E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.029 0.131 -9999.0 0.0 -0.39 19.0 19.0 KLHL20 -0.012 0.08 -9999.0 0.0 -0.173 20.0 20.0 CYFIP2 -0.032 0.117 -9999.0 0.0 -0.301 24.0 24.0 Rac1/GDP -0.002 0.083 -9999.0 0.0 -0.219 19.0 19.0 ENAH -0.032 0.132 -9999.0 0.0 -0.381 20.0 20.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.023 -9999.0 0.0 -0.202 2.0 2.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.023 0.046 -9999.0 0.0 -0.203 1.0 1.0 ABI1/Sra1/Nap1 -0.032 0.051 -9999.0 0.0 -0.143 19.0 19.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.032 0.088 -9999.0 0.0 -0.214 23.0 23.0 RAPGEF1 -0.019 0.116 -9999.0 0.0 -0.335 19.0 19.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.135 -9999.0 0.0 -0.405 19.0 19.0 CRK -0.026 0.125 -9999.0 0.0 -0.364 19.0 19.0 E-cadherin/gamma catenin/alpha catenin -0.04 0.093 -9999.0 0.0 -0.236 23.0 23.0 alphaE/beta7 Integrin 0.005 0.052 -9999.0 0.0 -0.288 3.0 3.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.022 -9999.0 0.0 -0.212 1.0 1.0 DLG1 -0.029 0.131 -9999.0 0.0 -0.39 19.0 19.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.034 -9999.0 0.0 -0.145 1.0 1.0 MLLT4 0.01 0.033 -9999.0 0.0 -0.418 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.011 0.054 -9999.0 0.0 -0.213 9.0 9.0 PI3K -0.021 0.043 -9999.0 0.0 -0.183 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.058 0.11 -9999.0 0.0 -0.288 23.0 23.0 TIAM1 -0.012 0.098 -9999.0 0.0 -0.397 10.0 10.0 E-cadherin(dimer)/Ca2+ -0.021 0.076 -9999.0 0.0 -0.194 19.0 19.0 AKT1 -0.01 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.011 0.017 -9999.0 0.0 -0.202 1.0 1.0 CDH1 -0.088 0.148 -9999.0 0.0 -0.272 59.0 59.0 RhoA/GDP -0.001 0.083 -9999.0 0.0 -0.219 19.0 19.0 actin cytoskeleton organization -0.007 0.06 -9999.0 0.0 -0.128 20.0 20.0 CDC42/GDP -0.001 0.083 -9999.0 0.0 -0.219 19.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.025 0.076 -9999.0 0.0 -0.205 23.0 23.0 ITGB7 -0.005 0.072 -9999.0 0.0 -0.261 11.0 11.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.022 0.081 -9999.0 0.0 -0.207 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.027 0.075 -9999.0 0.0 -0.199 19.0 19.0 mol:GDP -0.009 0.093 -9999.0 0.0 -0.254 19.0 19.0 CDC42/GTP/IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.002 0.066 -9999.0 0.0 -0.418 4.0 4.0 p120 catenin/RhoA/GDP -0.001 0.084 -9999.0 0.0 -0.222 19.0 19.0 RAC1/GTP/IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.016 0.071 -9999.0 0.0 -0.181 22.0 22.0 NME1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.029 0.131 -9999.0 0.0 -0.39 19.0 19.0 regulation of cell-cell adhesion -0.021 0.041 -9999.0 0.0 -0.18 1.0 1.0 WASF2 -0.015 0.028 -9999.0 0.0 -0.115 1.0 1.0 Rap1/GTP -0.003 0.066 -9999.0 0.0 -0.23 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.029 0.086 -9999.0 0.0 -0.195 27.0 27.0 CCND1 -0.02 0.087 -9999.0 0.0 -0.225 22.0 22.0 VAV2 -0.022 0.125 -9999.0 0.0 -0.36 19.0 19.0 RAP1/GDP -0.002 0.072 -9999.0 0.0 -0.183 19.0 19.0 adherens junction assembly -0.028 0.127 -9999.0 0.0 -0.378 19.0 19.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.024 0.082 -9999.0 0.0 -0.183 26.0 26.0 E-cadherin/beta catenin -0.04 0.099 -9999.0 0.0 -0.305 19.0 19.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.132 -9999.0 0.0 -0.39 19.0 19.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.056 0.103 -9999.0 0.0 -0.272 21.0 21.0 E-cadherin/beta catenin/alpha catenin -0.033 0.088 -9999.0 0.0 -0.235 19.0 19.0 ITGAE 0.01 0.023 -9999.0 0.0 -0.202 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.036 0.137 -9999.0 0.0 -0.414 19.0 19.0