rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(66), AR(2), BRAF(2), DAG1(1), EGFR(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), MAPK10(4), PHKA2(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), RAF1(2)	5018319	111	60	101	7	18	15	11	0	46	21	4.88e-08	<1.00e-15	<1.07e-13
2	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(5), ATM(10), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(5), TP53(45)	2001688	72	50	57	4	26	18	9	3	15	1	1.75e-05	<1.00e-15	<1.07e-13
3	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(10), ATR(4), CDC25C(1), TP53(45), YWHAH(1)	1621418	61	49	46	6	22	16	7	2	13	1	0.0153	<1.00e-15	<1.07e-13
4	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(1), IGF1R(1), PRKCA(2), RB1(3), TERF1(1), TP53(45), XRCC5(2)	2767314	55	48	40	6	22	9	9	2	13	0	0.00139	<1.00e-15	<1.07e-13
5	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(66), CDH1(1), CREBBP(4), EP300(2), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(4), TGFBR1(3)	2554178	85	57	75	4	5	10	8	0	44	18	5.23e-06	1.11e-15	1.07e-13
6	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(66), AXIN1(1), CREBBP(4), CTNNB1(4), EP300(2), FZD1(1), GSK3B(1), LDB1(2), TRRAP(4)	3136901	85	58	75	4	8	12	6	0	41	18	1.03e-06	1.22e-15	1.07e-13
7	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(66), AXIN1(1), BTRC(3), CREBBP(4), CSNK1D(1), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), PPARD(1)	2701685	84	58	74	4	8	9	8	0	41	18	1.81e-06	1.22e-15	1.07e-13
8	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(66), AXIN1(1), CTNNB1(4), DVL2(1), DVL3(2), FBXW2(1), FZD1(1), FZD10(2), FZD3(3), FZD6(3), GSK3B(1), LDLR(1), MAPK10(4), MAPK9(2), PLAU(1), PPP2R5C(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RHOA(1), SFRP4(1), TCF7(3), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1)	5514820	117	58	107	13	15	27	8	0	49	18	6.70e-06	1.44e-15	1.09e-13
9	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(10), CDK4(1), PCNA(1), RB1(3), TIMP3(1), TP53(45)	1820960	62	50	47	6	21	14	9	2	15	1	0.00200	1.67e-15	1.09e-13
10	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(1), APC(66), ATF2(1), AXIN1(1), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), MEF2C(2), NPPB(1), RFC1(4), TGFB2(4), TGFBR1(3), TGFBR3(3)	3414527	102	59	92	3	13	19	9	0	43	18	6.13e-09	1.78e-15	1.09e-13
11	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(66), CAV3(1), DAG1(1), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(6)	4224359	97	57	87	9	14	15	6	0	43	19	4.08e-06	2.00e-15	1.12e-13
12	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT2(1), AKT3(1), APC(66), AXIN1(1), AXIN2(2), CTNNB1(4), DACT1(1), DKK1(2), DKK2(1), DKK4(3), FSTL1(1), GSK3B(1), LRP1(3), SENP2(1), SFRP1(1), TSHB(1)	3759900	90	59	80	4	8	14	11	0	39	18	3.20e-07	2.44e-15	1.25e-13
13	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	APC(66), AXIN1(1), CTNNB1(4), FZD1(1), GJA1(4), GNAI1(1), GSK3B(1), MYD88(1), NFKB1(3), PIK3CA(7), PIK3R1(5), TLR4(3)	2809332	97	60	87	4	12	15	10	0	40	20	9.29e-08	2.78e-15	1.32e-13
14	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), MAP3K14(1), NFKB1(3), TP53(45)	924291	51	47	36	3	22	7	8	2	12	0	0.000558	3.00e-15	1.32e-13
15	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(66), CASP3(1), CREB3(1), CREB5(2), DAG1(1), EPHB2(1), FOS(1), GNAQ(1), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2)	2754563	88	58	78	3	7	9	7	2	45	18	4.57e-08	3.44e-15	1.41e-13
16	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(1), APC(66), AXIN1(1), BTRC(3), CTNNB1(4), DLL1(3), FZD1(1), GSK3B(1)	1945423	80	58	70	1	6	8	6	0	42	18	5.59e-09	3.77e-15	1.41e-13
17	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	SP3(1), TP53(45), WT1(2)	682832	48	46	33	2	21	7	6	2	12	0	2.94e-05	3.89e-15	1.41e-13
18	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(10), CDC25C(1), CDK4(1), MYT1(5), RB1(3), TP53(45), YWHAH(1)	1764616	66	50	51	5	24	16	9	2	14	1	0.000686	5.11e-15	1.75e-13
19	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(3), NFKB1(3), RB1(3), TP53(45), USH1C(3), WT1(2)	1809425	64	48	49	6	25	14	7	2	15	1	0.000432	5.55e-15	1.80e-13
20	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), ATM(10), CASP3(1), CASP6(1), PRKCA(2), TLN1(2), TP53(45)	2681206	62	49	47	5	20	16	8	2	15	1	0.000568	6.33e-15	1.95e-13
21	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(1), CDKN1B(2), PRB1(1), TP53(45)	748706	49	48	34	2	20	6	6	2	15	0	4.71e-05	7.44e-15	2.18e-13
22	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(10), BRCA1(1), MAPK8(5), MRE11A(5), NFKB1(3), RAD50(6), TP53(45)	2958783	75	49	60	7	26	22	10	3	13	1	0.000599	8.77e-15	2.46e-13
23	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), DAXX(1), PAX3(2), PML(1), RB1(3), SIRT1(1), TP53(45)	1828212	57	49	42	5	26	7	8	2	14	0	0.000340	9.66e-15	2.51e-13
24	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	PIK3CA(7), PIK3R1(5), POLR1A(3), POLR1B(2), RB1(3), TP53(45)	1942156	65	53	50	5	26	11	10	2	14	2	0.000113	9.77e-15	2.51e-13
25	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(10), ATR(4), BRCA1(1), BRCA2(11), FANCA(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(5), RAD17(2), RAD50(6), TP53(45)	4349343	93	49	78	7	27	31	16	2	16	1	8.50e-05	2.37e-12	5.84e-11
26	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), FAS(2), GZMB(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), MAPK10(4), NFKB1(3), TP53(45), TRAF1(1)	3579391	71	49	56	8	27	12	11	2	19	0	0.000321	3.69e-12	8.74e-11
27	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(10), ATR(4), BRCA1(1), CDC25C(1), EP300(2), MYT1(5), PRKDC(5), TP53(45), YWHAH(1)	3947163	74	49	59	8	27	20	10	2	14	1	0.00142	6.55e-12	1.49e-10
28	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(2), CPEB1(3), EGFR(1), ERBB2(4), ERBB4(5), ETS1(1), ETS2(1), ETV6(1), FMN2(3), GRB2(1), KRAS(38), MAP2K1(1), MAPK3(1), NOTCH2(2), NOTCH3(3), NOTCH4(4), PIWIL1(3), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(2), SOS1(2), SOS2(2), SPIRE1(1)	5169707	89	48	57	9	13	54	13	1	8	0	0.000109	1.86e-06	4.10e-05
29	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ATM(10), ATR(4), CCNA1(2), CDK4(1), CDKN1B(2), DHFR(1), GSK3B(1), RB1(3), TGFB2(4), TP53(45)	2967856	73	51	58	11	24	18	10	2	18	1	0.00914	1.67e-05	0.000356
30	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(1), IL1R1(1), MAP2K4(2), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(5), MAPK9(2), NFATC3(1), PAPPA(5), TP53(45), ZAK(2)	4934931	90	54	75	11	34	19	12	3	22	0	0.000279	1.99e-05	0.000408
31	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(7), PIK3R1(5), SYK(3), VAV1(2)	1789829	27	14	27	2	5	8	7	0	4	3	0.0281	0.000392	0.00780
32	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(5), NRG2(2), NRG3(4), PRKCA(2)	908762	14	9	14	1	4	5	1	1	3	0	0.0731	0.00145	0.0280
33	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	CDKN1B(2), GRB2(1), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), SOS1(2)	1853660	23	13	23	2	4	7	5	0	5	2	0.0548	0.00453	0.0845
34	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNGT1(1), PRKACA(1), PRKAR1A(4)	607553	10	8	10	1	3	4	1	0	2	0	0.197	0.00711	0.129
35	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	FOS(1), GRB2(1), INSR(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SLC2A4(1), SOS1(2)	2464448	37	15	37	3	10	11	8	1	5	2	0.00481	0.00940	0.165
36	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	73821	4	3	4	0	3	1	0	0	0	0	0.278	0.0125	0.211
37	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD80(1), CTLA4(1), GRB2(1), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(3), LCK(1), PIK3CA(7), PIK3R1(5), PTPN11(3)	1233614	26	13	26	4	9	10	3	0	2	2	0.140	0.0126	0.211
38	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	837086	11	10	11	2	3	5	1	0	2	0	0.311	0.0171	0.270
39	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	837086	11	10	11	2	3	5	1	0	2	0	0.311	0.0171	0.270
40	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(66), AXIN1(1), AXIN2(2), BTRC(3), CACYBP(1), CAMK2D(1), CHD8(2), CREBBP(4), CTNNB1(4), CUL1(1), DAAM1(1), DAAM2(4), DKK1(2), DKK2(1), DKK4(3), DVL2(1), DVL3(2), EP300(2), FBXW11(1), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GSK3B(1), LRP6(7), MAP3K7(2), MAPK10(4), MAPK8(5), MAPK9(2), MMP7(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PLCB3(1), PLCB4(1), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(1), SMAD2(5), SMAD3(3), SMAD4(8), TBL1X(1), TBL1Y(1), TCF7(3), TCF7L2(7), TP53(45), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	15218495	263	68	234	35	68	67	33	3	74	18	1.12e-09	0.0226	0.347
41	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CHUK(2), GH1(1), NFKB1(3), PIK3CA(7), PIK3R1(5), YWHAH(1)	1382903	19	11	19	3	7	5	4	0	1	2	0.197	0.0278	0.417
42	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(1), ATM(10), ATR(4), CASP3(1), CCNB3(3), CCNE2(1), CCNG1(1), CDK4(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGFBP3(2), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53(45), TP53I3(2), TSC2(1), ZMAT3(2)	6248919	98	52	83	14	35	30	13	2	17	1	0.000827	0.0312	0.453
43	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(2), LTB4R(1), P2RY1(3), P2RY2(1), P2RY6(1)	524943	11	6	11	0	5	5	1	0	0	0	0.0140	0.0316	0.453
44	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(1), FBXW7(12), RB1(3)	863506	16	10	14	3	7	2	3	0	4	0	0.210	0.0340	0.475
45	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), WASL(2)	1299034	23	11	23	4	6	5	7	0	3	2	0.237	0.0452	0.619
46	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	FOS(1), GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SOS1(2)	2391776	36	15	36	5	10	11	8	1	4	2	0.0319	0.0478	0.640
47	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), SOS1(2)	1507914	17	13	17	3	4	6	4	0	1	2	0.291	0.0531	0.696
48	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(7), PIK3R1(5), PRKCA(2), VAV1(2)	1260447	16	12	16	4	4	6	3	0	1	2	0.480	0.0555	0.712
49	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(1), MUSK(2), PIK3CA(7), PIK3R1(5), YWHAH(1)	1525204	16	11	16	3	4	5	3	0	2	2	0.272	0.0662	0.832
50	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	179749	2	2	2	1	1	0	1	0	0	0	0.776	0.0731	0.901
51	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RB1(3)	1915799	28	16	28	4	8	7	7	1	3	2	0.104	0.0759	0.917
52	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(4), ARHGEF1(1), F2(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(7), PIK3R1(5), PPP1R12B(4), PRKCA(2), ROCK1(7)	2517883	36	19	36	8	9	10	8	0	7	2	0.211	0.0848	1.000
53	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	FOS(1), GRB2(1), MAP2K1(1), MAPK3(1), MAPK8(5), NGFR(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2)	1840323	26	13	26	4	7	8	6	1	2	2	0.117	0.0879	1.000
54	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CDC42(1), CHUK(2), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RAF1(2), RALA(1), RALBP1(2), RHOA(1)	1860338	26	13	26	4	9	4	8	0	3	2	0.105	0.0882	1.000
55	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(4), CAMK2D(1), GRB2(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RPS6KA5(3), SOS1(2)	2804191	32	17	32	4	11	10	6	0	3	2	0.0368	0.0895	1.000
56	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), YWHAH(1)	1829749	24	13	24	4	6	7	6	0	3	2	0.146	0.0989	1.000
57	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(2), CREB3(1), CREB5(2), RAF1(2), SNX13(3), TERF2IP(1)	1091338	11	5	11	1	5	2	3	1	0	0	0.138	0.104	1.000
58	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(2), HDC(5), TPH1(2)	572489	10	7	10	2	3	5	1	0	1	0	0.317	0.107	1.000
59	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(1), MAPK3(1), MEF2A(1), MEF2C(2), PIK3CA(7), PIK3R1(5)	1760918	17	12	17	3	4	5	3	0	3	2	0.224	0.114	1.000
60	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(7), PIK3R1(5), RAF1(2), RB1(3)	1979729	25	13	25	5	10	3	5	0	5	2	0.201	0.121	1.000
61	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BCL2L11(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), CHUK(2), DFFA(1), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF3(2), IRF4(2), MAP2K4(2), MAP3K1(2), MAPK10(4), NFKB1(3), TNFRSF10B(4), TNFRSF21(1), TP53(45), TRAF1(1), TRAF3(2)	5568404	90	50	75	13	35	19	12	2	22	0	0.000900	0.123	1.000
62	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2), STAT5B(1), THPO(1)	2921813	32	15	32	3	8	11	6	0	4	3	0.0238	0.125	1.000
63	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(1), ERBB3(3), NRG1(6)	1030074	10	7	10	1	2	2	4	0	2	0	0.338	0.136	1.000
64	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), RB1(3), SP3(1)	671306	6	4	6	1	2	2	1	0	1	0	0.519	0.149	1.000
65	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(1), FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2)	3674529	37	17	37	4	11	12	7	1	4	2	0.0140	0.176	1.000
66	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(2), DNMT1(7), PTGDR(1), PTGFR(1)	1067165	11	7	11	1	7	3	0	1	0	0	0.0539	0.181	1.000
67	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(3), JAK3(2), PIAS1(1), PTPRU(6), REG1A(2)	1298234	15	9	15	2	8	3	1	0	2	1	0.180	0.181	1.000
68	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(2), SNCAIP(2), UBE2E2(1)	638436	6	4	6	1	1	4	1	0	0	0	0.479	0.193	1.000
69	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(1), GNGT1(1), NFKB1(3), NR3C1(1), PIK3CA(7), PIK3R1(5)	1706664	18	13	18	4	7	4	3	0	2	2	0.353	0.194	1.000
70	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(1), FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1)	2640665	34	15	34	4	9	11	6	1	4	3	0.0298	0.197	1.000
71	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2)	3399705	40	17	40	6	11	14	8	1	4	2	0.0451	0.206	1.000
72	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD22(2), CD72(1), CD79B(1), CHUK(2), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), KRAS(38), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASGRP3(3), SYK(3), VAV1(2), VAV2(2), VAV3(2)	7103047	115	49	84	17	30	64	11	0	8	2	0.000279	0.210	1.000
73	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(4), GNAI1(1), GNGT1(1), ITGAV(4), ITGB3(2), MAPK3(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), SPHK1(1)	2675905	32	18	32	9	8	11	6	0	5	2	0.422	0.217	1.000
74	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNGT1(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2)	902263	9	6	9	1	4	4	0	0	1	0	0.206	0.222	1.000
75	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT1(2), METTL2B(1), METTL6(3), PCYT1A(1), PRMT3(1), PRMT7(1), PRMT8(2)	1311197	12	7	12	2	3	4	2	1	2	0	0.218	0.232	1.000
76	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	421086	2	2	2	1	0	2	0	0	0	0	0.881	0.254	1.000
77	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(3), PTPRU(6), REG1A(2)	1115679	13	8	13	2	9	2	0	0	1	1	0.180	0.264	1.000
78	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), FYN(1), MAP2K1(1), MAPK3(1), MYLK(3), PIK3CA(7), PIK3R1(5), RAF1(2), ROCK1(7), TLN1(2)	3602588	32	14	32	6	9	10	8	0	3	2	0.158	0.269	1.000
79	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), SDHA(1)	619567	5	4	5	0	1	1	3	0	0	0	0.253	0.271	1.000
80	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(1), GRB2(1), IARS(1), IL13RA1(1), INPP5D(2), JAK1(1), JAK2(3), JAK3(2), PI3(1), PIK3CA(7), PPP1R13B(1), SERPINA4(3), SOS1(2), SOS2(2)	3526817	29	13	29	2	6	12	7	0	3	1	0.0163	0.276	1.000
