0	503.0	58.0	-0.154	0.03	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	8.0	1001.0	125.0	-0.117	0.037	1000.0	-1000.0	-0.087	-1000.0
IL27-mediated signaling events	8.0	422.0	51.0	-0.193	0.032	1000.0	-1000.0	-0.078	-1000.0
IL2 signaling events mediated by STAT5	8.0	180.0	22.0	-0.084	0.015	1000.0	-1000.0	-0.036	-1000.0
VEGFR1 specific signals	8.0	487.0	56.0	-0.099	0.014	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	678.0	78.0	-0.119	0.041	1000.0	-1000.0	-0.062	-1000.0
Regulation of Androgen receptor activity	8.0	622.0	70.0	-0.232	0.034	1000.0	-1000.0	-0.061	-1000.0
Cellular roles of Anthrax toxin	7.0	297.0	39.0	-0.088	0.017	1000.0	-1000.0	-0.022	-1000.0
FAS signaling pathway (CD95)	7.0	367.0	47.0	-0.247	0.03	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by PI3K	7.0	423.0	58.0	-0.087	0.03	1000.0	-1000.0	-0.083	-1000.0
TCGA08_rtk_signaling	7.0	182.0	26.0	-0.164	0.026	1000.0	-1000.0	-0.021	-1000.0
TCGA08_retinoblastoma	7.0	58.0	8.0	-0.014	0.017	1000.0	-1000.0	-0.016	-1000.0
Insulin Pathway	7.0	576.0	74.0	-0.146	0.028	1000.0	-1000.0	-0.091	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	892.0	136.0	-0.189	0.186	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	190.0	28.0	-0.099	0.023	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	516.0	85.0	-0.092	0.021	1000.0	-1000.0	-0.076	-1000.0
Aurora C signaling	6.0	48.0	7.0	-0.042	0.0	1000.0	-1000.0	-0.025	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	242.0	37.0	-0.129	0.024	1000.0	-1000.0	-0.053	-1000.0
S1P1 pathway	6.0	239.0	36.0	-0.098	0.014	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PRL	6.0	205.0	34.0	-0.053	0.021	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	5.0	127.0	22.0	-0.144	0.021	1000.0	-1000.0	-0.035	-1000.0
Plasma membrane estrogen receptor signaling	5.0	509.0	86.0	-0.099	0.033	1000.0	-1000.0	-0.073	-1000.0
S1P3 pathway	5.0	212.0	42.0	-0.099	0.035	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	180.0	33.0	-0.204	0.041	1000.0	-1000.0	-0.052	-1000.0
EPO signaling pathway	4.0	239.0	55.0	-0.11	0.05	1000.0	-1000.0	-0.085	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	392.0	83.0	-0.121	0.053	1000.0	-1000.0	-0.072	-1000.0
Regulation of p38-alpha and p38-beta	4.0	257.0	54.0	-0.097	0.037	1000.0	-1000.0	-0.055	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	331.0	74.0	-0.132	0.043	1000.0	-1000.0	-0.082	-1000.0
PDGFR-beta signaling pathway	4.0	475.0	97.0	-0.089	0.04	1000.0	-1000.0	-0.077	-1000.0
E-cadherin signaling in keratinocytes	4.0	209.0	43.0	-0.132	0.031	1000.0	-1000.0	-0.062	-1000.0
Canonical NF-kappaB pathway	3.0	135.0	39.0	-0.08	0.064	1000.0	-1000.0	-0.077	-1000.0
BARD1 signaling events	3.0	180.0	57.0	-0.016	0.057	1000.0	-1000.0	-0.057	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	225.0	65.0	-0.059	0.065	1000.0	-1000.0	-0.063	-1000.0
Arf6 downstream pathway	3.0	159.0	43.0	-0.031	0.021	1000.0	-1000.0	-0.035	-1000.0
PLK1 signaling events	3.0	268.0	85.0	-0.05	0.023	1000.0	-1000.0	-0.04	-1000.0
mTOR signaling pathway	3.0	203.0	53.0	-0.084	0.03	1000.0	-1000.0	-0.059	-1000.0
Ceramide signaling pathway	3.0	285.0	76.0	-0.079	0.023	1000.0	-1000.0	-0.043	-1000.0
S1P5 pathway	3.0	57.0	17.0	-0.038	0.02	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	167.0	45.0	-0.079	0.053	1000.0	-1000.0	-0.086	-1000.0
Effects of Botulinum toxin	3.0	96.0	26.0	-0.034	0.014	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	231.0	76.0	-0.062	0.039	1000.0	-1000.0	-0.078	-1000.0
Class I PI3K signaling events	3.0	219.0	73.0	-0.097	0.035	1000.0	-1000.0	-0.073	-1000.0
Regulation of Telomerase	3.0	320.0	102.0	-0.132	0.05	1000.0	-1000.0	-0.096	-1000.0
IGF1 pathway	3.0	210.0	57.0	-0.029	0.035	1000.0	-1000.0	-0.086	-1000.0
S1P4 pathway	3.0	83.0	25.0	-0.038	0.024	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	3.0	137.0	44.0	-0.116	0.031	1000.0	-1000.0	-0.063	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	0.004	0.017	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	2.0	64.0	32.0	-0.031	0.037	1000.0	-1000.0	-0.063	-1000.0
IFN-gamma pathway	2.0	186.0	68.0	-0.168	0.06	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class III	2.0	96.0	40.0	-0.047	0.025	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	2.0	113.0	49.0	-0.079	0.035	1000.0	-1000.0	-0.044	-1000.0
TCGA08_p53	2.0	16.0	7.0	-0.009	0.014	1000.0	-1000.0	-0.011	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	104.0	36.0	-0.036	0.031	1000.0	-1000.0	-0.068	-1000.0
Atypical NF-kappaB pathway	2.0	82.0	31.0	-0.033	0.034	1000.0	-1000.0	-0.042	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	38.0	23.0	-0.052	0.051	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by HDAC Class II	1.0	137.0	75.0	-0.032	0.039	1000.0	-1000.0	-0.042	-1000.0
Aurora A signaling	1.0	105.0	60.0	-0.04	0.037	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class I	1.0	168.0	104.0	-0.079	0.057	1000.0	-1000.0	-0.07	-1000.0
FoxO family signaling	1.0	70.0	64.0	-0.042	0.138	1000.0	-1000.0	-0.065	-1000.0
Arf6 trafficking events	1.0	108.0	71.0	-0.056	0.047	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	52.0	68.0	-0.041	0.054	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	-0.004	0.037	1000.0	-1000.0	-0.05	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.001	0.035	1000.0	-1000.0	-0.035	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.004	0.038	1000.0	-1000.0	-0.035	-1000.0
Total	1375	77909	7203	-19.2303496874	-994.492135256	131000	-131000	-8.09969943756	-131000