Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.063 -9999.0 0.0 -0.175 16.0 16.0 epithelial cell differentiation 0.039 0.067 -9999.0 0.0 -0.151 16.0 16.0 CYFIP2 0.006 0.076 -9999.0 0.0 -0.294 10.0 10.0 ENAH -0.019 0.057 0.159 3.0 -9999.0 0.0 3.0 EGFR 0.008 0.073 -9999.0 0.0 -0.294 9.0 9.0 EPHA2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.011 0.063 0.191 3.0 -9999.0 0.0 3.0 CTNNB1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.055 -9999.0 0.0 -0.176 9.0 9.0 AQP5 -0.027 0.129 0.237 2.0 -0.395 15.0 17.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.063 0.184 4.0 -9999.0 0.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.068 0.184 4.0 -9999.0 0.0 4.0 EGF -0.024 0.109 -9999.0 0.0 -0.294 23.0 23.0 NCKAP1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.008 0.08 0.271 1.0 -0.321 6.0 7.0 cortical microtubule organization 0.039 0.067 -9999.0 0.0 -0.151 16.0 16.0 GO:0000145 -0.012 0.056 0.17 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.044 0.07 -9999.0 0.0 -0.152 16.0 16.0 MLLT4 0.025 0.026 -9999.0 0.0 -0.294 1.0 1.0 ARF6/GDP -0.034 0.041 -9999.0 0.0 -0.15 15.0 15.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.064 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.065 0.182 3.0 -0.23 2.0 5.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.064 0.186 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.068 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.013 0.093 -9999.0 0.0 -0.294 16.0 16.0 EGFR/EGFR/EGF/EGF -0.003 0.088 -9999.0 0.0 -0.161 33.0 33.0 RhoA/GDP 0.039 0.066 -9999.0 0.0 -0.147 16.0 16.0 actin cytoskeleton organization -0.016 0.059 0.174 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer 0.018 0.05 -9999.0 0.0 -0.294 4.0 4.0 GIT1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.018 0.05 -9999.0 0.0 -0.294 4.0 4.0 IGF1 0.004 0.08 -9999.0 0.0 -0.294 11.0 11.0 DIAPH1 0.002 0.175 -9999.0 0.0 -0.52 16.0 16.0 Wnt receptor signaling pathway -0.039 0.067 0.151 16.0 -9999.0 0.0 16.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.041 -9999.0 0.0 -0.151 15.0 15.0 CTNNA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.06 0.176 3.0 -0.157 16.0 19.0 EFNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.019 0.07 0.179 3.0 -0.264 2.0 5.0 Ephrin A1/EPHA2 0.027 0.062 -9999.0 0.0 -0.149 15.0 15.0 SEC6/SEC8 -0.024 0.041 -9999.0 0.0 -0.151 11.0 11.0 MGAT3 -0.016 0.069 0.186 4.0 -9999.0 0.0 4.0 HGF/MET 0.017 0.075 -9999.0 0.0 -0.156 21.0 21.0 HGF 0.009 0.069 -9999.0 0.0 -0.294 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.063 -9999.0 0.0 -0.176 16.0 16.0 actin cable formation -0.004 0.084 0.258 4.0 -0.284 2.0 6.0 KIAA1543 -0.013 0.061 0.171 4.0 -9999.0 0.0 4.0 KIFC3 -0.012 0.065 0.186 4.0 -9999.0 0.0 4.0 NCK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.015 0.071 0.191 3.0 -0.271 2.0 5.0 NCK1/GIT1 0.041 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.039 0.067 -9999.0 0.0 -0.151 16.0 16.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.01 0.064 0.186 4.0 -9999.0 0.0 4.0 PIP5K1C -0.009 0.063 0.186 4.0 -9999.0 0.0 4.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.075 0.243 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.017 0.083 0.229 1.0 -0.275 5.0 6.0 IGF-1R heterotetramer/IGF1 0.015 0.078 -9999.0 0.0 -0.156 23.0 23.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.023 -9999.0 0.0 -0.206 1.0 1.0 MET 0.016 0.055 -9999.0 0.0 -0.294 5.0 5.0 PLEKHA7 -0.012 0.066 0.186 4.0 -9999.0 0.0 4.0 mol:GTP 0.061 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.013 0.102 0.29 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.008 0.063 -9999.0 0.0 -0.175 16.0 16.0 regulation of cell-cell adhesion -0.016 0.059 0.174 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.063 -9999.0 0.0 -0.176 16.0 16.0