Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	66.0	5868.0	88.0	-0.29	0.062	1000.0	-1000.0	-0.054	-1000.0
Ephrin A  reverse signaling	65.0	460.0	7.0	-0.041	-0.0	1000.0	-1000.0	-0.004	-1000.0
Signaling mediated by p38-alpha and p38-beta	64.0	2844.0	44.0	-0.159	0.028	1000.0	-1000.0	-0.018	-1000.0
Glypican 2 network	63.0	253.0	4.0	-0.023	-0.003	1000.0	-1000.0	0.013	-1000.0
Endothelins	57.0	5565.0	96.0	-0.179	0.028	1000.0	-1000.0	-0.04	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	47.0	1619.0	34.0	-0.044	0.028	1000.0	-1000.0	-0.017	-1000.0
Glucocorticoid receptor regulatory network	47.0	5428.0	114.0	-0.416	0.237	1000.0	-1000.0	-0.046	-1000.0
Aurora B signaling	40.0	2708.0	67.0	-0.114	0.047	1000.0	-1000.0	-0.027	-1000.0
Integrins in angiogenesis	39.0	3309.0	84.0	-0.099	0.052	1000.0	-1000.0	-0.026	-1000.0
IL23-mediated signaling events	39.0	2379.0	60.0	-0.342	0.04	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3042.0	78.0	-0.131	0.089	1000.0	-1000.0	-0.035	-1000.0
Thromboxane A2 receptor signaling	36.0	3876.0	105.0	-0.119	0.035	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	36.0	2044.0	56.0	-0.099	0.067	1000.0	-1000.0	-0.027	-1000.0
Aurora C signaling	32.0	228.0	7.0	-0.049	0.025	1000.0	-1000.0	-0.005	-1000.0
S1P5 pathway	31.0	532.0	17.0	-0.038	0.035	1000.0	-1000.0	-0.001	-1000.0
LPA receptor mediated events	31.0	3230.0	102.0	-0.106	0.036	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by the Hedgehog family	30.0	1569.0	52.0	-0.028	0.036	1000.0	-1000.0	-0.023	-1000.0
Noncanonical Wnt signaling pathway	30.0	801.0	26.0	-0.042	0.028	1000.0	-1000.0	-0.027	-1000.0
Ras signaling in the CD4+ TCR pathway	30.0	523.0	17.0	-0.07	0.045	1000.0	-1000.0	-0.014	-1000.0
IL6-mediated signaling events	29.0	2242.0	75.0	-0.182	0.036	1000.0	-1000.0	-0.04	-1000.0
p75(NTR)-mediated signaling	28.0	3525.0	125.0	-0.075	0.075	1000.0	-1000.0	-0.047	-1000.0
Glypican 1 network	28.0	1350.0	48.0	-0.069	0.048	1000.0	-1000.0	-0.015	-1000.0
amb2 Integrin signaling	28.0	2351.0	82.0	-0.13	0.036	1000.0	-1000.0	-0.02	-1000.0
S1P1 pathway	28.0	1028.0	36.0	-0.187	0.028	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	28.0	2433.0	85.0	-0.064	0.093	1000.0	-1000.0	-0.043	-1000.0
Wnt signaling	28.0	196.0	7.0	-0.04	0.023	1000.0	-1000.0	-0.005	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	28.0	1946.0	68.0	-0.175	0.059	1000.0	-1000.0	-0.059	-1000.0
EGFR-dependent Endothelin signaling events	28.0	601.0	21.0	-0.029	0.045	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	27.0	1340.0	48.0	-0.063	0.032	1000.0	-1000.0	-0.024	-1000.0
Nongenotropic Androgen signaling	27.0	1411.0	52.0	-0.104	0.051	1000.0	-1000.0	-0.022	-1000.0
FOXM1 transcription factor network	27.0	1399.0	51.0	-0.178	0.028	1000.0	-1000.0	-0.104	-1000.0
Syndecan-1-mediated signaling events	26.0	911.0	34.0	-0.106	0.028	1000.0	-1000.0	-0.022	-1000.0
Calcium signaling in the CD4+ TCR pathway	26.0	815.0	31.0	-0.097	0.028	1000.0	-1000.0	-0.039	-1000.0
Osteopontin-mediated events	24.0	921.0	38.0	-0.048	0.028	1000.0	-1000.0	-0.029	-1000.0
HIF-1-alpha transcription factor network	24.0	1856.0	76.0	-0.095	0.059	1000.0	-1000.0	-0.074	-1000.0
IL4-mediated signaling events	24.0	2206.0	91.0	-0.368	0.244	1000.0	-1000.0	-0.12	-1000.0
BMP receptor signaling	24.0	2015.0	81.0	-0.08	0.066	1000.0	-1000.0	-0.025	-1000.0
S1P4 pathway	24.0	601.0	25.0	-0.038	0.042	1000.0	-1000.0	-0.012	-1000.0
JNK signaling in the CD4+ TCR pathway	23.0	398.0	17.0	-0.116	0.055	1000.0	-1000.0	-0.033	-1000.0
Signaling events regulated by Ret tyrosine kinase	23.0	1947.0	82.0	-0.034	0.038	1000.0	-1000.0	-0.039	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	23.0	2826.0	120.0	-0.085	0.073	1000.0	-1000.0	-0.044	-1000.0
Effects of Botulinum toxin	22.0	592.0	26.0	-0.036	0.045	1000.0	-1000.0	-0.003	-1000.0
