E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.098 0.186 0.231 1.0 -0.37 91.0 92.0 KLHL20 -0.03 0.094 0.175 5.0 -0.225 24.0 29.0 CYFIP2 0.014 0.072 0.124 3.0 -0.331 12.0 15.0 Rac1/GDP -0.046 0.118 0.219 2.0 -0.233 67.0 69.0 ENAH -0.092 0.183 0.225 1.0 -0.378 81.0 82.0 AP1M1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.082 0.14 1.0 -0.159 61.0 62.0 ABI1/Sra1/Nap1 -0.04 0.054 -9999.0 0.0 -0.15 29.0 29.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.119 -9999.0 0.0 -0.184 90.0 90.0 RAPGEF1 -0.078 0.164 0.221 3.0 -0.344 73.0 76.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.095 0.195 -9999.0 0.0 -0.376 95.0 95.0 CRK -0.087 0.174 0.217 1.0 -0.354 83.0 84.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.116 -9999.0 0.0 -0.199 81.0 81.0 alphaE/beta7 Integrin 0.029 0.056 -9999.0 0.0 -0.227 13.0 13.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.03 -9999.0 0.0 -0.168 3.0 3.0 DLG1 -0.098 0.186 -9999.0 0.0 -0.369 93.0 93.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.048 -9999.0 0.0 -0.126 62.0 62.0 MLLT4 0.022 0.037 -9999.0 0.0 -0.331 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.042 0.05 -9999.0 0.0 -0.174 14.0 14.0 PI3K -0.036 0.071 -9999.0 0.0 -0.158 58.0 58.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.032 0.128 -9999.0 0.0 -0.235 82.0 82.0 TIAM1 0.011 0.076 -9999.0 0.0 -0.331 14.0 14.0 E-cadherin(dimer)/Ca2+ -0.0 0.105 -9999.0 0.0 -0.167 81.0 81.0 AKT1 -0.025 0.049 0.127 3.0 -0.138 3.0 6.0 PIK3R1 0.025 0.03 -9999.0 0.0 -0.331 2.0 2.0 CDH1 -0.067 0.164 -9999.0 0.0 -0.331 82.0 82.0 RhoA/GDP -0.043 0.127 0.274 3.0 -0.233 70.0 73.0 actin cytoskeleton organization -0.021 0.072 0.141 7.0 -0.164 24.0 31.0 CDC42/GDP -0.045 0.126 0.274 3.0 -0.233 70.0 73.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.039 0.097 -9999.0 0.0 -0.193 83.0 83.0 ITGB7 0.014 0.075 0.124 4.0 -0.331 13.0 17.0 RAC1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.0 0.112 -9999.0 0.0 -0.179 81.0 81.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.009 0.096 -9999.0 0.0 -0.163 81.0 81.0 mol:GDP -0.062 0.134 0.259 4.0 -0.264 71.0 75.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.033 0.124 7.0 -0.331 2.0 9.0 p120 catenin/RhoA/GDP -0.038 0.13 0.241 3.0 -0.239 68.0 71.0 RAC1/GTP/IQGAP1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.056 0.127 8.0 -0.118 24.0 32.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.101 0.187 -9999.0 0.0 -0.371 94.0 94.0 regulation of cell-cell adhesion -0.026 0.067 -9999.0 0.0 -0.142 61.0 61.0 WASF2 -0.014 0.04 0.091 3.0 -0.11 3.0 6.0 Rap1/GTP -0.021 0.094 0.189 11.0 -0.173 62.0 73.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.0 0.122 -9999.0 0.0 -0.178 88.0 88.0 CCND1 -0.015 0.066 0.145 8.0 -0.144 24.0 32.0 VAV2 -0.119 0.247 0.359 1.0 -0.664 28.0 29.0 RAP1/GDP -0.026 0.107 0.247 4.0 -0.191 66.0 70.0 adherens junction assembly -0.098 0.182 -9999.0 0.0 -0.36 94.0 94.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.011 0.112 0.246 1.0 -0.174 87.0 88.0 E-cadherin/beta catenin -0.066 0.131 -9999.0 0.0 -0.282 80.0 80.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.094 0.182 0.225 1.0 -0.369 86.0 87.0 PIK3CA 0.023 0.042 -9999.0 0.0 -0.331 4.0 4.0 Rac1/GTP -0.074 0.128 -9999.0 0.0 -0.362 26.0 26.0 E-cadherin/beta catenin/alpha catenin -0.013 0.113 -9999.0 0.0 -0.195 81.0 81.0 ITGAE 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.098 0.199 -9999.0 0.0 -0.384 95.0 95.0