81	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	149252	3	2	3	1	0	2	1	0	0	0	0.844	0.277	1.000
82	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(2)	202560	2	2	2	1	0	2	0	0	0	0	0.853	0.282	1.000
83	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), KERA(2), LUM(1)	351893	5	3	5	1	3	0	2	0	0	0	0.510	0.298	1.000
84	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FOS(1), FYN(1), GRB2(1), LAT(1), LCK(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(2), RASA1(4), SOS1(2), VAV1(2)	4630120	53	22	53	9	21	16	7	1	6	2	0.0228	0.302	1.000
85	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT3(1)	428255	4	3	4	1	3	1	0	0	0	0	0.551	0.303	1.000
86	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2L11(1), CASP8AP2(6), CES1(1)	964874	9	7	9	2	2	5	1	0	1	0	0.560	0.310	1.000
87	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(6), REG1A(2), STAT2(2)	1204991	11	8	11	2	9	1	0	0	1	0	0.200	0.311	1.000
88	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(2), CUL1(1), NEDD8(1), RB1(3), RBX1(1)	862374	8	6	8	4	3	0	1	0	4	0	0.770	0.325	1.000
89	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(3), CRY1(3)	837967	9	4	9	1	1	3	2	0	2	1	0.264	0.327	1.000
90	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(3), MMP9(5), RECK(2), TIMP1(1), TIMP3(1)	730518	12	6	12	3	6	3	2	0	1	0	0.326	0.327	1.000
91	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GRB2(1), INPP5D(2), KRAS(38), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MS4A2(2), NRAS(5), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PRKCA(2), PRKCE(2), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2), VAV2(2), VAV3(2)	6895353	126	49	95	19	28	63	16	2	15	2	0.000275	0.342	1.000
92	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2)	2600491	27	15	27	6	9	8	5	0	3	2	0.229	0.342	1.000
93	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(1), FGA(2), FGB(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2)	1331924	14	5	14	0	7	4	1	0	2	0	0.0110	0.345	1.000
94	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), GZMB(1), HLA-A(2), ITGAL(3), ITGB2(1)	797161	10	5	10	3	2	3	2	0	2	1	0.563	0.346	1.000
95	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(6), GOT1(1)	761666	9	4	9	2	2	3	1	0	3	0	0.511	0.355	1.000
96	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(1), CTH(1), MUT(1)	488948	4	3	4	0	1	2	0	0	1	0	0.423	0.355	1.000
97	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(3), JAK3(2), MAPK3(1)	1151176	7	5	7	1	0	3	0	0	3	1	0.504	0.358	1.000
98	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS3(1)	299468	3	2	3	1	2	1	0	0	0	0	0.632	0.366	1.000
99	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(3), RELN(9), VLDLR(2)	1390617	18	8	18	5	4	8	3	1	2	0	0.464	0.373	1.000
100	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA7(1), PSMB3(1), PSMB8(3)	874045	6	4	6	0	0	5	0	1	0	0	0.216	0.380	1.000
101	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGFR(1), TF(4), TFRC(1)	1295676	10	5	10	1	3	5	1	0	1	0	0.207	0.392	1.000
102	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(2), FOS(1), GRB2(1), HGF(3), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(5), MET(1), PAK1(1), PIK3CA(7), PIK3R1(5), PTEN(4), PTPN11(3), RAF1(2), RAP1A(1), RASA1(4), SOS1(2)	4226298	47	15	47	8	14	14	11	1	5	2	0.0403	0.401	1.000
103	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(1), LIMK1(1), MAP3K1(2), MYLK(3), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PLD1(3), PPP1R12B(4), RALBP1(2), TRIO(1), VAV1(2), WASF1(2)	3365202	39	17	39	6	11	14	8	0	4	2	0.0540	0.403	1.000
104	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(1)	737698	9	4	9	1	2	6	0	0	1	0	0.304	0.412	1.000
105	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	173065	3	2	3	0	0	2	1	0	0	0	0.432	0.417	1.000
106	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), CASP3(1), DAXX(1), FAS(2), HSPB2(1)	1090493	7	5	7	1	1	1	4	0	1	0	0.525	0.428	1.000
107	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(2)	313986	2	2	2	0	0	1	1	0	0	0	0.617	0.436	1.000
108	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(1), CSK(2), GRB2(1), PRKCA(2)	919047	6	4	6	1	2	4	0	0	0	0	0.408	0.440	1.000
109	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(1), EIF4B(1), EIF4G1(1), EIF4G3(3), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), TSC1(1), TSC2(1)	2641859	25	12	25	5	7	6	5	1	4	2	0.271	0.449	1.000
110	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1)	339042	1	1	1	1	1	0	0	0	0	0	0.907	0.451	1.000
111	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(2)	629137	2	2	2	0	0	1	0	1	0	0	0.611	0.454	1.000
112	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(1), CASP3(1), CASP8AP2(6), DAXX(1), DEDD(1), DFFA(1), EGFR(1), EPHB2(1), IL8(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), PTPN13(9), RALBP1(2), ROCK1(7), TP53(45), TPX2(1)	6826271	102	50	87	17	34	28	17	3	20	0	0.00313	0.455	1.000
113	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(2), HSD3B1(1), HSD3B2(1)	635516	4	4	4	2	1	2	0	0	1	0	0.829	0.465	1.000
114	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOC(2)	360104	3	2	3	0	2	0	1	0	0	0	0.405	0.466	1.000
115	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(8)	698944	10	4	10	3	1	4	5	0	0	0	0.614	0.473	1.000
116	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), PLCE1(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAP2B(1)	1360763	13	7	13	2	5	6	1	0	1	0	0.184	0.481	1.000
117	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), MAPK8(5), NFE2L2(3), PRKCA(2)	827527	11	4	11	0	4	4	1	1	1	0	0.0295	0.491	1.000
118	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K4(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), TRAF3(2), TRAF5(2)	3184325	39	19	39	9	11	9	6	1	10	2	0.177	0.498	1.000
119	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(2), FYN(1), IL7(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(7), PIK3R1(5), STAT5B(1)	2723120	27	12	27	6	7	13	3	0	2	2	0.288	0.521	1.000
120	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	148838	1	1	1	0	0	0	1	0	0	0	0.769	0.524	1.000
121	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1)	812348	6	4	6	2	1	3	1	0	1	0	0.702	0.526	1.000
122	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2)	1326337	11	7	11	3	4	3	1	1	2	0	0.420	0.529	1.000
123	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(1), TPK1(3)	638873	6	3	6	1	4	1	1	0	0	0	0.438	0.534	1.000
124	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GRB2(1), INSR(1), IRS1(3), JAK2(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), SLC2A4(1), SOS1(2), STAT5B(1)	3223684	31	14	31	5	8	9	6	0	5	3	0.111	0.534	1.000
125	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(1), EIF4G1(1), EIF4G3(3), IRS1(3), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), PTEN(4)	2705445	28	14	28	6	7	7	6	1	5	2	0.295	0.541	1.000
126	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(2), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	932800	13	6	13	3	5	3	2	0	3	0	0.232	0.544	1.000
127	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(10), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(1), FSHR(1), MLH1(3), MSH5(1), NCOR1(5), NRIP1(1), PRLR(2), VDR(1), ZP2(1)	3444179	32	12	32	9	7	11	6	1	6	1	0.474	0.555	1.000
128	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), DAG1(1), ETFA(1), ITGA9(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), RPS4X(1), SGCB(4)	4471957	47	17	47	7	14	15	8	0	6	4	0.0191	0.559	1.000
129	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(10), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CREB3(1), CREB3L3(2), E2F3(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MYT1(5), PCNA(1), POLE(4), POLE2(1), RB1(3), RBL1(2), TNXB(3), TP53(45)	7068990	91	53	75	16	31	25	12	3	19	1	0.00642	0.564	1.000
130	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1)	1214341	15	7	15	3	4	6	2	0	3	0	0.323	0.566	1.000
131	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(3)	202787	3	1	3	0	1	1	1	0	0	0	0.471	0.568	1.000
132	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(1), CTH(1), LCMT1(2), MARS(3), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT3(1), PRMT7(1), PRMT8(2), SEPHS1(2)	2324543	22	10	22	4	5	8	4	1	4	0	0.163	0.572	1.000
133	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNGT1(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2B(1)	1459537	17	9	17	3	10	5	1	0	1	0	0.159	0.584	1.000
134	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), TAT(2), TYR(1)	472621	4	2	4	2	1	2	0	0	1	0	0.806	0.586	1.000
135	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT2(1), AKT3(1), APAF1(1), ATM(10), BIRC2(2), BIRC3(5), CAPN2(1), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TNFRSF10B(4), TNFRSF10D(1), TP53(45)	8018489	126	54	111	21	45	34	19	2	23	3	0.00104	0.592	1.000
136	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(2), GLI3(4), GSK3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), SMO(1)	1559810	15	8	15	3	4	8	0	0	3	0	0.261	0.592	1.000
137	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), CFTR(4), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1223260	14	7	14	3	5	6	1	0	2	0	0.274	0.602	1.000
138	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(1), LDLR(1)	515773	3	2	3	2	3	0	0	0	0	0	0.830	0.608	1.000
139	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(2), CREB3(1), CREB5(2), DUSP6(1), EEF2K(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TRAF3(2)	2950759	28	10	28	2	8	9	7	1	3	0	0.0101	0.609	1.000
140	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K1(1), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(2)	752132	7	3	7	2	3	1	2	0	1	0	0.532	0.610	1.000
141	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1507626	11	6	11	2	3	5	2	0	1	0	0.289	0.616	1.000
142	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1507626	11	6	11	2	3	5	2	0	1	0	0.289	0.616	1.000
143	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1507626	11	6	11	2	3	5	2	0	1	0	0.289	0.616	1.000
144	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(1)	362911	3	2	3	0	0	2	0	0	1	0	0.478	0.619	1.000
145	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1)	326746	1	1	1	1	0	1	0	0	0	0	0.910	0.623	1.000
146	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1)	1005194	6	4	6	1	3	3	0	0	0	0	0.339	0.625	1.000
147	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), AKT3(1), GRB2(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PTEN(4), SOS1(2)	1965891	20	11	20	5	4	7	6	0	3	0	0.441	0.628	1.000
148	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(10), CDC25C(1), MYT1(5), YWHAH(1)	1370937	17	6	17	3	3	10	2	0	1	1	0.316	0.631	1.000
149	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	CBL(3), CFLAR(1), FOS(1), GRB2(1), IL2RB(1), IRS1(3), JAK1(1), JAK3(2), MAPK3(1), NMI(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3)	3481504	35	15	35	7	9	12	5	0	7	2	0.171	0.640	1.000
150	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), GH1(1), IGF1R(1), PIK3CA(7), PIK3R1(5)	1274034	15	12	15	7	4	4	4	0	1	2	0.842	0.642	1.000
151	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT2(1), AKT3(1), CDC42(1), KDR(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK13(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTGS2(1), RAF1(2), SH2D2A(1), SHC2(1), SPHK1(1)	6914915	99	50	68	19	27	50	10	0	10	2	0.00799	0.645	1.000
152	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1214821	8	5	8	3	4	2	0	0	2	0	0.575	0.651	1.000
153	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(2), AKT2(1), AKT3(1), BRAF(2), CAMK2D(1), CBL(3), CBLB(2), CDKN1B(2), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GRB2(1), GSK3B(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), NCK1(1), NRAS(5), NRG1(6), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), RAF1(2), RPS6KB2(1), SHC2(1), SOS1(2), SOS2(2), STAT5B(1)	10111519	144	54	111	20	31	68	22	2	19	2	6.55e-05	0.655	1.000
154	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), AKT3(1), GRB2(1), GSK3B(1), IRS1(3), JAK1(1), JAK3(2), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPP1R13B(1), RAF1(2), SOS1(2), SOS2(2)	3546478	34	15	34	5	9	11	7	0	5	2	0.0537	0.658	1.000
155	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(3), CBX3(2), CLOCK(3), CRY1(3), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(1), MYF6(1), NCKAP1(1), NCOA4(1), NR1D2(3), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(1), UGP2(2), ZFR(5)	3583945	40	11	40	5	5	15	13	0	6	1	0.0311	0.661	1.000
156	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	1592126	11	6	11	2	3	5	2	0	1	0	0.289	0.663	1.000
157	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(2)	266540	3	1	3	1	0	2	0	0	1	0	0.728	0.677	1.000
158	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), PRB1(1)	839371	7	4	7	3	1	1	1	0	4	0	0.731	0.680	1.000
159	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(3), ABCG2(4), BCHE(2), CES1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1)	2276078	17	7	17	3	5	8	2	1	1	0	0.156	0.680	1.000
160	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(2)	665555	8	6	8	4	1	2	4	0	1	0	0.875	0.692	1.000
161	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), MARS(3), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SEPHS1(2)	1179317	12	5	12	2	2	5	3	0	2	0	0.329	0.692	1.000
162	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2B(3), POLR2K(1)	1301290	6	4	6	1	3	2	1	0	0	0	0.399	0.693	1.000
163	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	2585771	19	11	19	5	4	10	1	0	4	0	0.409	0.698	1.000
164	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), CASP3(1), GZMB(1)	1224300	6	4	6	1	0	1	3	0	2	0	0.549	0.701	1.000
165	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(2), UXS1(1)	470002	5	2	5	0	0	3	1	0	1	0	0.299	0.701	1.000
166	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1)	1135213	6	4	6	1	3	3	0	0	0	0	0.323	0.724	1.000
167	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(3), CRY1(3), CSNK1D(1), PER3(2)	1667066	12	5	12	1	2	3	3	0	3	1	0.112	0.729	1.000
168	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(1), GNAQ(1), GNGT1(1), MYLK(3), PPP1R12B(4), PRKCA(2), ROCK1(7)	2013126	22	10	22	5	6	7	4	0	5	0	0.317	0.729	1.000
169	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), PRKCE(2)	701110	12	3	12	3	2	8	1	0	1	0	0.413	0.730	1.000
170	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK8(5), NFKB1(3), TNFSF13B(1), TRAF3(2), TRAF5(2)	1372419	16	4	16	4	4	5	4	1	2	0	0.430	0.731	1.000
171	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(1), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), PIK3CA(7), PIK3CD(1), SOS1(2)	1554961	16	9	16	4	3	7	6	0	0	0	0.408	0.737	1.000
172	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), HADHA(1)	537704	6	3	6	3	2	1	0	0	3	0	0.826	0.739	1.000
173	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST4(2), FUT8(1)	1189656	9	5	9	3	4	1	1	1	2	0	0.570	0.739	1.000
174	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2)	582054	6	2	6	1	3	1	0	1	1	0	0.291	0.742	1.000
175	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2)	582054	6	2	6	1	3	1	0	1	1	0	0.291	0.742	1.000
176	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CUL1(1), RB1(3)	884503	6	3	6	4	1	0	2	0	3	0	0.878	0.749	1.000
177	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1), HLA-DRB1(1)	224004	3	1	3	0	2	1	0	0	0	0	0.344	0.750	1.000
178	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), PON1(1)	2731083	24	9	24	7	8	5	8	0	2	1	0.446	0.757	1.000