EPO signaling pathway	21.0	1165.0	55.0	-0.023	0.05	1000.0	-1000.0	-0.023	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1126.0	52.0	-0.051	0.073	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PRL	21.0	729.0	34.0	-0.048	0.045	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Cones	20.0	778.0	38.0	-0.047	0.033	1000.0	-1000.0	-0.007	-1000.0
Arf6 signaling events	20.0	1297.0	62.0	-0.043	0.045	1000.0	-1000.0	-0.037	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	19.0	1648.0	85.0	-0.116	0.037	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	19.0	138.0	7.0	-0.02	0.027	1000.0	-1000.0	-0.012	-1000.0
TCR signaling in naïve CD8+ T cells	19.0	1822.0	93.0	-0.058	0.072	1000.0	-1000.0	-0.036	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1695.0	86.0	-0.118	0.056	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	19.0	386.0	20.0	-0.057	0.034	1000.0	-1000.0	-0.003	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	979.0	54.0	-0.099	0.067	1000.0	-1000.0	-0.019	-1000.0
Fc-epsilon receptor I signaling in mast cells	18.0	1824.0	97.0	-0.074	0.044	1000.0	-1000.0	-0.042	-1000.0
PLK1 signaling events	18.0	1610.0	85.0	-0.056	0.054	1000.0	-1000.0	-0.019	-1000.0
Presenilin action in Notch and Wnt signaling	17.0	1096.0	61.0	-0.129	0.076	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	17.0	783.0	44.0	-0.121	0.055	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	17.0	896.0	51.0	-0.128	0.098	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	17.0	946.0	54.0	-0.099	0.063	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	17.0	2145.0	125.0	-0.052	0.053	1000.0	-1000.0	-0.028	-1000.0
ErbB2/ErbB3 signaling events	16.0	1089.0	65.0	-0.079	0.039	1000.0	-1000.0	-0.065	-1000.0
BARD1 signaling events	16.0	945.0	57.0	-0.029	0.047	1000.0	-1000.0	-0.039	-1000.0
a4b1 and a4b7 Integrin signaling	16.0	83.0	5.0	0.01	0.027	1000.0	-1000.0	0.01	-1000.0
Signaling events mediated by PTP1B	16.0	1234.0	76.0	-0.16	0.043	1000.0	-1000.0	-0.035	-1000.0
FAS signaling pathway (CD95)	16.0	778.0	47.0	-0.239	0.045	1000.0	-1000.0	-0.036	-1000.0
IL27-mediated signaling events	16.0	830.0	51.0	-0.341	0.069	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	15.0	1311.0	87.0	-0.17	0.051	1000.0	-1000.0	-0.06	-1000.0
Syndecan-2-mediated signaling events	15.0	1077.0	69.0	-0.01	0.043	1000.0	-1000.0	-0.036	-1000.0
BCR signaling pathway	15.0	1487.0	99.0	-0.116	0.051	1000.0	-1000.0	-0.049	-1000.0
Visual signal transduction: Rods	15.0	803.0	52.0	-0.047	0.052	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	14.0	885.0	60.0	-0.075	0.05	1000.0	-1000.0	-0.013	-1000.0
IGF1 pathway	14.0	799.0	57.0	-0.011	0.062	1000.0	-1000.0	-0.029	-1000.0
Insulin Pathway	14.0	1045.0	74.0	-0.127	0.072	1000.0	-1000.0	-0.035	-1000.0
S1P3 pathway	14.0	619.0	42.0	-0.02	0.042	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	13.0	511.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.015	-1000.0
Nectin adhesion pathway	13.0	832.0	63.0	-0.043	0.065	1000.0	-1000.0	-0.035	-1000.0
IL1-mediated signaling events	13.0	844.0	62.0	-0.033	0.07	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	13.0	589.0	43.0	-0.033	0.043	1000.0	-1000.0	-0.042	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	990.0	74.0	-0.133	0.054	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	13.0	108.0	8.0	-0.02	0.032	1000.0	-1000.0	-0.002	-1000.0
Syndecan-4-mediated signaling events	13.0	884.0	67.0	-0.105	0.032	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	13.0	451.0	33.0	-0.069	0.064	1000.0	-1000.0	-0.026	-1000.0
Caspase cascade in apoptosis	12.0	902.0	74.0	-0.032	0.067	1000.0	-1000.0	-0.031	-1000.0
Regulation of nuclear SMAD2/3 signaling	12.0	1716.0	136.0	-0.186	0.088	1000.0	-1000.0	-0.041	-1000.0
Coregulation of Androgen receptor activity	12.0	950.0	76.0	-0.035	0.047	1000.0	-1000.0	-0.016	-1000.0
ErbB4 signaling events	12.0	873.0	69.0	-0.083	0.061	1000.0	-1000.0	-0.033	-1000.0
FOXA2 and FOXA3 transcription factor networks	12.0	578.0	46.0	-0.123	0.032	1000.0	-1000.0	-0.089	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	465.0	37.0	-0.016	0.059	1000.0	-1000.0	-0.026	-1000.0
