This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 10 different clustering approaches and 13 clinical features across 274 patients, 28 significant findings detected with P value < 0.05 and Q value < 0.25.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'PATHOLOGY.T.STAGE', 'PATHOLOGY.N.STAGE', 'COMPLETENESS.OF.RESECTION', 'NUMBER.OF.LYMPH.NODES', 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', 'GLEASON_SCORE', and 'PSA_RESULT_PREOP'.
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CNMF clustering analysis on RPPA data identified 3 subtypes that correlate to 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
-
Consensus hierarchical clustering analysis on RPPA data identified 3 subtypes that correlate to 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
-
CNMF clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 3 subtypes that correlate to 'GLEASON_SCORE_PRIMARY'.
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5 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'HISTOLOGICAL.TYPE' and 'GLEASON_SCORE_PRIMARY'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'PATHOLOGY.T.STAGE', 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes do not correlate to any clinical features.
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5 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'PATHOLOGY.T.STAGE', 'GLEASON_SCORE_COMBINED', 'GLEASON_SCORE_PRIMARY', and 'GLEASON_SCORE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
AGE | Kruskal-Wallis (anova) |
0.215 (1.00) |
0.00373 (0.366) |
0.0791 (1.00) |
0.0149 (1.00) |
0.496 (1.00) |
0.57 (1.00) |
0.379 (1.00) |
0.301 (1.00) |
0.0573 (1.00) |
0.636 (1.00) |
PATHOLOGY T STAGE | Fisher's exact test |
2e-05 (0.00244) |
0.0486 (1.00) |
0.0061 (0.573) |
0.0204 (1.00) |
0.017 (1.00) |
0.0087 (0.783) |
0.0124 (1.00) |
0.00014 (0.0164) |
0.419 (1.00) |
8e-05 (0.00952) |
PATHOLOGY N STAGE | Fisher's exact test |
0.00016 (0.0184) |
0.0138 (1.00) |
0.0542 (1.00) |
0.0163 (1.00) |
0.00909 (0.809) |
0.112 (1.00) |
0.193 (1.00) |
0.00299 (0.305) |
0.113 (1.00) |
0.0916 (1.00) |
HISTOLOGICAL TYPE | Fisher's exact test |
0.828 (1.00) |
0.678 (1.00) |
1 (1.00) |
0.336 (1.00) |
0.284 (1.00) |
0.33 (1.00) |
0.00064 (0.0691) |
0.577 (1.00) |
0.0408 (1.00) |
0.014 (1.00) |
COMPLETENESS OF RESECTION | Fisher's exact test |
0.00112 (0.119) |
0.461 (1.00) |
0.0204 (1.00) |
0.00354 (0.35) |
0.438 (1.00) |
0.251 (1.00) |
0.0301 (1.00) |
0.768 (1.00) |
0.435 (1.00) |
0.588 (1.00) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.000169 (0.0193) |
0.0235 (1.00) |
0.0381 (1.00) |
0.0119 (1.00) |
0.016 (1.00) |
0.0887 (1.00) |
0.148 (1.00) |
0.00463 (0.444) |
0.0953 (1.00) |
0.134 (1.00) |
GLEASON SCORE COMBINED | Kruskal-Wallis (anova) |
1.39e-09 (1.8e-07) |
0.00111 (0.119) |
0.00011 (0.013) |
4.87e-05 (0.00584) |
0.0543 (1.00) |
0.0062 (0.577) |
0.0301 (1.00) |
8.63e-06 (0.00109) |
0.0034 (0.34) |
0.000299 (0.0332) |
GLEASON SCORE PRIMARY | Kruskal-Wallis (anova) |
2.38e-09 (3.04e-07) |
0.000468 (0.051) |
1.56e-05 (0.00194) |
1.14e-05 (0.00142) |
0.00443 (0.43) |
0.000183 (0.0207) |
0.000358 (0.0394) |
1.63e-05 (0.00201) |
0.00568 (0.54) |
0.00148 (0.154) |
GLEASON SCORE SECONDARY | Kruskal-Wallis (anova) |
0.0806 (1.00) |
0.423 (1.00) |
0.45 (1.00) |
0.157 (1.00) |
0.831 (1.00) |
0.45 (1.00) |
0.25 (1.00) |
0.28 (1.00) |
0.333 (1.00) |
0.264 (1.00) |
GLEASON SCORE | Kruskal-Wallis (anova) |
2.08e-10 (2.71e-08) |
0.0015 (0.154) |
4.74e-05 (0.00573) |
7.53e-06 (0.000956) |
0.0301 (1.00) |
0.0124 (1.00) |
0.034 (1.00) |
0.00014 (0.0164) |
0.00761 (0.7) |
0.00113 (0.119) |
PSA RESULT PREOP | Kruskal-Wallis (anova) |
0.0202 (1.00) |
0.000198 (0.0222) |
0.0443 (1.00) |
0.0303 (1.00) |
0.00335 (0.338) |
