E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.026 0.137 -9999.0 0.0 -0.319 27.0 27.0 KLHL20 -0.008 0.088 0.189 6.0 -0.202 11.0 17.0 CYFIP2 0.006 0.076 -9999.0 0.0 -0.294 10.0 10.0 Rac1/GDP 0.01 0.098 0.257 5.0 -0.226 10.0 15.0 ENAH -0.027 0.138 -9999.0 0.0 -0.321 27.0 27.0 AP1M1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.007 0.057 0.124 4.0 -0.156 11.0 15.0 ABI1/Sra1/Nap1 -0.029 0.044 -9999.0 0.0 -0.136 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.079 -9999.0 0.0 -0.162 18.0 18.0 RAPGEF1 -0.023 0.128 0.22 5.0 -0.284 26.0 31.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.145 -9999.0 0.0 -0.315 31.0 31.0 CRK -0.023 0.128 0.214 1.0 -0.306 24.0 25.0 E-cadherin/gamma catenin/alpha catenin 0.03 0.08 -9999.0 0.0 -0.176 20.0 20.0 alphaE/beta7 Integrin 0.036 0.034 -9999.0 0.0 -0.186 3.0 3.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.026 -9999.0 0.0 -0.157 1.0 1.0 DLG1 -0.028 0.139 -9999.0 0.0 -0.312 30.0 30.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.022 0.033 -9999.0 0.0 -0.123 11.0 11.0 MLLT4 0.025 0.026 -9999.0 0.0 -0.294 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.038 0.049 -9999.0 0.0 -0.156 9.0 9.0 PI3K -0.025 0.044 -9999.0 0.0 -0.155 11.0 11.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.016 0.085 -9999.0 0.0 -0.206 20.0 20.0 TIAM1 0.009 0.073 -9999.0 0.0 -0.294 9.0 9.0 E-cadherin(dimer)/Ca2+ 0.044 0.07 -9999.0 0.0 -0.152 16.0 16.0 AKT1 -0.005 0.044 0.113 4.0 -9999.0 0.0 4.0 PIK3R1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.013 0.093 -9999.0 0.0 -0.294 16.0 16.0 RhoA/GDP 0.009 0.103 0.248 6.0 -0.224 11.0 17.0 actin cytoskeleton organization -0.001 0.074 0.175 9.0 -0.151 10.0 19.0 CDC42/GDP 0.006 0.1 0.238 5.0 -0.225 11.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.0 0.068 -9999.0 0.0 -0.176 20.0 20.0 ITGB7 0.02 0.043 -9999.0 0.0 -0.294 3.0 3.0 RAC1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.048 0.075 -9999.0 0.0 -0.163 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.062 -9999.0 0.0 -0.147 16.0 16.0 mol:GDP -0.005 0.108 0.252 6.0 -0.253 11.0 17.0 CDC42/GTP/IQGAP1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.02 0.049 -9999.0 0.0 -0.294 4.0 4.0 p120 catenin/RhoA/GDP 0.014 0.106 0.242 5.0 -0.23 11.0 16.0 RAC1/GTP/IQGAP1 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.064 0.162 3.0 -0.143 21.0 24.0 NME1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.132 -9999.0 0.0 -0.308 27.0 27.0 regulation of cell-cell adhesion -0.016 0.043 -9999.0 0.0 -0.139 11.0 11.0 WASF2 -0.007 0.038 0.093 6.0 -0.097 2.0 8.0 Rap1/GTP 0.01 0.065 0.165 5.0 -0.176 1.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.087 -9999.0 0.0 -0.154 22.0 22.0 CCND1 -0.012 0.077 0.164 4.0 -0.176 21.0 25.0 VAV2 -0.028 0.168 -9999.0 0.0 -0.553 6.0 6.0 RAP1/GDP 0.013 0.081 0.259 3.0 -0.181 11.0 14.0 adherens junction assembly -0.02 0.128 -9999.0 0.0 -0.307 25.0 25.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.032 0.079 0.185 2.0 -0.153 21.0 23.0 E-cadherin/beta catenin -0.006 0.083 -9999.0 0.0 -0.267 14.0 14.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.028 0.137 -9999.0 0.0 -0.315 28.0 28.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.048 0.101 -9999.0 0.0 -0.313 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.036 0.073 -9999.0 0.0 -0.176 16.0 16.0 ITGAE 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.147 -9999.0 0.0 -0.321 31.0 31.0