rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(66), AR(2), BRAF(2), DAG1(1), EGFR(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), MAPK10(4), PHKA2(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), RAF1(2) 5018319 111 60 101 7 18 15 11 0 46 21 4.88e-08 <1.00e-15 <1.07e-13 2 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(5), ATM(10), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(5), TP53(45) 2001688 72 50 57 4 26 18 9 3 15 1 1.75e-05 <1.00e-15 <1.07e-13 3 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(10), ATR(4), CDC25C(1), TP53(45), YWHAH(1) 1621418 61 49 46 6 22 16 7 2 13 1 0.0153 <1.00e-15 <1.07e-13 4 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(1), IGF1R(1), PRKCA(2), RB1(3), TERF1(1), TP53(45), XRCC5(2) 2767314 55 48 40 6 22 9 9 2 13 0 0.00139 <1.00e-15 <1.07e-13 5 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(66), CDH1(1), CREBBP(4), EP300(2), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(4), TGFBR1(3) 2554178 85 57 75 4 5 10 8 0 44 18 5.23e-06 1.11e-15 1.07e-13 6 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(66), AXIN1(1), CREBBP(4), CTNNB1(4), EP300(2), FZD1(1), GSK3B(1), LDB1(2), TRRAP(4) 3136901 85 58 75 4 8 12 6 0 41 18 1.03e-06 1.22e-15 1.07e-13 7 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(66), AXIN1(1), BTRC(3), CREBBP(4), CSNK1D(1), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), PPARD(1) 2701685 84 58 74 4 8 9 8 0 41 18 1.81e-06 1.22e-15 1.07e-13 8 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(66), AXIN1(1), CTNNB1(4), DVL2(1), DVL3(2), FBXW2(1), FZD1(1), FZD10(2), FZD3(3), FZD6(3), GSK3B(1), LDLR(1), MAPK10(4), MAPK9(2), PLAU(1), PPP2R5C(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RHOA(1), SFRP4(1), TCF7(3), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1) 5514820 117 58 107 13 15 27 8 0 49 18 6.70e-06 1.44e-15 1.09e-13 9 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(10), CDK4(1), PCNA(1), RB1(3), TIMP3(1), TP53(45) 1820960 62 50 47 6 21 14 9 2 15 1 0.00200 1.67e-15 1.09e-13 10 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(1), APC(66), ATF2(1), AXIN1(1), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CTNNB1(4), FZD1(1), GSK3B(1), MAP3K7(2), MEF2C(2), NPPB(1), RFC1(4), TGFB2(4), TGFBR1(3), TGFBR3(3) 3414527 102 59 92 3 13 19 9 0 43 18 6.13e-09 1.78e-15 1.09e-13 11 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(66), CAV3(1), DAG1(1), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(6) 4224359 97 57 87 9 14 15 6 0 43 19 4.08e-06 2.00e-15 1.12e-13 12 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT2(1), AKT3(1), APC(66), AXIN1(1), AXIN2(2), CTNNB1(4), DACT1(1), DKK1(2), DKK2(1), DKK4(3), FSTL1(1), GSK3B(1), LRP1(3), SENP2(1), SFRP1(1), TSHB(1) 3759900 90 59 80 4 8 14 11 0 39 18 3.20e-07 2.44e-15 1.25e-13 13 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 APC(66), AXIN1(1), CTNNB1(4), FZD1(1), GJA1(4), GNAI1(1), GSK3B(1), MYD88(1), NFKB1(3), PIK3CA(7), PIK3R1(5), TLR4(3) 2809332 97 60 87 4 12 15 10 0 40 20 9.29e-08 2.78e-15 1.32e-13 14 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), MAP3K14(1), NFKB1(3), TP53(45) 924291 51 47 36 3 22 7 8 2 12 0 0.000558 3.00e-15 1.32e-13 15 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(66), CASP3(1), CREB3(1), CREB5(2), DAG1(1), EPHB2(1), FOS(1), GNAQ(1), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2) 2754563 88 58 78 3 7 9 7 2 45 18 4.57e-08 3.44e-15 1.41e-13 16 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(1), APC(66), AXIN1(1), BTRC(3), CTNNB1(4), DLL1(3), FZD1(1), GSK3B(1) 1945423 80 58 70 1 6 8 6 0 42 18 5.59e-09 3.77e-15 1.41e-13 17 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP3(1), TP53(45), WT1(2) 682832 48 46 33 2 21 7 6 2 12 0 2.94e-05 3.89e-15 1.41e-13 18 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(10), CDC25C(1), CDK4(1), MYT1(5), RB1(3), TP53(45), YWHAH(1) 1764616 66 50 51 5 24 16 9 2 14 1 0.000686 5.11e-15 1.75e-13 19 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(3), NFKB1(3), RB1(3), TP53(45), USH1C(3), WT1(2) 1809425 64 48 49 6 25 14 7 2 15 1 0.000432 5.55e-15 1.80e-13 20 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 APAF1(1), ATM(10), CASP3(1), CASP6(1), PRKCA(2), TLN1(2), TP53(45) 2681206 62 49 47 5 20 16 8 2 15 1 0.000568 6.33e-15 1.95e-13 21 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDK4(1), CDKN1B(2), PRB1(1), TP53(45) 748706 49 48 34 2 20 6 6 2 15 0 4.71e-05 7.44e-15 2.18e-13 22 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(10), BRCA1(1), MAPK8(5), MRE11A(5), NFKB1(3), RAD50(6), TP53(45) 2958783 75 49 60 7 26 22 10 3 13 1 0.000599 8.77e-15 2.46e-13 23 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(1), PAX3(2), PML(1), RB1(3), SIRT1(1), TP53(45) 1828212 57 49 42 5 26 7 8 2 14 0 0.000340 9.66e-15 2.51e-13 24 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 PIK3CA(7), PIK3R1(5), POLR1A(3), POLR1B(2), RB1(3), TP53(45) 1942156 65 53 50 5 26 11 10 2 14 2 0.000113 9.77e-15 2.51e-13 25 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(10), ATR(4), BRCA1(1), BRCA2(11), FANCA(2), FANCD2(4), FANCF(1), FANCG(2), MRE11A(5), RAD17(2), RAD50(6), TP53(45) 4349343 93 49 78 7 27 31 16 2 16 1 8.50e-05 2.37e-12 5.84e-11 26 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), FAS(2), GZMB(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), MAPK10(4), NFKB1(3), TP53(45), TRAF1(1) 3579391 71 49 56 8 27 12 11 2 19 0 0.000321 3.69e-12 8.74e-11 27 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(10), ATR(4), BRCA1(1), CDC25C(1), EP300(2), MYT1(5), PRKDC(5), TP53(45), YWHAH(1) 3947163 74 49 59 8 27 20 10 2 14 1 0.00142 6.55e-12 1.49e-10 28 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(3), EGFR(1), ERBB2(4), ERBB4(5), ETS1(1), ETS2(1), ETV6(1), FMN2(3), GRB2(1), KRAS(38), MAP2K1(1), MAPK3(1), NOTCH2(2), NOTCH3(3), NOTCH4(4), PIWIL1(3), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(2), SOS1(2), SOS2(2), SPIRE1(1) 5169707 89 48 57 9 13 54 13 1 8 0 0.000109 1.86e-06 4.10e-05 29 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ATM(10), ATR(4), CCNA1(2), CDK4(1), CDKN1B(2), DHFR(1), GSK3B(1), RB1(3), TGFB2(4), TP53(45) 2967856 73 51 58 11 24 18 10 2 18 1 0.00914 1.67e-05 0.000356 30 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(1), IL1R1(1), MAP2K4(2), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(5), MAPK9(2), NFATC3(1), PAPPA(5), TP53(45), ZAK(2) 4934931 90 54 75 11 34 19 12 3 22 0 0.000279 1.99e-05 0.000408 31 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(2), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(7), PIK3R1(5), SYK(3), VAV1(2) 1789829 27 14 27 2 5 8 7 0 4 3 0.0281 0.000392 0.00780 32 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(5), NRG2(2), NRG3(4), PRKCA(2) 908762 14 9 14 1 4 5 1 1 3 0 0.0731 0.00145 0.0280 33 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 CDKN1B(2), GRB2(1), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), SOS1(2) 1853660 23 13 23 2 4 7 5 0 5 2 0.0548 0.00453 0.0845 34 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNGT1(1), PRKACA(1), PRKAR1A(4) 607553 10 8 10 1 3 4 1 0 2 0 0.197 0.00711 0.129 35 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 FOS(1), GRB2(1), INSR(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SLC2A4(1), SOS1(2) 2464448 37 15 37 3 10 11 8 1 5 2 0.00481 0.00940 0.165 36 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(4) 73821 4 3 4 0 3 1 0 0 0 0 0.278 0.0125 0.211 37 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD80(1), CTLA4(1), GRB2(1), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(3), LCK(1), PIK3CA(7), PIK3R1(5), PTPN11(3) 1233614 26 13 26 4 9 10 3 0 2 2 0.140 0.0126 0.211 38 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1) 837086 11 10 11 2 3 5 1 0 2 0 0.311 0.0171 0.270 39 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1) 837086 11 10 11 2 3 5 1 0 2 0 0.311 0.0171 0.270 40 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(66), AXIN1(1), AXIN2(2), BTRC(3), CACYBP(1), CAMK2D(1), CHD8(2), CREBBP(4), CTNNB1(4), CUL1(1), DAAM1(1), DAAM2(4), DKK1(2), DKK2(1), DKK4(3), DVL2(1), DVL3(2), EP300(2), FBXW11(1), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GSK3B(1), LRP6(7), MAP3K7(2), MAPK10(4), MAPK8(5), MAPK9(2), MMP7(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PLCB3(1), PLCB4(1), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(1), SMAD2(5), SMAD3(3), SMAD4(8), TBL1X(1), TBL1Y(1), TCF7(3), TCF7L2(7), TP53(45), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 15218495 263 68 234 35 68 67 33 3 74 18 1.12e-09 0.0226 0.347 41 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CHUK(2), GH1(1), NFKB1(3), PIK3CA(7), PIK3R1(5), YWHAH(1) 1382903 19 11 19 3 7 5 4 0 1 2 0.197 0.0278 0.417 42 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(10), ATR(4), CASP3(1), CCNB3(3), CCNE2(1), CCNG1(1), CDK4(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGFBP3(2), MDM4(1), PTEN(4), RFWD2(1), SERPINB5(2), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53(45), TP53I3(2), TSC2(1), ZMAT3(2) 6248919 98 52 83 14 35 30 13 2 17 1 0.000827 0.0312 0.453 43 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(2), LTB4R(1), P2RY1(3), P2RY2(1), P2RY6(1) 524943 11 6 11 0 5 5 1 0 0 0 0.0140 0.0316 0.453 44 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(1), FBXW7(12), RB1(3) 863506 16 10 14 3 7 2 3 0 4 0 0.210 0.0340 0.475 45 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), WASL(2) 1299034 23 11 23 4 6 5 7 0 3 2 0.237 0.0452 0.619 46 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 FOS(1), GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PTPN11(3), RAF1(2), RASA1(4), SOS1(2) 2391776 36 15 36 5 10 11 8 1 4 2 0.0319 0.0478 0.640 47 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 GRB2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), SOS1(2) 1507914 17 13 17 3 4 6 4 0 1 2 0.291 0.0531 0.696 48 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(7), PIK3R1(5), PRKCA(2), VAV1(2) 1260447 16 12 16 4 4 6 3 0 1 2 0.480 0.0555 0.712 49 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(2), PIK3CA(7), PIK3R1(5), YWHAH(1) 1525204 16 11 16 3 4 5 3 0 2 2 0.272 0.0662 0.832 50 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 179749 2 2 2 1 1 0 1 0 0 0 0.776 0.0731 0.901 51 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RB1(3) 1915799 28 16 28 4 8 7 7 1 3 2 0.104 0.0759 0.917 52 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(1), F2(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(7), PIK3R1(5), PPP1R12B(4), PRKCA(2), ROCK1(7) 2517883 36 19 36 8 9 10 8 0 7 2 0.211 0.0848 1.000 53 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 FOS(1), GRB2(1), MAP2K1(1), MAPK3(1), MAPK8(5), NGFR(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2) 1840323 26 13 26 4 7 8 6 1 2 2 0.117 0.0879 1.000 54 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CDC42(1), CHUK(2), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3CA(7), PIK3R1(5), RAF1(2), RALA(1), RALBP1(2), RHOA(1) 1860338 26 13 26 4 9 4 8 0 3 2 0.105 0.0882 1.000 55 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), CAMK2D(1), GRB2(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RPS6KA5(3), SOS1(2) 2804191 32 17 32 4 11 10 6 0 3 2 0.0368 0.0895 1.000 56 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), YWHAH(1) 1829749 24 13 24 4 6 7 6 0 3 2 0.146 0.0989 1.000 57 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(2), CREB3(1), CREB5(2), RAF1(2), SNX13(3), TERF2IP(1) 1091338 11 5 11 1 5 2 3 1 0 0 0.138 0.104 1.000 58 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(2), HDC(5), TPH1(2) 572489 10 7 10 2 3 5 1 0 1 0 0.317 0.107 1.000 59 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(1), MAPK3(1), MEF2A(1), MEF2C(2), PIK3CA(7), PIK3R1(5) 1760918 17 12 17 3 4 5 3 0 3 2 0.224 0.114 1.000 60 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(7), PIK3R1(5), RAF1(2), RB1(3) 1979729 25 13 25 5 10 3 5 0 5 2 0.201 0.121 1.000 61 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BCL2L11(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), CHUK(2), DFFA(1), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF3(2), IRF4(2), MAP2K4(2), MAP3K1(2), MAPK10(4), NFKB1(3), TNFRSF10B(4), TNFRSF21(1), TP53(45), TRAF1(1), TRAF3(2) 5568404 90 50 75 13 35 19 12 2 22 0 0.000900 0.123 1.000 62 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2), STAT5B(1), THPO(1) 2921813 32 15 32 3 8 11 6 0 4 3 0.0238 0.125 1.000 63 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGFR(1), ERBB3(3), NRG1(6) 1030074 10 7 10 1 2 2 4 0 2 0 0.338 0.136 1.000 64 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), RB1(3), SP3(1) 671306 6 4 6 1 2 2 1 0 1 0 0.519 0.149 1.000 65 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGFR(1), FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2) 3674529 37 17 37 4 11 12 7 1 4 2 0.0140 0.176 1.000 66 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), DNMT1(7), PTGDR(1), PTGFR(1) 1067165 11 7 11 1 7 3 0 1 0 0 0.0539 0.181 1.000 67 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(1), JAK2(3), JAK3(2), PIAS1(1), PTPRU(6), REG1A(2) 1298234 15 9 15 2 8 3 1 0 2 1 0.180 0.181 1.000 68 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(2), SNCAIP(2), UBE2E2(1) 638436 6 4 6 1 1 4 1 0 0 0 0.479 0.193 1.000 69 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(1), GNGT1(1), NFKB1(3), NR3C1(1), PIK3CA(7), PIK3R1(5) 1706664 18 13 18 4 7 4 3 0 2 2 0.353 0.194 1.000 70 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(1), FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1) 2640665 34 15 34 4 9 11 6 1 4 3 0.0298 0.197 1.000 71 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 FOS(1), GRB2(1), JAK1(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), RASA1(4), SOS1(2) 3399705 40 17 40 6 11 14 8 1 4 2 0.0451 0.206 1.000 72 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(3), CD22(2), CD72(1), CD79B(1), CHUK(2), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), KRAS(38), LILRB3(1), MALT1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASGRP3(3), SYK(3), VAV1(2), VAV2(2), VAV3(2) 7103047 115 49 84 17 30 64 11 0 8 2 0.000279 0.210 1.000 73 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), GNAI1(1), GNGT1(1), ITGAV(4), ITGB3(2), MAPK3(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PRKCA(2), SPHK1(1) 2675905 32 18 32 9 8 11 6 0 5 2 0.422 0.217 1.000 74 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNGT1(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2) 902263 9 6 9 1 4 4 0 0 1 0 0.206 0.222 1.000 75 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT1(2), METTL2B(1), METTL6(3), PCYT1A(1), PRMT3(1), PRMT7(1), PRMT8(2) 1311197 12 7 12 2 3 4 2 1 2 0 0.218 0.232 1.000 76 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(2) 421086 2 2 2 1 0 2 0 0 0 0 0.881 0.254 1.000 77 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(1), JAK2(3), PTPRU(6), REG1A(2) 1115679 13 8 13 2 9 2 0 0 1 1 0.180 0.264 1.000 78 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), FYN(1), MAP2K1(1), MAPK3(1), MYLK(3), PIK3CA(7), PIK3R1(5), RAF1(2), ROCK1(7), TLN1(2) 3602588 32 14 32 6 9 10 8 0 3 2 0.158 0.269 1.000 79 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(1), SDHA(1) 619567 5 4 5 0 1 1 3 0 0 0 0.253 0.271 1.000 80 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT2(1), AKT3(1), GRB2(1), IARS(1), IL13RA1(1), INPP5D(2), JAK1(1), JAK2(3), JAK3(2), PI3(1), PIK3CA(7), PPP1R13B(1), SERPINA4(3), SOS1(2), SOS2(2) 3526817 29 13 29 2 6 12 7 0 3 1 0.0163 0.276 1.000 81 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(2) 149252 3 2 3 1 0 2 1 0 0 0 0.844 0.277 1.000 82 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(2) 202560 2 2 2 1 0 2 0 0 0 0 0.853 0.282 1.000 83 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), KERA(2), LUM(1) 351893 5 3 5 1 3 0 2 0 0 0 0.510 0.298 1.000 84 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 FOS(1), FYN(1), GRB2(1), LAT(1), LCK(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAF1(2), RASA1(4), SOS1(2), VAV1(2) 4630120 53 22 53 9 21 16 7 1 6 2 0.0228 0.302 1.000 85 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT3(1) 