0.02 (1.00) |
0.0118 (1.00) |
0.188 (1.00) |
0.775 (1.00) |
0.0185 (1.00) |
PSA VALUE | Kruskal-Wallis (anova) |
0.241 (1.00) |
0.367 (1.00) |
0.163 (1.00) |
0.434 (1.00) |
0.264 (1.00) |
0.845 (1.00) |
0.131 (1.00) |
0.0193 (1.00) |
0.668 (1.00) |
0.149 (1.00) |
RACE | Fisher's exact test |
0.782 (1.00) |
0.745 (1.00) |
0.0271 (1.00) |
0.00836 (0.761) |
0.329 (1.00) |
0.0104 (0.916) |
0.417 (1.00) |
0.824 (1.00) |
0.828 (1.00) |
0.139 (1.00) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 165 | 59 | 47 |
P value = 0.215 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 60.3 (7.0) |
subtype1 | 162 | 59.8 (6.9) |
subtype2 | 59 | 61.3 (6.5) |
subtype3 | 47 | 60.7 (7.7) |
P value = 2e-05 (Fisher's exact test), Q value = 0.0024
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 128 | 136 | 5 |
subtype1 | 89 | 72 | 2 |
subtype2 | 12 | 45 | 2 |
subtype3 | 27 | 19 | 1 |
P value = 0.00016 (Fisher's exact test), Q value = 0.018
nPatients | 0 | 1 |
---|---|---|
ALL | 201 | 24 |
subtype1 | 123 | 5 |
subtype2 | 43 | 14 |
subtype3 | 35 | 5 |
P value = 0.828 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 5 | 266 |
subtype1 | 4 | 161 |
subtype2 | 1 | 58 |
subtype3 | 0 | 47 |
P value = 0.00112 (Fisher's exact test), Q value = 0.12
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 192 | 57 | 3 | 6 |
subtype1 | 129 | 21 | 2 | 5 |
subtype2 | 35 | 20 | 0 | 0 |
subtype3 | 28 | 16 | 1 | 1 |
P value = 0.000169 (Kruskal-Wallis (anova)), Q value = 0.019
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 223 | 0.2 (1.2) |
subtype1 | 126 | 0.1 (0.4) |
subtype2 | 57 | 0.7 (2.2) |
subtype3 | 40 | 0.1 (0.3) |
P value = 1.39e-09 (Kruskal-Wallis (anova)), Q value = 1.8e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 271 | 7.3 (0.8) |
subtype1 | 165 | 7.1 (0.7) |
subtype2 | 59 | 7.9 (0.9) |
subtype3 | 47 | 7.2 (0.6) |
P value = 2.38e-09 (Kruskal-Wallis (anova)), Q value = 3e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 271 | 3.5 (0.6) |
subtype1 | 165 | 3.4 (0.5) |
subtype2 | 59 | 3.9 (0.6) |
subtype3 | 47 | 3.4 (0.5) |
P value = 0.0806 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 271 | 3.8 (0.6) |
subtype1 | 165 | 3.7 (0.6) |
subtype2 | 59 | 4.0 (0.7) |
subtype3 | 47 | 3.8 (0.6) |
P value = 2.08e-10 (Kruskal-Wallis (anova)), Q value = 2.7e-08
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 271 | 7.3 (0.8) |
subtype1 | 165 | 7.1 (0.7) |
subtype2 | 59 | 8.0 (0.9) |
subtype3 | 47 | 7.2 (0.7) |
P value = 0.0202 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 269 | 10.4 (11.0) |
subtype1 | 164 | 9.3 (10.7) |
subtype2 | 59 | 14.1 (13.6) |
subtype3 | 46 | 9.4 (6.8) |
P value = 0.241 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 226 | 1.1 (3.9) |
subtype1 | 144 | 0.8 (2.8) |
subtype2 | 46 | 2.1 (6.5) |
subtype3 | 36 | 1.0 (3.1) |
P value = 0.782 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 146 |
subtype1 | 2 | 3 | 87 |
subtype2 | 0 | 2 | 32 |
subtype3 | 0 | 2 | 27 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 75 | 89 | 101 |
P value = 0.00373 (Kruskal-Wallis (anova)), Q value = 0.37
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 262 | 60.2 (7.0) |
subtype1 | 74 | 61.9 (7.0) |
subtype2 | 88 | 58.5 (7.0) |
subtype3 | 100 | 60.5 (6.8) |
P value = 0.0486 (Fisher's exact test), Q value = 1
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 123 | 135 | 5 |
subtype1 | 35 | 37 | 3 |
subtype2 | 49 | 38 | 0 |
subtype3 | 39 | 60 | 2 |
P value = 0.0138 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 194 | 24 |
subtype1 | 55 | 8 |
subtype2 | 68 | 2 |
subtype3 | 71 | 14 |
P value = 0.678 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 6 | 259 |
subtype1 | 2 | 73 |
subtype2 | 1 | 88 |
subtype3 | 3 | 98 |
