Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.06 0.036 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.213 0.154 -9999.0 0.0 -0.304 50.0 50.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.212 0.153 0.302 50.0 -9999.0 0.0 50.0 SMO/beta Arrestin2 0.059 0.044 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.051 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.035 0.158 -9999.0 0.0 -0.545 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 STIL -0.064 0.14 -9999.0 0.0 -0.459 1.0 1.0 DHH N/PTCH2 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.052 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.06 0.051 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.06 0.051 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.077 0.193 -9999.0 0.0 -0.428 16.0 16.0 DHH N/Hhip -0.074 0.173 -9999.0 0.0 -0.389 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.116 0.236 -9999.0 0.0 -0.544 16.0 16.0 HHAT 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.391 0.25 -9999.0 0.0 -0.545 50.0 50.0 somite specification 0.054 0.046 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.047 0.05 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.017 0.05 -9999.0 0.0 -0.274 2.0 2.0 SHH Np/Cholesterol/Megalin 0.012 0.061 -9999.0 0.0 -0.274 3.0 3.0 SHH 0.012 0.066 -9999.0 0.0 -0.367 2.0 2.0 catabolic process 0.05 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.054 0.051 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.056 0.155 -9999.0 0.0 -0.327 16.0 16.0 LRP2 0.006 0.064 -9999.0 0.0 -0.519 1.0 1.0 receptor-mediated endocytosis 0.058 0.05 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC -0.01 0.122 -9999.0 0.0 -0.384 6.0 6.0 SHH Np/Cholesterol/CDO -0.001 0.1 -9999.0 0.0 -0.344 5.0 5.0 mesenchymal cell differentiation 0.056 0.154 0.325 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 0.05 0.05 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDON -0.018 0.131 -9999.0 0.0 -0.545 4.0 4.0 IHH N/PTCH1 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.015 0.046 -9999.0 0.0 -0.367 1.0 1.0 PTCH2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.008 0.047 -9999.0 0.0 -0.282 2.0 2.0 PTCH1 0.05 0.024 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.116 0.236 -9999.0 0.0 -0.545 16.0 16.0