LPA4-mediated signaling events	11.0	140.0	12.0	-0.027	0.017	1000.0	-1000.0	-0.015	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	319.0	28.0	-0.025	0.054	1000.0	-1000.0	-0.008	-1000.0
mTOR signaling pathway	11.0	627.0	53.0	-0.152	0.054	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	11.0	891.0	76.0	-0.022	0.077	1000.0	-1000.0	-0.012	-1000.0
Regulation of Androgen receptor activity	11.0	802.0	70.0	-0.076	0.047	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	662.0	65.0	-0.221	0.069	1000.0	-1000.0	-0.041	-1000.0
ceramide signaling pathway	10.0	519.0	49.0	-0.0	0.04	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	10.0	628.0	58.0	-0.047	0.056	1000.0	-1000.0	-0.022	-1000.0
Class I PI3K signaling events	10.0	777.0	73.0	-0.043	0.064	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-gamma and p38-delta	9.0	135.0	15.0	-0.011	0.028	1000.0	-1000.0	-0.025	-1000.0
Retinoic acid receptors-mediated signaling	9.0	575.0	58.0	-0.042	0.051	1000.0	-1000.0	-0.028	-1000.0
TCGA08_rtk_signaling	9.0	259.0	26.0	-0.02	0.05	1000.0	-1000.0	-0.006	-1000.0
IL2 signaling events mediated by STAT5	9.0	204.0	22.0	-0.019	0.028	1000.0	-1000.0	-0.023	-1000.0
VEGFR1 specific signals	9.0	522.0	56.0	-0.052	0.043	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class III	8.0	344.0	40.0	-0.06	0.052	1000.0	-1000.0	-0.024	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	8.0	390.0	45.0	-0.003	0.068	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	7.0	506.0	68.0	-0.03	0.075	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	7.0	476.0	68.0	-0.035	0.052	1000.0	-1000.0	-0.02	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	646.0	83.0	-0.045	0.052	1000.0	-1000.0	-0.023	-1000.0
Paxillin-dependent events mediated by a4b1	7.0	259.0	36.0	-0.049	0.051	1000.0	-1000.0	-0.027	-1000.0
Syndecan-3-mediated signaling events	7.0	276.0	35.0	-0.021	0.075	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling in the nascent adherens junction	7.0	600.0	76.0	-0.007	0.06	1000.0	-1000.0	-0.038	-1000.0
PDGFR-beta signaling pathway	7.0	760.0	97.0	-0.109	0.071	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in keratinocytes	7.0	303.0	43.0	-0.014	0.047	1000.0	-1000.0	-0.02	-1000.0
Atypical NF-kappaB pathway	6.0	215.0	31.0	-0.011	0.032	1000.0	-1000.0	-0.009	-1000.0
Regulation of Telomerase	6.0	626.0	102.0	-0.08	0.055	1000.0	-1000.0	-0.049	-1000.0
p38 MAPK signaling pathway	6.0	287.0	44.0	-0.031	0.057	1000.0	-1000.0	-0.013	-1000.0
Canonical NF-kappaB pathway	5.0	221.0	39.0	-0.0	0.061	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	5.0	378.0	64.0	-0.04	0.054	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.025	0.025	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class II	4.0	339.0	75.0	-0.031	0.069	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	0.01	0.026	1000.0	-1000.0	-0.008	-1000.0
Circadian rhythm pathway	3.0	84.0	22.0	-0.008	0.041	1000.0	-1000.0	-0.029	-1000.0
TRAIL signaling pathway	3.0	156.0	48.0	-0.0	0.053	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class I	3.0	314.0	104.0	-0.054	0.067	1000.0	-1000.0	-0.022	-1000.0
Arf6 trafficking events	3.0	265.0	71.0	-0.048	0.052	1000.0	-1000.0	-0.022	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	68.0	23.0	0.006	0.056	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	2.0	87.0	32.0	-0.002	0.048	1000.0	-1000.0	-0.017	-1000.0
Arf6 downstream pathway	1.0	60.0	43.0	-0.055	0.056	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	1.0	75.0	54.0	-0.001	0.047	1000.0	-1000.0	-0.008	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.022	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.048	1000.0	-1000.0	0.013	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.0	0.074	1000.0	-1000.0	-0.0	-1000.0
Total	2414	140762	7203	-9.94405008524	6.85409045325	131000	-131000	-3.7616840844	-131000