P value = 0.461 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 188 | 56 | 2 | 6 |
subtype1 | 49 | 21 | 0 | 1 |
subtype2 | 66 | 16 | 0 | 2 |
subtype3 | 73 | 19 | 2 | 3 |
P value = 0.0235 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 216 | 0.2 (1.2) |
subtype1 | 63 | 0.2 (0.5) |
subtype2 | 68 | 0.0 (0.2) |
subtype3 | 85 | 0.5 (1.8) |
P value = 0.00111 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 7.3 (0.8) |
subtype1 | 75 | 7.5 (0.9) |
subtype2 | 89 | 7.0 (0.6) |
subtype3 | 101 | 7.4 (0.9) |
P value = 0.000468 (Kruskal-Wallis (anova)), Q value = 0.051
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 3.5 (0.6) |
subtype1 | 75 | 3.7 (0.6) |
subtype2 | 89 | 3.3 (0.5) |
subtype3 | 101 | 3.5 (0.6) |
P value = 0.423 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 3.8 (0.6) |
subtype1 | 75 | 3.9 (0.7) |
subtype2 | 89 | 3.7 (0.5) |
subtype3 | 101 | 3.8 (0.6) |
P value = 0.0015 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 7.3 (0.8) |
subtype1 | 75 | 7.6 (1.0) |
subtype2 | 89 | 7.1 (0.6) |
subtype3 | 101 | 7.4 (0.9) |
P value = 0.000198 (Kruskal-Wallis (anova)), Q value = 0.022
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 263 | 10.3 (10.5) |
subtype1 | 75 | 14.8 (15.4) |
subtype2 | 89 | 6.9 (3.7) |
subtype3 | 99 | 9.9 (8.7) |
P value = 0.367 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 221 | 1.1 (3.9) |
subtype1 | 57 | 1.3 (3.9) |
subtype2 | 77 | 0.2 (1.2) |
subtype3 | 87 | 1.7 (5.2) |
P value = 0.745 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 147 |
subtype1 | 0 | 3 | 40 |
subtype2 | 1 | 1 | 48 |
subtype3 | 1 | 3 | 59 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 42 | 55 | 61 |
P value = 0.0791 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 156 | 60.6 (7.1) |
subtype1 | 42 | 62.7 (6.3) |
subtype2 | 54 | 59.2 (7.8) |
subtype3 | 60 | 60.4 (6.7) |
P value = 0.0061 (Fisher's exact test), Q value = 0.57
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 58 | 94 | 5 |
subtype1 | 18 | 23 | 0 |
subtype2 | 27 | 27 | 1 |
subtype3 | 13 | 44 | 4 |
P value = 0.0542 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 123 | 17 |
subtype1 | 38 | 4 |
subtype2 | 43 | 2 |
subtype3 | 42 | 11 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 2 | 156 |
subtype1 | 0 | 42 |
subtype2 | 1 | 54 |
subtype3 | 1 | 60 |
P value = 0.0204 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 111 | 33 | 1 | 4 |
subtype1 | 36 | 4 | 0 | 1 |
subtype2 | 40 | 9 | 0 | 2 |
subtype3 | 35 | 20 | 1 | 1 |
P value = 0.0381 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 140 | 0.2 (0.7) |
subtype1 | 42 | 0.1 (0.5) |
subtype2 | 45 | 0.1 (0.3) |
subtype3 | 53 | 0.4 (1.1) |
P value = 0.00011 (Kruskal-Wallis (anova)), Q value = 0.013
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 7.4 (0.9) |
subtype1 | 42 | 7.1 (0.5) |
subtype2 | 55 | 7.3 (0.8) |
subtype3 | 61 | 7.8 (1.0) |
P value = 1.56e-05 (Kruskal-Wallis (anova)), Q value = 0.0019
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 3.5 (0.6) |
subtype1 | 42 | 3.3 (0.5) |
subtype2 | 55 | 3.4 (0.5) |
subtype3 | 61 | 3.8 (0.6) |
P value = 0.45 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 3.9 (0.7) |
subtype1 | 42 | 3.7 (0.5) |
subtype2 | 55 | 3.9 (0.7) |
subtype3 | 61 | 3.9 (0.8) |
P value = 4.74e-05 (Kruskal-Wallis (anova)), Q value = 0.0057
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 7.4 (0.9) |
subtype1 | 42 | 7.1 (0.6) |
subtype2 | 55 | 7.3 (0.8) |
subtype3 | 61 | 7.9 (1.0) |
P value = 0.0443 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 156 | 11.3 (11.2) |
subtype1 | 41 | 8.3 (5.0) |
subtype2 | 54 | 10.5 (13.4) |
subtype3 | 61 | 14.0 (11.7) |
P value = 0.163 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 143 | 1.4 (4.5) |