179	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(4), CAP1(1), CDC25C(1), GNAI1(1), GNGT1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1937554	21	11	21	4	8	9	2	0	2	0	0.137	0.757	1.000
180	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(2), CALCRL(1), CD97(2), CRHR1(1), CRHR2(1), ELTD1(2), EMR1(3), EMR2(4), GLP1R(5), GLP2R(2), GPR64(1), LPHN2(3), LPHN3(7), VIPR1(1)	2570211	36	13	36	11	15	14	5	0	2	0	0.268	0.758	1.000
181	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8)	2183790	28	10	28	5	12	11	2	0	3	0	0.0797	0.760	1.000
182	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8)	2183790	28	10	28	5	12	11	2	0	3	0	0.0797	0.760	1.000
183	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(1), BIN1(1), DNM1(3), EPN1(1), EPS15(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYNJ1(3), SYNJ2(1)	2151419	19	8	19	3	8	7	0	0	4	0	0.149	0.764	1.000
184	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(3), FURIN(1)	872415	5	3	5	1	2	0	0	0	3	0	0.491	0.769	1.000
185	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(3), ABCB4(3), ABCC1(3)	1336919	14	5	14	3	4	6	2	1	1	0	0.269	0.771	1.000
186	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(1)	159167	1	1	1	0	0	1	0	0	0	0	0.769	0.773	1.000
187	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), SQLE(1)	283519	2	1	2	0	0	1	1	0	0	0	0.615	0.774	1.000
188	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	FOS(1), GRB2(1), IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(3), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(3), RAF1(2), SOS1(2)	2346750	20	9	20	3	6	7	3	0	3	1	0.173	0.775	1.000
189	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(1), HADHB(1), HSD17B10(1), PPT2(1)	854446	5	4	5	4	1	2	0	0	2	0	0.950	0.775	1.000
190	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	GSK3B(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4)	1882392	20	12	20	5	4	7	4	0	3	2	0.488	0.777	1.000
191	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(1), THBS1(2)	699555	5	2	5	1	2	2	1	0	0	0	0.466	0.779	1.000
192	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFS1(2), NDUFS2(3)	689833	6	4	6	2	3	2	0	0	1	0	0.707	0.780	1.000
193	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12A(1), IL12RB2(1), IL18R1(2), JAK2(3), MAP2K6(1), MAPK8(5), STAT4(3)	1792782	17	4	17	3	1	8	4	1	2	1	0.394	0.782	1.000
194	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(1), ACTN3(1), CSK(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), PECAM1(1), VCL(1)	1799717	16	11	16	4	8	6	2	0	0	0	0.347	0.789	1.000
195	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(2), HEXB(2), LCT(5), MANBA(1), NEU1(1)	1589902	13	6	13	3	5	4	1	0	3	0	0.370	0.789	1.000
196	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12A(1), IL12RB2(1), JAK2(3), STAT4(3)	1421936	8	3	8	2	0	3	3	0	1	1	0.677	0.801	1.000
197	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1)	296217	1	1	1	0	1	0	0	0	0	0	0.688	0.803	1.000
198	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(8)	884866	12	3	12	1	3	6	1	0	2	0	0.124	0.806	1.000
199	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), FOS(1), GRB2(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(1), PIK3CA(7), PIK3R1(5), PLA2G4A(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SOS1(2), SYK(3), VAV1(2)	4187297	49	20	49	10	17	13	7	1	9	2	0.0923	0.807	1.000
200	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), UGDH(1)	808099	7	3	7	1	1	3	1	0	2	0	0.366	0.808	1.000
201	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ANKRD1(2), IFRD1(3), IL1R1(1), MYOG(1), NR4A3(2)	1023819	9	3	9	1	4	3	1	0	1	0	0.183	0.813	1.000
202	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(2), FUT1(3), FUT9(1), HEXB(2)	1019978	9	4	9	4	6	1	2	0	0	0	0.690	0.813	1.000
203	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1)	533650	5	3	5	4	0	2	2	0	1	0	0.939	0.815	1.000
204	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1)	1425907	6	6	6	2	4	2	0	0	0	0	0.557	0.816	1.000
205	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	4580041	42	18	42	9	9	19	6	1	7	0	0.123	0.818	1.000
206	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(2), WASL(2)	784397	9	2	9	1	4	1	2	0	2	0	0.206	0.822	1.000
207	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), FOS(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(2)	3332957	31	15	31	8	15	9	2	0	5	0	0.200	0.823	1.000
208	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), FHL5(3), FSHB(1), FSHR(1), XPO1(1)	917313	10	9	10	4	4	1	3	1	1	0	0.785	0.830	1.000
209	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), IFNGR2(1), JAK1(1), JAK2(3)	821804	6	2	6	1	1	2	0	0	2	1	0.522	0.831	1.000
210	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(2)	478687	3	3	3	2	0	0	2	0	1	0	0.925	0.832	1.000
211	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	1644435	9	4	9	1	2	5	0	0	2	0	0.221	0.834	1.000
212	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(4), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1139228	13	8	13	4	6	4	1	1	1	0	0.344	0.834	1.000
213	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CFLAR(1)	375833	2	1	2	0	0	1	1	0	0	0	0.630	0.840	1.000
214	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1)	1667605	23	8	23	5	7	9	4	0	3	0	0.256	0.841	1.000
215	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTR(1)	1706143	24	9	24	5	11	8	1	1	3	0	0.162	0.843	1.000
216	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(1), PSMD2(1), PSMD6(1)	1615752	12	3	12	0	5	5	1	0	1	0	0.0348	0.848	1.000
217	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	607065	4	2	4	1	1	1	2	0	0	0	0.689	0.851	1.000
218	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(3)	767938	5	3	5	3	1	2	1	0	1	0	0.860	0.851	1.000
219	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(1), EPHB2(1), GRB2(1), MAP2K1(1), MAP2K2(1), NFKB1(3), NFKB2(2), PI3(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(3), SOS1(2), SOS2(2), SYK(3), VAV1(2)	5104543	50	15	50	7	19	15	8	0	6	2	0.0116	0.852	1.000
220	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB9A(1)	404502	3	1	3	0	1	1	0	0	1	0	0.408	0.853	1.000
221	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), MAP2K1(1), MAPK3(1), NFKB1(3), PRKCA(2), RAF1(2)	1502300	13	4	13	5	7	2	2	0	2	0	0.591	0.853	1.000
222	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACPP(1), ALPPL2(1), CYP3A43(2), CYP3A7(2), DHRS2(1), PON1(1), PON2(1)	1680190	9	5	9	4	3	4	1	0	0	1	0.726	0.853	1.000
223	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT2(1), AKT3(1), CARD11(3), CBL(3), CBLB(2), CD28(1), CDC42(1), CDK4(1), CHUK(2), CTLA4(1), FOS(1), FYN(1), GRAP2(3), GRB2(1), IKBKB(2), IL10(1), IL2(1), ITK(3), KRAS(38), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCQ(1), PTPRC(8), RASGRP1(3), RHOA(1), SOS1(2), SOS2(2), TEC(2), VAV1(2), VAV2(2), VAV3(2)	9782442	145	49	114	20	41	74	17	0	11	2	3.52e-05	0.856	1.000
224	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT9(1), HEXB(2)	957438	6	4	6	3	4	1	1	0	0	0	0.764	0.856	1.000
225	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PRKCA(2)	657153	3	3	3	2	2	1	0	0	0	0	0.839	0.857	1.000
226	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), ALAS2(1), FECH(1), GATA1(1), HBB(1), UROD(1)	808781	7	3	7	1	3	4	0	0	0	0	0.330	0.858	1.000
227	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(2), YWHAH(1)	630244	10	5	10	3	1	6	0	0	3	0	0.514	0.859	1.000
228	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(1), PON2(1), RDH11(1), RDH12(1)	821981	5	4	5	3	3	2	0	0	0	0	0.844	0.860	1.000
229	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA7(1), PSMB3(1), PSMD14(1), RPN2(1), UBE3A(5)	1274716	10	3	10	1	2	6	2	0	0	0	0.216	0.862	1.000
230	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	344378	3	2	3	2	1	0	2	0	0	0	0.831	0.865	1.000
231	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(3), SPN(1), TGFB2(4), TNFRSF8(1)	1271781	13	5	13	4	3	4	3	0	3	0	0.619	0.866	1.000
232	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), STAT2(2)	1046865	4	2	4	2	1	2	0	0	1	0	0.800	0.866	1.000
233	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), SOS1(2)	865743	3	2	3	1	0	2	1	0	0	0	0.753	0.868	1.000
234	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), MAPK8(5), NFKB1(3), TNFRSF11A(1)	1062100	12	3	12	3	5	5	1	1	0	0	0.406	0.869	1.000
235	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRB(1), CP(3), CPOX(1), EPRS(2), FECH(1), HCCS(2), HMOX2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1)	2620737	19	10	19	3	5	9	3	0	2	0	0.156	0.871	1.000
236	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), DFFA(1)	1340449	11	3	11	1	3	4	1	0	3	0	0.227	0.871	1.000
237	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(2), IL10(1), IL12A(1), ITGAX(2), TLR2(4), TLR4(3), TLR7(3), TLR9(3)	1748675	23	6	23	3	7	10	5	0	1	0	0.0496	0.874	1.000
238	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), SUCLA2(2)	874830	3	3	3	5	0	2	0	0	1	0	0.999	0.874	1.000
239	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ6(1)	399280	2	1	2	0	0	1	1	0	0	0	0.621	0.874	1.000
240	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(10), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDAN1(2), CDC14A(3), CDC14B(1), CDC25C(1), CDC6(1), CDC7(1), CDH1(1), CDK4(1), E2F3(1), EP300(2), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MPEG1(2), MPL(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), SMAD4(8), TP53(45)	10491918	116	55	99	21	39	34	20	3	19	1	0.00623	0.875	1.000
241	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), IL2(1), TGFB2(4), TGFBR1(3), TGFBR3(3), TOB1(2)	1045862	14	4	14	2	3	5	3	0	3	0	0.202	0.880	1.000
242	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL2(1)	290167	2	1	2	1	0	2	0	0	0	0	0.883	0.882	1.000
243	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), ST3GAL6(3)	1499703	14	7	14	4	5	3	3	1	2	0	0.430	0.883	1.000
244	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), DBH(1), GAD1(2), HDC(5), MAOA(1), TPH1(2)	1373729	13	9	13	6	3	6	2	0	2	0	0.819	0.884	1.000
245	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADHA(1), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1)	1167155	7	4	7	4	1	2	1	0	3	0	0.899	0.884	1.000
246	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), NAGS(1), OAT(1), ODC1(3), OTC(1)	1694934	19	5	19	4	8	5	3	0	3	0	0.233	0.886	1.000
247	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1)	1164282	14	5	14	2	3	9	2	0	0	0	0.191	0.886	1.000
248	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXB(2), LCT(5), SLC33A1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2)	1600195	15	6	15	5	7	6	2	0	0	0	0.453	0.889	1.000
249	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CDK4(1), CDKN1B(2), RB1(3), RBL1(2)	1553631	10	5	10	3	3	1	2	0	4	0	0.558	0.890	1.000
250	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1)	387255	6	1	6	0	2	4	0	0	0	0	0.146	0.891	1.000
251	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFA(1), GZMB(1), TOP2A(3), TOP2B(4)	744111	10	2	10	2	1	4	3	0	2	0	0.508	0.893	1.000
252	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(1), ARHGEF11(2), CDC42(1), DLG4(1), LPA(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PI3(1), PLD1(3), PLD2(1), RDX(1), ROCK1(7), ROCK2(4), SERPINA4(3)	4748414	45	11	45	11	17	15	5	1	7	0	0.252	0.894	1.000
253	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR1B(1), BMPR2(3), CREBBP(4), CUL1(1), DCN(1), EP300(2), FST(1), GDF5(1), GDF6(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(1), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), RBL1(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RPS6KB2(1), SMAD2(5), SMAD3(3), SMAD4(8), SMAD5(1), SMAD9(1), SMURF1(2), TGFB2(4), TGFBR1(3), THBS1(2), THBS2(5), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(4)	9633613	97	32	94	16	31	36	17	0	12	1	0.00258	0.895	1.000
254	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), RAF1(2), SOS1(2), STAT5B(1)	1613530	12	4	12	2	3	4	2	0	2	1	0.345	0.900	1.000
255	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(3), FUT9(1), GCNT2(2)	582615	6	3	6	3	4	1	0	0	1	0	0.684	0.900	1.000
256	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(1), GPX3(2), GPX6(1), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), TXNDC12(2)	2061896	13	7	13	2	3	7	3	0	0	0	0.199	0.904	1.000
257	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), CASP6(1), CFLAR(1), DAXX(1), DFFA(1), LMNB1(2), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), PTPN13(9), RB1(3), SPTAN1(4)	3676887	41	10	41	9	9	13	9	1	9	0	0.269	0.905	1.000
258	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PSAT1(1)	476753	4	1	4	0	0	3	0	0	1	0	0.464	0.906	1.000
259	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(1), GFPT1(1), HEXB(2), HK3(1), PGM3(1)	1690753	9	3	9	1	2	5	2	0	0	0	0.243	0.906	1.000
260	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTAP(1), MTFMT(1), MTR(1), TAT(2)	2012975	29	9	29	5	11	13	1	1	3	0	0.0779	0.906	1.000
261	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(5), ITGAL(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3)	1154444	15	4	15	3	1	9	3	0	2	0	0.386	0.906	1.000
262	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3)	1016820	6	3	6	3	1	3	0	0	1	1	0.852	0.907	1.000
263	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3)	1016820	6	3	6	3	1	3	0	0	1	1	0.852	0.907	1.000
264	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1)	1932715	13	8	13	3	6	6	1	0	0	0	0.266	0.908	1.000
265	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1), SQLE(1)	393233	3	1	3	1	0	2	1	0	0	0	0.762	0.909	1.000
266	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), BECN1(1), IFNA10(2), IFNA2(1), PIK3C3(2), PRKAA1(1), PRKAA2(3), ULK1(1)	2028690	13	4	13	3	3	5	2	0	3	0	0.483	0.909	1.000
267	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C8B(1), C9(1), MASP1(3)	1998361	27	10	27	5	9	11	4	0	3	0	0.131	0.911	1.000
268	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(1), RPL11(1), RPL19(1), RPL28(1), RPL6(2), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1)	1972810	14	7	14	4	0	5	7	1	1	0	0.674	0.912	1.000
269	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), UROD(1)	765198	6	3	6	2	3	2	1	0	0	0	0.703	0.912	1.000
270	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), MAPK3(1)	1392679	7	3	7	2	3	3	0	0	1	0	0.557	0.912	1.000
271	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CHUK(2), CRADD(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK8(5), NFKB1(3), TANK(3)	2327308	28	11	28	7	9	10	6	2	1	0	0.278	0.912	1.000
272	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C5(4), C6(3), C7(3), IL6(1), IL8(1), ITGA4(5), ITGAL(3), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2)	2377656	27	9	27	9	9	10	3	0	5	0	0.471	0.915	1.000
273	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPPL2(1), DHFR(1)	562809	2	2	2	0	0	2	0	0	0	0	0.525	0.915	1.000
274	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TNFAIP3(1), TRAF3(2)	1737386	13	5	13	3	3	7	2	0	1	0	0.463	0.916	1.000
275	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(1)	287533	3	1	3	2	2	1	0	0	0	0	0.854	0.917	1.000
276	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA6(1), CYP11A1(2), EDNRB(5), PLA2G4A(3), PRL(1), PTGDR(1), PTGFR(1), PTGIS(1), PTGS1(2), PTGS2(1)	1996872	19	11	19	5	8	6	3	0	2	0	0.388	0.918	1.000
277	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1), MASP1(3)	2041951	26	10	26	6	9	10	4	0	3	0	0.225	0.919	1.000
