Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.07 -9999.0 0.0 -0.198 19.0 19.0 epithelial cell differentiation -0.022 0.074 -9999.0 0.0 -0.192 19.0 19.0 CYFIP2 -0.032 0.117 -9999.0 0.0 -0.301 24.0 24.0 ENAH 0.006 0.055 -9999.0 0.0 -0.194 1.0 1.0 EGFR -0.012 0.098 -9999.0 0.0 -0.396 10.0 10.0 EPHA2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.019 0.069 -9999.0 0.0 -0.179 19.0 19.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.001 0.07 -9999.0 0.0 -0.235 11.0 11.0 AQP5 -0.056 0.138 -9999.0 0.0 -0.435 16.0 16.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.018 0.068 -9999.0 0.0 -0.177 19.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.081 -9999.0 0.0 -0.18 32.0 32.0 EGF -0.071 0.155 -9999.0 0.0 -0.332 40.0 40.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.017 0.096 -9999.0 0.0 -0.468 4.0 4.0 cortical microtubule organization -0.022 0.074 -9999.0 0.0 -0.192 19.0 19.0 GO:0000145 -0.019 0.064 -9999.0 0.0 -0.169 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.076 -9999.0 0.0 -0.194 19.0 19.0 MLLT4 0.01 0.033 -9999.0 0.0 -0.418 1.0 1.0 ARF6/GDP -0.027 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.021 0.076 -9999.0 0.0 -0.237 5.0 5.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.069 -9999.0 0.0 -0.179 19.0 19.0 ARF6/GTP 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.088 0.148 -9999.0 0.0 -0.272 59.0 59.0 EGFR/EGFR/EGF/EGF -0.076 0.092 -9999.0 0.0 -0.201 48.0 48.0 RhoA/GDP -0.018 0.069 -9999.0 0.0 -0.178 19.0 19.0 actin cytoskeleton organization -0.014 0.067 -9999.0 0.0 -0.174 19.0 19.0 IGF-1R heterotetramer -0.003 0.077 -9999.0 0.0 -0.356 7.0 7.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.003 0.077 -9999.0 0.0 -0.356 7.0 7.0 IGF1 -0.038 0.125 -9999.0 0.0 -0.31 26.0 26.0 DIAPH1 -0.029 0.139 -9999.0 0.0 -0.549 11.0 11.0 Wnt receptor signaling pathway 0.022 0.074 0.192 19.0 -9999.0 0.0 19.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.027 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.068 -9999.0 0.0 -0.177 19.0 19.0 EFNA1 0.009 0.029 -9999.0 0.0 -0.202 3.0 3.0 LPP -0.031 0.085 -9999.0 0.0 -0.19 28.0 28.0 Ephrin A1/EPHA2 -0.035 0.056 -9999.0 0.0 -0.169 19.0 19.0 SEC6/SEC8 -0.029 0.049 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.033 0.082 -9999.0 0.0 -0.182 32.0 32.0 HGF/MET -0.058 0.083 -9999.0 0.0 -0.204 31.0 31.0 HGF -0.027 0.11 -9999.0 0.0 -0.291 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.07 -9999.0 0.0 -0.199 19.0 19.0 actin cable formation 0.006 0.062 -9999.0 0.0 -0.191 3.0 3.0 KIAA1543 -0.029 0.076 -9999.0 0.0 -0.173 24.0 24.0 KIFC3 -0.02 0.07 -9999.0 0.0 -0.179 20.0 20.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.082 -9999.0 0.0 -0.196 25.0 25.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.022 0.074 -9999.0 0.0 -0.192 19.0 19.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.019 0.069 -9999.0 0.0 -0.179 19.0 19.0 PIP5K1C -0.019 0.069 -9999.0 0.0 -0.179 19.0 19.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.058 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.016 0.075 -9999.0 0.0 -0.24 3.0 3.0 IGF-1R heterotetramer/IGF1 -0.059 0.083 -9999.0 0.0 -0.204 34.0 34.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.024 -9999.0 0.0 -0.288 1.0 1.0 MET -0.013 0.091 -9999.0 0.0 -0.295 14.0 14.0 PLEKHA7 -0.025 0.074 -9999.0 0.0 -0.176 25.0 25.0 mol:GTP 0.03 0.015 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.001 0.063 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.014 0.07 -9999.0 0.0 -0.198 19.0 19.0 regulation of cell-cell adhesion -0.014 0.067 -9999.0 0.0 -0.174 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.07 -9999.0 0.0 -0.199 19.0 19.0