subtype1 | 41 | 1.0 (2.8) |
subtype2 | 49 | 0.8 (3.4) |
subtype3 | 53 | 2.4 (6.0) |
P value = 0.0271 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 6 | 121 |
subtype1 | 0 | 0 | 39 |
subtype2 | 2 | 1 | 42 |
subtype3 | 0 | 5 | 40 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 48 | 64 | 46 |
P value = 0.0149 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 156 | 60.6 (7.1) |
subtype1 | 48 | 63.0 (6.2) |
subtype2 | 63 | 60.5 (6.7) |
subtype3 | 45 | 58.2 (7.8) |
P value = 0.0204 (Fisher's exact test), Q value = 1
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 58 | 94 | 5 |
subtype1 | 22 | 25 | 0 |
subtype2 | 15 | 45 | 4 |
subtype3 | 21 | 24 | 1 |
P value = 0.0163 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 123 | 17 |
subtype1 | 43 | 4 |
subtype2 | 43 | 12 |
subtype3 | 37 | 1 |
P value = 0.336 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 2 | 156 |
subtype1 | 0 | 48 |
subtype2 | 2 | 62 |
subtype3 | 0 | 46 |
P value = 0.00354 (Fisher's exact test), Q value = 0.35
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 111 | 33 | 1 | 4 |
subtype1 | 43 | 4 | 0 | 0 |
subtype2 | 35 | 20 | 1 | 3 |
subtype3 | 33 | 9 | 0 | 1 |
P value = 0.0119 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 140 | 0.2 (0.7) |
subtype1 | 47 | 0.1 (0.5) |
subtype2 | 55 | 0.4 (1.1) |
subtype3 | 38 | 0.0 (0.2) |
P value = 4.87e-05 (Kruskal-Wallis (anova)), Q value = 0.0058
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 7.4 (0.9) |
subtype1 | 48 | 7.0 (0.5) |
subtype2 | 64 | 7.8 (1.0) |
subtype3 | 46 | 7.3 (0.9) |
P value = 1.14e-05 (Kruskal-Wallis (anova)), Q value = 0.0014
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 3.5 (0.6) |
subtype1 | 48 | 3.4 (0.5) |
subtype2 | 64 | 3.8 (0.6) |
subtype3 | 46 | 3.4 (0.5) |
P value = 0.157 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 3.9 (0.7) |
subtype1 | 48 | 3.7 (0.6) |
subtype2 | 64 | 3.9 (0.8) |
subtype3 | 46 | 3.9 (0.6) |
P value = 7.53e-06 (Kruskal-Wallis (anova)), Q value = 0.00096
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 158 | 7.4 (0.9) |
subtype1 | 48 | 7.1 (0.6) |
subtype2 | 64 | 7.9 (1.0) |
subtype3 | 46 | 7.3 (0.9) |
P value = 0.0303 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 156 | 11.3 (11.2) |
subtype1 | 47 | 8.9 (6.4) |
subtype2 | 64 | 14.1 (12.3) |
subtype3 | 45 | 9.7 (12.9) |
P value = 0.434 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 143 | 1.4 (4.5) |
subtype1 | 47 | 1.4 (3.7) |
subtype2 | 55 | 2.0 (5.7) |
subtype3 | 41 | 0.6 (3.1) |
P value = 0.00836 (Fisher's exact test), Q value = 0.76
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 6 | 121 |
subtype1 | 0 | 0 | 45 |
subtype2 | 0 | 5 | 40 |
subtype3 | 2 | 1 | 36 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 86 | 85 | 97 |
P value = 0.496 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 60.2 (7.0) |
subtype1 | 84 | 60.7 (7.0) |
subtype2 | 85 | 59.5 (7.1) |
subtype3 | 96 | 60.4 (6.8) |
P value = 0.017 (Fisher's exact test), Q value = 1
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 134 | 5 |
subtype1 | 47 | 36 | 3 |
subtype2 | 45 | 37 | 1 |
subtype3 | 35 | 61 | 1 |
P value = 0.00909 (Fisher's exact test), Q value = 0.81
nPatients | 0 | 1 |
---|---|---|
ALL | 198 | 24 |
subtype1 | 62 | 8 |
subtype2 | 69 | 2 |
subtype3 | 67 | 14 |
P value = 0.284 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 5 | 263 |
subtype1 | 3 | 83 |
subtype2 | 0 | 85 |
subtype3 | 2 | 95 |
P value = 0.438 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 190 | 56 | 3 | 6 |
subtype1 | 57 | 24 | 1 | 1 |
subtype2 | 63 | 14 | 0 | 2 |
subtype3 | 70 | 18 | 2 | 3 |
P value = 0.016 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 220 | 0.2 (1.2) |
subtype1 | 70 | 0.2 (0.8) |
subtype2 | 69 | 0.0 (0.2) |