278	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(1), PLA2G4A(3), PLA2G6(2)	987794	8	5	8	3	6	1	0	0	1	0	0.543	0.921	1.000
279	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3), SELP(2)	1460023	20	7	20	6	3	11	3	0	3	0	0.527	0.923	1.000
280	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(4), DFFA(1), GZMA(1), GZMB(1)	987353	9	3	9	3	5	3	0	0	1	0	0.538	0.925	1.000
281	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	1569623	17	6	17	4	5	6	5	0	1	0	0.439	0.925	1.000
282	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GNS(3), HEXB(2), LCT(5), NAGLU(1)	1428507	11	5	11	3	5	4	1	0	1	0	0.382	0.926	1.000
283	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(1)	517094	6	5	6	4	2	2	1	0	1	0	0.910	0.926	1.000
284	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), DERA(1), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1), TKTL1(1), TKTL2(2)	2313347	17	10	17	5	7	7	2	0	1	0	0.332	0.928	1.000
285	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTR2(1), ACTR3(1), CDC42(1), FLNA(1), FLNC(2), LIMK1(1), MYH2(3), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	4578093	38	13	38	6	17	8	4	0	9	0	0.0162	0.930	1.000
286	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1)	2091888	17	5	17	2	4	6	3	1	2	1	0.134	0.932	1.000
287	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2)	778990	5	2	5	2	1	2	1	0	1	0	0.766	0.934	1.000
288	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2)	778990	5	2	5	2	1	2	1	0	1	0	0.766	0.934	1.000
289	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(3), EGFR(1), GRB2(1), MAP2K1(1), MAPK3(1), RAF1(2), RASA1(4), SOS1(2), SPRY1(1)	2248938	16	4	16	6	7	4	3	0	2	0	0.697	0.937	1.000
290	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(1), PTPRC(8)	1338810	20	4	20	6	4	10	3	0	3	0	0.499	0.941	1.000
291	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(1), PIR(1), PSMA7(1), WASF1(2), WASF3(2), WASL(2)	1494194	14	5	14	2	5	5	2	0	2	0	0.194	0.942	1.000
292	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ATF1(1), BRAF(2), CREB3(1), CREB5(2), CREBBP(4), DAG1(1), EGR1(1), EGR2(2), FRS2(2), GNAQ(1), MAP1B(12), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), OPN1LW(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PTPN11(3), RPS6KA3(2), TERF2IP(1)	4877204	66	21	66	16	19	24	9	2	10	2	0.0734	0.943	1.000
293	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2)	1363818	13	7	13	6	3	7	1	0	2	0	0.795	0.943	1.000
294	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(2), BTK(1), CDC42(1), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PPP1R13B(1), PTEN(4), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	6580984	75	18	75	10	29	20	9	0	14	3	0.000867	0.944	1.000
295	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	BRAF(2), CASP3(1), FAS(2), FCGR3A(1), FYN(1), GRB2(1), GZMB(1), HLA-A(2), HLA-G(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), ITGAL(3), ITGB2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), KRAS(38), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MICB(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PAK1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTPN11(3), RAF1(2), SH3BP2(1), SHC2(1), SOS1(2), SOS2(2), SYK(3), TNFRSF10B(4), TNFRSF10D(1), TYROBP(1), VAV1(2), VAV2(2), VAV3(2)	10875470	139	52	108	30	35	67	21	0	14	2	0.00897	0.945	1.000
296	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(1), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(4), F2(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(1), MAPK3(1), MAPK8(5), MEF2C(2), MYH2(3), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAF1(2)	4752966	57	21	57	16	23	18	6	1	7	2	0.215	0.945	1.000
297	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), PRKACG(1), PRKAR2B(1)	1006117	4	3	4	2	2	1	0	0	1	0	0.813	0.948	1.000
298	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(3), ITGB2(1), PTPRC(8)	1036055	13	4	13	5	3	6	1	0	3	0	0.630	0.949	1.000
299	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), GNAQ(1), MAPK8(5), PRKCA(2)	1308476	10	5	10	3	3	4	1	1	1	0	0.529	0.949	1.000
300	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT2(1), AKT3(1), DAG1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PLD1(3), PLD2(1)	4154098	32	7	32	4	14	9	1	1	6	1	0.0180	0.949	1.000
301	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B2(1), FLT1(3), FLT4(1), HIF1A(2), KDR(2), PIK3CA(7), PIK3R1(5), PRKCA(2), VHL(1)	3294877	25	14	25	7	8	6	6	0	3	2	0.431	0.949	1.000
302	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), GRHPR(1), HAO2(1), MTHFD1L(2)	1261511	5	4	5	5	1	2	0	1	1	0	0.984	0.950	1.000
303	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(1), ENPP3(1), TYR(1)	957917	3	2	3	5	1	1	0	0	0	1	0.994	0.950	1.000
304	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(1), JAK2(3), JAK3(2), PTPRU(6), REG1A(2)	1489304	16	10	16	4	10	3	0	0	2	1	0.381	0.950	1.000
305	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1)	1063811	7	4	7	2	3	1	3	0	0	0	0.580	0.950	1.000
306	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	CYP1A2(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A43(2), CYP3A7(2), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1)	2330834	20	5	20	6	9	4	5	0	2	0	0.458	0.950	1.000
307	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(1), COPS5(1), EP300(2), HIF1A(2), LDHA(1), VHL(1)	1639442	9	3	9	1	4	2	1	0	2	0	0.246	0.951	1.000
308	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), CPT1A(1), CPT2(1), HADHA(1), SLC25A20(1)	1678410	9	3	9	3	2	3	1	0	3	0	0.668	0.951	1.000
309	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(4), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), HADHA(1), LDHA(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1)	3308408	31	10	31	8	9	11	3	0	8	0	0.408	0.952	1.000
310	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	2437258	19	6	19	2	2	11	3	0	3	0	0.102	0.952	1.000
311	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(3), ITGB2(1), PTPRC(8)	1096258	13	4	13	5	3	6	1	0	3	0	0.633	0.954	1.000
312	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(4), ADCY8(1), ATF4(1), BRAF(2), CACNA1C(2), CAMK2D(1), CAMK4(1), CREBBP(4), EP300(2), GNAQ(1), GRIA1(1), GRIA2(3), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NRAS(5), PLCB3(1), PLCB4(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2)	9443744	127	51	96	29	32	67	16	0	10	2	0.0141	0.954	1.000
313	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAQ(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK3(1), PIK3C2G(2), PPP1R12B(4), PRKCA(2), RAF1(2), ROCK2(4)	2388876	20	8	20	5	6	6	2	0	6	0	0.421	0.954	1.000
314	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8IP3(1), PAPPA(5), RPS6KA3(2), SOS1(2), SYK(3), VAV1(2), VAV2(2), VAV3(2)	3122999	28	9	28	3	8	15	2	0	3	0	0.0264	0.954	1.000
315	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), HIF1A(2), JAK2(3), NFKB1(3)	1250122	9	2	9	4	4	1	0	0	3	1	0.825	0.955	1.000
316	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PAK1(1), PRKCA(2), RAF1(2), SOS1(2)	2800177	25	11	25	5	6	8	6	2	3	0	0.192	0.955	1.000
317	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	381841	1	1	1	1	0	1	0	0	0	0	0.952	0.955	1.000
318	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD2(2), GRM1(3), PPP3CA(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	1507971	14	7	14	6	8	3	1	0	2	0	0.635	0.957	1.000
319	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS2(1), SUCLA2(2)	1310590	4	3	4	6	0	3	0	0	1	0	0.998	0.957	1.000
320	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1L(2)	1319536	6	5	6	5	2	2	0	1	1	0	0.966	0.957	1.000
321	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(1), TAF1(5), TAF1L(6), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1)	3518797	28	9	28	3	7	9	5	0	7	0	0.0559	0.957	1.000
322	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFKB1(3), NSMAF(2), RAF1(2)	2020077	18	6	18	8	7	6	2	1	2	0	0.744	0.959	1.000
323	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AMD1(1), ARG2(1), ASL(2), ASS1(1), CPS1(6), MAOA(1), MAOB(1), NAGS(1), ODC1(3), OTC(1), SAT2(1)	2885873	29	9	28	7	10	11	3	0	5	0	0.210	0.959	1.000
324	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2)	985316	6	4	6	3	2	1	3	0	0	0	0.824	0.960	1.000
325	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(3), G6PD(1), GPX3(2), GSTA3(1), GSTM3(1), GSTO2(1)	1728903	9	5	9	2	2	5	2	0	0	0	0.406	0.961	1.000
326	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CDC42(1), CREB3(1), CREB5(2), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK13(1), MKNK2(1), NFKB1(3)	3311388	27	14	27	5	10	8	3	2	4	0	0.106	0.961	1.000
327	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(1), AKT3(1), CD40(1), CD80(1), CHUK(2), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA10(2), IFNA2(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(1), IL8(1), IRAK4(2), IRF3(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), TBK1(1), TICAM1(1), TLR1(3), TLR2(4), TLR3(1), TLR4(3), TLR5(1), TLR7(3), TLR8(3), TLR9(3), TRAF3(2)	8570589	99	29	99	18	27	36	19	2	12	3	0.00653	0.962	1.000
328	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), BCR(1), CAV1(1), CSK(2), FYN(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), PPP1R12B(4), RAF1(2), RAP1A(1), ROCK1(7), SOS1(2), TLN1(2), VCL(1), ZYX(1)	4419248	39	12	39	7	13	14	7	1	4	0	0.0549	0.963	1.000
329	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(1)	584775	2	1	2	1	0	1	0	0	1	0	0.805	0.963	1.000
330	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(5)	827337	5	2	5	2	2	2	0	0	1	0	0.630	0.963	1.000
331	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(6), MAP2(4), PRKACG(1), PRKAR2B(1), PRKCE(2)	1746430	14	6	13	7	2	7	3	0	2	0	0.938	0.963	1.000
332	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(1)	1186482	6	3	6	2	2	2	0	0	2	0	0.608	0.963	1.000
333	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(1), IL2(1), IL2RB(1), JAK1(1), JAK3(2), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3)	2270057	23	7	23	3	5	9	3	1	5	0	0.105	0.965	1.000
334	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(5), CASP3(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKB2(2), RALBP1(2), TNFAIP3(1)	2634776	22	8	22	5	9	5	4	0	4	0	0.266	0.965	1.000
335	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL12A(1), IL2(1), IL6(1), IL7(1), IL8(1), TGFB2(4)	1289605	13	3	13	5	3	8	1	0	1	0	0.700	0.965	1.000
336	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), LDHA(1), LDHB(2), NCL(1)	871424	8	5	8	4	3	5	0	0	0	0	0.825	0.965	1.000
337	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(2), SOS1(2), SYK(3), VAV1(2)	3728416	34	12	34	8	12	12	4	1	5	0	0.208	0.966	1.000
338	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDE6A(1), PDE6C(2), SLC6A13(1), TF(4)	3319199	25	6	25	1	9	11	1	0	3	1	0.00188	0.966	1.000
339	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(1), FUT8(1)	789292	3	3	3	2	1	1	0	0	1	0	0.889	0.966	1.000
340	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2)	2289009	18	4	18	6	5	10	2	0	1	0	0.538	0.967	1.000
341	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TANK(3), TNFAIP3(1), TRAF1(1), TRAF3(2)	2149248	17	5	17	5	6	7	3	0	1	0	0.473	0.967	1.000
342	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1)	2310763	19	8	19	3	8	8	2	0	1	0	0.139	0.968	1.000
343	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD28(1), CSK(2), CTLA4(1), DAG1(1), DTYMK(1), EPHB2(1), FBXW7(12), GRAP2(3), GRB2(1), ITK(3), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PTPRC(8), RAF1(2), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), SOS1(2), SOS2(2), VAV1(2)	5341405	70	18	68	9	29	24	8	0	9	0	0.00187	0.968	1.000
344	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2)	1249362	11	4	11	5	1	5	3	0	2	0	0.787	0.968	1.000
345	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(2), NCOA3(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	2003720	17	4	17	4	6	8	1	0	2	0	0.343	0.969	1.000
346	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(4), AKAP4(2), AKAP6(6), AKAP7(1), AKAP9(6), ARHGEF1(1), GNA14(1), GNAL(1), GNAQ(1), GNG4(1), GNGT1(1), IL18BP(2), ITPR1(8), KRAS(38), NRAS(5), PDE1A(1), PDE1B(1), PDE1C(2), PDE4B(3), PDE4D(1), PDE7B(1), PDE8B(1), PLCB3(1), PPP3CA(2), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKD3(2), RHOA(1), SLC9A1(2), USP5(1)	11118970	140	49	108	27	27	79	15	0	18	1	0.00304	0.969	1.000
347	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(3), OPHN1(3), PIP5K1B(1), PPP1R12B(4), ROCK1(7), TLN1(2), VCL(1)	4432390	33	12	33	7	8	9	9	0	7	0	0.184	0.970	1.000
348	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(2), PC(3), PDHA1(1)	878363	6	4	6	3	4	2	0	0	0	0	0.755	0.973	1.000
349	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3), CLTA(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1)	1631726	9	2	9	3	4	2	1	0	2	0	0.583	0.973	1.000
350	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(5), PGM1(2), PYGM(2)	1267706	9	5	9	2	8	1	0	0	0	0	0.250	0.974	1.000
351	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), JAK1(1), JAK2(3), JAK3(2), STAT5B(1)	1794083	8	4	8	3	0	4	0	0	3	1	0.799	0.976	1.000
352	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2F2(1), GTF2H1(2), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3B(5), POLR3E(3), POLR3K(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1)	3455124	26	11	26	4	10	8	3	0	5	0	0.109	0.976	1.000
353	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2), VNN1(1)	1695263	14	8	14	8	3	8	1	0	2	0	0.908	0.977	1.000
354	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), AKT3(1), BRAF(2), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRKAA1(1), PRKAA2(3), RICTOR(3), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), TSC1(1), TSC2(1), ULK1(1), VEGFC(3)	5136910	50	16	50	12	17	14	9	0	8	2	0.184	0.977	1.000
355	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3)	914872	13	5	13	4	2	8	1	0	2	0	0.546	0.977	1.000
356	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GNS(3), HEXB(2), HPSE2(3), LCT(5), NAGLU(1), SPAM1(3)	1995113	17	6	17	4	8	6	2	0	1	0	0.259	0.977	1.000
357	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), ATF2(1), EGFR(1), GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), MEF2A(1), MEF2C(2), PAK1(1), PRKCA(2), RAF1(2), SOS1(2)	3271594	29	8	29	4	7	11	5	1	5	0	0.0500	0.977	1.000
358	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), GNAI1(1), GNGT1(1), MAP2K1(1), MAPK3(1), PLA2G4A(3), PRKCA(2), PTGS1(2), RAF1(2), SYK(3)	2440328	17	8	17	5	6	5	2	0	4	0	0.480	0.978	1.000
359	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(2), IKBKB(2), IL2(1), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), TNFRSF9(1)	1906303	18	3	18	4	4	11	2	1	0	0	0.343	0.978	1.000
360	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), DHFR(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1)	1765173	10	5	10	4	4	5	0	0	1	0	0.603	0.979	1.000
361	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGT(1), AGTR2(1), EDNRB(5), EGFR(1), FOS(1), NFKB1(3), PRKCA(2)	2024999	17	8	17	5	7	6	3	0	1	0	0.448	0.979	1.000
362	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(1), ENPP3(1), LHPP(1), MTMR1(1), MTMR2(1), TYR(1)	1500005	6	4	6	6	4	1	0	0	0	1	0.974	0.980	1.000
363	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(1), CHKA(2), CHPT1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), ESCO1(4), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(1), GPD1L(1), GPD2(1), MYST3(5), MYST4(5), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1), PTDSS1(3), SH3GLB1(1)	6467775	63	21	63	17	23	19	13	0	8	0	0.217	0.981	1.000
