Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.045 0.106 -9999.0 0.0 -0.206 88.0 88.0 epithelial cell differentiation -0.048 0.109 -9999.0 0.0 -0.208 88.0 88.0 CYFIP2 -0.015 0.111 -9999.0 0.0 -0.431 20.0 20.0 ENAH -0.016 0.091 -9999.0 0.0 -0.258 12.0 12.0 EGFR -0.031 0.124 -9999.0 0.0 -0.362 36.0 36.0 EPHA2 -0.001 0.077 -9999.0 0.0 -0.392 11.0 11.0 MYO6 -0.048 0.109 -9999.0 0.0 -0.2 94.0 94.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.011 0.068 -9999.0 0.0 -0.242 20.0 20.0 AQP5 -0.043 0.095 -9999.0 0.0 -0.255 11.0 11.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.041 0.102 -9999.0 0.0 -0.191 88.0 88.0 regulation of calcium-dependent cell-cell adhesion -0.056 0.114 -9999.0 0.0 -0.208 95.0 95.0 EGF -0.098 0.19 -9999.0 0.0 -0.413 79.0 79.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.058 0.15 -9999.0 0.0 -0.498 20.0 20.0 cortical microtubule organization -0.048 0.109 -9999.0 0.0 -0.208 88.0 88.0 GO:0000145 -0.04 0.097 -9999.0 0.0 -0.183 88.0 88.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.046 0.112 -9999.0 0.0 -0.21 88.0 88.0 MLLT4 0.009 0.05 -9999.0 0.0 -0.418 4.0 4.0 ARF6/GDP -0.054 0.075 -9999.0 0.0 -0.293 5.0 5.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.045 -9999.0 0.0 -0.224 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.032 0.099 -9999.0 0.0 -0.238 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.043 0.105 -9999.0 0.0 -0.197 88.0 88.0 ARF6/GTP 0.032 0.042 -9999.0 0.0 -0.202 7.0 7.0 CDH1 -0.139 0.213 -9999.0 0.0 -0.43 104.0 104.0 EGFR/EGFR/EGF/EGF -0.123 0.145 -9999.0 0.0 -0.392 50.0 50.0 RhoA/GDP -0.042 0.102 -9999.0 0.0 -0.192 88.0 88.0 actin cytoskeleton organization -0.042 0.107 -9999.0 0.0 -0.361 3.0 3.0 IGF-1R heterotetramer 0.01 0.042 -9999.0 0.0 -0.407 3.0 3.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.042 -9999.0 0.0 -0.408 3.0 3.0 IGF1 -0.023 0.123 -9999.0 0.0 -0.421 26.0 26.0 DIAPH1 -0.027 0.137 -9999.0 0.0 -0.585 17.0 17.0 Wnt receptor signaling pathway 0.048 0.109 0.208 88.0 -9999.0 0.0 88.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.076 -9999.0 0.0 -0.294 5.0 5.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.043 0.108 -9999.0 0.0 -0.37 3.0 3.0 EFNA1 0.013 0.027 -9999.0 0.0 -0.45 1.0 1.0 LPP -0.037 0.1 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.066 0.09 -9999.0 0.0 -0.338 5.0 5.0 SEC6/SEC8 -0.055 0.074 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.056 0.116 -9999.0 0.0 -0.211 95.0 95.0 HGF/MET -0.103 0.129 -9999.0 0.0 -0.373 37.0 37.0 HGF -0.025 0.118 -9999.0 0.0 -0.368 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.045 0.106 -9999.0 0.0 -0.207 88.0 88.0 actin cable formation -0.003 0.088 -9999.0 0.0 -0.239 6.0 6.0 KIAA1543 -0.082 0.131 -9999.0 0.0 -0.353 29.0 29.0 KIFC3 -0.042 0.104 -9999.0 0.0 -0.194 89.0 89.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.019 -9999.0 0.0 -0.324 1.0 1.0 ACTN1 -0.045 0.105 -9999.0 0.0 -0.194 92.0 92.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.048 0.109 -9999.0 0.0 -0.208 88.0 88.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.042 0.103 -9999.0 0.0 -0.194 88.0 88.0 PIP5K1C -0.042 0.103 -9999.0 0.0 -0.194 88.0 88.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.019 0.091 -9999.0 0.0 -0.258 5.0 5.0 adherens junction assembly -0.063 0.126 -9999.0 0.0 -0.329 26.0 26.0 IGF-1R heterotetramer/IGF1 -0.076 0.101 -9999.0 0.0 -0.368 11.0 11.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.036 -9999.0 0.0 -0.287 4.0 4.0 MET -0.055 0.159 -9999.0 0.0 -0.414 49.0 49.0 PLEKHA7 -0.054 0.117 -9999.0 0.0 -0.211 97.0 97.0 mol:GTP 0.027 0.045 -9999.0 0.0 -0.223 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.019 0.094 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.045 0.106 -9999.0 0.0 -0.206 88.0 88.0 regulation of cell-cell adhesion -0.042 0.107 -9999.0 0.0 -0.361 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.045 0.106 -9999.0 0.0 -0.207 88.0 88.0