Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.041 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.149 0.122 -9999.0 0.0 -0.235 46.0 46.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.148 0.122 0.234 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.047 0.053 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.002 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.006 0.127 -9999.0 0.0 -0.419 6.0 6.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.0 0.075 0.353 1.0 -9999.0 0.0 1.0 DHH N/PTCH2 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.052 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.031 0.158 -9999.0 0.0 -0.331 15.0 15.0 DHH N/Hhip -0.03 0.143 -9999.0 0.0 -0.301 15.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.065 0.186 -9999.0 0.0 -0.418 15.0 15.0 HHAT 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.295 0.202 -9999.0 0.0 -0.419 50.0 50.0 somite specification 0.028 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.032 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.025 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.024 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.016 0.016 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.029 0.033 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.03 0.111 -9999.0 0.0 -0.24 15.0 15.0 LRP2 0.03 0.023 -9999.0 0.0 -0.157 1.0 1.0 receptor-mediated endocytosis 0.024 0.028 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.008 0.075 -9999.0 0.0 -0.257 5.0 5.0 SHH Np/Cholesterol/CDO 0.017 0.049 -9999.0 0.0 -0.232 2.0 2.0 mesenchymal cell differentiation 0.03 0.111 0.239 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 0.043 0.059 0.375 1.0 -9999.0 0.0 1.0 IHH N/PTCH2 0.053 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.076 -9999.0 0.0 -0.419 2.0 2.0 IHH N/PTCH1 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.066 0.186 -9999.0 0.0 -0.419 15.0 15.0