364	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	4858338	48	16	48	10	17	17	8	0	6	0	0.0595	0.981	1.000
365	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	4858338	48	16	48	10	17	17	8	0	6	0	0.0595	0.981	1.000
366	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1)	2301634	23	10	23	8	11	8	2	0	2	0	0.557	0.981	1.000
367	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(1)	484925	1	1	1	2	0	0	0	0	1	0	0.988	0.981	1.000
368	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(1), ENPP3(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5E(1)	1480509	12	3	12	6	2	5	2	0	3	0	0.897	0.982	1.000
369	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), NOS1(6), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2)	2433217	31	11	31	10	16	10	2	0	2	1	0.257	0.982	1.000
370	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(1), BTK(1), EEA1(4), GSK3B(1), PFKM(3), PRKCE(2), VAV2(2)	2395078	14	7	14	7	2	9	1	0	2	0	0.868	0.983	1.000
371	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), DHFR(1), MTFMT(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1)	1842430	11	5	11	4	4	6	0	0	1	0	0.554	0.983	1.000
372	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), AKT3(1), BTK(1), DAPP1(1), GRB2(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(7), PPP1R13B(1), PTEN(4), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TEC(2), YWHAH(1)	3433031	34	14	34	8	8	13	10	0	3	0	0.292	0.983	1.000
373	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), DFFA(1), GZMB(1), SCAP(1)	1781156	12	4	12	2	3	5	1	0	3	0	0.289	0.984	1.000
374	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(1)	525884	7	2	7	3	4	3	0	0	0	0	0.699	0.984	1.000
375	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(1), EGFR(1), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK13(1), MAPK3(1), MAPK8(5), NFKB1(3), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), RAF1(2)	4731861	41	15	41	12	15	13	8	2	3	0	0.296	0.985	1.000
376	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), GOSR2(1), SEC22B(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1)	1586776	15	4	15	3	4	4	3	0	4	0	0.304	0.985	1.000
377	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(2), FOS(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TLR10(3), TLR2(4), TLR3(1), TLR4(3), TLR7(3), TLR9(3)	3436977	43	9	43	8	11	17	9	2	3	1	0.0806	0.985	1.000
378	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(1), MAP2K5(2), MAPK8(5), PLD1(3), PLD2(1), RAF1(2), RASAL1(1), TEC(2), VAV1(2)	2663900	24	7	24	6	10	8	4	1	1	0	0.287	0.986	1.000
379	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH12(1)	467477	2	1	2	1	1	1	0	0	0	0	0.774	0.986	1.000
380	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IRS1(3), JAK1(1), JAK3(2)	1429891	7	3	7	2	1	3	1	0	2	0	0.618	0.987	1.000
381	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP3(1), INSR(1), MAGI1(3), MAGI2(5), WWP1(3)	2311224	15	5	15	3	5	2	5	0	3	0	0.332	0.987	1.000
382	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	2352919	25	9	25	9	6	9	8	0	2	0	0.708	0.987	1.000
383	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), DFFA(1), GZMB(1), LMNB1(2)	1899963	16	4	16	3	4	6	1	0	5	0	0.343	0.987	1.000
384	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(4), ACACB(1), ACADM(3), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), HIBCH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1)	3968715	35	10	35	7	8	14	4	0	9	0	0.186	0.987	1.000
385	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(1), ST6GALNAC1(1), WBSCR17(2)	3183203	28	9	28	7	5	14	7	0	2	0	0.366	0.987	1.000
386	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), DARS(1), EPRS(2), FARS2(1), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1)	3206399	23	10	23	5	3	9	7	1	3	0	0.356	0.988	1.000
387	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(2), HEXB(2), LCT(5), MAN2B1(1), MANBA(1), NEU1(1)	1946735	14	6	14	6	6	4	1	0	3	0	0.724	0.988	1.000
388	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), SP3(1)	2007830	13	7	13	5	8	2	0	0	3	0	0.577	0.989	1.000
389	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(1), DLST(1), IDH3A(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1)	1971597	16	9	16	9	3	8	2	0	3	0	0.946	0.989	1.000
390	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(1), AKT3(1), CAP1(1), CBL(3), CDC42(1), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPYR1(3), PTEN(4), PTPN1(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), SERPINB6(1), SLC2A4(1), SORBS1(4), SOS1(2), SOS2(2), YWHAH(1)	5721651	65	16	65	11	24	18	12	0	9	2	0.0142	0.989	1.000
391	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(1)	507137	2	1	2	1	1	0	1	0	0	0	0.837	0.990	1.000
392	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1)	600539	5	1	5	0	0	4	1	0	0	0	0.292	0.991	1.000
393	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(1), CIITA(1), CTSB(3), CTSL1(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFNA10(2), IFNA2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), LGMN(2), NFYA(2), PDIA3(1), TAP1(2), TAP2(1), TAPBP(2)	4408057	42	12	42	12	7	20	7	1	5	2	0.390	0.991	1.000
394	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACYP1(1), DHRS2(1), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1)	2489213	21	6	21	7	6	7	6	0	2	0	0.648	0.991	1.000
395	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), NCOA1(2), NCOA2(3)	1710934	11	4	11	2	6	3	2	0	0	0	0.268	0.991	1.000
396	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	NR3C1(1)	562520	1	1	1	1	0	0	0	0	1	0	0.913	0.991	1.000
397	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(1), CAV1(1), CHRNA1(2), FLT1(3), FLT4(1), KDR(2), PDE3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKG1(5), PRKG2(2), RYR2(11)	3634760	36	13	36	12	7	17	9	0	3	0	0.502	0.992	1.000
398	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1)	3067446	23	10	23	6	11	9	2	0	1	0	0.252	0.992	1.000
399	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(1), OXSM(1)	1586086	6	4	6	3	3	1	0	0	2	0	0.754	0.992	1.000
400	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(2), TGM2(2)	485402	6	3	6	2	3	3	0	0	0	0	0.494	0.992	1.000
401	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(1), AASS(2)	703013	4	3	4	3	0	1	2	0	1	0	0.960	0.993	1.000
402	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1), IL6(1), IL8(1)	634117	3	1	3	2	1	1	1	0	0	0	0.904	0.993	1.000
403	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1B2(1), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(1), EIF2B2(1), EIF4A2(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(2), PAIP1(3)	4169802	21	10	21	6	5	7	4	1	4	0	0.610	0.993	1.000
404	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN2(1), EGFR(1), MAPK3(1), MYLK(3), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TLN1(2)	3129679	15	6	15	7	6	6	1	0	2	0	0.747	0.993	1.000
405	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR3(1), CCR4(1), CCR7(2), CD28(1), CXCR4(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1), TGFB2(4)	1903153	17	4	17	4	4	9	2	0	2	0	0.290	0.993	1.000
406	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1F(2), CACNA1S(4), CAMK2D(1), CDC42(1), CGA(1), EGFR(1), FSHB(1), GNAQ(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MMP2(3), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PLD1(3), PLD2(1), PRKACA(1), PRKACG(1), PRKCA(2), RAF1(2), SOS1(2), SOS2(2)	12142466	143	53	112	25	36	69	16	2	19	1	0.000150	0.993	1.000
407	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1)	1464180	15	6	15	7	7	5	2	0	1	0	0.867	0.993	1.000
408	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H4(1)	510297	2	1	2	0	2	0	0	0	0	0	0.421	0.994	1.000
409	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(2), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(2), NFKB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1)	2665358	23	7	23	8	12	7	1	0	3	0	0.478	0.994	1.000
410	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(5), NEU1(1), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SPHK1(1), UGT8(2)	3301285	20	8	20	8	10	5	2	0	2	1	0.619	0.995	1.000
411	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(1), NT5C2(1), NT5E(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PRIM2(3), RFC5(1), RRM1(1), TK2(1), TXNRD1(1), TXNRD2(1), TYMS(1), UMPS(1), UPB1(2), UPP2(1), UPRT(1)	7933506	67	28	65	15	18	26	10	0	13	0	0.0895	0.995	1.000
412	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHFR(1), DHX58(1), EP400(2), ERCC3(1), MOV10L1(7), RAD54B(2), SETX(9), SKIV2L2(1), SMARCA2(2), SMARCA5(4)	6107954	44	12	44	4	12	13	8	0	11	0	0.00396	0.996	1.000
413	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	GAL3ST1(2), LCT(5), NEU1(1)	2250279	8	5	8	6	5	2	0	0	1	0	0.914	0.996	1.000
414	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), APC(66), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARPC2(1), ARPC5L(1), BAIAP2(1), BDKRB2(1), BRAF(2), CDC42(1), CHRM2(3), CHRM4(1), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGFR(1), F2(1), FGD1(2), FGD3(1), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FN1(4), GIT1(1), GRLF1(5), IQGAP1(3), IQGAP2(3), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KRAS(38), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MOS(1), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(2), MYLK(3), MYLK2(1), NCKAP1(1), NCKAP1L(4), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), RAF1(2), RDX(1), RHOA(1), ROCK1(7), ROCK2(4), RRAS2(1), SCIN(1), SLC9A1(2), SOS1(2), SOS2(2), SSH1(2), SSH3(1), TIAM1(5), TIAM2(2), VAV1(2), VAV2(2), VAV3(2), VCL(1), WASF1(2), WASL(2)	26346295	332	66	291	70	74	124	38	4	72	20	8.31e-05	0.996	1.000
415	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(1), LDHA(1), LDHB(2)	672010	6	2	6	2	2	3	0	0	1	0	0.665	0.996	1.000
416	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F3(1), F5(7), F7(1), FGA(2), FGB(1), PROS1(3), TFPI(3)	1618984	19	5	19	7	5	6	6	0	2	0	0.705	0.997	1.000
417	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CYP2C9(3), DHRS2(1), ESCO1(4), ESCO2(1), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1)	2984916	27	6	27	7	7	10	7	0	3	0	0.419	0.997	1.000
418	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK3(1), PFKFB1(1), PFKM(3), PMM1(2), SORD(2)	2329967	17	6	17	3	6	9	2	0	0	0	0.135	0.997	1.000
419	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(1), BRAF(2), DAG1(1), DRD2(2), EGFR(1), EPHB2(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), PI3(1), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(2), SOS2(2), TERF2IP(1)	5551006	38	10	38	6	18	10	5	0	4	1	0.0227	0.997	1.000
420	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), GNGT1(1), GRB2(1), IGF1R(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), NGFR(1), PDGFRA(4), PTPRR(4), RAF1(2), RPS6KA5(3), SOS1(2)	3281797	24	6	24	7	7	8	7	0	1	1	0.482	0.997	1.000
421	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1), RDH11(1), RDH12(1), UGP2(2)	3669281	28	10	28	7	11	12	4	0	1	0	0.204	0.997	1.000
422	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), B4GALT3(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), RPN2(1)	1904227	8	5	8	7	2	2	1	0	3	0	0.969	0.997	1.000
423	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), NDST1(1), NDST3(3)	1960864	17	9	17	9	5	6	3	1	2	0	0.870	0.997	1.000
424	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC3F(1), APOBEC3G(1), APOBEC4(2)	700306	5	2	5	2	2	2	1	0	0	0	0.765	0.998	1.000
425	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL1RN(1), IL6(1), IRAK3(2), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TGFB2(4)	2842769	34	7	34	6	10	12	7	2	3	0	0.103	0.998	1.000
426	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(1), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), HADHA(1), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1)	4297122	31	12	31	9	9	11	3	0	8	0	0.479	0.998	1.000
427	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNGT1(1), HTR2C(2), TUB(1)	704704	5	2	5	2	1	2	1	0	1	0	0.750	0.998	1.000
428	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), AKT3(1), BCR(1), BTK(1), DAPP1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDK1(2), PIK3CA(7), PLCG2(4), PPP1R13B(1), PREX1(2), PTEN(4), PTPRC(8), RPS6KA2(2), RPS6KA3(2), SYK(3), TEC(2), VAV1(2)	5148194	59	12	59	11	18	22	8	0	10	1	0.0261	0.998	1.000
429	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLB(2), POLE(4), POLE2(1), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(1), POLQ(4), PRIM2(3), REV1(3), REV3L(7), RFC5(1)	3994731	36	11	34	10	7	14	5	0	9	1	0.609	0.998	1.000
430	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(2), ESRRA(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D2(3), NR1I3(1), NR2E1(1), NR2F1(1), NR2F6(1), NR3C1(1), NR4A2(2), PPARD(1), RARB(2), ROR1(4), RXRB(1), RXRG(1), VDR(1)	4082294	32	12	32	7	11	9	9	0	3	0	0.178	0.998	1.000
431	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(4), EP300(2), IKBKB(2), NFKB1(3)	2219208	13	2	13	4	6	6	1	0	0	0	0.523	0.998	1.000
432	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(1), GCDH(2), HADHA(1)	766279	4	2	4	2	1	1	1	0	1	0	0.843	0.998	1.000
433	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A7(2), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2)	5303050	47	11	47	12	8	18	14	0	7	0	0.274	0.998	1.000
434	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM17(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(2), CSK(2), EGFR(1), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(2), MAP3K14(1), MAPK10(4), MAPK13(1), MAPK8(5), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG2(4), PTPN11(3), PTPRZ1(5), TJP1(2)	6883705	65	21	65	11	20	23	11	1	9	1	0.0133	0.998	1.000
435	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(2), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), TLR4(3), TNFAIP3(1)	2336699	18	4	18	3	5	7	5	0	1	0	0.193	0.998	1.000
436	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(5), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(1), SHMT1(1)	3623538	26	11	26	9	7	13	3	0	3	0	0.555	0.998	1.000
437	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRB1(1), CSNK1D(1), DRD2(2), EGFR(1), GJA1(4), GJD2(1), GNAI1(1), GNAQ(1), GRB2(1), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(1), HTR2C(2), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR2(1), NRAS(5), PDGFC(1), PDGFRA(4), PDGFRB(1), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), SOS1(2), SOS2(2), TJP1(2), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1)	12432974	166	52	135	35	42	86	22	0	14	2	0.00109	0.998	1.000
438	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(2), AGTR2(1), COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), REN(2)	2534203	17	5	17	5	5	8	1	0	3	0	0.527	0.998	1.000
439	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), HADHA(1), HADHB(1)	832973	3	3	3	5	0	2	0	0	1	0	0.995	0.998	1.000
440	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT5(2), FUT1(3), FUT3(1)	668667	6	3	6	2	4	1	1	0	0	0	0.627	0.998	1.000
441	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), ALAS2(1), BLVRB(1), COX15(2), CP(3), CPOX(1), EPRS(2), FECH(1), FTMT(1), HCCS(2), HMOX2(2), MMAB(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UROD(1)	3918773	35	12	35	7	9	18	5	0	3	0	0.143	0.999	1.000