428255 4 3 4 1 3 1 0 0 0 0 0.551 0.303 1.000 86 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL2L11(1), CASP8AP2(6), CES1(1) 964874 9 7 9 2 2 5 1 0 1 0 0.560 0.310 1.000 87 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 JAK1(1), PTPRU(6), REG1A(2), STAT2(2) 1204991 11 8 11 2 9 1 0 0 1 0 0.200 0.311 1.000 88 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(2), CUL1(1), NEDD8(1), RB1(3), RBX1(1) 862374 8 6 8 4 3 0 1 0 4 0 0.770 0.325 1.000 89 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(3), CRY1(3) 837967 9 4 9 1 1 3 2 0 2 1 0.264 0.327 1.000 90 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(5), RECK(2), TIMP1(1), TIMP3(1) 730518 12 6 12 3 6 3 2 0 1 0 0.326 0.327 1.000 91 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GRB2(1), INPP5D(2), KRAS(38), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MS4A2(2), NRAS(5), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PRKCA(2), PRKCE(2), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2), VAV2(2), VAV3(2) 6895353 126 49 95 19 28 63 16 2 15 2 0.000275 0.342 1.000 92 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2) 2600491 27 15 27 6 9 8 5 0 3 2 0.229 0.342 1.000 93 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(1), FGA(2), FGB(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2) 1331924 14 5 14 0 7 4 1 0 2 0 0.0110 0.345 1.000 94 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), GZMB(1), HLA-A(2), ITGAL(3), ITGB2(1) 797161 10 5 10 3 2 3 2 0 2 1 0.563 0.346 1.000 95 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(6), GOT1(1) 761666 9 4 9 2 2 3 1 0 3 0 0.511 0.355 1.000 96 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CBS(1), CTH(1), MUT(1) 488948 4 3 4 0 1 2 0 0 1 0 0.423 0.355 1.000 97 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(3), JAK3(2), MAPK3(1) 1151176 7 5 7 1 0 3 0 0 3 1 0.504 0.358 1.000 98 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS3(1) 299468 3 2 3 1 2 1 0 0 0 0 0.632 0.366 1.000 99 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(3), RELN(9), VLDLR(2) 1390617 18 8 18 5 4 8 3 1 2 0 0.464 0.373 1.000 100 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA7(1), PSMB3(1), PSMB8(3) 874045 6 4 6 0 0 5 0 1 0 0 0.216 0.380 1.000 101 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGFR(1), TF(4), TFRC(1) 1295676 10 5 10 1 3 5 1 0 1 0 0.207 0.392 1.000 102 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(2), FOS(1), GRB2(1), HGF(3), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(5), MET(1), PAK1(1), PIK3CA(7), PIK3R1(5), PTEN(4), PTPN11(3), RAF1(2), RAP1A(1), RASA1(4), SOS1(2) 4226298 47 15 47 8 14 14 11 1 5 2 0.0403 0.401 1.000 103 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(1), LIMK1(1), MAP3K1(2), MYLK(3), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(5), PLD1(3), PPP1R12B(4), RALBP1(2), TRIO(1), VAV1(2), WASF1(2) 3365202 39 17 39 6 11 14 8 0 4 2 0.0540 0.403 1.000 104 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(1) 737698 9 4 9 1 2 6 0 0 1 0 0.304 0.412 1.000 105 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 173065 3 2 3 0 0 2 1 0 0 0 0.432 0.417 1.000 106 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), CASP3(1), DAXX(1), FAS(2), HSPB2(1) 1090493 7 5 7 1 1 1 4 0 1 0 0.525 0.428 1.000 107 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2) 313986 2 2 2 0 0 1 1 0 0 0 0.617 0.436 1.000 108 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25C(1), CSK(2), GRB2(1), PRKCA(2) 919047 6 4 6 1 2 4 0 0 0 0 0.408 0.440 1.000 109 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(1), EIF4B(1), EIF4G1(1), EIF4G3(3), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4), TSC1(1), TSC2(1) 2641859 25 12 25 5 7 6 5 1 4 2 0.271 0.449 1.000 110 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1) 339042 1 1 1 1 1 0 0 0 0 0 0.907 0.451 1.000 111 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(2) 629137 2 2 2 0 0 1 0 1 0 0 0.611 0.454 1.000 112 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BTK(1), CAD(1), CASP3(1), CASP8AP2(6), DAXX(1), DEDD(1), DFFA(1), EGFR(1), EPHB2(1), IL8(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), PTPN13(9), RALBP1(2), ROCK1(7), TP53(45), TPX2(1) 6826271 102 50 87 17 34 28 17 3 20 0 0.00313 0.455 1.000 113 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(2), HSD3B1(1), HSD3B2(1) 635516 4 4 4 2 1 2 0 0 1 0 0.829 0.465 1.000 114 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOC(2) 360104 3 2 3 0 2 0 1 0 0 0 0.405 0.466 1.000 115 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(8) 698944 10 4 10 3 1 4 5 0 0 0 0.614 0.473 1.000 116 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(4), PLCE1(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAP2B(1) 1360763 13 7 13 2 5 6 1 0 1 0 0.184 0.481 1.000 117 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), MAPK8(5), NFE2L2(3), PRKCA(2) 827527 11 4 11 0 4 4 1 1 1 0 0.0295 0.491 1.000 118 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), TRAF3(2), TRAF5(2) 3184325 39 19 39 9 11 9 6 1 10 2 0.177 0.498 1.000 119 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(2), FYN(1), IL7(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(7), PIK3R1(5), STAT5B(1) 2723120 27 12 27 6 7 13 3 0 2 2 0.288 0.521 1.000 120 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 148838 1 1 1 0 0 0 1 0 0 0 0.769 0.524 1.000 121 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(2), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1) 812348 6 4 6 2 1 3 1 0 1 0 0.702 0.526 1.000 122 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2) 1326337 11 7 11 3 4 3 1 1 2 0 0.420 0.529 1.000 123 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(1), TPK1(3) 638873 6 3 6 1 4 1 1 0 0 0 0.438 0.534 1.000 124 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GRB2(1), INSR(1), IRS1(3), JAK2(3), MAP2K1(1), MAPK3(1), PIK3CA(7), PIK3R1(5), PRKCA(2), RAF1(2), SLC2A4(1), SOS1(2), STAT5B(1) 3223684 31 14 31 5 8 9 6 0 5 3 0.111 0.534 1.000 125 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(1), EIF4G1(1), EIF4G3(3), IRS1(3), MAPK3(1), PDK2(1), PIK3CA(7), PIK3R1(5), PRKCA(2), PTEN(4) 2705445 28 14 28 6 7 7 6 1 5 2 0.295 0.541 1.000 126 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(2), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1) 932800 13 6 13 3 5 3 2 0 3 0 0.232 0.544 1.000 127 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(10), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(1), FSHR(1), MLH1(3), MSH5(1), NCOR1(5), NRIP1(1), PRLR(2), VDR(1), ZP2(1) 3444179 32 12 32 9 7 11 6 1 6 1 0.474 0.555 1.000 128 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(1), DAG1(1), ETFA(1), ITGA9(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP2K1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), RPS4X(1), SGCB(4) 4471957 47 17 47 7 14 15 8 0 6 4 0.0191 0.559 1.000 129 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(10), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CREB3(1), CREB3L3(2), E2F3(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MYT1(5), PCNA(1), POLE(4), POLE2(1), RB1(3), RBL1(2), TNXB(3), TP53(45) 7068990 91 53 75 16 31 25 12 3 19 1 0.00642 0.564 1.000 130 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1) 1214341 15 7 15 3 4 6 2 0 3 0 0.323 0.566 1.000 131 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(3) 202787 3 1 3 0 1 1 1 0 0 0 0.471 0.568 1.000 132 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(1), CTH(1), LCMT1(2), MARS(3), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT3(1), PRMT7(1), PRMT8(2), SEPHS1(2) 2324543 22 10 22 4 5 8 4 1 4 0 0.163 0.572 1.000 133 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNGT1(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2B(1) 1459537 17 9 17 3 10 5 1 0 1 0 0.159 0.584 1.000 134 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(1), TAT(2), TYR(1) 472621 4 2 4 2 1 2 0 0 1 0 0.806 0.586 1.000 135 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT2(1), AKT3(1), APAF1(1), ATM(10), BIRC2(2), BIRC3(5), CAPN2(1), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TNFRSF10B(4), TNFRSF10D(1), TP53(45) 8018489 126 54 111 21 45 34 19 2 23 3 0.00104 0.592 1.000 136 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(2), GLI3(4), GSK3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), SMO(1) 1559810 15 8 15 3 4 8 0 0 3 0 0.261 0.592 1.000 137 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), CFTR(4), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1223260 14 7 14 3 5 6 1 0 2 0 0.274 0.602 1.000 138 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), IL6(1), LDLR(1) 515773 3 2 3 2 3 0 0 0 0 0 0.830 0.608 1.000 139 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(2), CREB3(1), CREB5(2), DUSP6(1), EEF2K(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TRAF3(2) 2950759 28 10 28 2 8 9 7 1 3 0 0.0101 0.609 1.000 140 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K1(1), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(2) 752132 7 3 7 2 3 1 2 0 1 0 0.532 0.610 1.000 141 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1507626 11 6 11 2 3 5 2 0 1 0 0.289 0.616 1.000 142 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1507626 11 6 11 2 3 5 2 0 1 0 0.289 0.616 1.000 143 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1507626 11 6 11 2 3 5 2 0 1 0 0.289 0.616 1.000 144 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(1) 362911 3 2 3 0 0 2 0 0 1 0 0.478 0.619 1.000 145 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1) 326746 1 1 1 1 0 1 0 0 0 0 0.910 0.623 1.000 146 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1) 1005194 6 4 6 1 3 3 0 0 0 0 0.339 0.625 1.000 147 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), AKT3(1), GRB2(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PTEN(4), SOS1(2) 1965891 20 11 20 5 4 7 6 0 3 0 0.441 0.628 1.000 148 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(10), CDC25C(1), MYT1(5), YWHAH(1) 1370937 17 6 17 3 3 10 2 0 1 1 0.316 0.631 1.000 149 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 CBL(3), CFLAR(1), FOS(1), GRB2(1), IL2RB(1), IRS1(3), JAK1(1), JAK3(2), MAPK3(1), NMI(1), PIK3CA(7), PIK3R1(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3) 3481504 35 15 35 7 9 12 5 0 7 2 0.171 0.640 1.000 150 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), GH1(1), IGF1R(1), PIK3CA(7), PIK3R1(5) 1274034 15 12 15 7 4 4 4 0 1 2 0.842 0.642 1.000 151 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT2(1), AKT3(1), CDC42(1), KDR(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK13(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLA2G4A(3), PLA2G6(2), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTGS2(1), RAF1(2), SH2D2A(1), SHC2(1), SPHK1(1) 6914915 99 50 68 19 27 50 10 0 10 2 0.00799 0.645 1.000 152 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1214821 8 5 8 3 4 2 0 0 2 0 0.575 0.651 1.000 153 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(2), AKT2(1), AKT3(1), BRAF(2), CAMK2D(1), CBL(3), CBLB(2), CDKN1B(2), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GRB2(1), GSK3B(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), NCK1(1), NRAS(5), NRG1(6), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), RAF1(2), RPS6KB2(1), SHC2(1), SOS1(2), SOS2(2), STAT5B(1) 10111519 144 54 111 20 31 68 22 2 19 2 6.55e-05 0.655 1.000 154 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(1), AKT3(1), GRB2(1), GSK3B(1), IRS1(3), JAK1(1), JAK3(2), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPP1R13B(1), RAF1(2), SOS1(2), SOS2(2) 3546478 34 15 34 5 9 11 7 0 5 2 0.0537 0.658 1.000 155 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(3), CBX3(2), CLOCK(3), CRY1(3), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(1), MYF6(1), NCKAP1(1), NCOA4(1), NR1D2(3), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(1), UGP2(2), ZFR(5) 3583945 40 11 40 5 5 15 13 0 6 1 0.0311 0.661 1.000 156 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1) 1592126 11 6 11 2 3 5 2 0 1 0 0.289 0.663 1.000 157 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(2) 266540 3 1 3 1 0 2 0 0 1 0 0.728 0.677 1.000 158 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), PRB1(1) 839371 7 4 7 3 1 1 1 0 4 0 0.731 0.680 1.000 159 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(3), ABCG2(4), BCHE(2), CES1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1) 2276078 17 7 17 3 5 8 2 1 1 0 0.156 0.680 1.000 160 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(2) 665555 8 6 8 4 1 2 4 0 1 0 0.875 0.692 1.000 161 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), MARS(3), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SEPHS1(2) 1179317 12 5 12 2 2 5 3 0 2 0 0.329 0.692 1.000 162 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2B(3), POLR2K(1) 1301290 6 4 6 1 3 2 1 0 0 0 0.399 0.693 1.000 163 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 2585771 19 11 19 5 4 10 1 0 4 0 0.409 0.698 1.000 164 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), CASP3(1), GZMB(1) 1224300 6 4 6 1 0 1 3 0 2 0 0.549 0.701 1.000 165 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(2), UXS1(1) 470002 5 2 5 0 0 3 1 0 1 0 0.299 0.701 1.000 166 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK3(1), PGM1(2), PGM3(1), TGDS(1) 1135213 6 4 6 1 3 3 0 0 0 0 0.323 0.724 1.000 167 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(3), CRY1(3), CSNK1D(1), PER3(2) 1667066 12 5 12 1 2 3 3 0 3 1 0.112 0.729 1.000 168 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(1), GNAQ(1), GNGT1(1), MYLK(3), PPP1R12B(4), PRKCA(2), ROCK1(7) 2013126 22 10 22 5 6 7 4 0 5 0 0.317 0.729 1.000 169 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), PRKCE(2) 701110 12 3 12 3 2 8 1 0 1 0 0.413 0.730 1.000 170 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(1), MAPK8(5), NFKB1(3), TNFSF13B(1), TRAF3(2), TRAF5(2) 1372419 16 4 16 4 4 5 4 1 2 0 0.430 0.731 1.000 171 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), AKT3(1), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), PIK3CA(7), PIK3CD(1), SOS1(2) 1554961 16 9 16 4 3 7 6 0 0 0 0.408 0.737 1.000 172 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), HADHA(1) 537704 6 3 6 3 2 1 0 0 3 0 0.826 0.739 1.000 173 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST4(2), FUT8(1) 1189656 9 5 9 3 4 1 1 1 2 0 0.570 0.739 1.000 174 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2) 582054 6 2 6 1 3 1 0 1 1 0 0.291 0.742 1.000 175 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST1(1), HS3ST2(2), XYLT1(2) 582054 6 2 6 1 3 1 0 1 1 0 0.291 0.742 1.000 176 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CUL1(1), RB1(3) 884503 6 3 6 4 1 0 2 0 3 0 0.878 0.749 1.000 177 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), HLA-DRA(1), HLA-DRB1(1) 224004 3 1 3 0 2 1 0 0 0 0 0.344 0.750 1.000 178 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), PON1(1) 2731083 24 9 24 7 8 5 8 0 2 1 0.446 0.757 1.000 179 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(4), CAP1(1), CDC25C(1), GNAI1(1), GNGT1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1937554 21 11 21 4 8 9 2 0 2 0 0.137 0.757 1.000 180 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(2), CALCRL(1), CD97(2), CRHR1(1), CRHR2(1), ELTD1(2), EMR1(3), EMR2(4), GLP1R(5), GLP2R(2), GPR64(1), LPHN2(3), LPHN3(7), VIPR1(1) 2570211 36 13 36 11 15 14 5 0 2 0 0.268 0.758 1.000 181 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8) 2183790 28 10 28 5 12 11 2 0 3 0 0.0797 0.760 1.000 182 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CREBBP(4), CSK(2), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PTPRC(8) 2183790 28 10 28 5 12 11 2 0 3 0 0.0797 0.760 1.000 183 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), AP2A1(1), BIN1(1), DNM1(3), EPN1(1), EPS15(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYNJ1(3), SYNJ2(1) 2151419 19 8 19 3 8 7 0 0 4 0 0.149 0.764 1.000 184 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(3), FURIN(1) 872415 5 3 5 1 2 0 0 0 3 0 0.491 0.769 1.000 185 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(3), ABCB4(3), ABCC1(3) 1336919 14 5 14 3 4 6 2 1 1 0 0.269 0.771 1.000 186 