E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.088 -9999.0 0.0 -0.247 43.0 43.0 KLHL20 0.02 0.045 0.159 6.0 -0.184 1.0 7.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.023 0.06 0.277 6.0 -9999.0 0.0 6.0 ENAH -0.004 0.085 -9999.0 0.0 -0.247 40.0 40.0 AP1M1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.018 -9999.0 0.0 -0.315 1.0 1.0 CTNNB1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.024 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.019 -9999.0 0.0 -0.129 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.053 0.044 -9999.0 0.0 -0.152 9.0 9.0 RAPGEF1 -0.002 0.077 0.208 7.0 -0.224 23.0 30.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.0 0.093 -9999.0 0.0 -0.252 44.0 44.0 CRK -0.002 0.074 -9999.0 0.0 -0.236 31.0 31.0 E-cadherin/gamma catenin/alpha catenin 0.047 0.022 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.03 0.045 -9999.0 0.0 -0.193 13.0 13.0 IQGAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.049 0.02 -9999.0 0.0 -0.163 1.0 1.0 DLG1 -0.004 0.084 -9999.0 0.0 -0.247 39.0 39.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.003 0.019 -9999.0 0.0 -0.219 1.0 1.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.046 0.032 -9999.0 0.0 -0.107 12.0 12.0 PI3K 0.007 0.025 -9999.0 0.0 -0.285 1.0 1.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.025 0.028 -9999.0 0.0 -0.278 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.027 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.009 0.027 0.097 11.0 -0.165 1.0 12.0 PIK3R1 0.023 0.032 -9999.0 0.0 -0.315 3.0 3.0 CDH1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.026 0.063 0.251 9.0 -9999.0 0.0 9.0 actin cytoskeleton organization 0.019 0.041 0.166 9.0 -0.136 1.0 10.0 CDC42/GDP 0.028 0.069 0.256 14.0 -9999.0 0.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.018 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.016 0.059 -9999.0 0.0 -0.29 13.0 13.0 RAC1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.041 0.02 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.015 0.073 0.265 15.0 -9999.0 0.0 15.0 CDC42/GTP/IQGAP1 0.038 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.031 0.061 0.328 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.017 0.037 0.165 10.0 -9999.0 0.0 10.0 NME1 0.021 0.04 -9999.0 0.0 -0.206 11.0 11.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.003 0.085 -9999.0 0.0 -0.247 39.0 39.0 regulation of cell-cell adhesion 0.015 0.019 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.01 0.021 0.084 4.0 -9999.0 0.0 4.0 Rap1/GTP 0.028 0.035 0.189 7.0 -9999.0 0.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.048 -9999.0 0.0 -0.152 7.0 7.0 CCND1 0.02 0.043 0.197 9.0 -9999.0 0.0 9.0 VAV2 0.014 0.091 0.331 1.0 -0.54 1.0 2.0 RAP1/GDP 0.036 0.048 0.221 10.0 -9999.0 0.0 10.0 adherens junction assembly -0.003 0.083 -9999.0 0.0 -0.241 39.0 39.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.047 0.042 0.187 4.0 -0.151 6.0 10.0 E-cadherin/beta catenin 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.087 -9999.0 0.0 -0.246 42.0 42.0 PIK3CA 0.023 0.034 -9999.0 0.0 -0.287 4.0 4.0 Rac1/GTP 0.003 0.046 -9999.0 0.0 -0.285 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.0 0.095 -9999.0 0.0 -0.256 44.0 44.0