subtype3 | 81 | 0.5 (1.8) |
P value = 0.0543 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 7.3 (0.8) |
subtype1 | 86 | 7.4 (0.9) |
subtype2 | 85 | 7.1 (0.6) |
subtype3 | 97 | 7.4 (0.9) |
P value = 0.00443 (Kruskal-Wallis (anova)), Q value = 0.43
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 3.5 (0.6) |
subtype1 | 86 | 3.6 (0.6) |
subtype2 | 85 | 3.3 (0.5) |
subtype3 | 97 | 3.6 (0.6) |
P value = 0.831 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 3.8 (0.6) |
subtype1 | 86 | 3.8 (0.7) |
subtype2 | 85 | 3.8 (0.5) |
subtype3 | 97 | 3.8 (0.6) |
P value = 0.0301 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 7.3 (0.8) |
subtype1 | 86 | 7.4 (0.9) |
subtype2 | 85 | 7.1 (0.6) |
subtype3 | 97 | 7.4 (0.9) |
P value = 0.00335 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 266 | 10.1 (10.2) |
subtype1 | 86 | 13.3 (14.3) |
subtype2 | 85 | 6.9 (3.5) |
subtype3 | 95 | 10.0 (8.7) |
P value = 0.264 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 1.1 (3.9) |
subtype1 | 68 | 0.7 (3.0) |
subtype2 | 74 | 0.6 (2.2) |
subtype3 | 82 | 1.8 (5.4) |
P value = 0.329 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 147 |
subtype1 | 0 | 3 | 38 |
subtype2 | 2 | 1 | 52 |
subtype3 | 0 | 3 | 57 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 97 | 82 | 89 |
P value = 0.57 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 265 | 60.2 (7.0) |
subtype1 | 96 | 60.4 (7.2) |
subtype2 | 81 | 59.5 (6.9) |
subtype3 | 88 | 60.6 (6.8) |
P value = 0.0087 (Fisher's exact test), Q value = 0.78
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 134 | 5 |
subtype1 | 56 | 39 | 2 |
subtype2 | 40 | 40 | 0 |
subtype3 | 31 | 55 | 3 |
P value = 0.112 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 198 | 24 |
subtype1 | 71 | 8 |
subtype2 | 67 | 4 |
subtype3 | 60 | 12 |
P value = 0.33 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 5 | 263 |
subtype1 | 2 | 95 |
subtype2 | 0 | 82 |
subtype3 | 3 | 86 |
P value = 0.251 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 190 | 56 | 3 | 6 |
subtype1 | 67 | 24 | 1 | 1 |
subtype2 | 64 | 11 | 0 | 2 |
subtype3 | 59 | 21 | 2 | 3 |
P value = 0.0887 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 220 | 0.2 (1.2) |
subtype1 | 79 | 0.2 (0.7) |
subtype2 | 69 | 0.1 (0.2) |
subtype3 | 72 | 0.5 (1.9) |
P value = 0.0062 (Kruskal-Wallis (anova)), Q value = 0.58
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 7.3 (0.8) |
subtype1 | 97 | 7.3 (0.8) |
subtype2 | 82 | 7.1 (0.6) |
subtype3 | 89 | 7.5 (0.9) |
P value = 0.000183 (Kruskal-Wallis (anova)), Q value = 0.021
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 3.5 (0.6) |
subtype1 | 97 | 3.5 (0.6) |
subtype2 | 82 | 3.3 (0.5) |
subtype3 | 89 | 3.7 (0.6) |
P value = 0.45 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 3.8 (0.6) |
subtype1 | 97 | 3.7 (0.6) |
subtype2 | 82 | 3.8 (0.5) |
subtype3 | 89 | 3.9 (0.7) |
P value = 0.0124 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 268 | 7.3 (0.8) |
subtype1 | 97 | 7.3 (0.8) |
subtype2 | 82 | 7.1 (0.6) |
subtype3 | 89 | 7.5 (1.0) |
P value = 0.02 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 266 | 10.1 (10.2) |
subtype1 | 97 | 12.2 (12.4) |
subtype2 | 82 | 7.5 (4.4) |
subtype3 | 87 | 10.3 (10.9) |
P value = 0.845 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 1.1 (3.9) |
subtype1 | 77 | 0.8 (3.0) |
subtype2 | 74 | 0.8 (2.9) |
subtype3 | 73 | 1.7 (5.3) |
P value = 0.0104 (Fisher's exact test), Q value = 0.92
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 147 |
subtype1 | 0 | 5 | 37 |
subtype2 | 2 | 0 | 63 |
subtype3 | 0 | 2 | 47 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 50 | 23 | 58 | 60 | 81 |
P value = 0.379 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 269 | 60.4 (7.0) |
