Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.049 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.002 0.073 0.177 39.0 -9999.0 0.0 39.0 EGFR -0.007 0.101 -9999.0 0.0 -0.315 36.0 36.0 EPHA2 -0.004 0.099 -9999.0 0.0 -0.308 35.0 35.0 MYO6 0.014 0.057 0.197 20.0 -9999.0 0.0 20.0 CTNNB1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.133 0.194 -9999.0 0.0 -0.385 137.0 137.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.023 0.042 0.189 21.0 -9999.0 0.0 21.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.05 0.19 20.0 -9999.0 0.0 20.0 EGF 0.0 0.082 -9999.0 0.0 -0.23 40.0 40.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.012 0.062 0.251 3.0 -0.361 8.0 11.0 cortical microtubule organization 0.049 0.025 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.004 0.045 0.178 21.0 -9999.0 0.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.027 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.021 0.032 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.066 0.196 1.0 -0.165 28.0 29.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.034 0.177 6.0 -9999.0 0.0 6.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.017 0.028 0.179 10.0 -9999.0 0.0 10.0 ARF6/GTP 0.051 0.066 -9999.0 0.0 -0.155 28.0 28.0 CDH1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.013 0.07 -9999.0 0.0 -0.159 30.0 30.0 RhoA/GDP 0.051 0.025 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.013 0.053 0.166 17.0 -0.207 2.0 19.0 IGF-1R heterotetramer 0.026 0.022 -9999.0 0.0 -0.26 2.0 2.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.022 -9999.0 0.0 -0.26 2.0 2.0 IGF1 -0.003 0.093 -9999.0 0.0 -0.276 37.0 37.0 DIAPH1 0.035 0.108 -9999.0 0.0 -0.579 3.0 3.0 Wnt receptor signaling pathway -0.049 0.025 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.054 0.168 17.0 -0.211 2.0 19.0 EFNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.006 0.049 0.192 13.0 -9999.0 0.0 13.0 Ephrin A1/EPHA2 0.028 0.056 -9999.0 0.0 -0.147 21.0 21.0 SEC6/SEC8 0.012 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.019 0.05 0.192 20.0 -9999.0 0.0 20.0 HGF/MET 0.02 0.071 -9999.0 0.0 -0.268 10.0 10.0 HGF 0.004 0.08 -9999.0 0.0 -0.281 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.029 0.103 0.279 35.0 -0.222 5.0 40.0 KIAA1543 0.002 0.043 0.183 17.0 -9999.0 0.0 17.0 KIFC3 0.018 0.034 0.18 15.0 -9999.0 0.0 15.0 NCK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.021 0.04 0.195 16.0 -9999.0 0.0 16.0 NCK1/GIT1 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.049 0.025 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.022 0.04 0.192 18.0 -9999.0 0.0 18.0 PIP5K1C 0.024 0.043 0.191 21.0 -9999.0 0.0 21.0 LIMA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.005 0.081 0.188 45.0 -9999.0 0.0 45.0 adherens junction assembly -0.002 0.097 0.242 14.0 -0.543 6.0 20.0 IGF-1R heterotetramer/IGF1 0.03 0.052 -9999.0 0.0 -0.148 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.002 0.093 -9999.0 0.0 -0.315 30.0 30.0 PLEKHA7 0.022 0.04 0.194 17.0 -9999.0 0.0 17.0 mol:GTP 0.043 0.065 0.191 1.0 -0.164 28.0 29.0 establishment of epithelial cell apical/basal polarity 0.014 0.086 0.262 32.0 -9999.0 0.0 32.0 cortical actin cytoskeleton stabilization 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.013 0.053 0.166 17.0 -0.207 2.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0