Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.039 0.182 -9999.0 0.0 -0.509 19.0 19.0 IHH -0.01 0.059 -9999.0 0.0 -0.202 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.004 0.064 -9999.0 0.0 -0.233 11.0 11.0 LRPAP1 0.008 0.047 -9999.0 0.0 -0.418 2.0 2.0 dorsoventral neural tube patterning 0.004 0.064 0.232 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.035 0.155 -9999.0 0.0 -0.486 10.0 10.0 SMO -0.044 0.162 -9999.0 0.0 -0.403 19.0 19.0 AKT1 -0.003 0.076 -9999.0 0.0 -0.254 5.0 5.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.023 0.117 -9999.0 0.0 -0.389 15.0 15.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.043 0.16 -9999.0 0.0 -0.397 19.0 19.0 STIL -0.015 0.103 -9999.0 0.0 -0.354 7.0 7.0 DHH N/PTCH2 -0.02 0.103 -9999.0 0.0 -0.307 17.0 17.0 DHH N/PTCH1 -0.028 0.126 -9999.0 0.0 -0.307 21.0 21.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.097 -9999.0 0.0 -0.346 12.0 12.0 PTHLH -0.074 0.28 -9999.0 0.0 -0.826 19.0 19.0 determination of left/right symmetry -0.043 0.16 -9999.0 0.0 -0.397 19.0 19.0 PIK3R1 0.011 0.017 -9999.0 0.0 -0.202 1.0 1.0 skeletal system development -0.072 0.277 -9999.0 0.0 -0.816 19.0 19.0 IHH N/Hhip -0.053 0.109 -9999.0 0.0 -0.245 30.0 30.0 DHH N/Hhip -0.053 0.115 -9999.0 0.0 -0.31 21.0 21.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.16 -9999.0 0.0 -0.397 19.0 19.0 pancreas development -0.066 0.133 -9999.0 0.0 -0.262 47.0 47.0 HHAT 0.004 0.059 -9999.0 0.0 -0.364 4.0 4.0 PI3K 0.018 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.092 -9999.0 0.0 -0.418 8.0 8.0 somite specification -0.043 0.16 -9999.0 0.0 -0.397 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.019 0.109 -9999.0 0.0 -0.276 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.009 0.064 -9999.0 0.0 -0.217 12.0 12.0 SHH Np/Cholesterol/Megalin -0.001 0.044 -9999.0 0.0 -0.209 4.0 4.0 SHH -0.002 0.049 -9999.0 0.0 -0.294 3.0 3.0 catabolic process -0.024 0.125 -9999.0 0.0 -0.327 20.0 20.0 SMO/Vitamin D3 -0.029 0.132 -9999.0 0.0 -0.444 9.0 9.0 SHH Np/Cholesterol/Hhip -0.034 0.079 -9999.0 0.0 -0.222 18.0 18.0 LRP2 -0.002 0.048 -9999.0 0.0 -0.202 9.0 9.0 receptor-mediated endocytosis -0.025 0.129 -9999.0 0.0 -0.405 11.0 11.0 SHH Np/Cholesterol/BOC -0.012 0.076 -9999.0 0.0 -0.236 15.0 15.0 SHH Np/Cholesterol/CDO 0.0 0.051 -9999.0 0.0 -0.212 7.0 7.0 mesenchymal cell differentiation 0.033 0.079 0.221 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.016 0.11 -9999.0 0.0 -0.277 18.0 18.0 IHH N/PTCH2 -0.016 0.091 -9999.0 0.0 -0.279 15.0 15.0 CDON -0.0 0.065 -9999.0 0.0 -0.295 7.0 7.0 IHH N/PTCH1 -0.02 0.127 -9999.0 0.0 -0.329 20.0 20.0 Megalin/LRPAP1 0.005 0.046 -9999.0 0.0 -0.291 2.0 2.0 PTCH2 -0.018 0.103 -9999.0 0.0 -0.332 15.0 15.0 SHH Np/Cholesterol 0.0 0.037 -9999.0 0.0 -0.222 3.0 3.0 PTCH1 -0.024 0.125 -9999.0 0.0 -0.328 20.0 20.0 HHIP -0.066 0.133 -9999.0 0.0 -0.262 47.0 47.0