subtype1 | 50 | 59.0 (7.2) |
subtype2 | 23 | 60.0 (7.3) |
subtype3 | 58 | 60.9 (7.1) |
subtype4 | 60 | 61.6 (6.5) |
subtype5 | 78 | 59.9 (7.1) |
P value = 0.0124 (Fisher's exact test), Q value = 1
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 139 | 4 |
subtype1 | 23 | 25 | 0 |
subtype2 | 16 | 6 | 1 |
subtype3 | 22 | 36 | 0 |
subtype4 | 23 | 34 | 3 |
subtype5 | 43 | 38 | 0 |
P value = 0.193 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 203 | 23 |
subtype1 | 39 | 2 |
subtype2 | 17 | 1 |
subtype3 | 42 | 6 |
subtype4 | 46 | 10 |
subtype5 | 59 | 4 |
P value = 0.00064 (Fisher's exact test), Q value = 0.069
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 6 | 266 |
subtype1 | 0 | 50 |
subtype2 | 0 | 23 |
subtype3 | 6 | 52 |
subtype4 | 0 | 60 |
subtype5 | 0 | 81 |
P value = 0.0301 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 193 | 57 | 3 | 6 |
subtype1 | 35 | 9 | 0 | 2 |
subtype2 | 15 | 6 | 1 | 0 |
subtype3 | 35 | 19 | 0 | 2 |
subtype4 | 45 | 15 | 0 | 0 |
subtype5 | 63 | 8 | 2 | 2 |
P value = 0.148 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 0.2 (1.2) |
subtype1 | 39 | 0.1 (0.2) |
subtype2 | 18 | 0.1 (0.2) |
subtype3 | 48 | 0.5 (2.2) |
subtype4 | 56 | 0.4 (1.1) |
subtype5 | 63 | 0.1 (0.3) |
P value = 0.0301 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 50 | 7.1 (0.6) |
subtype2 | 23 | 7.2 (1.0) |
subtype3 | 58 | 7.5 (1.0) |
subtype4 | 60 | 7.4 (0.8) |
subtype5 | 81 | 7.1 (0.7) |
P value = 0.000358 (Kruskal-Wallis (anova)), Q value = 0.039
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.5 (0.6) |
subtype1 | 50 | 3.3 (0.5) |
subtype2 | 23 | 3.3 (0.5) |
subtype3 | 58 | 3.6 (0.6) |
subtype4 | 60 | 3.7 (0.6) |
subtype5 | 81 | 3.4 (0.5) |
P value = 0.25 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.8 (0.6) |
subtype1 | 50 | 3.8 (0.5) |
subtype2 | 23 | 3.9 (0.6) |
subtype3 | 58 | 3.9 (0.7) |
subtype4 | 60 | 3.8 (0.7) |
subtype5 | 81 | 3.7 (0.6) |
P value = 0.034 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 50 | 7.2 (0.6) |
subtype2 | 23 | 7.2 (1.1) |
subtype3 | 58 | 7.6 (1.0) |
subtype4 | 60 | 7.5 (0.8) |
subtype5 | 81 | 7.2 (0.7) |
P value = 0.0118 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 270 | 10.5 (11.2) |
subtype1 | 50 | 7.2 (3.7) |
subtype2 | 23 | 11.6 (16.3) |
subtype3 | 58 | 11.7 (14.0) |
subtype4 | 58 | 13.9 (14.1) |
subtype5 | 81 | 8.8 (6.3) |
P value = 0.131 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 228 | 1.1 (3.9) |
subtype1 | 44 | 0.7 (2.6) |
subtype2 | 22 | 0.4 (1.7) |
subtype3 | 42 | 1.1 (4.2) |
subtype4 | 54 | 2.4 (6.1) |
subtype5 | 66 | 0.5 (1.8) |
P value = 0.417 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 146 |
subtype1 | 0 | 0 | 25 |
subtype2 | 0 | 1 | 8 |
subtype3 | 0 | 0 | 2 |
subtype4 | 1 | 1 | 50 |
subtype5 | 1 | 5 | 61 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 94 | 50 | 128 |
P value = 0.301 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 269 | 60.4 (7.0) |
subtype1 | 94 | 59.7 (6.5) |
subtype2 | 49 | 60.0 (7.2) |
subtype3 | 126 | 61.0 (7.3) |
P value = 0.00014 (Fisher's exact test), Q value = 0.016
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 139 | 4 |
subtype1 | 44 | 48 | 0 |
subtype2 | 31 | 15 | 4 |
subtype3 | 52 | 76 | 0 |
P value = 0.00299 (Fisher's exact test), Q value = 0.3
nPatients | 0 | 1 |
---|---|---|
ALL | 203 | 23 |
subtype1 | 77 | 5 |
subtype2 | 37 | 0 |
subtype3 | 89 | 18 |
P value = 0.577 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 6 | 266 |
subtype1 | 3 | 91 |
subtype2 | 0 | 50 |
subtype3 | 3 | 125 |
P value = 0.768 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 193 | 57 | 3 | 6 |
subtype1 | 70 | 16 | 0 | 2 |
subtype2 | 34 | 12 | 1 | 1 |
subtype3 | 89 | 29 | 2 | 3 |