442	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(1), GRB2(1), GSK3B(1), INPP5D(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PTPRC(8), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2)	6910631	79	19	79	10	29	28	8	0	11	3	0.000284	0.999	1.000
443	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUL(1), HAL(1)	1859986	12	3	12	5	4	6	0	0	2	0	0.745	0.999	1.000
444	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), SLC23A2(1), SLC2A1(1)	2482249	10	5	10	5	4	3	0	0	3	0	0.843	0.999	1.000
445	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), MAP3K14(1), NFKB1(3), SPTAN1(4), TNFRSF10B(4)	3245861	26	6	26	6	10	7	4	0	5	0	0.284	0.999	1.000
446	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), CRADD(1), DAXX(1), DFFA(1), LMNB1(2), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK8(5), NFKB1(3), NUMA1(2), PAK2(1), PRKDC(5), RASA1(4), RB1(3), SPTAN1(4), TRAF1(1)	6457575	50	11	50	10	17	14	9	1	9	0	0.107	0.999	1.000
447	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPN2(1), EP300(2), NFATC1(1), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2)	2318218	14	8	14	5	7	4	1	0	2	0	0.525	0.999	1.000
448	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), PRKCA(2)	825669	6	2	6	4	4	1	0	0	1	0	0.880	0.999	1.000
449	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO3(1), FARS2(1), GOT1(1), TAT(2)	836448	5	2	5	2	0	3	0	0	2	0	0.718	0.999	1.000
450	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(2), IL6(1), IL9(1), TGFB2(4)	829325	8	2	8	5	1	5	1	0	1	0	0.925	0.999	1.000
451	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(1), GRB2(1), HSPB2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MEF2A(1), MEF2C(2), PLA2G4A(3), RPS6KA5(3), TGFB2(4), TGFBR1(3)	3501750	31	8	31	9	10	9	5	0	7	0	0.406	0.999	1.000
452	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(4), EP300(2), IKBKB(2), IL1B(1), IL8(1), MAP2K3(4), MAP2K6(1), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), NR3C1(1), TGFBR1(3), TLR2(4)	2876420	32	7	32	7	9	10	8	1	4	0	0.221	0.999	1.000
453	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2F1(2), NCOA1(2), NCOA2(3), NCOA3(5)	2377537	13	4	13	4	4	4	4	0	1	0	0.554	0.999	1.000
454	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSB(1), GOT1(1), TAT(2), YARS2(1)	871015	6	2	6	2	0	5	0	0	1	0	0.666	0.999	1.000
455	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(2), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2)	3679066	33	12	33	11	12	11	5	1	4	0	0.516	0.999	1.000
456	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUD2(2), GLUL(1), HAL(1)	2072706	14	5	14	6	4	8	0	0	2	0	0.776	0.999	1.000
457	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL10(1), IL12A(1), IL16(4), IL2(1), IL6(1), IL8(1), IL9(1)	950295	10	1	10	5	2	7	0	0	1	0	0.834	0.999	1.000
458	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), FUCA1(2), GNS(3), HEXB(2), HPSE2(3), LCT(5), MAN2B1(1), MANBA(1), NAGLU(1), NEU1(1), SPAM1(3)	3295730	24	7	24	9	10	8	2	0	4	0	0.608	1.000	1.000
459	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(5), APOC1(1), APOC2(1), CETP(1), HMGCR(1), LDLR(1), LIPC(1), LRP1(3), SCARB1(1)	2459953	15	5	15	5	9	4	1	0	1	0	0.461	1.000	1.000
460	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), AOX1(3), HADHA(1), HADHB(1), HMGCL(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1)	3566871	28	11	28	9	8	10	3	0	7	0	0.588	1.000	1.000
461	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(1), ENPP3(1), NADK(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5C1B(1), NT5C2(1), NT5E(1)	2173649	15	6	15	7	5	5	2	0	3	0	0.833	1.000	1.000
462	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(1), CMAS(3), CYB5R1(2), GFPT1(1), GFPT2(1), HEXB(2), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), NANS(1), NPL(1), PGM3(1)	2856288	17	8	17	7	7	5	3	1	1	0	0.727	1.000	1.000
463	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), EGFR(1), EP300(2), ERBB2(4), FER(2), FGFR1(1), FYN(1), IGF1R(1), INSR(1), IQGAP1(3), LMO7(1), MAP3K7(2), MAPK3(1), MET(1), MLLT4(3), PARD3(2), PTPN1(1), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), RHOA(1), SMAD2(5), SMAD3(3), SMAD4(8), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(7), TGFBR1(3), TJP1(2), VCL(1), WASF1(2), WASF3(2), WASL(2)	11386531	110	33	106	24	40	44	13	0	12	1	0.0230	1.000	1.000
464	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(1), ARHGEF12(2), CDC42(1), CXCR4(1), DCC(2), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(1), EPHA1(3), EPHA3(3), EPHA4(2), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(3), EPHB2(1), EPHB4(3), FYN(1), GNAI1(1), GSK3B(1), KRAS(38), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK3(1), MET(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), NTN1(1), NTN4(2), NTNG1(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASA1(4), RGS3(2), RHOA(1), ROBO1(9), ROBO2(3), ROBO3(3), ROCK1(7), ROCK2(4), SEMA3A(3), SEMA3C(1), SEMA3D(4), SEMA3E(4), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(4), SEMA6B(2), SEMA6C(1), SEMA6D(4), SLIT1(2), SLIT2(3), SLIT3(2), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(3)	18342705	206	59	175	37	68	87	25	2	24	0	1.87e-05	1.000	1.000
465	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), PPAT(3), QARS(1)	3240227	19	7	19	6	5	8	3	0	3	0	0.556	1.000	1.000
466	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	IL8(1), NFKB1(3)	995858	4	1	4	2	3	1	0	0	0	0	0.763	1.000	1.000
467	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1)	894973	8	3	8	2	1	5	2	0	0	0	0.518	1.000	1.000
468	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GMPPA(1), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), PFKFB1(1), PFKM(3), PMM1(2), RDH11(1), RDH12(1), SORD(2)	3654387	21	7	21	7	9	10	2	0	0	0	0.419	1.000	1.000
469	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(1), DIAPH2(3), MCM10(2), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), POLE(4), POLE2(1), RFC1(4), RFC5(1), RPA4(1), UBB(1)	4841187	27	10	26	8	7	16	1	0	3	0	0.477	1.000	1.000
470	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2D3(1), UBE2I(1), UBE3A(5)	1018069	8	1	8	0	2	4	2	0	0	0	0.0998	1.000	1.000
471	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(1), AKT2(1), AKT3(1), BRAF(2), CBL(3), CBLB(2), EXOC7(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GRB2(1), GSK3B(1), GYS1(1), GYS2(3), IKBKB(2), INPP5D(2), INSR(1), IRS1(3), IRS4(4), KRAS(38), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MKNK2(1), NRAS(5), PCK1(3), PDE3B(1), PFKM(3), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R3A(5), PPP1R3C(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKACG(1), PRKAG2(1), PRKAG3(2), PRKAR1A(4), PRKAR2B(1), PTPN1(1), PTPRF(1), PYGM(2), RAF1(2), RAPGEF1(2), RPS6KB2(1), SHC2(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(4), SOS1(2), SOS2(2), TSC1(1), TSC2(1)	15520345	177	53	146	37	48	79	25	1	22	2	0.00141	1.000	1.000
472	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CHUK(2), CPT1A(1), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(4), JAK1(1), JAK2(3), JAK3(2), LEPR(4), MAPK10(4), MAPK8(5), MAPK9(2), NFKB1(3), NFKB2(2), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(3), RXRB(1), RXRG(1), SLC2A1(1), SLC2A4(1)	8088515	66	16	66	16	19	26	7	2	11	1	0.103	1.000	1.000
473	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), MPO(2), PRDX1(1), TPO(3), TYR(1)	885030	9	6	9	5	6	2	0	0	1	0	0.805	1.000	1.000
474	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), GSK3B(1)	1122331	3	2	3	2	0	3	0	0	0	0	0.916	1.000	1.000
475	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(5), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CX3CR1(1), CXCR4(1), EDNRB(5), FSHR(1), GALR1(1), GPR77(1), MC2R(3), MC4R(1), MC5R(2), NPY5R(1), NTSR2(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR4(2), TACR3(3), TRHR(2), TSHR(1)	4850643	55	19	55	21	22	18	11	1	3	0	0.388	1.000	1.000
476	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(1), ADCY9(2), ARF4(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), PDIA4(1), PLCG2(4), PRKCA(2), TRIM23(4)	3618661	28	10	28	5	12	8	5	0	3	0	0.0795	1.000	1.000
477	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	AGT(1), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(1), REN(2)	939582	8	2	8	4	1	5	0	0	2	0	0.728	1.000	1.000
478	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(1), BMP7(1), BTRC(3), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(2), GLI3(4), GSK3B(1), HHIP(1), LRP2(13), PRKACA(1), PRKACG(1), PTCH1(1), PTCH2(2), RAB23(1), SMO(1), STK36(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	5735218	47	17	47	14	19	18	3	0	7	0	0.240	1.000	1.000
479	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP4A11(1), CYP4F3(1), GPX3(2), GPX6(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1)	3733718	24	9	24	9	11	6	5	0	2	0	0.655	1.000	1.000
480	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(10), CDR1(1), DGKI(4), FAU(1), IL6ST(1), PIGK(1), RPL10(1), RPL11(1), RPL19(1), RPL28(1), RPL5(1), RPL6(2), RPL9(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS4X(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), SLC36A2(1), UBB(1)	4903532	40	18	40	11	13	12	9	1	5	0	0.463	1.000	1.000
481	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB2(1), C1R(1), C1S(3), C2(4), C3(1), C3AR1(2), C4BPA(5), C5(4), C5AR1(1), C6(3), C7(3), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(6), CPB2(1), CR1(3), CR2(2), F13A1(2), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), KLKB1(2), KNG1(1), MASP1(3), PLAT(1), PLAU(1), PLAUR(1), PLG(2), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(5)	8657981	103	25	103	27	27	41	22	0	13	0	0.119	1.000	1.000
482	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1)	1216013	10	2	10	2	3	5	1	0	1	0	0.318	1.000	1.000
483	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DAK(1), DGAT2(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(5), LIPC(1), LIPF(2), MGLL(1), PNLIP(2), PNLIPRP2(1)	5645977	52	16	52	16	20	19	8	0	5	0	0.258	1.000	1.000
484	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2D(1), F2(1), FYN(1), GNAI1(1), GNGT1(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), MAPT(1), MYLK(3), PRKCA(2), RAF1(2), SOS1(2)	4128607	29	8	29	10	7	13	5	1	2	1	0.606	1.000	1.000
485	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), HGD(1), HPD(1), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), MYST3(5), MYST4(5), PRMT3(1), PRMT7(1), PRMT8(2), SH3GLB1(1), TAT(2), TPO(3), TYR(1)	5605296	54	18	54	18	11	25	9	1	8	0	0.501	1.000	1.000
486	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1)	1161032	6	2	6	2	1	4	0	0	1	0	0.692	1.000	1.000
487	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CREB3(1), CREB5(2), ERBB4(5), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), MET(1), NOLC1(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(4), PTPN1(1), RPS6KA2(2), RPS6KA3(2), SLC2A4(1), SOS1(2), SOS2(2), TSC1(1), TSC2(1), YWHAH(1)	7465646	67	17	67	16	19	23	12	1	12	0	0.106	1.000	1.000
488	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(1), MAP2K6(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(2), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), YWHAH(1)	3228754	33	16	33	12	11	11	3	0	6	2	0.553	1.000	1.000
489	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHA(1)	1196103	6	2	6	4	1	2	1	0	2	0	0.938	1.000	1.000
490	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CTH(1), GOT1(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), SULT1B1(1), SULT1C2(1)	1242605	10	2	10	4	3	4	2	0	1	0	0.741	1.000	1.000
491	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), INPP4A(1), INPP4B(2), INPP5D(2), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), OCRL(4), PI4KA(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(4), SYNJ1(3), SYNJ2(1)	11735339	102	29	102	26	38	36	13	0	12	3	0.0719	1.000	1.000
492	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(5), ATP4A(2), ATP5A1(3), ATP5C1(2), ATP5L(2), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX15(2), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(1), UQCRC2(1)	5498742	48	17	48	12	17	17	9	0	5	0	0.153	1.000	1.000
493	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH4A1(1), AMD1(1), ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), DAO(4), GOT1(1), MAOA(1), MAOB(1), NOS1(6), OAT(1), ODC1(3), OTC(1), P4HA1(1), P4HA3(1), RARS(2)	4266252	46	11	45	16	18	14	5	1	8	0	0.485	1.000	1.000
494	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(1), AASS(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(2)	3579636	23	6	23	8	7	7	4	0	5	0	0.627	1.000	1.000
495	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2), HSPB2(1), MTA3(1), TUBA8(1)	994490	5	3	5	2	2	2	1	0	0	0	0.657	1.000	1.000
496	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(3), SCAP(1)	1168441	5	1	5	2	3	2	0	0	0	0	0.616	1.000	1.000
497	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), EPX(1), LPO(1), MPO(2), PRDX1(1), SHMT1(1), TPO(3)	1086970	10	7	10	7	5	3	1	0	1	0	0.924	1.000	1.000
498	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	CREBBP(4), EP300(2), MAPK3(1), ME1(2), NCOA1(2), NCOR1(5), NR2F1(1), NRIP1(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PTGS2(1), RB1(3), STAT5B(1)	6031166	43	18	43	13	18	12	6	0	5	2	0.394	1.000	1.000
499	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), CYP4F3(1), EPX(1), LPO(1), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGIS(1), PTGS1(2), PTGS2(1), TPO(3)	2617125	20	10	20	9	12	5	1	0	2	0	0.704	1.000	1.000
500	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	1268352	7	3	7	3	3	2	2	0	0	0	0.714	1.000	1.000
501	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ANAPC1(1), ANAPC4(3), ANAPC5(1), ATM(10), ATR(4), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC25C(1), CDC27(4), CDC6(1), CDC7(1), CDK4(1), CDKN1B(2), CREBBP(4), CUL1(1), DBF4(3), E2F3(1), EP300(2), GSK3B(1), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), RBX1(1), SMAD2(5), SMAD3(3), SMAD4(8), SMC1B(2), TGFB2(4), TP53(45), YWHAH(1)	12994047	147	55	130	32	44	49	26	3	24	1	0.0332	1.000	1.000
502	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), F2(1), F5(7), F8(3), FGA(2), FGB(1), KLKB1(2), PROS1(3), SERPING1(2)	4428846	29	6	29	9	8	12	5	0	4	0	0.498	1.000	1.000
503	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), DHFR(1), IMPDH1(1), POLB(2), POLG(1), RRM1(1)	1197127	7	4	7	3	4	1	1	0	1	0	0.723	1.000	1.000
504	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(1), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), PGM1(2), PGM3(1), PYGM(2), SI(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1)	5276061	35	10	35	10	10	12	6	0	7	0	0.372	1.000	1.000
505	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), CPT1A(1), CPT2(1), CYP4A11(1), CYP8B1(1), FABP2(1), FABP7(1), FADS2(1), GK2(3), HMGCS2(1), ME1(2), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(1), SLC27A6(5), SORBS1(4)	6301000	42	10	42	11	17	14	6	1	4	0	0.196	1.000	1.000
506	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT2(1), GALNT6(1), GALNT7(1), GALNT8(1), GCNT1(2), WBSCR17(2)	1390998	8	3	8	3	3	3	2	0	0	0	0.674	1.000	1.000
507	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(2), FARS2(1), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), MTFMT(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(2), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1)	5343246	35	11	35	10	7	16	8	1	3	0	0.503	1.000	1.000
