Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.025 0.039 -9999.0 0.0 -0.46 1.0 1.0 ENAH -0.003 0.052 0.275 3.0 -9999.0 0.0 3.0 EGFR -0.04 0.141 -9999.0 0.0 -0.274 35.0 35.0 EPHA2 0.023 0.039 -9999.0 0.0 -0.46 1.0 1.0 MYO6 0.011 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.031 -9999.0 0.0 -0.279 1.0 1.0 AQP5 -0.057 0.18 -9999.0 0.0 -0.456 26.0 26.0 CTNND1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.042 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.056 -9999.0 0.0 -0.228 3.0 3.0 EGF 0.019 0.033 -9999.0 0.0 -0.165 5.0 5.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.012 0.12 -9999.0 0.0 -0.445 10.0 10.0 cortical microtubule organization 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.007 0.038 0.164 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.062 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.018 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.05 0.055 -9999.0 0.0 -0.243 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.041 0.177 2.0 -0.318 1.0 3.0 PVRL2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.006 0.05 0.18 3.0 -0.242 2.0 5.0 ARF6/GTP 0.057 0.051 -9999.0 0.0 -0.215 2.0 2.0 CDH1 0.001 0.065 -9999.0 0.0 -0.165 21.0 21.0 EGFR/EGFR/EGF/EGF 0.016 0.081 -9999.0 0.0 -0.229 11.0 11.0 RhoA/GDP 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.025 0.039 -9999.0 0.0 -0.46 1.0 1.0 GIT1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.039 -9999.0 0.0 -0.46 1.0 1.0 IGF1 0.011 0.087 -9999.0 0.0 -0.376 7.0 7.0 DIAPH1 0.03 0.122 -9999.0 0.0 -0.587 4.0 4.0 Wnt receptor signaling pathway -0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.013 0.071 -9999.0 0.0 -0.312 6.0 6.0 LPP -0.01 0.034 0.173 2.0 -9999.0 0.0 2.0 Ephrin A1/EPHA2 0.036 0.046 -9999.0 0.0 -0.212 2.0 2.0 SEC6/SEC8 0.003 0.027 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.057 -9999.0 0.0 -0.231 3.0 3.0 HGF/MET 0.021 0.08 -9999.0 0.0 -0.224 10.0 10.0 HGF -0.021 0.123 -9999.0 0.0 -0.267 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.036 0.092 0.245 16.0 -0.403 1.0 17.0 KIAA1543 -0.02 0.068 0.167 3.0 -0.238 10.0 13.0 KIFC3 0.005 0.056 -9999.0 0.0 -0.228 4.0 4.0 NCK1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.008 0.039 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.038 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.011 0.044 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.01 0.042 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.01 0.075 0.298 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.005 0.103 0.275 3.0 -0.331 7.0 10.0 IGF-1R heterotetramer/IGF1 0.039 0.056 -9999.0 0.0 -0.217 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.008 0.065 -9999.0 0.0 -0.186 14.0 14.0 PLEKHA7 -0.006 0.075 -9999.0 0.0 -0.249 10.0 10.0 mol:GTP 0.048 0.054 -9999.0 0.0 -0.242 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.022 0.09 0.409 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0