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 IL8(1) 159167 1 1 1 0 0 1 0 0 0 0 0.769 0.773 1.000 187 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), SQLE(1) 283519 2 1 2 0 0 1 1 0 0 0 0.615 0.774 1.000 188 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 FOS(1), GRB2(1), IL6(1), IL6R(1), IL6ST(1), JAK1(1), JAK2(3), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(3), RAF1(2), SOS1(2) 2346750 20 9 20 3 6 7 3 0 3 1 0.173 0.775 1.000 189 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HADHA(1), HADHB(1), HSD17B10(1), PPT2(1) 854446 5 4 5 4 1 2 0 0 2 0 0.950 0.775 1.000 190 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 GSK3B(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(7), PIK3R1(5), PTEN(4) 1882392 20 12 20 5 4 7 4 0 3 2 0.488 0.777 1.000 191 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(1), THBS1(2) 699555 5 2 5 1 2 2 1 0 0 0 0.466 0.779 1.000 192 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA4(1), NDUFS1(2), NDUFS2(3) 689833 6 4 6 2 3 2 0 0 1 0 0.707 0.780 1.000 193 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 ETV5(1), IL12A(1), IL12RB2(1), IL18R1(2), JAK2(3), MAP2K6(1), MAPK8(5), STAT4(3) 1792782 17 4 17 3 1 8 4 1 2 1 0.394 0.782 1.000 194 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(1), ACTN3(1), CSK(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), PECAM1(1), VCL(1) 1799717 16 11 16 4 8 6 2 0 0 0 0.347 0.789 1.000 195 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(2), HEXB(2), LCT(5), MANBA(1), NEU1(1) 1589902 13 6 13 3 5 4 1 0 3 0 0.370 0.789 1.000 196 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12RB2(1), JAK2(3), STAT4(3) 1421936 8 3 8 2 0 3 3 0 1 1 0.677 0.801 1.000 197 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1) 296217 1 1 1 0 1 0 0 0 0 0 0.688 0.803 1.000 198 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(8) 884866 12 3 12 1 3 6 1 0 2 0 0.124 0.806 1.000 199 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), FOS(1), GRB2(1), MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(1), PIK3CA(7), PIK3R1(5), PLA2G4A(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SOS1(2), SYK(3), VAV1(2) 4187297 49 20 49 10 17 13 7 1 9 2 0.0923 0.807 1.000 200 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), UGDH(1) 808099 7 3 7 1 1 3 1 0 2 0 0.366 0.808 1.000 201 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ANKRD1(2), IFRD1(3), IL1R1(1), MYOG(1), NR4A3(2) 1023819 9 3 9 1 4 3 1 0 1 0 0.183 0.813 1.000 202 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(2), FUT1(3), FUT9(1), HEXB(2) 1019978 9 4 9 4 6 1 2 0 0 0 0.690 0.813 1.000 203 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1) 533650 5 3 5 4 0 2 2 0 1 0 0.939 0.815 1.000 204 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1) 1425907 6 6 6 2 4 2 0 0 0 0 0.557 0.816 1.000 205 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 4580041 42 18 42 9 9 19 6 1 7 0 0.123 0.818 1.000 206 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(2), WASL(2) 784397 9 2 9 1 4 1 2 0 2 0 0.206 0.822 1.000 207 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), FOS(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), RAF1(2), RPS6KA3(2) 3332957 31 15 31 8 15 9 2 0 5 0 0.200 0.823 1.000 208 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), FHL5(3), FSHB(1), FSHR(1), XPO1(1) 917313 10 9 10 4 4 1 3 1 1 0 0.785 0.830 1.000 209 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), IFNGR2(1), JAK1(1), JAK2(3) 821804 6 2 6 1 1 2 0 0 2 1 0.522 0.831 1.000 210 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(2) 478687 3 3 3 2 0 0 2 0 1 0 0.925 0.832 1.000 211 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1) 1644435 9 4 9 1 2 5 0 0 2 0 0.221 0.834 1.000 212 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(4), NFATC1(1), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1139228 13 8 13 4 6 4 1 1 1 0 0.344 0.834 1.000 213 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CFLAR(1) 375833 2 1 2 0 0 1 1 0 0 0 0.630 0.840 1.000 214 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1) 1667605 23 8 23 5 7 9 4 0 3 0 0.256 0.841 1.000 215 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTR(1) 1706143 24 9 24 5 11 8 1 1 3 0 0.162 0.843 1.000 216 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(1), PSMD2(1), PSMD6(1) 1615752 12 3 12 0 5 5 1 0 1 0 0.0348 0.848 1.000 217 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(3) 607065 4 2 4 1 1 1 2 0 0 0 0.689 0.851 1.000 218 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(3) 767938 5 3 5 3 1 2 1 0 1 0 0.860 0.851 1.000 219 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(1), EPHB2(1), GRB2(1), MAP2K1(1), MAP2K2(1), NFKB1(3), NFKB2(2), PI3(1), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(3), SOS1(2), SOS2(2), SYK(3), VAV1(2) 5104543 50 15 50 7 19 15 8 0 6 2 0.0116 0.852 1.000 220 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB9A(1) 404502 3 1 3 0 1 1 0 0 1 0 0.408 0.853 1.000 221 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), MAP2K1(1), MAPK3(1), NFKB1(3), PRKCA(2), RAF1(2) 1502300 13 4 13 5 7 2 2 0 2 0 0.591 0.853 1.000 222 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACPP(1), ALPPL2(1), CYP3A43(2), CYP3A7(2), DHRS2(1), PON1(1), PON2(1) 1680190 9 5 9 4 3 4 1 0 0 1 0.726 0.853 1.000 223 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT2(1), AKT3(1), CARD11(3), CBL(3), CBLB(2), CD28(1), CDC42(1), CDK4(1), CHUK(2), CTLA4(1), FOS(1), FYN(1), GRAP2(3), GRB2(1), IKBKB(2), IL10(1), IL2(1), ITK(3), KRAS(38), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCQ(1), PTPRC(8), RASGRP1(3), RHOA(1), SOS1(2), SOS2(2), TEC(2), VAV1(2), VAV2(2), VAV3(2) 9782442 145 49 114 20 41 74 17 0 11 2 3.52e-05 0.856 1.000 224 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT9(1), HEXB(2) 957438 6 4 6 3 4 1 1 0 0 0 0.764 0.856 1.000 225 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PRKCA(2) 657153 3 3 3 2 2 1 0 0 0 0 0.839 0.857 1.000 226 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(1), ALAS2(1), FECH(1), GATA1(1), HBB(1), UROD(1) 808781 7 3 7 1 3 4 0 0 0 0 0.330 0.858 1.000 227 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(2), YWHAH(1) 630244 10 5 10 3 1 6 0 0 3 0 0.514 0.859 1.000 228 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS2(1), PON1(1), PON2(1), RDH11(1), RDH12(1) 821981 5 4 5 3 3 2 0 0 0 0 0.844 0.860 1.000 229 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA7(1), PSMB3(1), PSMD14(1), RPN2(1), UBE3A(5) 1274716 10 3 10 1 2 6 2 0 0 0 0.216 0.862 1.000 230 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 344378 3 2 3 2 1 0 2 0 0 0 0.831 0.865 1.000 231 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(3), SPN(1), TGFB2(4), TNFRSF8(1) 1271781 13 5 13 4 3 4 3 0 3 0 0.619 0.866 1.000 232 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), JAK1(1), STAT2(2) 1046865 4 2 4 2 1 2 0 0 1 0 0.800 0.866 1.000 233 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), SOS1(2) 865743 3 2 3 1 0 2 1 0 0 0 0.753 0.868 1.000 234 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), MAPK8(5), NFKB1(3), TNFRSF11A(1) 1062100 12 3 12 3 5 5 1 1 0 0 0.406 0.869 1.000 235 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRB(1), CP(3), CPOX(1), EPRS(2), FECH(1), HCCS(2), HMOX2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1) 2620737 19 10 19 3 5 9 3 0 2 0 0.156 0.871 1.000 236 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), DFFA(1) 1340449 11 3 11 1 3 4 1 0 3 0 0.227 0.871 1.000 237 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD5(2), IL10(1), IL12A(1), ITGAX(2), TLR2(4), TLR4(3), TLR7(3), TLR9(3) 1748675 23 6 23 3 7 10 5 0 1 0 0.0496 0.874 1.000 238 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), SUCLA2(2) 874830 3 3 3 5 0 2 0 0 1 0 0.999 0.874 1.000 239 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ6(1) 399280 2 1 2 0 0 1 1 0 0 0 0.621 0.874 1.000 240 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(10), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDAN1(2), CDC14A(3), CDC14B(1), CDC25C(1), CDC6(1), CDC7(1), CDH1(1), CDK4(1), E2F3(1), EP300(2), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), MPEG1(2), MPL(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), SMAD4(8), TP53(45) 10491918 116 55 99 21 39 34 20 3 19 1 0.00623 0.875 1.000 241 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), IL2(1), TGFB2(4), TGFBR1(3), TGFBR3(3), TOB1(2) 1045862 14 4 14 2 3 5 3 0 3 0 0.202 0.880 1.000 242 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IL12A(1), IL2(1) 290167 2 1 2 1 0 2 0 0 0 0 0.883 0.882 1.000 243 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), ST3GAL6(3) 1499703 14 7 14 4 5 3 3 1 2 0 0.430 0.883 1.000 244 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), DBH(1), GAD1(2), HDC(5), MAOA(1), TPH1(2) 1373729 13 9 13 6 3 6 2 0 2 0 0.819 0.884 1.000 245 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADHA(1), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1) 1167155 7 4 7 4 1 2 1 0 3 0 0.899 0.884 1.000 246 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), NAGS(1), OAT(1), ODC1(3), OTC(1) 1694934 19 5 19 4 8 5 3 0 3 0 0.233 0.886 1.000 247 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1) 1164282 14 5 14 2 3 9 2 0 0 0 0.191 0.886 1.000 248 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), HEXB(2), LCT(5), SLC33A1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2) 1600195 15 6 15 5 7 6 2 0 0 0 0.453 0.889 1.000 249 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CDK4(1), CDKN1B(2), RB1(3), RBL1(2) 1553631 10 5 10 3 3 1 2 0 4 0 0.558 0.890 1.000 250 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1) 387255 6 1 6 0 2 4 0 0 0 0 0.146 0.891 1.000 251 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), DFFA(1), GZMB(1), TOP2A(3), TOP2B(4) 744111 10 2 10 2 1 4 3 0 2 0 0.508 0.893 1.000 252 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT2(1), AKT3(1), ARHGEF11(2), CDC42(1), DLG4(1), LPA(1), MAP2K4(2), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PI3(1), PLD1(3), PLD2(1), RDX(1), ROCK1(7), ROCK2(4), SERPINA4(3) 4748414 45 11 45 11 17 15 5 1 7 0 0.252 0.894 1.000 253 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR1B(1), BMPR2(3), CREBBP(4), CUL1(1), DCN(1), EP300(2), FST(1), GDF5(1), GDF6(1), INHBA(2), INHBC(1), INHBE(1), LTBP1(1), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), RBL1(2), RBX1(1), RHOA(1), ROCK1(7), ROCK2(4), RPS6KB2(1), SMAD2(5), SMAD3(3), SMAD4(8), SMAD5(1), SMAD9(1), SMURF1(2), TGFB2(4), TGFBR1(3), THBS1(2), THBS2(5), THBS3(1), THBS4(1), ZFYVE16(3), ZFYVE9(4) 9633613 97 32 94 16 31 36 17 0 12 1 0.00258 0.895 1.000 254 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), RAF1(2), SOS1(2), STAT5B(1) 1613530 12 4 12 2 3 4 2 0 2 1 0.345 0.900 1.000 255 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(3), FUT9(1), GCNT2(2) 582615 6 3 6 3 4 1 0 0 1 0 0.684 0.900 1.000 256 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(1), GPX3(2), GPX6(1), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), TXNDC12(2) 2061896 13 7 13 2 3 7 3 0 0 0 0.199 0.904 1.000 257 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP3(1), CASP6(1), CFLAR(1), DAXX(1), DFFA(1), LMNB1(2), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), PTPN13(9), RB1(3), SPTAN1(4) 3676887 41 10 41 9 9 13 9 1 9 0 0.269 0.905 1.000 258 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PSAT1(1) 476753 4 1 4 0 0 3 0 0 1 0 0.464 0.906 1.000 259 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(1), GFPT1(1), HEXB(2), HK3(1), PGM3(1) 1690753 9 3 9 1 2 5 2 0 0 0 0.243 0.906 1.000 260 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(7), DNMT3A(2), DNMT3B(5), MARS(3), MARS2(1), MAT2B(1), MTAP(1), MTFMT(1), MTR(1), TAT(2) 2012975 29 9 29 5 11 13 1 1 3 0 0.0779 0.906 1.000 261 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(5), ITGAL(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3) 1154444 15 4 15 3 1 9 3 0 2 0 0.386 0.906 1.000 262 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3) 1016820 6 3 6 3 1 3 0 0 1 1 0.852 0.907 1.000 263 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(1), JAK1(1), JAK2(3) 1016820 6 3 6 3 1 3 0 0 1 1 0.852 0.907 1.000 264 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1) 1932715 13 8 13 3 6 6 1 0 0 0 0.266 0.908 1.000 265 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), GGPS1(1), SQLE(1) 393233 3 1 3 1 0 2 1 0 0 0 0.762 0.909 1.000 266 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), BECN1(1), IFNA10(2), IFNA2(1), PIK3C3(2), PRKAA1(1), PRKAA2(3), ULK1(1) 2028690 13 4 13 3 3 5 2 0 3 0 0.483 0.909 1.000 267 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C8B(1), C9(1), MASP1(3) 1998361 27 10 27 5 9 11 4 0 3 0 0.131 0.911 1.000 268 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), RPL10A(1), RPL11(1), RPL19(1), RPL28(1), RPL6(2), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1) 1972810 14 7 14 4 0 5 7 1 1 0 0.674 0.912 1.000 269 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(1), ALAS2(1), CPOX(1), FECH(1), UROD(1) 765198 6 3 6 2 3 2 1 0 0 0 0.703 0.912 1.000 270 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), MAPK3(1) 1392679 7 3 7 2 3 3 0 0 1 0 0.557 0.912 1.000 271 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CHUK(2), CRADD(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK8(5), NFKB1(3), TANK(3) 2327308 28 11 28 7 9 10 6 2 1 0 0.278 0.912 1.000 272 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C5(4), C6(3), C7(3), IL6(1), IL8(1), ITGA4(5), ITGAL(3), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2) 2377656 27 9 27 9 9 10 3 0 5 0 0.471 0.915 1.000 273 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPPL2(1), DHFR(1) 562809 2 2 2 0 0 2 0 0 0 0 0.525 0.915 1.000 274 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TNFAIP3(1), TRAF3(2) 1737386 13 5 13 3 3 7 2 0 1 0 0.463 0.916 1.000 275 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(1) 287533 3 1 3 2 2 1 0 0 0 0 0.854 0.917 1.000 276 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA6(1), CYP11A1(2), EDNRB(5), PLA2G4A(3), PRL(1), PTGDR(1), PTGFR(1), PTGIS(1), PTGS1(2), PTGS2(1) 1996872 19 11 19 5 8 6 3 0 2 0 0.388 0.918 1.000 277 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(3), C2(4), C3(1), C5(4), C6(3), C7(3), C8A(3), C9(1), MASP1(3) 2041951 26 10 26 6 9 10 4 0 3 0 0.225 0.919 1.000 278 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(2), FADS2(1), PLA2G4A(3), PLA2G6(2) 987794 8 5 8 3 6 1 0 0 1 0 0.543 0.921 1.000 279 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3), SELP(2) 1460023 20 7 20 6 3 11 3 0 3 0 0.527 0.923 1.000 280 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(4), DFFA(1), GZMA(1), GZMB(1) 987353 9 3 9 3 5 3 0 0 1 0 0.538 0.925 1.000 281 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 1569623 17 6 17 4 5 6 5 0 1 0 0.439 0.925 1.000 282 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GNS(3), HEXB(2), LCT(5), NAGLU(1) 1428507 11 5 11 3 5 4 1 0 1 0 0.382 0.926 1.000 283 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(1) 517094 6 5 6 4 2 2 1 0 1 0 0.910 0.926 1.000 284 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), DERA(1), FBP2(1), G6PD(1), GPI(1), H6PD(1), PFKM(3), PGM1(2), PGM3(1), PRPS1(1), TKTL1(1), TKTL2(2) 2313347 17 10 17 5 7 7 2 0 1 0 0.332 0.928 1.000 285 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR2(1), ACTR3(1), CDC42(1), FLNA(1), FLNC(2), LIMK1(1), MYH2(3), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2) 4578093 38 13 38 6 17 8 4 0 9 0 0.0162 0.930 1.000 286 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 FOS(1), GRB2(1), JAK2(3), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1) 2091888 17 5 17 2 4 6 3 1 2 1 0.134 0.932 1.000 287 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2) 778990 5 2 5 2 1 2 1 0 1 0 0.766 0.934 1.000 288 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2) 778990 5 2 5 2 1 2 1 0 1 0 0.766 0.934 1.000 289 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(3), EGFR(1), GRB2(1), MAP2K1(1), MAPK3(1), RAF1(2), RASA1(4), SOS1(2), SPRY1(1) 2248938 16 4 16 6 7 4 3 0 2 0 0.697 0.937 1.000 290 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(1), PTPRC(8) 1338810 20 4 20 6 