508	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), HSD17B10(1), NSD1(3), OGDHL(3), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(1), SETDB1(1), SHMT1(1), SPCS3(1), SUV39H2(1), TMLHE(2)	5650596	37	9	37	10	13	11	6	0	7	0	0.302	1.000	1.000
509	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), NT5E(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), RRM1(1), TK2(1), TXNRD1(1), TYMS(1), UMPS(1), UPB1(2)	5575126	38	18	37	12	11	13	7	0	7	0	0.448	1.000	1.000
510	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(3), FYN(1), L1CAM(2), SELP(2)	1455667	11	5	11	6	5	4	1	0	1	0	0.842	1.000	1.000
511	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), CTCFL(1), EHMT2(2), EZH1(1), FBXO11(1), HSF4(1), MEN1(1), MLL(6), MLL2(3), MLL3(6), MLL4(3), MLL5(6), NSD1(3), OGT(1), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(6), PRMT7(1), PRMT8(2), SATB1(1), SETD1A(1), SETD2(6), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(1), SUV39H2(1), SUV420H1(3), SUZ12(1), WHSC1(1)	11155750	79	18	79	12	23	28	10	0	17	1	0.0140	1.000	1.000
512	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), GCDH(2), HADHA(1), HSD17B10(1), INMT(1), KMO(2), KYNU(1), LCMT1(2), LNX1(4), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), NFX1(3), OGDHL(3), PRMT3(1), PRMT7(1), PRMT8(2), TDO2(2), TPH1(2), TPH2(3), WARS(1), WARS2(1)	5818043	54	17	54	18	13	23	8	1	9	0	0.518	1.000	1.000
513	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT2(3), CPS1(6), DAO(4), EPRS(2), GLUD2(2), GOT1(1), LAP3(1), NOS1(6), OAT(1), OTC(1), P4HA1(1), P4HA3(1), RARS(2), RARS2(2)	3484088	39	10	39	12	13	14	5	1	6	0	0.414	1.000	1.000
514	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(2), CHUK(2), DAXX(1), FOS(1), GRB2(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK6(1), MAPK8(5), MAPK9(2), MEF2A(1), MEF2C(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KB2(1), TGFB2(4), TGFBR1(3)	9074563	84	23	84	16	20	24	21	2	17	0	0.0182	1.000	1.000
515	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGPAT1(1), AGPAT4(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), LCT(5), LIPC(1), LIPF(2), PNLIP(2), PNLIPRP2(1)	4621163	38	12	38	14	15	12	6	0	5	0	0.473	1.000	1.000
516	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(2), ACVRL1(1), BMPR2(3), BUB1(2), CDKL1(2), CDS1(1), CLK1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), INPP4A(1), INPP4B(2), INPPL1(1), MAP3K10(1), MOS(1), NEK1(2), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKG1(5), RAF1(2), RPS6KA2(2), RPS6KA3(2), TGFBR1(3), VRK1(1)	10857504	99	34	99	29	31	35	20	1	12	0	0.320	1.000	1.000
517	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX3(2), FADS2(1), HADHA(1)	1430750	4	4	4	6	2	1	0	0	1	0	0.991	1.000	1.000
518	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), PPAT(3), QARS(1)	3854660	22	10	22	9	5	10	3	1	3	0	0.756	1.000	1.000
519	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4)	1628498	12	5	11	5	2	4	3	0	3	0	0.778	1.000	1.000
520	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT3(1), CHST11(1), CHST12(1), CHST13(1), DSE(1), XYLT1(2)	1313738	7	3	7	3	3	3	1	0	0	0	0.663	1.000	1.000
521	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1)	1725529	7	4	7	8	5	1	0	0	1	0	0.988	1.000	1.000
522	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(2), CREBBP(4), CTNNB1(4), DCT(4), DVL2(1), DVL3(2), EDNRB(5), EP300(2), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GNAI1(1), GNAQ(1), GSK3B(1), KIT(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), MITF(3), NRAS(5), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), TCF7(3), TCF7L2(7), TYR(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1)	10368285	134	52	103	35	30	79	11	1	13	0	0.0291	1.000	1.000
523	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), EGFR(1), GRB2(1), MET(1), PDGFRA(4), PRKCA(2), SH3GLB1(1)	1940943	13	3	13	4	6	5	2	0	0	0	0.522	1.000	1.000
524	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(1), MAP2K1(1), MAP3K1(2)	1712375	4	1	4	2	1	2	1	0	0	0	0.815	1.000	1.000
525	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(2), CSTF3(2), DDX20(1), DHX15(2), DHX38(1), DHX9(1), DICER1(1), LSM2(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), PRPF18(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(2), RNMT(1), RNPS1(1), SF3A1(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(1), XRN2(2)	10289274	56	14	56	13	16	23	11	0	6	0	0.283	1.000	1.000
526	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE2(3), AGT(1), AGTR1(2), AGTR2(1), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(2), REN(2)	2084547	25	7	25	7	8	11	4	0	2	0	0.309	1.000	1.000
527	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(1), HDAC5(1), MEF2A(1), MEF2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), SLC2A4(1), YWHAH(1)	1932116	17	5	17	6	7	7	0	0	3	0	0.549	1.000	1.000
528	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), AMY2A(2), AMY2B(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(1), ENPP3(1), EP400(2), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), MOV10L1(7), PGM1(2), PGM3(1), PYGM(2), RAD54B(2), SETX(9), SI(3), SKIV2L2(1), SMARCA2(2), SMARCA5(4), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UXS1(1)	11682363	89	21	89	17	22	30	18	0	19	0	0.0261	1.000	1.000
529	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BRAF(2), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CACNA2D1(3), CACNA2D3(3), CACNB2(1), CACNB3(1), CACNB4(2), CACNG2(1), CACNG3(3), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(2), DAXX(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(1), ECSIT(1), EGFR(1), ELK4(1), FAS(2), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FLNA(1), FLNB(2), FLNC(2), FOS(1), GRB2(1), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), MAPT(1), MEF2C(2), MKNK2(1), MOS(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(4), PDGFRB(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN7(1), PTPRR(4), RAF1(2), RAP1A(1), RAPGEF2(5), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KA6(2), RRAS2(1), SOS1(2), SOS2(2), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TP53(45), ZAK(2)	26577830	337	67	291	78	113	113	58	5	44	4	0.000105	1.000	1.000
530	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), CES1(1), CES7(1), DDHD1(2), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1)	2440634	21	8	21	9	5	8	6	0	2	0	0.820	1.000	1.000
531	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(2), CAMK4(1), CD69(1), CNR1(2), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(5), GSK3B(1), IL10(1), IL1B(1), IL2(1), IL6(1), IL8(1), ITK(3), MAPK8(5), MAPK9(2), MEF2A(1), MYF5(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(2), NPPB(1), NUP214(2), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(1), PTPRC(8), SP3(1), TRPV6(2), VAV1(2), VAV2(2), VAV3(2), XPO5(1)	8560868	74	17	74	23	29	25	8	1	11	0	0.253	1.000	1.000
532	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(2), CACNA1A(9), CRHR1(1), GNAI1(1), GNAQ(1), GRIA1(1), GRIA2(3), GRIA3(3), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NOS1(6), NPR2(1), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), RYR1(6)	10438584	150	51	118	38	40	75	23	0	11	1	0.0290	1.000	1.000
533	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(3), ABCA12(11), ABCA13(17), ABCA3(1), ABCA4(4), ABCA5(2), ABCA6(5), ABCA8(7), ABCA9(6), ABCB1(5), ABCB11(3), ABCB4(3), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(1), ABCC1(3), ABCC11(2), ABCC12(4), ABCC2(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(4), ABCD2(1), ABCG1(1), ABCG2(4), CFTR(4), TAP1(2), TAP2(1)	11301743	113	16	113	31	29	51	17	1	14	1	0.0843	1.000	1.000
534	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ARHGAP5(3), CDC42(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), CXCR4(1), CYBB(1), GNAI1(1), GRLF1(5), ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), ITK(3), MAPK13(1), MLLT4(3), MMP2(3), MMP9(5), MSN(3), MYL9(2), NCF2(1), NCF4(1), NOX3(3), PECAM1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), PTPN11(3), RAP1A(1), RAPGEF3(1), RHOA(1), ROCK1(7), ROCK2(4), TXK(1), VAV1(2), VAV2(2), VAV3(2), VCAM1(2), VCL(1)	11680790	124	35	124	34	48	47	18	0	9	2	0.0740	1.000	1.000
535	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), ITGB3(2), SPTAN1(4), TLN1(2)	2646085	13	5	13	6	6	6	0	0	1	0	0.767	1.000	1.000
536	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(1), CREBBP(4), DLL1(3), DLL3(1), DLL4(1), DTX2(1), DTX3(1), DVL2(1), DVL3(2), EP300(2), JAG1(1), MAML1(2), NOTCH2(2), NOTCH3(3), NOTCH4(4), PTCRA(1), RBPJ(4), SNW1(1)	6419192	35	9	35	12	14	11	4	0	6	0	0.402	1.000	1.000
537	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD80(1), CDH1(1), CDH15(1), CDH2(6), CDH3(2), CDH4(4), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CNTN1(5), CNTN2(2), CNTNAP1(1), CNTNAP2(4), CTLA4(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGB2(1), ITGB8(1), L1CAM(2), MAG(2), NCAM1(4), NCAM2(7), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(1), NRXN3(2), PECAM1(1), PTPRC(8), PTPRF(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(1), SDC2(1), SDC3(1), SELE(2), SELL(3), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(13)	14183287	163	35	163	47	48	70	23	3	19	0	0.0802	1.000	1.000
538	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTTN(1), EPB41L1(1), EPB41L3(3), EXOC4(3), GNAI1(1), HCLS1(1), IGSF5(2), INADL(2), KRAS(38), LLGL2(2), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(7), MYH10(2), MYH11(6), MYH13(5), MYH14(3), MYH15(4), MYH2(3), MYH3(5), MYH4(1), MYH6(4), MYH7(4), MYH7B(2), MYH8(3), MYH9(3), MYL9(2), NRAS(5), PARD3(2), PARD6A(2), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP2R3A(2), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PTEN(4), RHOA(1), RRAS2(1), SPTAN1(4), TJAP1(1), TJP1(2), ZAK(2)	18256670	201	53	169	54	59	97	20	0	24	1	0.0678	1.000	1.000
539	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(4), ADCY2(3), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(2), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), ATP2B4(3), AVPR1A(1), BDKRB2(1), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CAMK2D(1), CAMK4(1), CCKAR(1), CCKBR(2), CD38(1), CHRM2(3), CHRM5(1), CHRNA7(1), CYSLTR2(1), EDNRB(5), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GNA14(1), GNAL(1), GNAQ(1), GRIN2A(6), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), ITPR1(8), ITPR2(6), ITPR3(1), MYLK(3), MYLK2(1), NOS1(6), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), PDE1A(1), PDE1B(1), PDE1C(2), PDGFRA(4), PDGFRB(1), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A2(1), SLC8A3(3), SPHK1(1), TACR3(3), TRHR(2), TRPC1(1)	24478667	229	48	227	83	91	88	27	1	20	2	0.263	1.000	1.000
540	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(1), ADORA1(3), ADORA2A(2), ADRA1B(1), ADRA2B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR2(1), DRD2(2), DRD5(4), EDNRB(5), F2(1), F2RL1(1), F2RL2(1), FSHB(1), FSHR(1), GABBR1(2), GABBR2(4), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB2(3), GABRB3(4), GABRG1(2), GABRG2(3), GABRP(2), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(2), GRIA1(1), GRIA2(3), GRIA3(3), GRIA4(7), GRID1(1), GRID2(2), GRIK2(4), GRIK3(4), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRIN3A(3), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM6(1), GRM7(4), GRM8(2), GZMA(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LEPR(4), LTB4R(1), MAS1(1), MC2R(3), MC4R(1), MC5R(2), MCHR2(1), NMUR2(3), NPFFR2(1), NPY5R(1), NR3C1(1), NTSR2(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(1), P2RY14(2), P2RY2(1), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PTGDR(1), PTGER3(1), PTGFR(1), PTH2R(1), RXFP1(1), RXFP2(2), SSTR1(1), SSTR2(1), SSTR4(2), TAAR1(1), TAAR5(1), TAAR6(3), TAAR8(1), TAAR9(2), TACR3(3), TRHR(2), TRPV1(1), TSHB(1), TSHR(1), VIPR1(1)	21117924	247	45	246	98	94	92	39	3	18	1	0.408	1.000	1.000
541	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(3), BIRC2(2), BIRC3(5), BRAF(2), CAPN2(1), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), CTNNB1(4), DOCK1(2), EGFR(1), ERBB2(4), FIGF(2), FLNA(1), FLNB(2), FLNC(2), FLT1(3), FN1(4), FYN(1), GRB2(1), GRLF1(5), GSK3B(1), HGF(3), IGF1R(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KDR(2), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), MAP2K1(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MET(1), MYL9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFC(1), PDGFRA(4), PDGFRB(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(2), PTEN(4), RAF1(2), RAP1A(1), RAPGEF1(2), RELN(9), RHOA(1), ROCK1(7), ROCK2(4), SHC2(1), SOS1(2), SOS2(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TLN1(2), TLN2(3), TNC(3), TNN(2), TNR(2), TNXB(3), VAV1(2), VAV2(2), VAV3(2), VCL(1), VEGFC(3), VTN(3), VWF(5), ZYX(1)	35447113	303	44	301	114	108	105	45	4	38	3	0.572	1.000	1.000
542	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRA1B(1), ADRB1(1), ANXA6(1), ATP1A4(2), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(4), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(3), CHRM2(3), CHRM4(1), CHRM5(1), GJA1(4), GJB3(1), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(3), MYCBP(1), NME7(2), PLCB3(1), PLN(1), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A3(3), USP5(1), YWHAH(1)	16877394	174	36	174	62	67	73	17	0	16	1	0.282	1.000	1.000
543	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF1(1), ATF2(1), ATF4(1), ATP2A2(1), ATP2A3(1), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(1), DGKZ(1), ETS2(1), FOS(1), GABPB2(1), GJA1(4), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), GUCY1A3(5), IGFBP3(2), IL1B(1), IL6(1), ITPR1(8), ITPR2(6), ITPR3(1), MIB1(3), MYL4(1), MYLK2(1), NFKB1(3), NOS1(6), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(1), PRKD1(5), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), TNXB(3), USP5(1), YWHAH(1)	15657718	158	36	158	47	56	71	11	1	18	1	0.0683	1.000	1.000
544	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(3), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(4), EDNRB(5), F2RL1(1), F2RL2(1), FSHR(1), GALR1(1), GPR174(1), GPR37(1), GPR6(1), GPR63(2), GPR77(1), GPR87(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MAS1(1), MC4R(1), MC5R(2), NMUR2(3), NPY5R(1), NTSR2(1), OPRM1(2), OR12D3(3), OR1C1(2), OR2H1(2), OR5V1(1), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY14(2), P2RY2(1), P2RY6(1), PPYR1(3), PTGDR(1), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(1), SSTR4(2), SUCNR1(2), TRHR(2)	11332289	127	34	127	42	45	50	24	2	6	0	0.0726	1.000	1.000
545	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADSS(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP3(1), ENTPD5(1), ENTPD6(1), GMPR(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NME6(1), NME7(2), NPR2(1), NT5C1B(1), NT5C2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(5), PDE11A(1), PDE1A(1), PDE1C(2), PDE3B(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE7B(1), PDE8B(1), PDE9A(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PPAT(3), PRIM2(3), PRPS1(1), PRUNE(1), RFC5(1), RRM1(1)	15964960	128	34	126	38	40	49	16	0	23	0	0.204	1.000	1.000
