Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.124 -9999.0 0.0 -0.453 17.0 17.0 IHH 0.031 0.051 0.141 4.0 -0.131 22.0 26.0 SHH Np/Cholesterol/GAS1 0.017 0.028 -9999.0 0.0 -0.175 5.0 5.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.016 0.028 0.174 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 0.006 0.132 -9999.0 0.0 -0.36 17.0 17.0 SMO -0.015 0.122 -9999.0 0.0 -0.377 18.0 18.0 AKT1 -0.0 0.102 -9999.0 0.0 -0.402 10.0 10.0 ARRB2 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.071 -9999.0 0.0 -0.331 11.0 11.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.121 -9999.0 0.0 -0.372 18.0 18.0 STIL 0.018 0.09 0.187 33.0 -0.263 14.0 47.0 DHH N/PTCH2 0.034 0.07 0.18 2.0 -0.231 17.0 19.0 DHH N/PTCH1 0.021 0.112 -9999.0 0.0 -0.33 21.0 21.0 PIK3CA 0.023 0.042 -9999.0 0.0 -0.331 4.0 4.0 DHH 0.022 0.081 -9999.0 0.0 -0.331 13.0 13.0 PTHLH -0.006 0.183 -9999.0 0.0 -0.64 20.0 20.0 determination of left/right symmetry -0.015 0.121 -9999.0 0.0 -0.372 18.0 18.0 PIK3R1 0.025 0.03 -9999.0 0.0 -0.331 2.0 2.0 skeletal system development -0.006 0.181 -9999.0 0.0 -0.634 20.0 20.0 IHH N/Hhip 0.043 0.041 0.181 1.0 -9999.0 0.0 1.0 DHH N/Hhip 0.038 0.065 0.18 4.0 -0.232 13.0 17.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.121 -9999.0 0.0 -0.372 18.0 18.0 pancreas development 0.031 0.024 0.123 18.0 -9999.0 0.0 18.0 HHAT 0.02 0.047 -9999.0 0.0 -0.331 5.0 5.0 PI3K 0.035 0.042 -9999.0 0.0 -0.269 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.037 0.124 1.0 -0.331 3.0 4.0 somite specification -0.015 0.121 -9999.0 0.0 -0.372 18.0 18.0 SHH Np/Cholesterol/PTCH1 0.009 0.074 -9999.0 0.0 -0.256 17.0 17.0 SHH Np/Cholesterol/PTCH2 0.019 0.033 0.159 2.0 -0.178 6.0 8.0 SHH Np/Cholesterol/Megalin -0.007 0.105 0.194 11.0 -0.179 70.0 81.0 SHH -0.008 0.028 -9999.0 0.0 -0.234 3.0 3.0 catabolic process 0.011 0.104 -9999.0 0.0 -0.353 21.0 21.0 SMO/Vitamin D3 0.005 0.103 0.248 4.0 -0.303 18.0 22.0 SHH Np/Cholesterol/Hhip 0.016 0.036 0.159 6.0 -0.175 3.0 9.0 LRP2 -0.045 0.181 0.124 82.0 -0.331 82.0 164.0 receptor-mediated endocytosis -0.034 0.129 0.211 3.0 -0.376 21.0 24.0 SHH Np/Cholesterol/BOC 0.015 0.045 -9999.0 0.0 -0.192 11.0 11.0 SHH Np/Cholesterol/CDO 0.015 0.032 -9999.0 0.0 -0.177 7.0 7.0 mesenchymal cell differentiation -0.016 0.036 0.174 3.0 -0.157 6.0 9.0 mol:Vitamin D3 0.035 0.103 0.221 37.0 -0.258 17.0 54.0 IHH N/PTCH2 0.038 0.05 -9999.0 0.0 -0.251 4.0 4.0 CDON 0.021 0.042 -9999.0 0.0 -0.331 4.0 4.0 IHH N/PTCH1 0.021 0.11 -9999.0 0.0 -0.355 21.0 21.0 Megalin/LRPAP1 -0.017 0.135 -9999.0 0.0 -0.231 82.0 82.0 PTCH2 0.025 0.044 0.124 6.0 -0.331 4.0 10.0 SHH Np/Cholesterol 0.01 0.02 -9999.0 0.0 -0.174 3.0 3.0 PTCH1 0.011 0.104 -9999.0 0.0 -0.354 21.0 21.0 HHIP 0.031 0.024 0.124 18.0 -9999.0 0.0 18.0