P value = 0.00463 (Kruskal-Wallis (anova)), Q value = 0.44
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 0.2 (1.2) |
subtype1 | 80 | 0.1 (0.4) |
subtype2 | 37 | 0.0 (0.0) |
subtype3 | 107 | 0.4 (1.6) |
P value = 8.63e-06 (Kruskal-Wallis (anova)), Q value = 0.0011
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 94 | 7.1 (0.7) |
subtype2 | 50 | 7.0 (0.7) |
subtype3 | 128 | 7.5 (0.9) |
P value = 1.63e-05 (Kruskal-Wallis (anova)), Q value = 0.002
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.5 (0.6) |
subtype1 | 94 | 3.4 (0.5) |
subtype2 | 50 | 3.3 (0.5) |
subtype3 | 128 | 3.7 (0.6) |
P value = 0.28 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.8 (0.6) |
subtype1 | 94 | 3.8 (0.6) |
subtype2 | 50 | 3.7 (0.6) |
subtype3 | 128 | 3.9 (0.7) |
P value = 0.00014 (Kruskal-Wallis (anova)), Q value = 0.016
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 94 | 7.1 (0.7) |
subtype2 | 50 | 7.1 (0.8) |
subtype3 | 128 | 7.5 (0.9) |
P value = 0.188 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 270 | 10.5 (11.2) |
subtype1 | 93 | 9.1 (10.3) |
subtype2 | 50 | 10.6 (13.2) |
subtype3 | 127 | 11.4 (11.0) |
P value = 0.0193 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 228 | 1.1 (3.9) |
subtype1 | 85 | 1.0 (3.0) |
subtype2 | 47 | 0.1 (0.2) |
subtype3 | 96 | 1.7 (5.2) |
P value = 0.824 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 146 |
subtype1 | 1 | 1 | 50 |
subtype2 | 0 | 2 | 28 |
subtype3 | 1 | 4 | 68 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 73 | 99 | 100 |
P value = 0.0573 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 269 | 60.4 (7.0) |
subtype1 | 73 | 62.0 (6.7) |
subtype2 | 96 | 59.3 (7.1) |
subtype3 | 100 | 60.2 (7.0) |
P value = 0.419 (Fisher's exact test), Q value = 1
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 139 | 4 |
subtype1 | 31 | 42 | 0 |
subtype2 | 51 | 47 | 1 |
subtype3 | 45 | 50 | 3 |
P value = 0.113 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 203 | 23 |
subtype1 | 50 | 10 |
subtype2 | 72 | 8 |
subtype3 | 81 | 5 |
P value = 0.0408 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 6 | 266 |
subtype1 | 4 | 69 |
subtype2 | 0 | 99 |
subtype3 | 2 | 98 |
P value = 0.435 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 193 | 57 | 3 | 6 |
subtype1 | 48 | 21 | 0 | 2 |
subtype2 | 73 | 15 | 2 | 2 |
subtype3 | 72 | 21 | 1 | 2 |
P value = 0.0953 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 0.2 (1.2) |
subtype1 | 60 | 0.4 (1.0) |
subtype2 | 80 | 0.3 (1.7) |
subtype3 | 84 | 0.1 (0.4) |
P value = 0.0034 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 73 | 7.6 (0.9) |
subtype2 | 99 | 7.2 (0.7) |
subtype3 | 100 | 7.2 (0.7) |
P value = 0.00568 (Kruskal-Wallis (anova)), Q value = 0.54
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.5 (0.6) |
subtype1 | 73 | 3.7 (0.6) |
subtype2 | 99 | 3.4 (0.5) |
subtype3 | 100 | 3.4 (0.5) |
P value = 0.333 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.8 (0.6) |
subtype1 | 73 | 3.9 (0.7) |
subtype2 | 99 | 3.8 (0.6) |
subtype3 | 100 | 3.8 (0.6) |
P value = 0.00761 (Kruskal-Wallis (anova)), Q value = 0.7
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 73 | 7.6 (1.0) |
subtype2 | 99 | 7.2 (0.7) |
subtype3 | 100 | 7.2 (0.8) |
P value = 0.775 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 270 | 10.5 (11.2) |
subtype1 | 72 | 12.0 (12.4) |
subtype2 | 99 | 10.0 (10.7) |
subtype3 | 99 | 9.9 (10.8) |
P value = 0.668 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 228 | 1.1 (3.9) |
subtype1 | 54 | 1.7 (4.4) |
subtype2 | 81 | 0.5 (1.6) |
subtype3 | 93 | 1.3 (4.8) |
P value = 0.828 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 146 |
subtype1 | 0 | 0 | 19 |
subtype2 | 1 | 5 | 69 |