546	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	CHAD(1), COL11A1(6), COL11A2(1), COL17A1(2), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DSC1(1), DSC3(1), DSG1(2), DSG4(4), FN1(4), GJA1(4), GJA10(4), GJA8(1), GJA9(1), GJB3(1), GJB7(1), GJC3(1), GJD2(1), ITGA6(1), ITGB4(1), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT20(1), KRT24(2), KRT27(1), KRT3(1), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT5(1), KRT6A(1), KRT7(2), KRT73(2), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT82(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), LMNB1(2), NES(1), PRPH(1), RELN(9), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VIM(1), VTN(3), VWF(5)	23567280	182	33	182	88	71	66	21	3	20	1	0.967	1.000	1.000
547	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), GP5(1), GP6(1), HMMR(2), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), RELN(9), SDC1(1), SDC2(1), SDC3(1), SV2A(1), SV2B(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VTN(3), VWF(5)	21583967	163	30	163	73	56	61	20	4	21	1	0.915	1.000	1.000
548	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT2(1), AKT3(1), CBL(3), CBLB(2), CREBBP(4), CSF3R(1), EP300(2), GH1(1), GH2(2), GRB2(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL13RA2(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(1), JAK2(3), JAK3(2), LEPR(4), LIFR(5), MPL(1), OSMR(2), PIAS1(1), PIAS2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRL(1), PRLR(2), PTPN11(3), SOCS2(1), SOCS4(1), SOCS5(2), SOS1(2), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT2(2), STAT4(3), STAT5B(1), TPO(3)	13749953	113	30	113	39	28	51	16	1	14	3	0.646	1.000	1.000
549	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL18(1), CCL22(1), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(2), EGFR(1), FAS(2), FLT1(3), FLT3(2), FLT4(1), GDF5(1), GH1(1), GH2(2), HGF(3), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(2), LEPR(4), LIFR(5), LTBR(1), MET(1), MPL(1), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF13B(1), TPO(3), VEGFC(3), XCR1(1)	17050706	148	28	148	46	36	63	26	1	21	1	0.275	1.000	1.000
550	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(1), CAPN11(1), CAPN2(1), CAPN6(1), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(1), GIT2(1), GRB2(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), RAPGEF1(2), RHO(1), ROCK1(7), ROCK2(4), SEPP1(1), SORBS1(4), SOS1(2), TLN1(2), TNS1(3), VAV2(2), VAV3(2), VCL(1), ZYX(1)	12696202	105	27	105	32	29	43	16	4	13	0	0.231	1.000	1.000
551	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(1), ACTN3(1), ACTN4(1), DMD(11), FAM48A(2), MYBPC1(2), MYBPC3(1), MYH3(5), MYH6(4), MYH7(4), MYH8(3), MYL4(1), MYL9(2), MYOM1(4), NEB(16), TMOD1(1), TPM2(1), TPM3(1), TPM4(1), TTN(87), VIM(1)	10234902	151	26	151	41	45	63	30	0	11	2	0.180	1.000	1.000
552	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(3), ATP5C1(2), DCK(1), ENPP3(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NPR2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE6C(2), PDE7B(1), PDE9A(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), PPAT(3), PRPS1(1), PRUNE(1), RRM1(1)	12395536	96	24	95	31	31	34	15	0	16	0	0.378	1.000	1.000
553	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ACTN1(2), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(3), BRAF(2), CAV1(1), CDC42(1), DOCK1(2), EPHB2(1), FYN(1), GRB2(1), GRLF1(5), ITGA10(4), ITGA11(2), ITGA2(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PLCG2(4), PTEN(4), RAF1(2), RALA(1), RHO(1), ROCK1(7), ROCK2(4), SOS1(2), SOS2(2), TERF2IP(1), TLN1(2), TLN2(3), ZYX(1)	11697774	109	24	109	37	35	33	20	3	18	0	0.460	1.000	1.000
554	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(2), ALG1(1), ALG10B(3), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST4(2), DPAGT1(1), EXT1(1), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), NDST1(1), NDST3(3), OGT(1), RPN2(1), ST6GALNAC1(1), STT3B(2), WBSCR17(2), XYLT1(2)	10519954	79	23	79	31	22	30	17	2	8	0	0.718	1.000	1.000
555	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD1A(1), CD1B(1), CD1C(1), CD1D(1), CD1E(1), CD22(2), CD33(1), CD38(1), CD5(2), CD55(1), CR1(3), CR2(2), CSF1(1), CSF3R(1), DNTT(2), FLT3(2), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(4), IL5RA(2), IL6(1), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGAM(3), ITGB3(2), KIT(2), MME(4), TFRC(1), THPO(1), TPO(3)	7606253	67	18	67	27	22	31	10	1	3	0	0.689	1.000	1.000
556	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(1), INPP4B(2), INPPL1(1), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4)	4246537	34	18	34	11	10	13	8	0	3	0	0.611	1.000	1.000
557	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	CCKBR(2), CCR3(1), CELSR2(1), CHRM2(3), EMR2(4), EMR3(1), FSHR(1), GPR116(4), GPR133(1), GPR18(2), GPR56(1), GPR77(1), GPR84(3), GRM1(3), LPHN2(3), LPHN3(7), PTGFR(1), SMO(1), SSTR2(1), TAAR5(1), TSHR(1)	6041522	43	16	43	23	18	14	8	1	2	0	0.912	1.000	1.000
558	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(1), INPP4B(2), INPPL1(1), MINPP1(1), OCRL(4), PI4KA(4), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PTEN(4), SYNJ1(3), SYNJ2(1)	7069394	45	16	45	16	10	20	8	0	7	0	0.635	1.000	1.000
559	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ASPA(2), HAL(1), HARS2(2), HDC(5), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), PRPS1(1), UROC1(2)	3736053	32	15	32	13	11	13	3	1	4	0	0.627	1.000	1.000
560	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC4(3), ANAPC5(1), BTRC(3), CDC16(1), CDC27(4), CUL1(1), CUL2(1), FBXW11(1), FBXW7(12), RBX1(1), SMURF1(2), UBA1(1), UBE2D3(1), UBE2E2(1), VHL(1), WWP1(3)	3980748	38	15	36	12	14	11	7	0	6	0	0.555	1.000	1.000
561	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(1), ADCY8(1), CACNA1A(9), CACNA1B(4), GNAT3(1), ITPR3(1), KCNB1(3), PDE1A(1), PRKACA(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(3), TAS2R14(1), TAS2R16(2), TAS2R38(1), TAS2R39(1), TAS2R4(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2)	5060253	48	15	48	21	23	14	9	0	2	0	0.754	1.000	1.000
562	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(4), IGF1R(1), KIT(2), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), YWHAH(1)	2003770	26	14	26	11	9	9	4	0	2	2	0.709	1.000	1.000
563	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(1), CHKA(2), CLC(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), GNPAT(1), GPD2(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLCG2(4)	4841774	38	14	38	14	18	7	7	0	6	0	0.615	1.000	1.000
564	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACMSD(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), GCDH(2), HADHA(1), KMO(2), KYNU(1), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS(1), WARS2(1)	5278149	45	14	45	18	11	19	10	0	5	0	0.804	1.000	1.000
565	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PLCG2(4), SARDH(1), SARS(1), SHMT1(1), TARS(3)	4044169	32	13	32	13	14	12	3	0	3	0	0.694	1.000	1.000
566	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PSAT1(1), RDH11(1), RDH12(1), SARDH(1), SARS(1), SHMT1(1), TARS(3), TARS2(1)	4156240	32	12	32	14	13	14	3	0	2	0	0.773	1.000	1.000
567	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), FAH(1), GOT1(1), HGD(1), HPD(1), MAOA(1), MAOB(1), TAT(2), TPO(3), TYR(1)	2984843	28	12	28	12	4	16	3	0	5	0	0.736	1.000	1.000
568	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), UPB1(2)	2845953	22	11	22	12	6	8	2	0	6	0	0.915	1.000	1.000
569	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5B(1), GPRC5C(1), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM7(4), GRM8(2)	1976045	21	11	21	11	6	10	2	0	3	0	0.800	1.000	1.000
570	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1)	4670913	34	10	34	17	11	12	7	0	4	0	0.872	1.000	1.000
571	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1)	4670913	34	10	34	17	11	12	7	0	4	0	0.872	1.000	1.000
572	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1), PGM1(2), PGM3(1)	5509680	40	10	40	18	11	17	8	0	4	0	0.794	1.000	1.000
573	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CLYBL(1), DLD(1), DLST(1), IDH3A(3), OGDHL(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1)	2866536	20	10	20	11	4	8	5	0	3	0	0.949	1.000	1.000
574	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(2), ALDH3B1(1), EPX(1), ESCO1(4), ESCO2(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), MYST3(5), MYST4(5), SH3GLB1(1), TAT(2), TPO(3)	3288373	32	10	32	12	10	14	5	0	3	0	0.664	1.000	1.000
575	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), HIBCH(1), UPB1(2)	2640521	22	10	22	11	5	9	2	0	6	0	0.873	1.000	1.000
576	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B4GALNT1(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2), ST3GAL6(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2)	4612564	38	10	38	14	12	17	6	1	2	0	0.565	1.000	1.000
577	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP3(1), CRADD(1), DFFA(1), LMNB1(2), MADD(1), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), RB1(3), SPTAN1(4)	3602566	31	10	31	10	10	6	7	1	7	0	0.591	1.000	1.000
578	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(2), F2(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), LPA(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2), VWF(5)	3436522	30	9	30	13	10	13	4	0	3	0	0.788	1.000	1.000
579	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ASPA(2), HAL(1), HDC(5), MAOA(1), MAOB(1), PRPS1(1)	2349283	17	9	17	12	5	8	2	0	2	0	0.970	1.000	1.000
580	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), HADHB(1), RDH11(1), RDH12(1), SLC27A5(1), SRD5A2(1)	3050293	22	9	22	13	4	11	5	0	2	0	0.932	1.000	1.000
581	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(1), ACOT12(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2)	4590685	37	9	37	14	10	16	4	1	6	0	0.661	1.000	1.000
582	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(1), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACG(1), PRKG1(5), PRKG2(2)	3038134	26	9	26	11	6	14	4	0	2	0	0.731	1.000	1.000
583	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1B(1), ADRB1(1), CHRM2(3), CHRM4(1), CHRM5(1), DRD2(2), DRD5(4), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1)	2389658	27	9	27	14	13	9	3	1	1	0	0.689	1.000	1.000
584	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACYP1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2)	3593356	29	9	29	15	10	11	3	1	4	0	0.918	1.000	1.000
585	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2A1(3), CASP3(1), CASP4(2), CASP6(1), CD40(1), CRADD(1), DAXX(1), DFFA(1), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(1), PTPN13(9), TRAF1(1), TRAF3(2)	4150448	32	8	32	13	7	12	7	0	6	0	0.791	1.000	1.000
586	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GOT1(1), GPI(1), HK3(1), LDHA(1), LDHAL6B(1), LDHB(2), PC(3), PCK1(3), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1)	4052089	28	8	28	17	9	12	3	0	4	0	0.943	1.000	1.000
587	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CPT1A(1), CPT2(1), CYP4A11(1), GCDH(2), HADHA(1), HADHB(1), HSD17B10(1)	4722049	28	8	28	13	5	12	4	1	6	0	0.840	1.000	1.000
588	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(1), DHDDS(1), DPAGT1(1), FUT8(1), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), RPN2(1), STT3B(2)	4022193	25	8	25	11	7	9	5	0	4	0	0.786	1.000	1.000
589	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(1), DLD(1), DLST(1), IDH3A(3), PC(3), PDHA1(1), PDHA2(2), PDK1(2), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SUCLA2(2), SUCLG1(1)	2746170	22	8	22	11	7	8	4	0	3	0	0.911	1.000	1.000
590	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3B1(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), TAT(2), TPO(3)	2081296	17	8	17	10	6	8	0	0	3	0	0.872	1.000	1.000
591	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHB(1), SRD5A2(1)	2249790	15	7	15	12	2	7	4	0	2	0	0.984	1.000	1.000
592	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ADSS(1), ASL(2), ASPA(2), ASS1(1), CAD(1), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GOT1(1), NARS(1), NARS2(3), PC(3), PDHA1(1), PDHA2(2)	3686789	25	7	25	15	12	7	4	0	2	0	0.959	1.000	1.000
593	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), EPX(1), LPO(1), MPO(2), MTHFR(1), SHMT1(1), TPO(3)	1074331	10	7	10	6	6	3	1	0	0	0	0.874	1.000	1.000
594	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKTL1(1), TKTL2(2)	1933205	11	7	11	11	6	3	1	0	1	0	0.989	1.000	1.000
595	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSS(1), ASL(2), ASPA(2), CAD(1), DARS(1), GAD1(2), GOT1(1), NARS(1), PC(3)	2531474	15	6	15	11	7	5	2	0	1	0	0.972	1.000	1.000
596	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DDHD1(2), GAD1(2), HADHA(1), HMGCL(1), HMGCS2(1), HSD17B10(1), PDHA1(1), PDHA2(2), RDH11(1), RDH12(1)	4013313	23	6	23	15	8	8	3	0	4	0	0.968	1.000	1.000
597	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), GAD1(2), HADHA(1), HMGCL(1), PDHA1(1), PDHA2(2)	2563642	13	5	13	11	5	4	2	0	2	0	0.988	1.000	1.000
598	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(1), ETS1(1), ETS2(1), ETV3(1), FOS(1), HDAC5(1), RBL1(2), SIN3A(6), SIN3B(1)	2546507	16	5	16	9	7	7	2	0	0	0	0.891	1.000	1.000
599	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), MPO(2), TPO(3)	763972	7	5	7	4	5	2	0	0	0	0	0.819	1.000	1.000
600	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(4), EP300(2), ERCC3(1), GRIP1(1), GTF2F1(2), HDAC5(1), HDAC6(2), MEF2C(2), NR0B1(1), NRIP1(1)	4475662	18	4	18	8	7	10	1	0	0	0	0.726	1.000	1.000
601	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	1861431	11	4	11	5	5	4	2	0	0	0	0.756	1.000	1.000
602	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2)	1797401	6	4	6	6	2	1	3	0	0	0	0.986	1.000	1.000
603	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	SDHA(1), SUCLA2(2)	892444	3	3	3	4	0	3	0	0	0	0	0.990	1.000	1.000
604	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	CES1(1), ESD(1)	548943	2	2	2	5	0	2	0	0	0	0	0.998	1.000	1.000
605	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST6GALNAC2(1), ST6GALNAC4(1)	540652	2	2	2	2	0	2	0	0	0	0	0.917	1.000	1.000
606	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(1), HMGCS2(1)	722287	2	2	2	2	2	0	0	0	0	0	0.913	1.000	1.000
607	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(1), GAD1(2)	537660	3	2	3	3	1	2	0	0	0	0	0.954	1.000	1.000
608	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1)	567717	2	2	2	3	2	0	0	0	0	0	0.983	1.000	1.000
609	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CSNK1D(1), GSK3B(1), MAPT(1)	803493	4	2	4	4	3	1	0	0	0	0	0.949	1.000	1.000
610	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(1), XPO1(1)	878710	2	2	2	2	1	1	0	0	0	0	0.963	1.000	1.000
611	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	PDE1A(1), PDE1B(1), PRL(1), TRH(1)	1109175	4	2	4	3	1	3	0	0	0	0	0.918	1.000	1.000
612	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), IL2(1), IL6(1), IL7(1), IL8(1), IL9(1)	614059	6	2	6	4	2	4	0	0	0	0	0.918	1.000	1.000
613	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	GPI(1)	867282	1	1	1	4	0	0	1	0	0	0	0.998	1.000	1.000
614	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(1)	462794	1	1	1	2	0	1	0	0	0	0	0.978	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		52175	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		118540	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
