Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.2 -9999.0 0.0 -0.551 31.0 31.0 IHH -0.003 0.058 -9999.0 0.0 -0.268 6.0 6.0 SHH Np/Cholesterol/GAS1 0.003 0.058 -9999.0 0.0 -0.197 22.0 22.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.058 0.195 22.0 -9999.0 0.0 22.0 SMO/beta Arrestin2 -0.034 0.153 -9999.0 0.0 -0.456 20.0 20.0 SMO -0.042 0.16 -9999.0 0.0 -0.484 20.0 20.0 AKT1 -0.005 0.087 -9999.0 0.0 -0.344 4.0 4.0 ARRB2 0.013 0.019 -9999.0 0.0 -0.324 1.0 1.0 BOC -0.014 0.104 -9999.0 0.0 -0.39 21.0 21.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.041 0.158 -9999.0 0.0 -0.477 20.0 20.0 STIL -0.011 0.111 -9999.0 0.0 -0.368 15.0 15.0 DHH N/PTCH2 -0.027 0.107 -9999.0 0.0 -0.254 53.0 53.0 DHH N/PTCH1 -0.039 0.15 -9999.0 0.0 -0.372 32.0 32.0 PIK3CA 0.007 0.056 -9999.0 0.0 -0.425 5.0 5.0 DHH -0.042 0.136 -9999.0 0.0 -0.363 45.0 45.0 PTHLH -0.059 0.26 -9999.0 0.0 -0.749 31.0 31.0 determination of left/right symmetry -0.041 0.158 -9999.0 0.0 -0.477 20.0 20.0 PIK3R1 0.011 0.038 -9999.0 0.0 -0.45 2.0 2.0 skeletal system development -0.058 0.257 -9999.0 0.0 -0.74 31.0 31.0 IHH N/Hhip -0.006 0.069 -9999.0 0.0 -0.25 19.0 19.0 DHH N/Hhip -0.035 0.11 -9999.0 0.0 -0.251 59.0 59.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.041 0.158 -9999.0 0.0 -0.477 20.0 20.0 pancreas development -0.01 0.079 -9999.0 0.0 -0.323 18.0 18.0 HHAT 0.007 0.059 -9999.0 0.0 -0.45 5.0 5.0 PI3K 0.014 0.053 -9999.0 0.0 -0.341 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.005 0.062 -9999.0 0.0 -0.429 6.0 6.0 somite specification -0.041 0.158 -9999.0 0.0 -0.477 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.016 0.116 -9999.0 0.0 -0.392 15.0 15.0 SHH Np/Cholesterol/PTCH2 0.001 0.059 -9999.0 0.0 -0.187 26.0 26.0 SHH Np/Cholesterol/Megalin -0.111 0.121 -9999.0 0.0 -0.212 155.0 155.0 SHH -0.002 0.06 -9999.0 0.0 -0.244 17.0 17.0 catabolic process -0.019 0.137 -9999.0 0.0 -0.383 27.0 27.0 SMO/Vitamin D3 -0.028 0.134 -9999.0 0.0 -0.419 20.0 20.0 SHH Np/Cholesterol/Hhip -0.006 0.065 -9999.0 0.0 -0.188 31.0 31.0 LRP2 -0.208 0.205 -9999.0 0.0 -0.387 167.0 167.0 receptor-mediated endocytosis -0.102 0.16 -9999.0 0.0 -0.466 30.0 30.0 SHH Np/Cholesterol/BOC -0.008 0.073 -9999.0 0.0 -0.193 37.0 37.0 SHH Np/Cholesterol/CDO 0.004 0.053 -9999.0 0.0 -0.235 9.0 9.0 mesenchymal cell differentiation 0.006 0.065 0.187 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.014 0.118 -9999.0 0.0 -0.393 15.0 15.0 IHH N/PTCH2 0.003 0.063 -9999.0 0.0 -0.283 11.0 11.0 CDON 0.008 0.053 -9999.0 0.0 -0.45 4.0 4.0 IHH N/PTCH1 -0.017 0.139 -9999.0 0.0 -0.385 27.0 27.0 Megalin/LRPAP1 -0.136 0.146 -9999.0 0.0 -0.263 167.0 167.0 PTCH2 0.001 0.07 -9999.0 0.0 -0.374 10.0 10.0 SHH Np/Cholesterol -0.0 0.046 -9999.0 0.0 -0.182 17.0 17.0 PTCH1 -0.019 0.138 -9999.0 0.0 -0.384 27.0 27.0 HHIP -0.01 0.079 -9999.0 0.0 -0.324 18.0 18.0