Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.144 -9999.0 0.0 -0.649 6.0 6.0 IHH 0.007 0.077 -9999.0 0.0 -0.459 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.11 0.202 -9999.0 0.0 -0.478 33.0 33.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.109 0.2 0.474 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 0.013 0.09 -9999.0 0.0 -0.483 2.0 2.0 SMO 0.008 0.094 -9999.0 0.0 -0.511 2.0 2.0 AKT1 0.022 0.053 -9999.0 0.0 -0.307 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.069 -9999.0 0.0 -0.39 5.0 5.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.008 0.093 -9999.0 0.0 -0.504 2.0 2.0 STIL -0.048 0.171 -9999.0 0.0 -0.509 2.0 2.0 DHH N/PTCH2 -0.003 0.093 -9999.0 0.0 -0.563 3.0 3.0 DHH N/PTCH1 0.017 0.087 -9999.0 0.0 -0.509 1.0 1.0 PIK3CA 0.01 0.031 -9999.0 0.0 -0.39 1.0 1.0 DHH -0.003 0.076 -9999.0 0.0 -0.39 6.0 6.0 PTHLH 0.015 0.158 -9999.0 0.0 -0.803 4.0 4.0 determination of left/right symmetry 0.008 0.093 -9999.0 0.0 -0.504 2.0 2.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.015 0.157 -9999.0 0.0 -0.794 4.0 4.0 IHH N/Hhip -0.023 0.117 -9999.0 0.0 -0.318 20.0 20.0 DHH N/Hhip -0.027 0.104 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.008 0.093 -9999.0 0.0 -0.504 2.0 2.0 pancreas development -0.037 0.132 -9999.0 0.0 -0.389 20.0 20.0 HHAT 0.01 0.031 -9999.0 0.0 -0.39 1.0 1.0 PI3K 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.066 0.165 -9999.0 0.0 -0.401 31.0 31.0 somite specification 0.008 0.093 -9999.0 0.0 -0.504 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.055 0.18 -9999.0 0.0 -0.399 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.077 0.19 -9999.0 0.0 -0.445 34.0 34.0 SHH Np/Cholesterol/Megalin -0.114 0.229 -9999.0 0.0 -0.488 42.0 42.0 SHH -0.094 0.229 -9999.0 0.0 -0.555 32.0 32.0 catabolic process 0.021 0.088 -9999.0 0.0 -0.493 2.0 2.0 SMO/Vitamin D3 -0.044 0.172 -9999.0 0.0 -0.536 2.0 2.0 SHH Np/Cholesterol/Hhip -0.095 0.192 -9999.0 0.0 -0.463 31.0 31.0 LRP2 -0.063 0.217 -9999.0 0.0 -0.743 15.0 15.0 receptor-mediated endocytosis -0.06 0.185 -9999.0 0.0 -0.565 7.0 7.0 SHH Np/Cholesterol/BOC -0.075 0.184 -9999.0 0.0 -0.445 31.0 31.0 SHH Np/Cholesterol/CDO -0.07 0.186 -9999.0 0.0 -0.451 31.0 31.0 mesenchymal cell differentiation 0.094 0.19 0.46 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.053 0.181 -9999.0 0.0 -0.397 32.0 32.0 IHH N/PTCH2 0.004 0.095 -9999.0 0.0 -0.535 4.0 4.0 CDON 0.01 0.031 -9999.0 0.0 -0.39 1.0 1.0 IHH N/PTCH1 0.023 0.089 -9999.0 0.0 -0.499 2.0 2.0 Megalin/LRPAP1 -0.039 0.167 -9999.0 0.0 -0.563 15.0 15.0 PTCH2 -0.002 0.102 -9999.0 0.0 -0.743 3.0 3.0 SHH Np/Cholesterol -0.076 0.183 -9999.0 0.0 -0.451 31.0 31.0 PTCH1 0.021 0.088 -9999.0 0.0 -0.495 2.0 2.0 HHIP -0.037 0.132 -9999.0 0.0 -0.39 20.0 20.0