Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.013 0.098 -9999.0 0.0 -0.494 3.0 3.0 IHH 0.021 0.074 -9999.0 0.0 -0.419 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.06 0.132 0.179 2.0 -0.239 52.0 54.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.059 0.131 0.238 52.0 -0.177 2.0 54.0 SMO/beta Arrestin2 0.023 0.082 -9999.0 0.0 -0.403 2.0 2.0 SMO 0.006 0.074 -9999.0 0.0 -0.432 2.0 2.0 AKT1 0.002 0.103 -9999.0 0.0 -0.424 3.0 3.0 ARRB2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.067 -9999.0 0.0 -0.357 5.0 5.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.007 0.074 -9999.0 0.0 -0.426 2.0 2.0 STIL -0.017 0.114 0.317 2.0 -0.346 2.0 4.0 DHH N/PTCH2 0.023 0.072 -9999.0 0.0 -0.273 9.0 9.0 DHH N/PTCH1 0.025 0.078 -9999.0 0.0 -0.356 2.0 2.0 PIK3CA 0.026 0.03 -9999.0 0.0 -0.357 1.0 1.0 DHH 0.01 0.073 -9999.0 0.0 -0.357 6.0 6.0 PTHLH 0.006 0.118 -9999.0 0.0 -0.71 3.0 3.0 determination of left/right symmetry 0.007 0.074 -9999.0 0.0 -0.426 2.0 2.0 PIK3R1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.006 0.117 -9999.0 0.0 -0.703 3.0 3.0 IHH N/Hhip -0.001 0.113 -9999.0 0.0 -0.291 20.0 20.0 DHH N/Hhip -0.004 0.103 -9999.0 0.0 -0.249 24.0 24.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.007 0.074 -9999.0 0.0 -0.426 2.0 2.0 pancreas development -0.017 0.121 -9999.0 0.0 -0.356 18.0 18.0 HHAT 0.025 0.03 -9999.0 0.0 -0.357 1.0 1.0 PI3K 0.037 0.025 -9999.0 0.0 -0.25 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.047 0.153 -9999.0 0.0 -0.36 31.0 31.0 somite specification 0.007 0.074 -9999.0 0.0 -0.426 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.02 0.108 -9999.0 0.0 -0.36 2.0 2.0 SHH Np/Cholesterol/PTCH2 -0.026 0.11 0.179 2.0 -0.243 32.0 34.0 SHH Np/Cholesterol/Megalin -0.046 0.131 0.172 2.0 -0.267 39.0 41.0 SHH -0.041 0.138 0.347 3.0 -0.316 29.0 32.0 catabolic process 0.02 0.071 -9999.0 0.0 -0.361 3.0 3.0 SMO/Vitamin D3 -0.018 0.104 -9999.0 0.0 -0.353 3.0 3.0 SHH Np/Cholesterol/Hhip -0.045 0.121 0.179 2.0 -0.238 42.0 44.0 LRP2 -0.038 0.132 -9999.0 0.0 -0.443 15.0 15.0 receptor-mediated endocytosis -0.032 0.111 -9999.0 0.0 -0.374 5.0 5.0 SHH Np/Cholesterol/BOC -0.028 0.109 0.179 2.0 -0.236 33.0 35.0 SHH Np/Cholesterol/CDO -0.021 0.105 0.179 2.0 -0.242 29.0 31.0 mesenchymal cell differentiation 0.045 0.121 0.237 42.0 -0.177 2.0 44.0 mol:Vitamin D3 -0.013 0.118 0.355 1.0 -0.361 2.0 3.0 IHH N/PTCH2 0.028 0.071 -9999.0 0.0 -0.288 7.0 7.0 CDON 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.029 0.073 -9999.0 0.0 -0.364 3.0 3.0 Megalin/LRPAP1 0.003 0.103 -9999.0 0.0 -0.318 15.0 15.0 PTCH2 0.019 0.064 -9999.0 0.0 -0.443 3.0 3.0 SHH Np/Cholesterol -0.031 0.098 -9999.0 0.0 -0.24 29.0 29.0 PTCH1 0.02 0.071 -9999.0 0.0 -0.362 3.0 3.0 HHIP -0.017 0.121 -9999.0 0.0 -0.357 18.0 18.0