4 10 3 0 3 0 0.499 0.941 1.000 291 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(1), PIR(1), PSMA7(1), WASF1(2), WASF3(2), WASL(2) 1494194 14 5 14 2 5 5 2 0 2 0 0.194 0.942 1.000 292 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ATF1(1), BRAF(2), CREB3(1), CREB5(2), CREBBP(4), DAG1(1), EGR1(1), EGR2(2), FRS2(2), GNAQ(1), MAP1B(12), MAP2K4(2), MAPK10(4), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), OPN1LW(1), PIK3C2G(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PTPN11(3), RPS6KA3(2), TERF2IP(1) 4877204 66 21 66 16 19 24 9 2 10 2 0.0734 0.943 1.000 293 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2) 1363818 13 7 13 6 3 7 1 0 2 0 0.795 0.943 1.000 294 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF11(2), BTK(1), CDC42(1), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), LIMK1(1), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PPP1R13B(1), PTEN(4), RHO(1), ROCK1(7), ROCK2(4), RPS4X(1), WASF1(2), WASL(2) 6580984 75 18 75 10 29 20 9 0 14 3 0.000867 0.944 1.000 295 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 BRAF(2), CASP3(1), FAS(2), FCGR3A(1), FYN(1), GRB2(1), GZMB(1), HLA-A(2), HLA-G(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), ITGAL(3), ITGB2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), KRAS(38), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MICB(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), PAK1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), PRKCG(2), PTPN11(3), RAF1(2), SH3BP2(1), SHC2(1), SOS1(2), SOS2(2), SYK(3), TNFRSF10B(4), TNFRSF10D(1), TYROBP(1), VAV1(2), VAV2(2), VAV3(2) 10875470 139 52 108 30 35 67 21 0 14 2 0.00897 0.945 1.000 296 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(1), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(4), F2(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(1), MAPK3(1), MAPK8(5), MEF2C(2), MYH2(3), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), RAF1(2) 4752966 57 21 57 16 23 18 6 1 7 2 0.215 0.945 1.000 297 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), PRKACG(1), PRKAR2B(1) 1006117 4 3 4 2 2 1 0 0 1 0 0.813 0.948 1.000 298 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ITGAL(3), ITGB2(1), PTPRC(8) 1036055 13 4 13 5 3 6 1 0 3 0 0.630 0.949 1.000 299 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), FOS(1), GNAQ(1), MAPK8(5), PRKCA(2) 1308476 10 5 10 3 3 4 1 1 1 0 0.529 0.949 1.000 300 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT2(1), AKT3(1), DAG1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(1), NFKB1(3), NFKB2(2), PDK1(2), PHKA2(1), PLD1(3), PLD2(1) 4154098 32 7 32 4 14 9 1 1 6 1 0.0180 0.949 1.000 301 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B2(1), FLT1(3), FLT4(1), HIF1A(2), KDR(2), PIK3CA(7), PIK3R1(5), PRKCA(2), VHL(1) 3294877 25 14 25 7 8 6 6 0 3 2 0.431 0.949 1.000 302 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), GRHPR(1), HAO2(1), MTHFD1L(2) 1261511 5 4 5 5 1 2 0 1 1 0 0.984 0.950 1.000 303 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP3(1), TYR(1) 957917 3 2 3 5 1 1 0 0 0 1 0.994 0.950 1.000 304 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(1), JAK2(3), JAK3(2), PTPRU(6), REG1A(2) 1489304 16 10 16 4 10 3 0 0 2 1 0.381 0.950 1.000 305 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1) 1063811 7 4 7 2 3 1 3 0 0 0 0.580 0.950 1.000 306 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 CYP1A2(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A43(2), CYP3A7(2), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1) 2330834 20 5 20 6 9 4 5 0 2 0 0.458 0.950 1.000 307 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(1), COPS5(1), EP300(2), HIF1A(2), LDHA(1), VHL(1) 1639442 9 3 9 1 4 2 1 0 2 0 0.246 0.951 1.000 308 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), CPT1A(1), CPT2(1), HADHA(1), SLC25A20(1) 1678410 9 3 9 3 2 3 1 0 3 0 0.668 0.951 1.000 309 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(4), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), HADHA(1), LDHA(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1) 3308408 31 10 31 8 9 11 3 0 8 0 0.408 0.952 1.000 310 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 2437258 19 6 19 2 2 11 3 0 3 0 0.102 0.952 1.000 311 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), ITGAL(3), ITGB2(1), PTPRC(8) 1096258 13 4 13 5 3 6 1 0 3 0 0.633 0.954 1.000 312 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(1), ATF4(1), BRAF(2), CACNA1C(2), CAMK2D(1), CAMK4(1), CREBBP(4), EP300(2), GNAQ(1), GRIA1(1), GRIA2(3), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NRAS(5), PLCB3(1), PLCB4(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), RAP1A(1), RAPGEF3(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2) 9443744 127 51 96 29 32 67 16 0 10 2 0.0141 0.954 1.000 313 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNAQ(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK3(1), PIK3C2G(2), PPP1R12B(4), PRKCA(2), RAF1(2), ROCK2(4) 2388876 20 8 20 5 6 6 2 0 6 0 0.421 0.954 1.000 314 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8IP3(1), PAPPA(5), RPS6KA3(2), SOS1(2), SYK(3), VAV1(2), VAV2(2), VAV3(2) 3122999 28 9 28 3 8 15 2 0 3 0 0.0264 0.954 1.000 315 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), HIF1A(2), JAK2(3), NFKB1(3) 1250122 9 2 9 4 4 1 0 0 3 1 0.825 0.955 1.000 316 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), PAK1(1), PRKCA(2), RAF1(2), SOS1(2) 2800177 25 11 25 5 6 8 6 2 3 0 0.192 0.955 1.000 317 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 381841 1 1 1 1 0 1 0 0 0 0 0.952 0.955 1.000 318 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD2(2), GRM1(3), PPP3CA(2), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 1507971 14 7 14 6 8 3 1 0 2 0 0.635 0.957 1.000 319 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(1), ACSS2(1), SUCLA2(2) 1310590 4 3 4 6 0 3 0 0 1 0 0.998 0.957 1.000 320 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1L(2) 1319536 6 5 6 5 2 2 0 1 1 0 0.966 0.957 1.000 321 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(1), TAF1(5), TAF1L(6), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6(1), TAF7(1), TAF7L(1), TAF9(1) 3518797 28 9 28 3 7 9 5 0 7 0 0.0559 0.957 1.000 322 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K1(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), NFKB1(3), NSMAF(2), RAF1(2) 2020077 18 6 18 8 7 6 2 1 2 0 0.744 0.959 1.000 323 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AMD1(1), ARG2(1), ASL(2), ASS1(1), CPS1(6), MAOA(1), MAOB(1), NAGS(1), ODC1(3), OTC(1), SAT2(1) 2885873 29 9 28 7 10 11 3 0 5 0 0.210 0.959 1.000 324 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2) 985316 6 4 6 3 2 1 3 0 0 0 0.824 0.960 1.000 325 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(1), GPX3(2), GSTA3(1), GSTM3(1), GSTO2(1) 1728903 9 5 9 2 2 5 2 0 0 0 0.406 0.961 1.000 326 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CDC42(1), CREB3(1), CREB5(2), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAPK13(1), MKNK2(1), NFKB1(3) 3311388 27 14 27 5 10 8 3 2 4 0 0.106 0.961 1.000 327 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT2(1), AKT3(1), CD40(1), CD80(1), CHUK(2), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA10(2), IFNA2(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(1), IL8(1), IRAK4(2), IRF3(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), TBK1(1), TICAM1(1), TLR1(3), TLR2(4), TLR3(1), TLR4(3), TLR5(1), TLR7(3), TLR8(3), TLR9(3), TRAF3(2) 8570589 99 29 99 18 27 36 19 2 12 3 0.00653 0.962 1.000 328 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), BCR(1), CAV1(1), CSK(2), FYN(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), PPP1R12B(4), RAF1(2), RAP1A(1), ROCK1(7), SOS1(2), TLN1(2), VCL(1), ZYX(1) 4419248 39 12 39 7 13 14 7 1 4 0 0.0549 0.963 1.000 329 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(1) 584775 2 1 2 1 0 1 0 0 1 0 0.805 0.963 1.000 330 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(5) 827337 5 2 5 2 2 2 0 0 1 0 0.630 0.963 1.000 331 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(6), MAP2(4), PRKACG(1), PRKAR2B(1), PRKCE(2) 1746430 14 6 13 7 2 7 3 0 2 0 0.938 0.963 1.000 332 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(1), JAK1(1) 1186482 6 3 6 2 2 2 0 0 2 0 0.608 0.963 1.000 333 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 FOS(1), GRB2(1), IL2(1), IL2RB(1), JAK1(1), JAK3(2), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(5), RAF1(2), SOS1(2), STAT5B(1), SYK(3) 2270057 23 7 23 3 5 9 3 1 5 0 0.105 0.965 1.000 334 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), BIRC3(5), CASP3(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKB2(2), RALBP1(2), TNFAIP3(1) 2634776 22 8 22 5 9 5 4 0 4 0 0.266 0.965 1.000 335 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL12A(1), IL2(1), IL6(1), IL7(1), IL8(1), TGFB2(4) 1289605 13 3 13 5 3 8 1 0 1 0 0.700 0.965 1.000 336 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), LDHA(1), LDHB(2), NCL(1) 871424 8 5 8 4 3 5 0 0 0 0 0.825 0.965 1.000 337 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(1), MAP2K1(1), MAP3K1(2), MAPK3(1), MAPK8(5), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), RAF1(2), SOS1(2), SYK(3), VAV1(2) 3728416 34 12 34 8 12 12 4 1 5 0 0.208 0.966 1.000 338 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDE6A(1), PDE6C(2), SLC6A13(1), TF(4) 3319199 25 6 25 1 9 11 1 0 3 1 0.00188 0.966 1.000 339 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(1), FUT8(1) 789292 3 3 3 2 1 1 0 0 1 0 0.889 0.966 1.000 340 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2) 2289009 18 4 18 6 5 10 2 0 1 0 0.538 0.967 1.000 341 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(3), TANK(3), TNFAIP3(1), TRAF1(1), TRAF3(2) 2149248 17 5 17 5 6 7 3 0 1 0 0.473 0.967 1.000 342 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1) 2310763 19 8 19 3 8 8 2 0 1 0 0.139 0.968 1.000 343 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(1), CSK(2), CTLA4(1), DAG1(1), DTYMK(1), EPHB2(1), FBXW7(12), GRAP2(3), GRB2(1), ITK(3), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PTPRC(8), RAF1(2), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), SOS1(2), SOS2(2), VAV1(2) 5341405 70 18 68 9 29 24 8 0 9 0 0.00187 0.968 1.000 344 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2) 1249362 11 4 11 5 1 5 3 0 2 0 0.787 0.968 1.000 345 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(2), NCOA3(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 2003720 17 4 17 4 6 8 1 0 2 0 0.343 0.969 1.000 346 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), AKAP10(1), AKAP11(3), AKAP12(3), AKAP3(4), AKAP4(2), AKAP6(6), AKAP7(1), AKAP9(6), ARHGEF1(1), GNA14(1), GNAL(1), GNAQ(1), GNG4(1), GNGT1(1), IL18BP(2), ITPR1(8), KRAS(38), NRAS(5), PDE1A(1), PDE1B(1), PDE1C(2), PDE4B(3), PDE4D(1), PDE7B(1), PDE8B(1), PLCB3(1), PPP3CA(2), PPP3CC(1), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKD3(2), RHOA(1), SLC9A1(2), USP5(1) 11118970 140 49 108 27 27 79 15 0 18 1 0.00304 0.969 1.000 347 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(3), OPHN1(3), PIP5K1B(1), PPP1R12B(4), ROCK1(7), TLN1(2), VCL(1) 4432390 33 12 33 7 8 9 9 0 7 0 0.184 0.970 1.000 348 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ME1(2), PC(3), PDHA1(1) 878363 6 4 6 3 4 2 0 0 0 0 0.755 0.973 1.000 349 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3), CLTA(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1) 1631726 9 2 9 3 4 2 1 0 2 0 0.583 0.973 1.000 350 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(5), PGM1(2), PYGM(2) 1267706 9 5 9 2 8 1 0 0 0 0 0.250 0.974 1.000 351 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), JAK1(1), JAK2(3), JAK3(2), STAT5B(1) 1794083 8 4 8 3 0 4 0 0 3 1 0.799 0.976 1.000 352 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2F2(1), GTF2H1(2), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3B(5), POLR3E(3), POLR3K(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1) 3455124 26 11 26 4 10 8 3 0 5 0 0.109 0.976 1.000 353 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(6), DPYS(1), ENPP3(1), PANK3(1), PPCS(1), UPB1(2), VNN1(1) 1695263 14 8 14 8 3 8 1 0 2 0 0.908 0.977 1.000 354 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), AKT3(1), BRAF(2), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRKAA1(1), PRKAA2(3), RICTOR(3), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), TSC1(1), TSC2(1), ULK1(1), VEGFC(3) 5136910 50 16 50 12 17 14 9 0 8 2 0.184 0.977 1.000 355 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(3), ITGAM(3), ITGB2(1), PECAM1(1), SELE(2), SELL(3) 914872 13 5 13 4 2 8 1 0 2 0 0.546 0.977 1.000 356 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GNS(3), HEXB(2), HPSE2(3), LCT(5), NAGLU(1), SPAM1(3) 1995113 17 6 17 4 8 6 2 0 1 0 0.259 0.977 1.000 357 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(1), EGFR(1), GNAQ(1), GRB2(1), MAP2K1(1), MAP2K2(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(5), MEF2A(1), MEF2C(2), PAK1(1), PRKCA(2), RAF1(2), SOS1(2) 3271594 29 8 29 4 7 11 5 1 5 0 0.0500 0.977 1.000 358 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), GNAI1(1), GNGT1(1), MAP2K1(1), MAPK3(1), PLA2G4A(3), PRKCA(2), PTGS1(2), RAF1(2), SYK(3) 2440328 17 8 17 5 6 5 2 0 4 0 0.480 0.978 1.000 359 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(2), IKBKB(2), IL2(1), MAP3K1(2), MAP3K5(1), MAPK8(5), NFKB1(3), TNFRSF9(1) 1906303 18 3 18 4 4 11 2 1 0 0 0.343 0.978 1.000 360 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), DHFR(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1) 1765173 10 5 10 4 4 5 0 0 1 0 0.603 0.979 1.000 361 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGT(1), AGTR2(1), EDNRB(5), EGFR(1), FOS(1), NFKB1(3), PRKCA(2) 2024999 17 8 17 5 7 6 3 0 1 0 0.448 0.979 1.000 362 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP3(1), LHPP(1), MTMR1(1), MTMR2(1), TYR(1) 1500005 6 4 6 6 4 1 0 0 0 1 0.974 0.980 1.000 363 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(1), CHKA(2), CHPT1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), ESCO1(4), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(1), GPD1L(1), GPD2(1), MYST3(5), MYST4(5), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1), PTDSS1(3), SH3GLB1(1) 6467775 63 21 63 17 23 19 13 0 8 0 0.217 0.981 1.000 364 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2) 4858338 48 16 48 10 17 17 8 0 6 0 0.0595 0.981 1.000 365 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(4), CTTN(1), FYN(1), HCLS1(1), NCK1(1), NCL(1), PRKCA(2), RHOA(1), ROCK1(7), ROCK2(4), TLR4(3), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2) 4858338 48 16 48 10 17 17 8 0 6 0 0.0595 0.981 1.000 366 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(1) 2301634 23 10 23 8 11 8 2 0 2 0 0.557 0.981 1.000 367 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1) 484925 1 1 1 2 0 0 0 0 1 0 0.988 0.981 1.000 368 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), CD38(1), ENPP3(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5E(1) 1480509 12 3 12 6 2 5 2 0 3 0 0.897 0.982 1.000 369 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), NOS1(6), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2) 2433217 31 11 31 10 16 10 2 0 2 1 0.257 0.982 1.000 370 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(1), BTK(1), EEA1(4), GSK3B(1), PFKM(3), PRKCE(2), VAV2(2) 2395078 14 7 14 7 2 9 1 0 2 0 0.868 0.983 1.000 371 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), DHFR(1), MTFMT(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(1) 1842430 11 5 11 4 4 6 0 0 1 0 0.554 0.983 1.000 372 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), AKT3(1), BTK(1), DAPP1(1), GRB2(1), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(7), PPP1R13B(1), PTEN(4), RPS6KA2(2), RPS6KA3(2), SOS1(2), SOS2(2), TEC(2), YWHAH(1) 3433031 34 14 34 8 8 13 10 0 3 0 0.292 0.983 1.000 373 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), DFFA(1), GZMB(1), SCAP(1) 1781156 12 4 12 2 3 5 1 0 3 0 0.289 0.984 1.000 374 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(1) 525884 7 2 7 3 4 3 0 0 0 0 0.699 0.984 1.000 375 