Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.001 0.161 -9999.0 0.0 -0.61 18.0 18.0 IHH -0.048 0.185 -9999.0 0.0 -0.535 46.0 46.0 SHH Np/Cholesterol/GAS1 -0.078 0.157 -9999.0 0.0 -0.293 120.0 120.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.078 0.156 0.291 120.0 -9999.0 0.0 120.0 SMO/beta Arrestin2 -0.0 0.117 -9999.0 0.0 -0.42 15.0 15.0 SMO -0.007 0.123 -9999.0 0.0 -0.44 16.0 16.0 AKT1 0.011 0.087 -9999.0 0.0 -0.441 7.0 7.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.076 -9999.0 0.0 -0.458 10.0 10.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.007 0.122 -9999.0 0.0 -0.434 16.0 16.0 STIL -0.061 0.164 -9999.0 0.0 -0.439 31.0 31.0 DHH N/PTCH2 0.01 0.061 -9999.0 0.0 -0.338 11.0 11.0 DHH N/PTCH1 -0.001 0.118 -9999.0 0.0 -0.421 13.0 13.0 PIK3CA 0.008 0.052 -9999.0 0.0 -0.491 4.0 4.0 DHH 0.001 0.077 -9999.0 0.0 -0.488 9.0 9.0 PTHLH -0.009 0.203 -9999.0 0.0 -0.806 18.0 18.0 determination of left/right symmetry -0.007 0.122 -9999.0 0.0 -0.434 16.0 16.0 PIK3R1 0.007 0.054 -9999.0 0.0 -0.458 5.0 5.0 skeletal system development -0.009 0.201 -9999.0 0.0 -0.796 18.0 18.0 IHH N/Hhip -0.05 0.163 -9999.0 0.0 -0.376 71.0 71.0 DHH N/Hhip -0.021 0.112 -9999.0 0.0 -0.325 44.0 44.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.007 0.122 -9999.0 0.0 -0.434 16.0 16.0 pancreas development -0.031 0.138 -9999.0 0.0 -0.461 35.0 35.0 HHAT 0.007 0.054 -9999.0 0.0 -0.458 5.0 5.0 PI3K 0.012 0.058 -9999.0 0.0 -0.366 8.0 8.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.038 0.147 -9999.0 0.0 -0.458 41.0 41.0 somite specification -0.007 0.122 -9999.0 0.0 -0.434 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.055 0.156 -9999.0 0.0 -0.423 27.0 27.0 SHH Np/Cholesterol/PTCH2 -0.052 0.133 -9999.0 0.0 -0.339 37.0 37.0 SHH Np/Cholesterol/Megalin -0.081 0.161 -9999.0 0.0 -0.299 121.0 121.0 SHH -0.075 0.17 -9999.0 0.0 -0.365 93.0 93.0 catabolic process -0.002 0.121 -9999.0 0.0 -0.474 9.0 9.0 SMO/Vitamin D3 -0.046 0.157 -9999.0 0.0 -0.433 26.0 26.0 SHH Np/Cholesterol/Hhip -0.074 0.159 -9999.0 0.0 -0.308 110.0 110.0 LRP2 -0.043 0.157 -9999.0 0.0 -0.477 43.0 43.0 receptor-mediated endocytosis -0.062 0.173 -9999.0 0.0 -0.439 39.0 39.0 SHH Np/Cholesterol/BOC -0.057 0.139 -9999.0 0.0 -0.281 99.0 99.0 SHH Np/Cholesterol/CDO -0.054 0.135 -9999.0 0.0 -0.278 96.0 96.0 mesenchymal cell differentiation 0.074 0.158 0.306 110.0 -9999.0 0.0 110.0 mol:Vitamin D3 -0.053 0.157 -9999.0 0.0 -0.424 27.0 27.0 IHH N/PTCH2 -0.018 0.117 -9999.0 0.0 -0.338 34.0 34.0 CDON 0.007 0.059 -9999.0 0.0 -0.558 4.0 4.0 IHH N/PTCH1 -0.001 0.122 -9999.0 0.0 -0.479 9.0 9.0 Megalin/LRPAP1 -0.021 0.113 -9999.0 0.0 -0.333 43.0 43.0 PTCH2 0.011 0.034 -9999.0 0.0 -0.458 2.0 2.0 SHH Np/Cholesterol -0.059 0.13 -9999.0 0.0 -0.281 93.0 93.0 PTCH1 -0.002 0.121 -9999.0 0.0 -0.476 9.0 9.0 HHIP -0.031 0.139 -9999.0 0.0 -0.462 35.0 35.0