subtype3 | 1 | 2 | 58 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 44 | 25 | 55 | 62 | 86 |
P value = 0.636 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 269 | 60.4 (7.0) |
subtype1 | 44 | 60.6 (6.6) |
subtype2 | 25 | 59.4 (7.8) |
subtype3 | 55 | 61.4 (7.0) |
subtype4 | 62 | 60.7 (7.0) |
subtype5 | 83 | 59.7 (7.1) |
P value = 8e-05 (Fisher's exact test), Q value = 0.0095
nPatients | T2 | T3 | T4 |
---|---|---|---|
ALL | 127 | 139 | 4 |
subtype1 | 25 | 18 | 0 |
subtype2 | 14 | 7 | 4 |
subtype3 | 20 | 35 | 0 |
subtype4 | 22 | 39 | 0 |
subtype5 | 46 | 40 | 0 |
P value = 0.0916 (Fisher's exact test), Q value = 1
nPatients | 0 | 1 |
---|---|---|
ALL | 203 | 23 |
subtype1 | 33 | 0 |
subtype2 | 19 | 1 |
subtype3 | 40 | 7 |
subtype4 | 50 | 9 |
subtype5 | 61 | 6 |
P value = 0.014 (Fisher's exact test), Q value = 1
nPatients | PROSTATE ADENOCARCINOMA OTHER SUBTYPE | PROSTATE ADENOCARCINOMA ACINAR TYPE |
---|---|---|
ALL | 6 | 266 |
subtype1 | 3 | 41 |
subtype2 | 0 | 25 |
subtype3 | 3 | 52 |
subtype4 | 0 | 62 |
subtype5 | 0 | 86 |
P value = 0.588 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 193 | 57 | 3 | 6 |
subtype1 | 29 | 10 | 0 | 1 |
subtype2 | 16 | 7 | 1 | 0 |
subtype3 | 37 | 15 | 0 | 2 |
subtype4 | 48 | 13 | 0 | 1 |
subtype5 | 63 | 12 | 2 | 2 |
P value = 0.134 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 224 | 0.2 (1.2) |
subtype1 | 31 | 0.0 (0.0) |
subtype2 | 20 | 0.1 (0.2) |
subtype3 | 47 | 0.3 (1.0) |
subtype4 | 59 | 0.3 (0.7) |
subtype5 | 67 | 0.3 (1.9) |
P value = 0.000299 (Kruskal-Wallis (anova)), Q value = 0.033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 44 | 7.1 (0.6) |
subtype2 | 25 | 7.2 (0.9) |
subtype3 | 55 | 7.7 (1.0) |
subtype4 | 62 | 7.3 (0.8) |
subtype5 | 86 | 7.2 (0.7) |
P value = 0.00148 (Kruskal-Wallis (anova)), Q value = 0.15
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.5 (0.6) |
subtype1 | 44 | 3.4 (0.5) |
subtype2 | 25 | 3.5 (0.6) |
subtype3 | 55 | 3.8 (0.6) |
subtype4 | 62 | 3.4 (0.6) |
subtype5 | 86 | 3.4 (0.5) |
P value = 0.264 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 3.8 (0.6) |
subtype1 | 44 | 3.7 (0.5) |
subtype2 | 25 | 3.7 (0.6) |
subtype3 | 55 | 4.0 (0.7) |
subtype4 | 62 | 3.8 (0.6) |
subtype5 | 86 | 3.7 (0.6) |
P value = 0.00113 (Kruskal-Wallis (anova)), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 272 | 7.3 (0.8) |
subtype1 | 44 | 7.1 (0.6) |
subtype2 | 25 | 7.4 (1.0) |
subtype3 | 55 | 7.7 (1.0) |
subtype4 | 62 | 7.3 (0.8) |
subtype5 | 86 | 7.2 (0.7) |
P value = 0.0185 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 270 | 10.5 (11.2) |
subtype1 | 44 | 9.1 (13.8) |
subtype2 | 25 | 13.3 (17.2) |
subtype3 | 55 | 12.6 (12.8) |
subtype4 | 60 | 10.8 (8.3) |
subtype5 | 86 | 8.9 (7.5) |
P value = 0.149 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 228 | 1.1 (3.9) |
subtype1 | 37 | 0.6 (2.1) |
subtype2 | 25 | 0.1 (0.2) |
subtype3 | 36 | 1.7 (4.7) |
subtype4 | 60 | 2.1 (6.0) |
subtype5 | 70 | 0.5 (1.7) |
P value = 0.139 (Fisher's exact test), Q value = 1
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 2 | 7 | 146 |
subtype1 | 0 | 0 | 4 |
subtype2 | 0 | 2 | 11 |
subtype3 | 0 | 1 | 9 |
subtype4 | 1 | 0 | 61 |
subtype5 | 1 | 4 | 61 |
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Cluster data file = PRAD-TP.mergedcluster.txt
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Clinical data file = PRAD-TP.merged_data.txt
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Number of patients = 274
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Number of clustering approaches = 10
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Number of selected clinical features = 13
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Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.