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(1), EGFR(1), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK13(1), MAPK3(1), MAPK8(5), NFKB1(3), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), RAF1(2) 4731861 41 15 41 12 15 13 8 2 3 0 0.296 0.985 1.000 376 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR1(1), GOSR2(1), SEC22B(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1) 1586776 15 4 15 3 4 4 3 0 4 0 0.304 0.985 1.000 377 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(2), FOS(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TLR10(3), TLR2(4), TLR3(1), TLR4(3), TLR7(3), TLR9(3) 3436977 43 9 43 8 11 17 9 2 3 1 0.0806 0.985 1.000 378 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(1), MAP2K5(2), MAPK8(5), PLD1(3), PLD2(1), RAF1(2), RASAL1(1), TEC(2), VAV1(2) 2663900 24 7 24 6 10 8 4 1 1 0 0.287 0.986 1.000 379 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(1), RDH12(1) 467477 2 1 2 1 1 1 0 0 0 0 0.774 0.986 1.000 380 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(1), IRS1(3), JAK1(1), JAK3(2) 1429891 7 3 7 2 1 3 1 0 2 0 0.618 0.987 1.000 381 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(1), CASP3(1), INSR(1), MAGI1(3), MAGI2(5), WWP1(3) 2311224 15 5 15 3 5 2 5 0 3 0 0.332 0.987 1.000 382 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), DHRS2(1), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 2352919 25 9 25 9 6 9 8 0 2 0 0.708 0.987 1.000 383 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP4(2), CASP6(1), DFFA(1), GZMB(1), LMNB1(2) 1899963 16 4 16 3 4 6 1 0 5 0 0.343 0.987 1.000 384 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(4), ACACB(1), ACADM(3), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), HADHA(1), HIBCH(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), MCEE(1), MUT(1), PCCA(6), PCCB(1), SUCLA2(2), SUCLG1(1) 3968715 35 10 35 7 8 14 4 0 9 0 0.186 0.987 1.000 385 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(1), ST6GALNAC1(1), WBSCR17(2) 3183203 28 9 28 7 5 14 7 0 2 0 0.366 0.987 1.000 386 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), DARS(1), EPRS(2), FARS2(1), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1) 3206399 23 10 23 5 3 9 7 1 3 0 0.356 0.988 1.000 387 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA1(2), HEXB(2), LCT(5), MAN2B1(1), MANBA(1), NEU1(1) 1946735 14 6 14 6 6 4 1 0 3 0 0.724 0.988 1.000 388 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2), SP3(1) 2007830 13 7 13 5 8 2 0 0 3 0 0.577 0.989 1.000 389 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), DLD(1), DLST(1), IDH3A(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1) 1971597 16 9 16 9 3 8 2 0 3 0 0.946 0.989 1.000 390 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(1), AKT3(1), CAP1(1), CBL(3), CDC42(1), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PPYR1(3), PTEN(4), PTPN1(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), SERPINB6(1), SLC2A4(1), SORBS1(4), SOS1(2), SOS2(2), YWHAH(1) 5721651 65 16 65 11 24 18 12 0 9 2 0.0142 0.989 1.000 391 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), OAT(1) 507137 2 1 2 1 1 0 1 0 0 0 0.837 0.990 1.000 392 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1) 600539 5 1 5 0 0 4 1 0 0 0 0.292 0.991 1.000 393 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(1), CIITA(1), CTSB(3), CTSL1(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFNA10(2), IFNA2(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), LGMN(2), NFYA(2), PDIA3(1), TAP1(2), TAP2(1), TAPBP(2) 4408057 42 12 42 12 7 20 7 1 5 2 0.390 0.991 1.000 394 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACYP1(1), DHRS2(1), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1) 2489213 21 6 21 7 6 7 6 0 2 0 0.648 0.991 1.000 395 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), NCOA1(2), NCOA2(3) 1710934 11 4 11 2 6 3 2 0 0 0 0.268 0.991 1.000 396 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 NR3C1(1) 562520 1 1 1 1 0 0 0 0 1 0 0.913 0.991 1.000 397 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), BDKRB2(1), CAV1(1), CHRNA1(2), FLT1(3), FLT4(1), KDR(2), PDE3B(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKG1(5), PRKG2(2), RYR2(11) 3634760 36 13 36 12 7 17 9 0 3 0 0.502 0.992 1.000 398 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1) 3067446 23 10 23 6 11 9 2 0 1 0 0.252 0.992 1.000 399 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(1), OXSM(1) 1586086 6 4 6 3 3 1 0 0 2 0 0.754 0.992 1.000 400 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(2), TGM2(2) 485402 6 3 6 2 3 3 0 0 0 0 0.494 0.992 1.000 401 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), AASDHPPT(1), AASS(2) 703013 4 3 4 3 0 1 2 0 1 0 0.960 0.993 1.000 402 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD58(1), IL6(1), IL8(1) 634117 3 1 3 2 1 1 1 0 0 0 0.904 0.993 1.000 403 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1B2(1), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(1), EIF2B2(1), EIF4A2(1), EIF4EBP2(1), EIF4G1(1), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(2), PAIP1(3) 4169802 21 10 21 6 5 7 4 1 4 0 0.610 0.993 1.000 404 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN2(1), EGFR(1), MAPK3(1), MYLK(3), PRKACG(1), PRKAR1A(4), PRKAR2B(1), TLN1(2) 3129679 15 6 15 7 6 6 1 0 2 0 0.747 0.993 1.000 405 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR3(1), CCR4(1), CCR7(2), CD28(1), CXCR4(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1), TGFB2(4) 1903153 17 4 17 4 4 9 2 0 2 0 0.290 0.993 1.000 406 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1F(2), CACNA1S(4), CAMK2D(1), CDC42(1), CGA(1), EGFR(1), FSHB(1), GNAQ(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK9(2), MMP2(3), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PLD1(3), PLD2(1), PRKACA(1), PRKACG(1), PRKCA(2), RAF1(2), SOS1(2), SOS2(2) 12142466 143 53 112 25 36 69 16 2 19 1 0.000150 0.993 1.000 407 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1) 1464180 15 6 15 7 7 5 2 0 1 0 0.867 0.993 1.000 408 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H4(1) 510297 2 1 2 0 2 0 0 0 0 0 0.421 0.994 1.000 409 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(2), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(2), NFKB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1) 2665358 23 7 23 8 12 7 1 0 3 0 0.478 0.994 1.000 410 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(5), NEU1(1), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SPHK1(1), UGT8(2) 3301285 20 8 20 8 10 5 2 0 2 1 0.619 0.995 1.000 411 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(2), NT5C1B(1), NT5C2(1), NT5E(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PRIM2(3), RFC5(1), RRM1(1), TK2(1), TXNRD1(1), TXNRD2(1), TYMS(1), UMPS(1), UPB1(2), UPP2(1), UPRT(1) 7933506 67 28 65 15 18 26 10 0 13 0 0.0895 0.995 1.000 412 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHFR(1), DHX58(1), EP400(2), ERCC3(1), MOV10L1(7), RAD54B(2), SETX(9), SKIV2L2(1), SMARCA2(2), SMARCA5(4) 6107954 44 12 44 4 12 13 8 0 11 0 0.00396 0.996 1.000 413 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 GAL3ST1(2), LCT(5), NEU1(1) 2250279 8 5 8 6 5 2 0 0 1 0 0.914 0.996 1.000 414 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), APC(66), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARPC2(1), ARPC5L(1), BAIAP2(1), BDKRB2(1), BRAF(2), CDC42(1), CHRM2(3), CHRM4(1), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGFR(1), F2(1), FGD1(2), FGD3(1), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FN1(4), GIT1(1), GRLF1(5), IQGAP1(3), IQGAP2(3), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KRAS(38), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MOS(1), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(2), MYLK(3), MYLK2(1), NCKAP1(1), NCKAP1L(4), NRAS(5), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFRA(4), PDGFRB(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), RAF1(2), RDX(1), RHOA(1), ROCK1(7), ROCK2(4), RRAS2(1), SCIN(1), SLC9A1(2), SOS1(2), SOS2(2), SSH1(2), SSH3(1), TIAM1(5), TIAM2(2), VAV1(2), VAV2(2), VAV3(2), VCL(1), WASF1(2), WASL(2) 26346295 332 66 291 70 74 124 38 4 72 20 8.31e-05 0.996 1.000 415 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), GOT1(1), LDHA(1), LDHB(2) 672010 6 2 6 2 2 3 0 0 1 0 0.665 0.996 1.000 416 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F3(1), F5(7), F7(1), FGA(2), FGB(1), PROS1(3), TFPI(3) 1618984 19 5 19 7 5 6 6 0 2 0 0.705 0.997 1.000 417 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CYP2C9(3), DHRS2(1), ESCO1(4), ESCO2(1), HADHA(1), MYST3(5), MYST4(5), SH3GLB1(1) 2984916 27 6 27 7 7 10 7 0 3 0 0.419 0.997 1.000 418 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GCK(1), GMPPA(1), HK3(1), PFKFB1(1), PFKM(3), PMM1(2), SORD(2) 2329967 17 6 17 3 6 9 2 0 0 0 0.135 0.997 1.000 419 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT2(1), AKT3(1), BRAF(2), DAG1(1), DRD2(2), EGFR(1), EPHB2(1), GRB2(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNJ5(1), KCNJ9(1), PI3(1), PLCB3(1), PLCB4(1), RAF1(2), RGS20(1), SOS1(2), SOS2(2), TERF2IP(1) 5551006 38 10 38 6 18 10 5 0 4 1 0.0227 0.997 1.000 420 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(1), GNGT1(1), GRB2(1), IGF1R(1), MAP2K1(1), MAP2K2(1), MAPK3(1), MKNK2(1), NGFR(1), PDGFRA(4), PTPRR(4), RAF1(2), RPS6KA5(3), SOS1(2) 3281797 24 6 24 7 7 8 7 0 1 1 0.482 0.997 1.000 421 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(1), HK3(1), LALBA(1), LCT(5), MGAM(4), PFKM(3), PGM1(2), PGM3(1), RDH11(1), RDH12(1), UGP2(2) 3669281 28 10 28 7 11 12 4 0 1 0 0.204 0.997 1.000 422 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(1), B4GALT3(1), DPAGT1(1), FUT8(1), MAN1A1(1), MGAT1(1), RPN2(1) 1904227 8 5 8 7 2 2 1 0 3 0 0.969 0.997 1.000 423 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), NDST1(1), NDST3(3) 1960864 17 9 17 9 5 6 3 1 2 0 0.870 0.997 1.000 424 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC3F(1), APOBEC3G(1), APOBEC4(2) 700306 5 2 5 2 2 2 1 0 0 0 0.765 0.998 1.000 425 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL1RN(1), IL6(1), IRAK3(2), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(5), MYD88(1), NFKB1(3), TGFB2(4) 2842769 34 7 34 6 10 12 7 2 3 0 0.103 0.998 1.000 426 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA2(1), ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), HADHA(1), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1) 4297122 31 12 31 9 9 11 3 0 8 0 0.479 0.998 1.000 427 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNGT1(1), HTR2C(2), TUB(1) 704704 5 2 5 2 1 2 1 0 1 0 0.750 0.998 1.000 428 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), AKT3(1), BCR(1), BTK(1), DAPP1(1), ITPR1(8), ITPR2(6), ITPR3(1), PDK1(2), PIK3CA(7), PLCG2(4), PPP1R13B(1), PREX1(2), PTEN(4), PTPRC(8), RPS6KA2(2), RPS6KA3(2), SYK(3), TEC(2), VAV1(2) 5148194 59 12 59 11 18 22 8 0 10 1 0.0261 0.998 1.000 429 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLB(2), POLE(4), POLE2(1), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(1), POLQ(4), PRIM2(3), REV1(3), REV3L(7), RFC5(1) 3994731 36 11 34 10 7 14 5 0 9 1 0.609 0.998 1.000 430 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(2), ESRRA(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D2(3), NR1I3(1), NR2E1(1), NR2F1(1), NR2F6(1), NR3C1(1), NR4A2(2), PPARD(1), RARB(2), ROR1(4), RXRB(1), RXRG(1), VDR(1) 4082294 32 12 32 7 11 9 9 0 3 0 0.178 0.998 1.000 431 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(4), EP300(2), IKBKB(2), NFKB1(3) 2219208 13 2 13 4 6 6 1 0 0 0 0.523 0.998 1.000 432 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), GCDH(2), HADHA(1) 766279 4 2 4 2 1 1 1 0 1 0 0.843 0.998 1.000 433 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A43(2), CYP3A7(2), GSTA3(1), GSTA5(1), GSTM3(1), GSTO2(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2) 5303050 47 11 47 12 8 18 14 0 7 0 0.274 0.998 1.000 434 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM17(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(2), CSK(2), EGFR(1), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(2), MAP3K14(1), MAPK10(4), MAPK13(1), MAPK8(5), MAPK9(2), MET(1), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG2(4), PTPN11(3), PTPRZ1(5), TJP1(2) 6883705 65 21 65 11 20 23 11 1 9 1 0.0133 0.998 1.000 435 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(2), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), TLR4(3), TNFAIP3(1) 2336699 18 4 18 3 5 7 5 0 1 0 0.193 0.998 1.000 436 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(5), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(1), SHMT1(1) 3623538 26 11 26 9 7 13 3 0 3 0 0.555 0.998 1.000 437 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRB1(1), CSNK1D(1), DRD2(2), EGFR(1), GJA1(4), GJD2(1), GNAI1(1), GNAQ(1), GRB2(1), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(1), HTR2C(2), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR2(1), NRAS(5), PDGFC(1), PDGFRA(4), PDGFRB(1), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), SOS1(2), SOS2(2), TJP1(2), TUBA1B(2), TUBA1C(2), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1) 12432974 166 52 135 35 42 86 22 0 14 2 0.00109 0.998 1.000 438 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(2), AGTR2(1), COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), REN(2) 2534203 17 5 17 5 5 8 1 0 3 0 0.527 0.998 1.000 439 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), HADHA(1), HADHB(1) 832973 3 3 3 5 0 2 0 0 1 0 0.995 0.998 1.000 440 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT5(2), FUT1(3), FUT3(1) 668667 6 3 6 2 4 1 1 0 0 0 0.627 0.998 1.000 441 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(1), ALAS2(1), BLVRB(1), COX15(2), CP(3), CPOX(1), EPRS(2), FECH(1), FTMT(1), HCCS(2), HMOX2(2), MMAB(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UROD(1) 3918773 35 12 35 7 9 18 5 0 3 0 0.143 0.999 1.000 442 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(1), GRB2(1), GSK3B(1), INPP5D(2), ITPR1(8), ITPR2(6), ITPR3(1), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(2), PIK3CA(7), PIK3CD(1), PIK3R1(5), PLCG2(4), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PTPRC(8), RAF1(2), SOS1(2), SOS2(2), SYK(3), VAV1(2) 6910631 79 19 79 10 29 28 8 0 11 3 0.000284 0.999 1.000 443 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUL(1), HAL(1) 1859986 12 3 12 5 4 6 0 0 2 0 0.745 0.999 1.000 444 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), SLC23A2(1), SLC2A1(1) 2482249 10 5 10 5 4 3 0 0 3 0 0.843 0.999 1.000 445 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), DFFA(1), MAP3K14(1), NFKB1(3), SPTAN1(4), TNFRSF10B(4) 3245861 26 6 26 6 10 7 4 0 5 0 0.284 0.999 1.000 446 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(1), CFLAR(1), CHUK(2), CRADD(1), DAXX(1), DFFA(1), LMNB1(2), MAP3K1(2), MAP3K14(1), MAP3K5(1), MAPK8(5), NFKB1(3), NUMA1(2), PAK2(1), PRKDC(5), RASA1(4), RB1(3), SPTAN1(4), TRAF1(1) 6457575 50 11 50 10 17 14 9 1 9 0 0.107 0.999 1.000 447 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPN2(1), EP300(2), NFATC1(1), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(2) 2318218 14 8 14 5 7 4 1 0 2 0 0.525 0.999 1.000 448 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), PRKCA(2) 825669 6 2 6 4 4 1 0 0 1 0 0.880 0.999 1.000 449 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO3(1), FARS2(1), GOT1(1), TAT(2) 836448 5 2 5 2 0 3 0 0 2 0 0.718 0.999 1.000 450 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(2), IL6(1), IL9(1), TGFB2(4) 829325 8 2 8 5 1 5 1 0 1 0 0.925 0.999 1.000 451 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(1), GRB2(1), HSPB2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MEF2A(1), MEF2C(2), PLA2G4A(3), RPS6KA5(3), TGFB2(4), TGFBR1(3) 3501750 31 8 31 9 10 9 5 0 7 0 0.406 0.999 1.000 452 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(4), EP300(2), IKBKB(2), IL1B(1), IL8(1), MAP2K3(4), MAP2K6(1), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(3), NR3C1(1), TGFBR1(3), TLR2(4) 2876420 32 7 32 7 9 10 8 1 4 0 0.221 0.999 1.000 453 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2F1(2), NCOA1(2), NCOA2(3), NCOA3(5) 