Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.009 0.115 -9999.0 0.0 -0.479 16.0 16.0 IHH 0.015 0.079 0.219 4.0 -0.188 39.0 43.0 SHH Np/Cholesterol/GAS1 -0.022 0.081 0.179 1.0 -0.152 95.0 96.0 LRPAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.022 0.08 0.152 95.0 -0.177 1.0 96.0 SMO/beta Arrestin2 0.015 0.091 -9999.0 0.0 -0.334 13.0 13.0 SMO 0.003 0.086 -9999.0 0.0 -0.328 18.0 18.0 AKT1 0.004 0.097 -9999.0 0.0 -0.408 10.0 10.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.056 -9999.0 0.0 -0.315 10.0 10.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.004 0.086 -9999.0 0.0 -0.324 18.0 18.0 STIL -0.015 0.093 0.197 15.0 -0.261 19.0 34.0 DHH N/PTCH2 0.035 0.04 -9999.0 0.0 -0.201 10.0 10.0 DHH N/PTCH1 0.02 0.081 -9999.0 0.0 -0.257 19.0 19.0 PIK3CA 0.023 0.034 -9999.0 0.0 -0.287 4.0 4.0 DHH 0.021 0.047 -9999.0 0.0 -0.287 8.0 8.0 PTHLH -0.004 0.153 -9999.0 0.0 -0.622 17.0 17.0 determination of left/right symmetry 0.004 0.086 -9999.0 0.0 -0.324 18.0 18.0 PIK3R1 0.023 0.032 -9999.0 0.0 -0.315 3.0 3.0 skeletal system development -0.003 0.151 -9999.0 0.0 -0.616 17.0 17.0 IHH N/Hhip 0.016 0.109 0.174 3.0 -0.274 41.0 44.0 DHH N/Hhip 0.013 0.08 -9999.0 0.0 -0.211 41.0 41.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.004 0.086 -9999.0 0.0 -0.324 18.0 18.0 pancreas development -0.002 0.097 -9999.0 0.0 -0.311 33.0 33.0 HHAT 0.024 0.031 -9999.0 0.0 -0.315 3.0 3.0 PI3K 0.032 0.038 -9999.0 0.0 -0.234 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.005 0.1 -9999.0 0.0 -0.315 35.0 35.0 somite specification 0.004 0.086 -9999.0 0.0 -0.324 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.015 0.085 0.184 1.0 -0.268 18.0 19.0 SHH Np/Cholesterol/PTCH2 -0.009 0.072 0.162 3.0 -0.141 78.0 81.0 SHH Np/Cholesterol/Megalin -0.024 0.085 0.162 3.0 -0.173 73.0 76.0 SHH -0.028 0.086 0.229 3.0 -0.186 77.0 80.0 catabolic process 0.005 0.084 -9999.0 0.0 -0.31 17.0 17.0 SMO/Vitamin D3 -0.009 0.096 0.45 1.0 -0.325 15.0 16.0 SHH Np/Cholesterol/Hhip -0.021 0.088 0.162 3.0 -0.159 94.0 97.0 LRP2 -0.005 0.097 -9999.0 0.0 -0.3 36.0 36.0 receptor-mediated endocytosis -0.024 0.103 -9999.0 0.0 -0.335 18.0 18.0 SHH Np/Cholesterol/BOC -0.012 0.073 0.154 2.0 -0.166 53.0 55.0 SHH Np/Cholesterol/CDO -0.01 0.07 0.162 3.0 -0.138 80.0 83.0 mesenchymal cell differentiation 0.021 0.087 0.158 94.0 -0.161 3.0 97.0 mol:Vitamin D3 -0.004 0.098 0.214 16.0 -0.269 18.0 34.0 IHH N/PTCH2 0.036 0.067 0.174 3.0 -0.209 20.0 23.0 CDON 0.025 0.025 -9999.0 0.0 -0.242 3.0 3.0 IHH N/PTCH1 0.024 0.092 0.227 2.0 -0.312 17.0 19.0 Megalin/LRPAP1 0.015 0.073 -9999.0 0.0 -0.205 36.0 36.0 PTCH2 0.026 0.025 -9999.0 0.0 -0.315 2.0 2.0 SHH Np/Cholesterol -0.018 0.064 -9999.0 0.0 -0.137 79.0 79.0 PTCH1 0.005 0.084 -9999.0 0.0 -0.311 17.0 17.0 HHIP -0.002 0.097 -9999.0 0.0 -0.311 33.0 33.0