2377537 13 4 13 4 4 4 4 0 1 0 0.554 0.999 1.000 454 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSB(1), GOT1(1), TAT(2), YARS2(1) 871015 6 2 6 2 0 5 0 0 1 0 0.666 0.999 1.000 455 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(2), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2) 3679066 33 12 33 11 12 11 5 1 4 0 0.516 0.999 1.000 456 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA3(1), CA5A(1), CA8(1), CPS1(6), CTH(1), GLUD2(2), GLUL(1), HAL(1) 2072706 14 5 14 6 4 8 0 0 2 0 0.776 0.999 1.000 457 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL10(1), IL12A(1), IL16(4), IL2(1), IL6(1), IL8(1), IL9(1) 950295 10 1 10 5 2 7 0 0 1 0 0.834 0.999 1.000 458 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), FUCA1(2), GNS(3), HEXB(2), HPSE2(3), LCT(5), MAN2B1(1), MANBA(1), NAGLU(1), NEU1(1), SPAM1(3) 3295730 24 7 24 9 10 8 2 0 4 0 0.608 1.000 1.000 459 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(5), APOC1(1), APOC2(1), CETP(1), HMGCR(1), LDLR(1), LIPC(1), LRP1(3), SCARB1(1) 2459953 15 5 15 5 9 4 1 0 1 0 0.461 1.000 1.000 460 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH6A1(1), AOX1(3), HADHA(1), HADHB(1), HMGCL(1), MCCC1(1), MCEE(1), MUT(1), PCCA(6), PCCB(1) 3566871 28 11 28 9 8 10 3 0 7 0 0.588 1.000 1.000 461 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), CD38(1), ENPP3(1), NADK(1), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(2), NT5C1B(1), NT5C2(1), NT5E(1) 2173649 15 6 15 7 5 5 2 0 3 0 0.833 1.000 1.000 462 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(1), CMAS(3), CYB5R1(2), GFPT1(1), GFPT2(1), HEXB(2), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), NANS(1), NPL(1), PGM3(1) 2856288 17 8 17 7 7 5 3 1 1 0 0.727 1.000 1.000 463 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), EGFR(1), EP300(2), ERBB2(4), FER(2), FGFR1(1), FYN(1), IGF1R(1), INSR(1), IQGAP1(3), LMO7(1), MAP3K7(2), MAPK3(1), MET(1), MLLT4(3), PARD3(2), PTPN1(1), PTPRF(1), PTPRJ(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), RHOA(1), SMAD2(5), SMAD3(3), SMAD4(8), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(7), TGFBR1(3), TJP1(2), VCL(1), WASF1(2), WASF3(2), WASL(2) 11386531 110 33 106 24 40 44 13 0 12 1 0.0230 1.000 1.000 464 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(1), ARHGEF12(2), CDC42(1), CXCR4(1), DCC(2), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(1), EPHA1(3), EPHA3(3), EPHA4(2), EPHA5(6), EPHA7(3), EPHA8(2), EPHB1(3), EPHB2(1), EPHB4(3), FYN(1), GNAI1(1), GSK3B(1), KRAS(38), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(2), MAPK3(1), MET(1), NCK1(1), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NRAS(5), NTN1(1), NTN4(2), NTNG1(2), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), RASA1(4), RGS3(2), RHOA(1), ROBO1(9), ROBO2(3), ROBO3(3), ROCK1(7), ROCK2(4), SEMA3A(3), SEMA3C(1), SEMA3D(4), SEMA3E(4), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(4), SEMA4G(1), SEMA5A(1), SEMA5B(4), SEMA6B(2), SEMA6C(1), SEMA6D(4), SLIT1(2), SLIT2(3), SLIT3(2), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(3) 18342705 206 59 175 37 68 87 25 2 24 0 1.87e-05 1.000 1.000 465 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), PPAT(3), QARS(1) 3240227 19 7 19 6 5 8 3 0 3 0 0.556 1.000 1.000 466 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 IL8(1), NFKB1(3) 995858 4 1 4 2 3 1 0 0 0 0 0.763 1.000 1.000 467 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(1) 894973 8 3 8 2 1 5 2 0 0 0 0.518 1.000 1.000 468 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOC(2), FBP2(1), FPGT(2), GMPPA(1), HK3(1), LHPP(1), MTMR1(1), MTMR2(1), PFKFB1(1), PFKM(3), PMM1(2), RDH11(1), RDH12(1), SORD(2) 3654387 21 7 21 7 9 10 2 0 0 0 0.419 1.000 1.000 469 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), DIAPH2(3), MCM10(2), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), POLE(4), POLE2(1), RFC1(4), RFC5(1), RPA4(1), UBB(1) 4841187 27 10 26 8 7 16 1 0 3 0 0.477 1.000 1.000 470 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2D3(1), UBE2I(1), UBE3A(5) 1018069 8 1 8 0 2 4 2 0 0 0 0.0998 1.000 1.000 471 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(4), ACACB(1), AKT2(1), AKT3(1), BRAF(2), CBL(3), CBLB(2), EXOC7(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GRB2(1), GSK3B(1), GYS1(1), GYS2(3), IKBKB(2), INPP5D(2), INSR(1), IRS1(3), IRS4(4), KRAS(38), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MKNK2(1), NRAS(5), PCK1(3), PDE3B(1), PFKM(3), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R3A(5), PPP1R3C(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKACG(1), PRKAG2(1), PRKAG3(2), PRKAR1A(4), PRKAR2B(1), PTPN1(1), PTPRF(1), PYGM(2), RAF1(2), RAPGEF1(2), RPS6KB2(1), SHC2(1), SLC2A4(1), SOCS2(1), SOCS4(1), SORBS1(4), SOS1(2), SOS2(2), TSC1(1), TSC2(1) 15520345 177 53 146 37 48 79 25 1 22 2 0.00141 1.000 1.000 472 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CHUK(2), CPT1A(1), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(4), JAK1(1), JAK2(3), JAK3(2), LEPR(4), MAPK10(4), MAPK8(5), MAPK9(2), NFKB1(3), NFKB2(2), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(3), RXRB(1), RXRG(1), SLC2A1(1), SLC2A4(1) 8088515 66 16 66 16 19 26 7 2 11 1 0.103 1.000 1.000 473 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), LPO(1), MPO(2), PRDX1(1), TPO(3), TYR(1) 885030 9 6 9 5 6 2 0 0 1 0 0.805 1.000 1.000 474 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(1), GSK3B(1) 1122331 3 2 3 2 0 3 0 0 0 0 0.916 1.000 1.000 475 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(5), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CX3CR1(1), CXCR4(1), EDNRB(5), FSHR(1), GALR1(1), GPR77(1), MC2R(3), MC4R(1), MC5R(2), NPY5R(1), NTSR2(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(1), SSTR4(2), TACR3(3), TRHR(2), TSHR(1) 4850643 55 19 55 21 22 18 11 1 3 0 0.388 1.000 1.000 476 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(1), ADCY9(2), ARF4(1), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), PDIA4(1), PLCG2(4), PRKCA(2), TRIM23(4) 3618661 28 10 28 5 12 8 5 0 3 0 0.0795 1.000 1.000 477 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 AGT(1), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(1), REN(2) 939582 8 2 8 4 1 5 0 0 2 0 0.728 1.000 1.000 478 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(1), BMP7(1), BTRC(3), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(1), GLI2(2), GLI3(4), GSK3B(1), HHIP(1), LRP2(13), PRKACA(1), PRKACG(1), PTCH1(1), PTCH2(2), RAB23(1), SMO(1), STK36(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 5735218 47 17 47 14 19 18 3 0 7 0 0.240 1.000 1.000 479 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP4A11(1), CYP4F3(1), GPX3(2), GPX6(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(2), PTGS2(1) 3733718 24 9 24 9 11 6 5 0 2 0 0.655 1.000 1.000 480 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(10), CDR1(1), DGKI(4), FAU(1), IL6ST(1), PIGK(1), RPL10(1), RPL11(1), RPL19(1), RPL28(1), RPL5(1), RPL6(2), RPL9(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS4X(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(2), RPS6KB2(1), SLC36A2(1), UBB(1) 4903532 40 18 40 11 13 12 9 1 5 0 0.463 1.000 1.000 481 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB2(1), C1R(1), C1S(3), C2(4), C3(1), C3AR1(2), C4BPA(5), C5(4), C5AR1(1), C6(3), C7(3), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(6), CPB2(1), CR1(3), CR2(2), F13A1(2), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), KLKB1(2), KNG1(1), MASP1(3), PLAT(1), PLAU(1), PLAUR(1), PLG(2), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(5) 8657981 103 25 103 27 27 41 22 0 13 0 0.119 1.000 1.000 482 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12RB2(1), IL18R1(2), IL2(1) 1216013 10 2 10 2 3 5 1 0 1 0 0.318 1.000 1.000 483 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DAK(1), DGAT2(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(5), LIPC(1), LIPF(2), MGLL(1), PNLIP(2), PNLIPRP2(1) 5645977 52 16 52 16 20 19 8 0 5 0 0.258 1.000 1.000 484 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2D(1), F2(1), FYN(1), GNAI1(1), GNGT1(1), GRB2(1), JAK2(3), MAP2K1(1), MAP2K2(1), MAPK3(1), MAPK8(5), MAPT(1), MYLK(3), PRKCA(2), RAF1(2), SOS1(2) 4128607 29 8 29 10 7 13 5 1 2 1 0.606 1.000 1.000 485 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), HGD(1), HPD(1), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), MYST3(5), MYST4(5), PRMT3(1), PRMT7(1), PRMT8(2), SH3GLB1(1), TAT(2), TPO(3), TYR(1) 5605296 54 18 54 18 11 25 9 1 8 0 0.501 1.000 1.000 486 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1) 1161032 6 2 6 2 1 4 0 0 1 0 0.692 1.000 1.000 487 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CREB3(1), CREB5(2), ERBB4(5), F2RL2(1), GRB2(1), GSK3B(1), INPPL1(1), IRS1(3), IRS4(4), MET(1), NOLC1(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PARD3(2), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(4), PTPN1(1), RPS6KA2(2), RPS6KA3(2), SLC2A4(1), SOS1(2), SOS2(2), TSC1(1), TSC2(1), YWHAH(1) 7465646 67 17 67 16 19 23 12 1 12 0 0.106 1.000 1.000 488 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(1), MAP2K6(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(2), PIK3CA(7), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), YWHAH(1) 3228754 33 16 33 12 11 11 3 0 6 2 0.553 1.000 1.000 489 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHA(1) 1196103 6 2 6 4 1 2 1 0 2 0 0.938 1.000 1.000 490 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CTH(1), GOT1(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), SULT1B1(1), SULT1C2(1) 1242605 10 2 10 4 3 4 2 0 1 0 0.741 1.000 1.000 491 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKI(4), DGKZ(1), INPP4A(1), INPP4B(2), INPP5D(2), INPPL1(1), ITPR1(8), ITPR2(6), ITPR3(1), OCRL(4), PI4KA(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(4), SYNJ1(3), SYNJ2(1) 11735339 102 29 102 26 38 36 13 0 12 3 0.0719 1.000 1.000 492 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(5), ATP4A(2), ATP5A1(3), ATP5C1(2), ATP5L(2), ATP6V0A1(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX15(2), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(1), UQCRC2(1) 5498742 48 17 48 12 17 17 9 0 5 0 0.153 1.000 1.000 493 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH4A1(1), AMD1(1), ARG2(1), ASL(2), CKM(1), CKMT2(3), CPS1(6), DAO(4), GOT1(1), MAOA(1), MAOB(1), NOS1(6), OAT(1), ODC1(3), OTC(1), P4HA1(1), P4HA3(1), RARS(2) 4266252 46 11 45 16 18 14 5 1 8 0 0.485 1.000 1.000 494 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(1), AASDHPPT(1), AASS(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(2) 3579636 23 6 23 8 7 7 4 0 5 0 0.627 1.000 1.000 495 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2), HSPB2(1), MTA3(1), TUBA8(1) 994490 5 3 5 2 2 2 1 0 0 0 0.657 1.000 1.000 496 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(3), SCAP(1) 1168441 5 1 5 2 3 2 0 0 0 0 0.616 1.000 1.000 497 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), EPX(1), LPO(1), MPO(2), PRDX1(1), SHMT1(1), TPO(3) 1086970 10 7 10 7 5 3 1 0 1 0 0.924 1.000 1.000 498 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 CREBBP(4), EP300(2), MAPK3(1), ME1(2), NCOA1(2), NCOR1(5), NR2F1(1), NRIP1(1), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PTGS2(1), RB1(3), STAT5B(1) 6031166 43 18 43 13 18 12 6 0 5 2 0.394 1.000 1.000 499 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CYP4F3(1), EPX(1), LPO(1), MPO(2), PLA2G4A(3), PLA2G6(2), PRDX1(1), PTGIS(1), PTGS1(2), PTGS2(1), TPO(3) 2617125 20 10 20 9 12 5 1 0 2 0 0.704 1.000 1.000 500 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 1268352 7 3 7 3 3 2 2 0 0 0 0.714 1.000 1.000 501 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ANAPC1(1), ANAPC4(3), ANAPC5(1), ATM(10), ATR(4), BUB1(2), BUB1B(3), CCNA1(2), CCNB3(3), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC25C(1), CDC27(4), CDC6(1), CDC7(1), CDK4(1), CDKN1B(2), CREBBP(4), CUL1(1), DBF4(3), E2F3(1), EP300(2), GSK3B(1), MAD1L1(1), MCM3(2), MCM5(3), MCM6(1), MCM7(1), PCNA(1), PLK1(2), PRKDC(5), RB1(3), RBL1(2), RBX1(1), SMAD2(5), SMAD3(3), SMAD4(8), SMC1B(2), TGFB2(4), TP53(45), YWHAH(1) 12994047 147 55 130 32 44 49 26 3 24 1 0.0332 1.000 1.000 502 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(2), F2(1), F5(7), F8(3), FGA(2), FGB(1), KLKB1(2), PROS1(3), SERPING1(2) 4428846 29 6 29 9 8 12 5 0 4 0 0.498 1.000 1.000 503 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), DHFR(1), IMPDH1(1), POLB(2), POLG(1), RRM1(1) 1197127 7 4 7 3 4 1 1 0 1 0 0.723 1.000 1.000 504 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(1), AMY2A(2), AMY2B(1), ENPP3(1), G6PC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), PGM1(2), PGM3(1), PYGM(2), SI(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1) 5276061 35 10 35 10 10 12 6 0 7 0 0.372 1.000 1.000 505 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), CPT1A(1), CPT2(1), CYP4A11(1), CYP8B1(1), FABP2(1), FABP7(1), FADS2(1), GK2(3), HMGCS2(1), ME1(2), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(1), SLC27A6(5), SORBS1(4) 6301000 42 10 42 11 17 14 6 1 4 0 0.196 1.000 1.000 506 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT2(1), GALNT6(1), GALNT7(1), GALNT8(1), GCNT1(2), WBSCR17(2) 1390998 8 3 8 3 3 3 2 0 0 0 0.674 1.000 1.000 507 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(2), FARS2(1), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(3), MARS2(1), MTFMT(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(2), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1) 5343246 35 11 35 10 7 16 8 1 3 0 0.503 1.000 1.000 508 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), BBOX1(2), DLST(1), EHMT2(2), GCDH(2), HADHA(1), HSD17B10(1), NSD1(3), OGDHL(3), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(1), SETDB1(1), SHMT1(1), SPCS3(1), SUV39H2(1), TMLHE(2) 5650596 37 9 37 10 13 11 6 0 7 0 0.302 1.000 1.000 509 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CTPS(1), DCK(1), DHODH(1), DPYD(6), DPYS(1), DTYMK(1), NT5E(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), RRM1(1), TK2(1), TXNRD1(1), TYMS(1), UMPS(1), UPB1(2) 5575126 38 18 37 12 11 13 7 0 7 0 0.448 1.000 1.000 510 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(3), FYN(1), L1CAM(2), SELP(2) 1455667 11 5 11 6 5 4 1 0 1 0 0.842 1.000 1.000 511 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(7), CTCFL(1), EHMT2(2), EZH1(1), FBXO11(1), HSF4(1), MEN1(1), MLL(6), MLL2(3), MLL3(6), MLL4(3), MLL5(6), NSD1(3), OGT(1), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(6), PRMT7(1), PRMT8(2), SATB1(1), SETD1A(1), SETD2(6), SETD7(1), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(1), SUV39H2(1), SUV420H1(3), SUZ12(1), WHSC1(1) 11155750 79 18 79 12 23 28 10 0 17 1 0.0140 1.000 1.000 512 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 ACMSD(1), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), GCDH(2), HADHA(1), HSD17B10(1), INMT(1), KMO(2), KYNU(1), LCMT1(2), LNX1(4), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), NFX1(3), OGDHL(3), PRMT3(1), PRMT7(1), PRMT8(2), TDO2(2), TPH1(2), TPH2(3), WARS(1), WARS2(1) 5818043 54 17 54 18 13 23 8 1 9 0 0.518 1.000 1.000 513 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT2(3), CPS1(6), DAO(4), EPRS(2), GLUD2(2), GOT1(1), LAP3(1), NOS1(6), OAT(1), OTC(1), P4HA1(1), P4HA3(1), RARS(2), RARS2(2) 3484088 39 10 39 12 13 14 5 1 6 0 0.414 1.000 1.000 514 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(2), CHUK(2), DAXX(1), FOS(1), GRB2(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK6(1), MAPK8(5), MAPK9(2), MEF2A(1), MEF2C(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(2), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KB2(1), TGFB2(4), TGFBR1(3) 9074563 84 23 84 16 20 24 21 2 17 0 0.0182 1.000 1.000 515 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AGPAT1(1), AGPAT4(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), LCT(5), LIPC(1), LIPF(2), PNLIP(2), PNLIPRP2(1) 4621163 38 12 38 14 15 12 6 0 5 0 0.473 1.000 1.000 516 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(2), ACVRL1(1), BMPR2(3), BUB1(2), CDKL1(2), CDS1(1), CLK1(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), INPP4A(1), INPP4B(2), INPPL1(1), MAP3K10(1), MOS(1), NEK1(2), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), PRKG1(5), RAF1(2), RPS6KA2(2), RPS6KA3(2), TGFBR1(3), VRK1(1) 10857504 99 34 99 29 31 35 20 1 12 0 0.320 1.000 1.000 517 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(2), FADS2(1), HADHA(1) 1430750 4 4 4 6 2 1 0 0 1 0 0.991 1.000 1.000 518 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), CAD(1), CPS1(6), EPRS(2), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), PPAT(3), QARS(1) 3854660 22 10 22 9 5 10 3 1 3 0 0.756 1.000 1.000 519 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4) 1628498 12 5 11 5 2 4 3 0 3 0 0.778 1.000 1.000 520 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT3(1), CHST11(1), CHST12(1), CHST13(1), DSE(1), XYLT1(2) 1313738 7 3 7 3 3 3 1 0 0 0 0.663 1.000 1.000 521 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1) 1725529 7 4 7 8 5 1 0 0 1 0 0.988 1.000 1.000 522 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), CAMK2D(1), CREB3(1), CREB3L2(1), CREB3L3(2), CREBBP(4), CTNNB1(4), DCT(4), DVL2(1), DVL3(2), EDNRB(5), EP300(2), FZD1(1), FZD10(2), FZD3(3), FZD4(1), FZD6(3), GNAI1(1), GNAQ(1), GSK3B(1), KIT(2), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), MITF(3), NRAS(5), PLCB3(1), PLCB4(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), RAF1(2), TCF7(3), TCF7L2(7), TYR(1), WNT10B(1), WNT2(1), WNT2B(2), WNT6(1), WNT8A(1), WNT9B(1) 10368285 134 52 103 35 30 79 11 1 13 0 0.0291 1.000 1.000 523 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), EGFR(1), GRB2(1), MET(1), PDGFRA(4), PRKCA(2), SH3GLB1(1) 1940943 13 3 13 4 6 5 2 0 0 0 0.522 1.000 1.000 524 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGFR(1), MAP2K1(1), MAP3K1(2) 1712375 4 1 4 2 1 2 1 0 0 0 0.815 1.000 1.000 525 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(2), CSTF3(2), DDX20(1), DHX15(2), DHX38(1), DHX9(1), DICER1(1), LSM2(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), PRPF18(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(2), RNMT(1), RNPS1(1), SF3A1(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(1), XRN2(2) 10289274 56 14 56 13 16 23 11 0 6 0 0.283 1.000 1.000 526 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE2(3), AGT(1), AGTR1(2), AGTR2(1), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(2), REN(2) 2084547 25 7 25 7 8 11 4 0 2 0 0.309 1.000 1.000 527 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(1), HDAC5(1), MEF2A(1), MEF2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), SLC2A4(1), YWHAH(1) 1932116 17 5 17 6 7 7 0 0 3 0 0.549 1.000 1.000 528 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(1), AMY2A(2), AMY2B(1), ASCC3(5), DDX18(1), DDX19A(1), DDX4(1), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(1), ENPP3(1), EP400(2), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GBE1(1), GCK(1), GPI(1), GYS1(1), GYS2(3), HK3(1), MGAM(4), MOV10L1(7), PGM1(2), PGM3(1), PYGM(2), RAD54B(2), SETX(9), SI(3), SKIV2L2(1), SMARCA2(2), SMARCA5(4), UGDH(1), UGP2(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(3), UGT2B28(1), UGT2B4(1), UGT2B7(2), UXS1(1) 11682363 89 21 89 17 22 30 18 0 19 0 0.0261 1.000 1.000 529 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BRAF(2), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CACNA2D1(3), CACNA2D3(3), CACNB2(1), CACNB3(1), CACNB4(2), CACNG2(1), CACNG3(3), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(2), DAXX(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(1), ECSIT(1), EGFR(1), ELK4(1), FAS(2), FGF11(1), FGF12(1), FGF13(1), FGF19(1), FGF20(1), FGF5(2), FGFR1(1), FGFR2(5), FLNA(1), FLNB(2), FLNC(2), FOS(1), GRB2(1), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), KRAS(38), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(4), MAPK13(1), MAPK3(1), MAPK8(5), MAPK8IP3(1), MAPK9(2), MAPT(1), MEF2C(2), MKNK2(1), MOS(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(5), NTRK2(1), PAK1(1), PAK2(1), PDGFRA(4), PDGFRB(1), PLA2G4A(3), PLA2G6(2), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN7(1), PTPRR(4), RAF1(2), RAP1A(1), RAPGEF2(5), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), RPS6KA2(2), RPS6KA3(2), RPS6KA5(3), RPS6KA6(2), RRAS2(1), SOS1(2), SOS2(2), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TP53(45), ZAK(2) 26577830 337 67 291 78 113 113 58 5 44 4 0.000105 1.000 1.000 530 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), CES1(1), CES7(1), DDHD1(2), ESCO1(4), ESCO2(1), MYST3(5), MYST4(5), SH3GLB1(1) 2440634 21 8 21 9 5 8 6 0 2 0 0.820 1.000 1.000 531 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(2), CAMK4(1), CD69(1), CNR1(2), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(5), GSK3B(1), IL10(1), IL1B(1), IL2(1), IL6(1), IL8(1), ITK(3), MAPK8(5), MAPK9(2), MEF2A(1), MYF5(2), NFATC1(1), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(2), NPPB(1), NUP214(2), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(1), PTPRC(8), SP3(1), TRPV6(2), VAV1(2), VAV2(2), VAV3(2), XPO5(1) 8560868 74 17 74 23 29 25 8 1 11 0 0.253 1.000 1.000 532 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(2), CACNA1A(9), CRHR1(1), GNAI1(1), GNAQ(1), GRIA1(1), GRIA2(3), GRIA3(3), GRID2(2), GRM1(3), GRM5(3), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(1), ITPR1(8), ITPR2(6), ITPR3(1), KRAS(38), MAP2K1(1), MAP2K2(1), MAPK3(1), NOS1(6), NPR2(1), NRAS(5), PLA2G4A(3), PLA2G6(2), PLCB3(1), PLCB4(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(5), PRKG2(2), RAF1(2), RYR1(6) 10438584 150 51 118 38 40 75 23 0 11 1 0.0290 1.000 1.000 533 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(3), ABCA12(11), ABCA13(17), ABCA3(1), ABCA4(4), ABCA5(2), ABCA6(5), ABCA8(7), ABCA9(6), ABCB1(5), ABCB11(3), ABCB4(3), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(1), ABCC1(3), ABCC11(2), ABCC12(4), ABCC2(3), ABCC5(2), ABCC6(2), ABCC8(1), ABCC9(4), ABCD2(1), ABCG1(1), ABCG2(4), CFTR(4), TAP1(2), TAP2(1) 11301743 113 16 113 31 29 51 17 1 14 1 0.0843 1.000 1.000 534 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), ARHGAP5(3), CDC42(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTNND1(1), CXCR4(1), CYBB(1), GNAI1(1), GRLF1(5), ITGA4(5), ITGAL(3), ITGAM(3), ITGB2(1), ITK(3), MAPK13(1), MLLT4(3), MMP2(3), MMP9(5), MSN(3), MYL9(2), NCF2(1), NCF4(1), NOX3(3), PECAM1(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PLCG2(4), PRKCA(2), PRKCG(2), PTPN11(3), RAP1A(1), RAPGEF3(1), RHOA(1), ROCK1(7), ROCK2(4), TXK(1), VAV1(2), VAV2(2), VAV3(2), VCAM1(2), VCL(1) 11680790 124 35 124 34 48 47 18 0 9 2 0.0740 1.000 1.000 535 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(2), ACTN2(1), ACTN3(1), ITGB3(2), SPTAN1(4), TLN1(2) 2646085 13 5 13 6 6 6 0 0 1 0 0.767 1.000 1.000 536 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(1), CREBBP(4), DLL1(3), DLL3(1), DLL4(1), DTX2(1), DTX3(1), DVL2(1), DVL3(2), EP300(2), JAG1(1), MAML1(2), NOTCH2(2), NOTCH3(3), NOTCH4(4), PTCRA(1), RBPJ(4), SNW1(1) 6419192 35 9 35 12 14 11 4 0 6 0 0.402 1.000 1.000 537 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD80(1), CDH1(1), CDH15(1), CDH2(6), CDH3(2), CDH4(4), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CNTN1(5), CNTN2(2), CNTNAP1(1), CNTNAP2(4), CTLA4(1), HLA-A(2), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGB2(1), ITGB8(1), L1CAM(2), MAG(2), NCAM1(4), NCAM2(7), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(1), NRXN3(2), PECAM1(1), PTPRC(8), PTPRF(1), PTPRM(8), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(1), SDC2(1), SDC3(1), SELE(2), SELL(3), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(13) 14183287 163 35 163 47 48 70 23 3 19 0 0.0802 1.000 1.000 538 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), AMOTL1(3), ASH1L(7), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN8(2), CTNNA1(2), CTNNA2(2), CTNNB1(4), CTTN(1), EPB41L1(1), EPB41L3(3), EXOC4(3), GNAI1(1), HCLS1(1), IGSF5(2), INADL(2), KRAS(38), LLGL2(2), MAGI1(3), MAGI2(5), MAGI3(2), MLLT4(3), MPDZ(4), MYH1(7), MYH10(2), MYH11(6), MYH13(5), MYH14(3), MYH15(4), MYH2(3), MYH3(5), MYH4(1), MYH6(4), MYH7(4), MYH7B(2), MYH8(3), MYH9(3), MYL9(2), NRAS(5), PARD3(2), PARD6A(2), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(2), PPP2R2C(1), PPP2R3A(2), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PTEN(4), RHOA(1), RRAS2(1), SPTAN1(4), TJAP1(1), TJP1(2), ZAK(2) 18256670 201 53 169 54 59 97 20 0 24 1 0.0678 1.000 1.000 539 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(4), ADCY2(3), ADCY3(1), ADCY7(1), ADCY8(1), ADCY9(2), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), ATP2B4(3), AVPR1A(1), BDKRB2(1), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1F(2), CACNA1I(2), CACNA1S(4), CAMK2D(1), CAMK4(1), CCKAR(1), CCKBR(2), CD38(1), CHRM2(3), CHRM5(1), CHRNA7(1), CYSLTR2(1), EDNRB(5), EGFR(1), ERBB2(4), ERBB3(3), ERBB4(5), GNA14(1), GNAL(1), GNAQ(1), GRIN2A(6), GRIN2C(2), GRIN2D(2), GRM1(3), GRM5(3), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), ITPR1(8), ITPR2(6), ITPR3(1), MYLK(3), MYLK2(1), NOS1(6), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), PDE1A(1), PDE1B(1), PDE1C(2), PDGFRA(4), PDGFRB(1), PHKA1(4), PHKA2(1), PHKB(2), PHKG2(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACA(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGER3(1), PTGFR(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A2(1), SLC8A3(3), SPHK1(1), TACR3(3), TRHR(2), TRPC1(1) 24478667 229 48 227 83 91 88 27 1 20 2 0.263 1.000 1.000 540 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(1), ADORA1(3), ADORA2A(2), ADRA1B(1), ADRA2B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CRHR1(1), CRHR2(1), CTSG(1), CYSLTR2(1), DRD2(2), DRD5(4), EDNRB(5), F2(1), F2RL1(1), F2RL2(1), FSHB(1), FSHR(1), GABBR1(2), GABBR2(4), GABRA1(2), GABRA2(3), GABRA3(1), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB2(3), GABRB3(4), GABRG1(2), GABRG2(3), GABRP(2), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(2), GRIA1(1), GRIA2(3), GRIA3(3), GRIA4(7), GRID1(1), GRID2(2), GRIK2(4), GRIK3(4), GRIK4(1), GRIK5(1), GRIN2A(6), GRIN2B(2), GRIN2C(2), GRIN2D(2), GRIN3A(3), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM6(1), GRM7(4), GRM8(2), GZMA(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LEPR(4), LTB4R(1), MAS1(1), MC2R(3), MC4R(1), MC5R(2), MCHR2(1), NMUR2(3), NPFFR2(1), NPY5R(1), NR3C1(1), NTSR2(1), OPRM1(2), OXTR(1), P2RX2(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(1), P2RY14(2), P2RY2(1), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PTGDR(1), PTGER3(1), PTGFR(1), PTH2R(1), RXFP1(1), RXFP2(2), SSTR1(1), SSTR2(1), SSTR4(2), TAAR1(1), TAAR5(1), TAAR6(3), TAAR8(1), TAAR9(2), TACR3(3), TRHR(2), TRPV1(1), TSHB(1), TSHR(1), VIPR1(1) 21117924 247 45 246 98 94 92 39 3 18 1 0.408 1.000 1.000 541 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTN1(2), ACTN2(1), ACTN3(1), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(3), BIRC2(2), BIRC3(5), BRAF(2), CAPN2(1), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), CTNNB1(4), DOCK1(2), EGFR(1), ERBB2(4), FIGF(2), FLNA(1), FLNB(2), FLNC(2), FLT1(3), FN1(4), FYN(1), GRB2(1), GRLF1(5), GSK3B(1), HGF(3), IGF1R(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), KDR(2), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), MAP2K1(1), MAPK10(4), MAPK3(1), MAPK8(5), MAPK9(2), MET(1), MYL9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PDGFC(1), PDGFRA(4), PDGFRB(1), PGF(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PIP5K1C(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(2), PRKCG(2), PTEN(4), RAF1(2), RAP1A(1), RAPGEF1(2), RELN(9), RHOA(1), ROCK1(7), ROCK2(4), SHC2(1), SOS1(2), SOS2(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TLN1(2), TLN2(3), TNC(3), TNN(2), TNR(2), TNXB(3), VAV1(2), VAV2(2), VAV3(2), VCL(1), VEGFC(3), VTN(3), VWF(5), ZYX(1) 35447113 303 44 301 114 108 105 45 4 38 3 0.572 1.000 1.000 542 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADRA1B(1), ADRB1(1), ANXA6(1), ATP1A4(2), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(4), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(4), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(3), CHRM2(3), CHRM4(1), CHRM5(1), GJA1(4), GJB3(1), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), ITPR1(8), ITPR2(6), ITPR3(1), KCNB1(3), KCNJ5(1), MIB1(3), MYCBP(1), NME7(2), PLCB3(1), PLN(1), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(1), PRKD1(5), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), SLC8A3(3), USP5(1), YWHAH(1) 16877394 174 36 174 62 67 73 17 0 16 1 0.282 1.000 1.000 543 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ATF1(1), ATF2(1), ATF4(1), ATP2A2(1), ATP2A3(1), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(1), DGKZ(1), ETS2(1), FOS(1), GABPB2(1), GJA1(4), GNAQ(1), GNG4(1), GNGT1(1), GRK5(1), GUCY1A3(5), IGFBP3(2), IL1B(1), IL6(1), ITPR1(8), ITPR2(6), ITPR3(1), MIB1(3), MYL4(1), MYLK2(1), NFKB1(3), NOS1(6), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(4), PRKACA(1), PRKAR1A(4), PRKAR2B(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(1), PRKD1(5), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(2), RGS4(1), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(6), RYR2(11), RYR3(11), SLC8A1(2), TNXB(3), USP5(1), YWHAH(1) 15657718 158 36 158 47 56 71 11 1 18 1 0.0683 1.000 1.000 544 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(3), ADORA2A(2), ADRA1B(1), ADRB1(1), AGTR1(2), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(2), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(1), CHRM2(3), CHRM4(1), CHRM5(1), CNR1(2), CX3CR1(1), CXCR4(1), DRD2(2), DRD5(4), EDNRB(5), F2RL1(1), F2RL2(1), FSHR(1), GALR1(1), GPR174(1), GPR37(1), GPR6(1), GPR63(2), GPR77(1), GPR87(1), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MAS1(1), MC4R(1), MC5R(2), NMUR2(3), NPY5R(1), NTSR2(1), OPRM1(2), OR12D3(3), OR1C1(2), OR2H1(2), OR5V1(1), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY14(2), P2RY2(1), P2RY6(1), PPYR1(3), PTGDR(1), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(1), SSTR4(2), SUCNR1(2), TRHR(2) 11332289 127 34 127 42 45 50 24 2 6 0 0.0726 1.000 1.000 545 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADCY9(2), ADSS(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), DCK(1), ENPP3(1), ENTPD5(1), ENTPD6(1), GMPR(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NME6(1), NME7(2), NPR2(1), NT5C1B(1), NT5C2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(5), PDE11A(1), PDE1A(1), PDE1C(2), PDE3B(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE7B(1), PDE8B(1), PDE9A(1), PNPT1(5), POLA1(3), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(5), POLR3K(1), PPAT(3), PRIM2(3), PRPS1(1), PRUNE(1), RFC5(1), RRM1(1) 15964960 128 34 126 38 40 49 16 0 23 0 0.204 1.000 1.000 546 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 CHAD(1), COL11A1(6), COL11A2(1), COL17A1(2), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DSC1(1), DSC3(1), DSG1(2), DSG4(4), FN1(4), GJA1(4), GJA10(4), GJA8(1), GJA9(1), GJB3(1), GJB7(1), GJC3(1), GJD2(1), ITGA6(1), ITGB4(1), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT20(1), KRT24(2), KRT27(1), KRT3(1), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT5(1), KRT6A(1), KRT7(2), KRT73(2), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT82(2), KRT84(4), KRT85(1), KRT9(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), LMNB1(2), NES(1), PRPH(1), RELN(9), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VIM(1), VTN(3), VWF(5) 23567280 182 33 182 88 71 66 21 3 20 1 0.967 1.000 1.000 547 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 CHAD(1), COL11A1(6), COL11A2(1), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(1), COL4A4(2), COL5A1(2), COL5A2(3), COL5A3(5), COL6A2(1), COL6A3(12), COL6A6(5), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), GP5(1), GP6(1), HMMR(2), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), LAMA1(2), LAMA2(3), LAMA3(6), LAMA4(2), LAMB2(3), LAMB4(4), LAMC1(4), LAMC2(3), LAMC3(2), RELN(9), SDC1(1), SDC2(1), SDC3(1), SV2A(1), SV2B(2), THBS1(2), THBS2(5), THBS3(1), THBS4(1), TNC(3), TNN(2), TNR(2), TNXB(3), VTN(3), VWF(5) 21583967 163 30 163 73 56 61 20 4 21 1 0.915 1.000 1.000 548 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 146 AKT2(1), AKT3(1), CBL(3), CBLB(2), CREBBP(4), CSF3R(1), EP300(2), GH1(1), GH2(2), GRB2(1), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL13RA2(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(1), JAK2(3), JAK3(2), LEPR(4), LIFR(5), MPL(1), OSMR(2), PIAS1(1), PIAS2(1), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIK3R1(5), PIK3R3(4), PRL(1), PRLR(2), PTPN11(3), SOCS2(1), SOCS4(1), SOCS5(2), SOS1(2), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT2(2), STAT4(3), STAT5B(1), TPO(3) 13749953 113 30 113 39 28 51 16 1 14 3 0.646 1.000 1.000 549 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(1), ACVR1B(2), ACVR2A(1), ACVR2B(1), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL18(1), CCL22(1), CCR3(1), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(2), EGFR(1), FAS(2), FLT1(3), FLT3(2), FLT4(1), GDF5(1), GH1(1), GH2(2), HGF(3), IFNA10(2), IFNA2(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(1), IL2(1), IL20(1), IL20RA(1), IL21R(2), IL23R(1), IL2RB(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(2), INHBC(1), INHBE(1), KDR(2), KIT(2), LEPR(4), LIFR(5), LTBR(1), MET(1), MPL(1), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF13B(1), TPO(3), VEGFC(3), XCR1(1) 17050706 148 28 148 46 36 63 26 1 21 1 0.275 1.000 1.000 550 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT3(1), CAPN11(1), CAPN2(1), CAPN6(1), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(1), GIT2(1), GRB2(1), ITGA10(4), ITGA11(2), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(1), ITGB3(2), ITGB4(1), ITGB5(1), ITGB8(1), MAP2K1(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), RAPGEF1(2), RHO(1), ROCK1(7), ROCK2(4), SEPP1(1), SORBS1(4), SOS1(2), TLN1(2), TNS1(3), VAV2(2), VAV3(2), VCL(1), ZYX(1) 12696202 105 27 105 32 29 43 16 4 13 0 0.231 1.000 1.000 551 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(1), ACTN3(1), ACTN4(1), DMD(11), FAM48A(2), MYBPC1(2), MYBPC3(1), MYH3(5), MYH6(4), MYH7(4), MYH8(3), MYL4(1), MYL9(2), MYOM1(4), NEB(16), TMOD1(1), TPM2(1), TPM3(1), TPM4(1), TTN(87), VIM(1) 10234902 151 26 151 41 45 63 30 0 11 2 0.180 1.000 1.000 552 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(4), ADCY2(3), ADCY3(1), ADCY5(3), ADCY7(1), ADCY8(1), ADSS(1), AK2(1), AK5(1), ALLC(2), AMPD1(2), AMPD2(1), AMPD3(1), ATP5A1(3), ATP5C1(2), DCK(1), ENPP3(1), GUCY1A2(4), GUCY1A3(5), GUCY1B3(2), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(3), NPR2(1), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE6C(2), PDE7B(1), PDE9A(1), POLB(2), POLE(4), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2B(3), POLR2K(1), PPAT(3), PRPS1(1), PRUNE(1), RRM1(1) 12395536 96 24 95 31 31 34 15 0 16 0 0.378 1.000 1.000 553 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ARHGEF6(3), BRAF(2), CAV1(1), CDC42(1), DOCK1(2), EPHB2(1), FYN(1), GRB2(1), GRLF1(5), ITGA10(4), ITGA11(2), ITGA2(1), ITGA4(5), ITGA6(1), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K4(2), MAPK10(4), MAPK8(5), MAPK8IP3(1), MAPK9(2), MYLK(3), MYLK2(1), PAK1(1), PAK2(1), PAK3(2), PAK7(3), PIK3CA(7), PLCG2(4), PTEN(4), RAF1(2), RALA(1), RHO(1), ROCK1(7), ROCK2(4), SOS1(2), SOS2(2), TERF2IP(1), TLN1(2), TLN2(3), ZYX(1) 11697774 109 24 109 37 35 33 20 3 18 0 0.460 1.000 1.000 554 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(2), ALG1(1), ALG10B(3), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B3GNT7(2), B4GALT1(1), B4GALT3(1), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST4(2), DPAGT1(1), EXT1(1), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT14(1), GALNT2(1), GALNT5(4), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), NDST1(1), NDST3(3), OGT(1), RPN2(1), ST6GALNAC1(1), STT3B(2), WBSCR17(2), XYLT1(2) 10519954 79 23 79 31 22 30 17 2 8 0 0.718 1.000 1.000 555 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(3), CD1A(1), CD1B(1), CD1C(1), CD1D(1), CD1E(1), CD22(2), CD33(1), CD38(1), CD5(2), CD55(1), CR1(3), CR2(2), CSF1(1), CSF3R(1), DNTT(2), FLT3(2), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(4), IL5RA(2), IL6(1), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA4(5), ITGA6(1), ITGAM(3), ITGB3(2), KIT(2), MME(4), TFRC(1), THPO(1), TPO(3) 7606253 67 18 67 27 22 31 10 1 3 0 0.689 1.000 1.000 556 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(2), INPPL1(1), OCRL(4), PIK3C2A(3), PIK3C2B(5), PIK3C2G(2), PIK3CA(7), PIK3CG(2), PLCB3(1), PLCB4(1), PLCD1(1), PLCG2(4) 4246537 34 18 34 11 10 13 8 0 3 0 0.611 1.000 1.000 557 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 CCKBR(2), CCR3(1), CELSR2(1), CHRM2(3), EMR2(4), EMR3(1), FSHR(1), GPR116(4), GPR133(1), GPR18(2), GPR56(1), GPR77(1), GPR84(3), GRM1(3), LPHN2(3), LPHN3(7), PTGFR(1), SMO(1), SSTR2(1), TAAR5(1), TSHR(1) 6041522 43 16 43 23 18 14 8 1 2 0 0.912 1.000 1.000 558 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(2), INPPL1(1), MINPP1(1), OCRL(4), PI4KA(4), PIK3C3(2), PIK3CA(7), PIK3CD(1), PIK3CG(2), PIP5K1B(1), PIP5K1C(1), PLCB3(1), PLCB4(1), PLCD1(1), PLCE1(2), PLCG2(4), PLCZ1(1), PTEN(4), SYNJ1(3), SYNJ2(1) 7069394 45 16 45 16 10 20 8 0 7 0 0.635 1.000 1.000 559 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ASPA(2), HAL(1), HARS2(2), HDC(5), LCMT1(2), MAOA(1), MAOB(1), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(1), PRMT8(2), PRPS1(1), UROC1(2) 3736053 32 15 32 13 11 13 3 1 4 0 0.627 1.000 1.000 560 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC4(3), ANAPC5(1), BTRC(3), CDC16(1), CDC27(4), CUL1(1), CUL2(1), FBXW11(1), FBXW7(12), RBX1(1), SMURF1(2), UBA1(1), UBE2D3(1), UBE2E2(1), VHL(1), WWP1(3) 3980748 38 15 36 12 14 11 7 0 6 0 0.555 1.000 1.000 561 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(1), ADCY8(1), CACNA1A(9), CACNA1B(4), GNAT3(1), ITPR3(1), KCNB1(3), PDE1A(1), PRKACA(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(3), TAS2R14(1), TAS2R16(2), TAS2R38(1), TAS2R39(1), TAS2R4(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2) 5060253 48 15 48 21 23 14 9 0 2 0 0.754 1.000 1.000 562 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(4), IGF1R(1), KIT(2), PIK3CA(7), PIK3R1(5), PRKACG(1), PRKAR1A(4), PRKAR2B(1), YWHAH(1) 2003770 26 14 26 11 9 9 4 0 2 2 0.709 1.000 1.000 563 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(1), CHKA(2), CLC(1), DGKB(2), DGKD(3), DGKE(2), DGKH(5), DGKZ(1), GNPAT(1), GPD2(1), PAFAH2(1), PCYT1A(1), PISD(2), PLA2G4A(3), PLA2G6(2), PLCG2(4) 4841774 38 14 38 14 18 7 7 0 6 0 0.615 1.000 1.000 564 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ACMSD(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2F1(1), CYP3A7(2), CYP4B1(1), GCDH(2), HADHA(1), KMO(2), KYNU(1), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS(1), WARS2(1) 5278149 45 14 45 18 11 19 10 0 5 0 0.804 1.000 1.000 565 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PLCG2(4), SARDH(1), SARS(1), SHMT1(1), TARS(3) 4044169 32 13 32 13 14 12 3 0 3 0 0.694 1.000 1.000 566 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ALAS1(1), ALAS2(1), BHMT(2), CBS(1), CHDH(1), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(1), MAOB(1), PISD(2), PSAT1(1), RDH11(1), RDH12(1), SARDH(1), SARS(1), SHMT1(1), TARS(3), TARS2(1) 4156240 32 12 32 14 13 14 3 0 2 0 0.773 1.000 1.000 567 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH3B1(1), AOX1(3), DBH(1), DCT(4), FAH(1), GOT1(1), HGD(1), HPD(1), MAOA(1), MAOB(1), TAT(2), TPO(3), TYR(1) 2984843 28 12 28 12 4 16 3 0 5 0 0.736 1.000 1.000 568 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), UPB1(2) 2845953 22 11 22 12 6 8 2 0 6 0 0.915 1.000 1.000 569 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5B(1), GPRC5C(1), GRM1(3), GRM2(1), GRM3(2), GRM5(3), GRM7(4), GRM8(2) 1976045 21 11 21 11 6 10 2 0 3 0 0.800 1.000 1.000 570 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1) 4670913 34 10 34 17 11 12 7 0 4 0 0.872 1.000 1.000 571 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGM1(2), PGM3(1) 4670913 34 10 34 17 11 12 7 0 4 0 0.872 1.000 1.000 572 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ALDH7A1(2), ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GPI(1), HK3(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1), PGM1(2), PGM3(1) 5509680 40 10 40 18 11 17 8 0 4 0 0.794 1.000 1.000 573 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(1), CLYBL(1), DLD(1), DLST(1), IDH3A(3), OGDHL(3), PC(3), PCK1(3), SDHA(1), SUCLA2(2), SUCLG1(1) 2866536 20 10 20 11 4 8 5 0 3 0 0.949 1.000 1.000 574 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(2), ALDH3B1(1), EPX(1), ESCO1(4), ESCO2(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), MYST3(5), MYST4(5), SH3GLB1(1), TAT(2), TPO(3) 3288373 32 10 32 12 10 14 5 0 3 0 0.664 1.000 1.000 575 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DPYD(6), DPYS(1), GAD1(2), HADHA(1), HIBCH(1), UPB1(2) 2640521 22 10 22 11 5 9 2 0 6 0 0.873 1.000 1.000 576 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B4GALNT1(1), B4GALT1(1), B4GALT3(1), FUT1(3), FUT3(1), FUT9(1), GCNT2(2), PIGB(1), PIGG(2), PIGK(1), PIGM(2), PIGN(1), PIGO(1), PIGT(1), PIGU(1), PIGV(2), PIGX(2), ST3GAL6(3), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(2) 4612564 38 10 38 14 12 17 6 1 2 0 0.565 1.000 1.000 577 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP3(1), CRADD(1), DFFA(1), LMNB1(2), MADD(1), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(5), PAK1(1), PAK2(1), PRKDC(5), RB1(3), SPTAN1(4) 3602566 31 10 31 10 10 6 7 1 7 0 0.591 1.000 1.000 578 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(2), F2(1), F5(7), F7(1), F8(3), FGA(2), FGB(1), LPA(1), PLAT(1), PLAU(1), PLG(2), SERPINB2(1), SERPINE1(2), VWF(5) 3436522 30 9 30 13 10 13 4 0 3 0 0.788 1.000 1.000 579 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH3B1(1), ASPA(2), HAL(1), HDC(5), MAOA(1), MAOB(1), PRPS1(1) 2349283 17 9 17 12 5 8 2 0 2 0 0.970 1.000 1.000 580 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), HADHB(1), RDH11(1), RDH12(1), SLC27A5(1), SRD5A2(1) 3050293 22 9 22 13 4 11 5 0 2 0 0.932 1.000 1.000 581 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(1), ACOT12(3), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHAL6A(1), LDHAL6B(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2) 4590685 37 9 37 14 10 16 4 1 6 0 0.661 1.000 1.000 582 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(1), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACG(1), PRKG1(5), PRKG2(2) 3038134 26 9 26 11 6 14 4 0 2 0 0.731 1.000 1.000 583 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRB1(1), CHRM2(3), CHRM4(1), CHRM5(1), DRD2(2), DRD5(4), HTR1A(2), HTR1B(2), HTR1E(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(3), HTR7(1) 2389658 27 9 27 14 13 9 3 1 1 0 0.689 1.000 1.000 584 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACYP1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(1), LDHB(2), ME1(2), ME3(1), PC(3), PCK1(3), PDHA1(1), PDHA2(2) 3593356 29 9 29 15 10 11 3 1 4 0 0.918 1.000 1.000 585 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2A1(3), CASP3(1), CASP4(2), CASP6(1), CD40(1), CRADD(1), DAXX(1), DFFA(1), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(1), PTPN13(9), TRAF1(1), TRAF3(2) 4150448 32 8 32 13 7 12 7 0 6 0 0.791 1.000 1.000 586 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), DLAT(1), DLD(1), ENO3(1), FBP2(1), G6PC(1), GCK(1), GOT1(1), GPI(1), HK3(1), LDHA(1), LDHAL6B(1), LDHB(2), PC(3), PCK1(3), PDHA1(1), PDHA2(2), PFKM(3), PGK2(1) 4052089 28 8 28 17 9 12 3 0 4 0 0.943 1.000 1.000 587 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(3), ACOX3(2), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), CPT1A(1), CPT2(1), CYP4A11(1), GCDH(2), HADHA(1), HADHB(1), HSD17B10(1) 4722049 28 8 28 13 5 12 4 1 6 0 0.840 1.000 1.000 588 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(1), DHDDS(1), DPAGT1(1), FUT8(1), MAN1A1(1), MAN1C1(3), MAN2A1(4), MGAT1(1), RPN2(1), STT3B(2) 4022193 25 8 25 11 7 9 5 0 4 0 0.786 1.000 1.000 589 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(1), DLD(1), DLST(1), IDH3A(3), PC(3), PDHA1(1), PDHA2(2), PDK1(2), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SUCLA2(2), SUCLG1(1) 2746170 22 8 22 11 7 8 4 0 3 0 0.911 1.000 1.000 590 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3B1(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), TAT(2), TPO(3) 2081296 17 8 17 10 6 8 0 0 3 0 0.872 1.000 1.000 591 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(1), ADH6(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), HADHB(1), SRD5A2(1) 2249790 15 7 15 12 2 7 4 0 2 0 0.984 1.000 1.000 592 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ADSS(1), ASL(2), ASPA(2), ASS1(1), CAD(1), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GOT1(1), NARS(1), NARS2(3), PC(3), PDHA1(1), PDHA2(2) 3686789 25 7 25 15 12 7 4 0 2 0 0.959 1.000 1.000 593 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), EPX(1), LPO(1), MPO(2), MTHFR(1), SHMT1(1), TPO(3) 1074331 10 7 10 6 6 3 1 0 0 0 0.874 1.000 1.000 594 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), FBP2(1), GOT1(1), ME1(2), ME3(1), PGK2(1), TKTL1(1), TKTL2(2) 1933205 11 7 11 11 6 3 1 0 1 0 0.989 1.000 1.000 595 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSS(1), ASL(2), ASPA(2), CAD(1), DARS(1), GAD1(2), GOT1(1), NARS(1), PC(3) 2531474 15 6 15 11 7 5 2 0 1 0 0.972 1.000 1.000 596 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH7A1(2), DDHD1(2), GAD1(2), HADHA(1), HMGCL(1), HMGCS2(1), HSD17B10(1), PDHA1(1), PDHA2(2), RDH11(1), RDH12(1) 4013313 23 6 23 15 8 8 3 0 4 0 0.968 1.000 1.000 597 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), GAD1(2), HADHA(1), HMGCL(1), PDHA1(1), PDHA2(2) 2563642 13 5 13 11 5 4 2 0 2 0 0.988 1.000 1.000 598 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), DDX20(1), ETS1(1), ETS2(1), ETV3(1), FOS(1), HDAC5(1), RBL1(2), SIN3A(6), SIN3B(1) 2546507 16 5 16 9 7 7 2 0 0 0 0.891 1.000 1.000 599 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), LPO(1), MPO(2), TPO(3) 763972 7 5 7 4 5 2 0 0 0 0 0.819 1.000 1.000 600 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(4), EP300(2), ERCC3(1), GRIP1(1), GTF2F1(2), HDAC5(1), HDAC6(2), MEF2C(2), NR0B1(1), NRIP1(1) 4475662 18 4 18 8 7 10 1 0 0 0 0.726 1.000 1.000 601 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1) 1861431 11 4 11 5 5 4 2 0 0 0 0.756 1.000 1.000 602 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(2) 1797401 6 4 6 6 2 1 3 0 0 0 0.986 1.000 1.000 603 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 SDHA(1), SUCLA2(2) 892444 3 3 3 4 0 3 0 0 0 0 0.990 1.000 1.000 604 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 CES1(1), ESD(1) 548943 2 2 2 5 0 2 0 0 0 0 0.998 1.000 1.000 605 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST6GALNAC2(1), ST6GALNAC4(1) 540652 2 2 2 2 0 2 0 0 0 0 0.917 1.000 1.000 606 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(1), HMGCS2(1) 722287 2 2 2 2 2 0 0 0 0 0 0.913 1.000 1.000 607 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(1), GAD1(2) 537660 3 2 3 3 1 2 0 0 0 0 0.954 1.000 1.000 608 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1) 567717 2 2 2 3 2 0 0 0 0 0 0.983 1.000 1.000 609 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CSNK1D(1), GSK3B(1), MAPT(1) 803493 4 2 4 4 3 1 0 0 0 0 0.949 1.000 1.000 610 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25C(1), XPO1(1) 878710 2 2 2 2 1 1 0 0 0 0 0.963 1.000 1.000 611 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 PDE1A(1), PDE1B(1), PRL(1), TRH(1) 1109175 4 2 4 3 1 3 0 0 0 0 0.918 1.000 1.000 612 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(1), IL2(1), IL6(1), IL7(1), IL8(1), IL9(1) 614059 6 2 6 4 2 4 0 0 0 0 0.918 1.000 1.000 613 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 GPI(1) 867282 1 1 1 4 0 0 1 0 0 0 0.998 1.000 1.000 614 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT1(1) 462794 1 1 1 2 0 1 0 0 0 0 0.978 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 52175 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 118540 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000